Diabetes Mellitus Wound Research Articles

THE EFFECT OF SIGPROCARE HOCl 0.01% ON TIME MANAGEMENT OF DIABETIC MELLITUS WOUNDS IN BUKITTINGGI CITY IN 2024

Diabetes mellitus is a chronic disease cause by high leves of glucose in the blood, as well as accompanying metabolic disoders. One of the main factors causing diabetes mellitus wwounds is lifestyle, including the consumption of high-sugar foods. This research aims to determine the effect of using Sifprocare HOC1 0.01% on the wound healing proceess of diabeetes mellitus in Bukittinggi City. The method used was quantitative research with a Quasi-Ecperimental design and One Group Pretest-Posttest approach. The populastion in this research were all patients with indications of diabetes mellitus wounds in Bukittinggi City, and the research was conducted from February to June 2024. The research sample amounted to 10 respondents who were selected purposively. Data were analyzed univariately and bivariately using the BWAT (Bates-Jensen Wound Assessment Tool) obervation sheet and wound care SOP with Sigprocare HOC1 0.01%. The results of univariate analysis showed that the average diabetes mellitus wound score before Sigprocare HOC1 0.01% was 35.3, and after teatment the average dropped to 25.7. The result of biavariate analysis showed a significant effect of using Sigprocare HOC10.01% in the wound healing process of diabetes mellitus with a P value (0.000) < a (0.05). The implication of thi research shows that Sigprocare HOC1 0.01% is effective in helping in healing process of diabetes mellitus wounds, so it is hoped that repondents can apply its use and maintain wound hygiene to accelerate recovery.

ETS1 Expression in Diabetic Foot Ulcers: Implications for Fibroblast Phenotype and Wound Healing Through the PP2A/YAP Pathway.

Diabetic foot ulcers (DFUs) are a serious complication of diabetes, characterized by impaired wound healing and high morbidity and mortality risks. While ETS1 is known to influence fibroblast pathological remodeling, its specific role in DFU and fibroblast wound healing remains unclear. Skin tissue samples from DFU patients were categorized by Wagner grades to analyze ETS1 expression. Primary fibroblasts derived from diabetes mellitus wound (DMFBs) were collected from wound margins to test migration ability and analyze cell phenotype by immunofluorescence; they were further treated with siETS1 and the ETS1 inhibitor YK-4-279. Techniques including Western blotting, quantitative Real-Time PCR (qRT-PCR), and immunofluorescence were used to assess the expressionof ETS1, Collagen I, and phenotype in DMFBs. Additionally, the binding sites between human ETS1 and the PP2A promoter were predicted by the UCSC and JASPAR databases. It intended to explore the negative transcriptional regulation of PP2A by ETS1 and its implications in fibroblast function and wound healing. Fibroblasts derived from Wagner Grades II-IV exhibit differences in cell morphology, migratory ability, and phenotype. Our findings indicate a significant upregulation of ETS1 in Wagner III and IV. The downregulation of ETS1 was observed to enhance DMFB migration and increase the expression of Collagen I and α-SMA. These changes suggest a potential mechanism by which PP2A regulates the YAP/Hippo pathway in diabetic wound healing. ETS1 appears to impede the repair processes in DFUs, likely through the negative regulation of PP2A, affecting fibroblast function and wound healing.

Penerapan Joging untuk Menurunkan Kadar Gula Darah Puasa pada Penderita Diabetes Mellitus Tipe 2 di Keluarga Wilayah Puskesmas Sekaran Semarang

Diabetes Mellitus (DM) is a chronic metabolic disorder characterized by increased blood glucose (hyperglycemia). The aim of the case study is to describe the application of jogging to reduce fasting blood sugar levels in people with type 2 diabetes mellitus. The research used descriptive research with jogging carried out 3 times during 3 consecutive days for 30 minutes by checking fasting blood sugar before and after jogging. Researchers used 2 clients whose inclusion did not have dangerous diseases such as heart disease, kidney failure, asthma. Have a history of Type 2 Diabetes Mellitus for more than 2 years, age more than 45 years, no diabetes mellitus wounds on the legs, fasting blood sugar measurement results before the procedure 126mg/dl – 200mg/dl. Subject 1's results from measuring pre-test fasting blood sugar levels were 175 mg/dl and post-test results were 166 mg/dl. The results of subject 2 from measuring pre-test fasting blood sugar levels were 134 mg/dl, and the post-test results were 127 mg/dl, the results of both subjects experienced a significant decrease in fasting blood sugar levels. The results of this case study are the basis for further case studies, especially those related to jogging or other physical activities for people with type 2 diabetes mellitus.

Nitric oxide-based treatments improve wound healing associated with diabetes mellitus.

Non-healing wounds are long-term complications of diabetes mellitus (DM) that increase mortality risk and amputation-related disability and decrease the quality of life. Nitric oxide (NO·)-based treatments (i.e., use of both systemic and topical NO· donors, NO· precursors, and NO· inducers) have received more attention as complementary approaches in treatments of DM wounds. Here, we aimed to highlight the potential benefits of NO·-based treatments on DM wounds through a literature review of experimental and clinical evidence. Various topical NO·-based treatments have been used. In rodents, topical NO·-based therapy facilitates wound healing, manifested as an increased healing rate and a decreased half-closure time. The wound healing effect of NO·-based treatments is attributed to increasing local blood flow, angiogenesis induction, collagen synthesis and deposition, re-epithelization, anti-inflammatory and anti-oxidative properties, and potent broad-spectrum antibacterial effects. The existing literature lacks human clinical evidence on the safety and efficacy of NO·-based treatments for DM wounds. Translating experimental favors of NO·-based treatments of DM wounds into human clinical practice needs conducting clinical trials with well-predefined effect sizes, i.e., wound reduction area, rate of wound healing, and hospital length of stay.

PEMBERIAN PENYULUHAN DAN DEMONSTRASI PERAWATAN LUKA DIABETES MELITUS

One of the potential causes of the increasing prevalence of diabetes mellitus isinjury occurs. Uncontrolled wounds will become worse and hinder the healing process. The aim of providing counseling and demonstrations on diabetes mellitus wound care to families and Diabetes Mellitus sufferers is to increase knowledge and skills that can help families and Diabetes Mellitus sufferers to care for diabetes mellitus wounds and speed up the wound healing process. Method of providing wound care at the Scania care center with counseling and demonstration. Results Providing counseling and demonstrations on wound care for diabetes mellitus patients, patients and their families can care for wounds and speed up the healing process. Conclusion: Providing counseling and demonstrating correct wound care for Diabetes Mellitus patients can increase the knowledge and skills of families and patients in caring for wounds of Diabetes Mellitus patients. Kata Kunci: Perawatan Luka, Pasien Diabetes Melitus

Earthing Method as a Lifestyle Medicine to Accelerate the Healing of Chronic Diabetic Wounds

Diabetes mellitus (DM) type 2 is a non-communicable disease that causes death number 6 worldwide. Caused by resistance to insulin, accompanied by many complications, including neuropathy (peripheral nerve damage), diabetic ulcers, heart disease, kidney failure, hypertension, retinopathy (damage to the retina in the eyes), blindness, leg amputation, stroke, and death. Diabetic wounds do not heal because of microbial infections in the wounds, accompanied by high blood sugar levels. This study aims to analyze the effect of earthing/grounding on chronic diabetes wound healing. This research was conducted in June-December 2023 in Karanganyar Regency, Central Java. The population in this study were clients with type 2 diabetes mellitus. Earthing intervention was carried out for 1 hour every day for 30 days. The sample size was 21 respondents taken by the purposive sampling method. Statistical analysis shows a P value of 0.000<0.000 and a Z-score of -4.032. Shows the significant effect of earthing/grounding therapy on accelerating diabetes mellitus wound healing. It is highly recommended for clients with type 2 DM to apply earthing/grounding as part of Lifestyle Medicine, which is integrated into life habits to cure infections and speed up wound healing, thereby preventing amputations.

Anti-Inflammatory Effect of Channa micropeltes Extract in Angiogenesis of Diabetes Mellitus Wound Healing

OBJECTIVE: Channa micropeltes extract contains albumin and omega-6 which possess antioxidant and anti-inflammatory agents that can promote macrophages in the wound healing process associated with diabetes mellitus (DM). In this study, we analyzed Nuclear Factor kappa B (NF-κB) and Vascular Endothelial Growth Factor (VEGF) expression as well as neovascular cells in the inflammatory stage of DM wound healing. METHODS: The 24 males Rattus novergicus were divided into 3 groups that were 20% Channa micropeltes ointment (Group I), 10% Channa striata extract ointment (Group II), and placebo ointment as a control (Group III). Ointments were applied 3 times daily. RESULTS: The highest expression of NF-κB was observed in Group III on Day 4 (15.50 ± 2.38), and the lowest was in treatment of Group I and Group II on Day 8 (4.75 ± 0.96). The highest expression of VEGF was observed in Group I on Day 8 (14.75 ± 0.96), and the lowest was Group III on Day 4 (7.00 ± 1.41). The highest count of neovascular cells was observed in Group I on Day 8 (11.00 ± 2.16), and the lowest was in Group III on Day 4 (5.50 ± 0.58). CONCLUSIONS: Channa micropeltes has an anti-inflammatory effect by regulating NF-κB expression and elevating VEGF expression in the angiogenesis process of DM wound healing.

Literatur Review; Pengaruh Pemberian Olahan Ikan Gabus Terhadap Proses Penyembuhan Luka DM

Introduction: Diabetes mellitus wound is one of the complications where there is a wound that is experienced by people with diabetes mellitus with a long prognosis and poor control of blood sugar levels. This study aims to identify the effectiveness of snakehead fish gourd (Channa Striata) on wound healing of diabetes mellitus with a regular consumption range. Method: This study uses a Literature Review research method The systematic review searched six bases of electronic data (Google Scholar, Scopus, PubMed, Science Direct, CINAHL, and ProQuest) for previous studies using cross-sectional designs published between 2015-2020. Analysis: With various processed processes, snakehead fish tend to have benefits and ingredients in the wound healing process with a sustainable consumption period. Result: The results obtained 10 journals and articles that meet the inclusion and exclusion criteria according to the research topic. The results showed that snakehead fish with a high protein content has the potential not only to improve healing in diabetes mellitus wounds but also improve nutritional status and hypoalbumin improvement.Keywords: Fish Cork (Channa Striata); Diabetes Mellitus Wounds; Wound Healing; Albumin

The Effectiveness of Wound Book Diabetic Ulcer and Dressing on the Improvement of Modern Wound Care Knowledge in Professional Nurse Students of Universitas Muhammadiyah Purwokerto

Wound care has developed very rapidly, especially in the last two decades which has been supported by advance health technology. In addition, the current issue of wound care management is related to changes in patient profiles which are increasingly accompanied by degenerative disease conditions and metabolic disorders. These conditions usually require proper treatment so that the healing process can be optimal, such as diabetes mellitus wounds. Based on these problems, innovation is needed that can help students learn about modern wound dressing in a book entitled wound book. It is an innovation in the form of a book to learn about proper and correct diabetic wound management and therapies that can accelerate the healing process of diabetic wounds with modern dressings. This study aimed to analyze the effectiveness of diabetic ulcers and dressings on the improvement of modern wound care knowledge in nurse students at Universitas Muhammadiyah Purwokerto. This was quantitative research that employed a one-group pretest-posttest design. The test was carried out to determine the improvement of knowledge before and after the study. The data were analyzed using the paired-sample t- test formula, in which it involved 30 nurse student. The result of the expert test showed that both media and material were in a very appropriate category. Moreover, the average scores were 4,64 and 4.60, respectively. The result above indicated that the average value of respondents' knowledge before and after being given a wound book media was 65.00 12.03 and 88.17 7,007, respectively. Meanwhile, the results of bivariate analysis using the paired-sample t-test revealed that the significance value was 0.000 (p-value 0.005).

Surgical Site Infection in a Tertiary Care Teaching Hospital

Introduction: Surgical site infections [SSIs] are the Third most common nosocomial infections, According to the National Nosocomial Infections Surveillance, patients who are hospitalized account for 15 to 18 percent of all nosocomial infections .increased mortality and morbidity rates associated with Surgery.
 Surgical wounds are divided into four categories: clean, clean-contaminated, contaminated and dirty wounds.
 Materials and Methods: This was a retrospective study, done throughout for two years period, from June 2018 to May 2020 .785 patients underwent surgery in the Dept. of General Surgery in Saveetha Medical College and Hospital, Thandalam.
 Were taken as part of this study. Elective surgical procedures were performed on 495 patients. And 290 were taken to the hospital for emergency treatment. An in-depth examination of these cases was conducted, taking into account the date of admission, clinical features, history, types of surgery [emergency or elective], pre-operative preparation, drain used, and its type and postoperative findings.
 Results: Surgical Site Infections were found in 58 cases out of 785 surgeries. In elective clean and contaminated patients, the overall postoperative SSI rate is 4.34 percent of all cases, whereas emergency cases account for 12.41 percent. According to the research, that the most prevalent type of surgical site infection is superficial surgical site infection accounting for 72.1 percent of all SSIs in elective cases and 61.11 percent in emergency cases, and deep surgical site infection accounting for 23.25 percent of elective cases and 30.55 percent of emergency cases.
 Conclusion: The most common bacteria found in elective surgical wounds are E. coli. Proteus mirabilis is the most prevalent organism isolated from emergency surgical wounds. A shift in the pre-operative period antibiotics may even diminish the occurrence. Pre-existing medical conditions like diabetes mellitus wound type, operation time, emergency procedures, and wound contamination all had a significant impact on the development of surgical site infection.

Hospital Bed for Diabetes Care: An Invention to Support Professional and Hygienic Nursing Practice

Appropriate diabetes mellitus (DM) wound care requires safe and comfortable space and facilities for patients and nurses. However, the existing hospital bed for DM has not supported the safety and comfort for nurses to serve patients, including the problem of liquid waste and some DM wounds emit a foul smell. Therefore, a hospital bed for DM wound care was designed in this research to support professional, efficient, ergonomic, and safe nursing practice. Multidisciplinary collaboration by engineers, wound nursing practitioners, and industry is carried out in this project. The level of risk of work disturbances was evaluated using a rapid entire body assessment (REBA), the level of risk of contamination was evaluated by a qualitative exposure assessment, and the level of comfort was measured using the visual analog method. Trials on 30 respondents consisting of 28 nurses and 2 doctors indicated that they were comfortable working with the new design of this prototype with lower risk.

FAKTOR PENGHAMBAT PENYEMBUHAN LUKA DI RS MELATI PERBAUNGAN

Diabetes mellitus, a chronic metabolic disorder characterized by high blood sugar levels as a result of insulin insufficiency. This is due to a disruption in the definition of insulin production, the beta cells of the pancreas gland are due to the lack of responsiveness of the body's cells to insulin. Chronic wounds that are difficult to heal due to disruption of wound healing by systemic, local and other factors so that the wound does not heal with normal wound healing time. Chronic wounds occur because primary healing is delayed and repeated over a period of time. This research is a descriptive study, the aim of which is to look at "Factors That Inhibit The Healing Process Of Diabetes Mellitus Wounds At Melati Hospital. Perbaungan 2019, using a total sampling of 30 respondents, obtained results with old wound healing based on the majority age> 45 years as many as 25 people (83.3%), based on the majority gender based on female gender as many as 21 people (70%) The majority of treatment duration was based on length of treatment> 20 weeks as many as 20 people (66.6%), based on the majority of wound stages based on stage III-IV as many as 21 people (70%). Based on the results of the study, it is recommended that health workers provide information about the factors that hinder the healing process of diabetes mellitus wounds

Literatur Review: Efektivitas Madu untuk Mengobati Luka pada Pasien Diabetes Mellitus

Introduction: Diabetes mellitus is the level of glucose in the blood excess, which is caused by disruption of secretion or work of insulin hormone. Diabetics in Indonesia ranks fourth after India, China, United States. Diabetes mellitus lesions can be treated using honey, this supports the belief of the people of Indonesia about honey can cure all diseases. Method: Journal search is done electronically using database, they are: Google Scholar, Pubmed. Keywords used are honey / honey, wound / injury, and diabetes mellitus; there are 3 journals taken to create a review literature from 2010-2017. Objective: To prove the effectiveness of honey to treat patients with diabetes mellitus wound by analyzing 3 journals. Results: Honey therapy has a good effectiveness against wound healing diabetes mellitus. Discussion: The use of honey to treat wounds, effectively accelerate wound healing diabetes mellitus. Conclusion: Honey therapy effectively accelerates the healing of diabetes mellitus wounds.

Limberg Flap Method for Pilonidal Sinus Disease

Sacrococcygeal pilonidal sinus disease is a common chronic inflammation of the natal cleft and is mainly seen in young adults. Authors of some earlier works regarded the condition as congenital. Recently, it has become widely accepted that the condition is acquired, and thought to originate from hair follicles. Many treatment options has described in literature, thus in this study we present our results with Limberg flap reconstruction on pilonidal sinus disease. 38 patients underwent limberg flap reconstruction for pilonidal sinus disease enrolled in this study. No bleeding has occur intra and postoperatively, 2 patients developed urinary retention (%5.2), on 1 patient with diabetes mellitus wound dehiscence has developed which has treated with 3 week long simple debridement method (%2.6). 1 patient developed superficial infection treated with basic antibiotics (%2.6). No other complications has developed. No recurrence has seen in -mean -11.2 month period. We think limberg flap closure on pilonidal sinus disease is an effective and safe option.

Antibiotic-Resistant-Bacterial Infection of Diabetes Mellitus-Induced Ulcers: A Narrative Review on a Healing Ointment

Gangrene is the main reason why diabetes mellitus patient’s leg amputation should be done. Natural compounds which are contained in coffee grounds extract can actually act as antibacterial substances by inhibiting the growth of Methicillin-Resistant Staphylococcus aureus (MRSA) that resistant to several antibiotics. Coffee grounds become waste caused by people are underusing this material and the high production level of coffee grounds in Indonesia. The purpose of this study was to examine the content of antimicrobial compounds from coffee grounds that can heal wounds caused by diabetes mellitus and to create a formulation of coffee ground based ointment for diabetes mellitus wound healing. Methods used in this research are narrative review from literatures, normality test, and T-test. The conclusion of this narrative review, natural compounds such a trigonelline, caffeine, and chlorogenic acid found in coffee grounds are capable of MRSA growth inhibition at concentration 44%. Coffee grounds based ointment with 1% (w/w) of ointment preparation is expected to reduce coffee grounds waste by developing new product as diabetes mellitus wound healer.

Perawatan Luka Diabetes Mellitus Menggunakan Teknik Modern Dressing

Background: The most common complication in patients with diabetes mellitus tippe 2 (DM) is diabetic ulcers, where the tissue deformity occurs either partially (Partial Thickness) or completely (Full Thickness). If not handled properly and appropriately, ulcers can become infected. Where leg ulcers, infection, neuroarthropathy and peripheral artery disease are the causes of gangrene and lower limb amputations. The aim of this study is to determine the effectiveness of wound healing in the treatment of diabetes mellitus wounds using modern dressing techniques. Methods: the literature review (LR) method uses meta-analysis where the data used is a database of searches using MEDLINE (PubMed), Google Scholar, Science Direct, Surgery Science and Sci-Hub. Reports published from 2010-2020 that focused on modern wound care dressings for wound healing of type 2 diabetes mellitus were identified. Results: Based on the analysis of the journal, there are nursing implications that have been compared from 10 journals, it was found that the treatment of type two diabetes mellitus wounds using modern dressing techniques is more effective in wound healing, by accelerating granulation and healing of the various types of dressings used, each of which has advantages. in terms of wound healing type 2 diabetes mellitus. Conclusion: The use of modern dressing techniques is effective in wound healing in the treatment of type 2 diabetes mellitus wounds. Researchers suggest that they be able to conduct research related to modern wound care dressings such as the use of alginate dressings, foam dressings, hydrogel dressings, moisture dressings, silver dressings, hydrophilic polyurethane foam dressings, acellular matrix dressings, and others related to wound care using modern dressing techniques. . Further research needs to be done by paying attention to the latest evidence-based practice journals to enrich knowledge about wound care with modern dressing techniques for diabetes mellitus wounds.

A Narrative Review on Modern Wound Dressing for Diabetes Mellitus Wound

Introduction: Diabetic foot is a wide-ranging term for foot disorders includes infection, ulceration, or destruction of deep tissue due to peripheral neuropathy and ischemia from peripheral vascular disease. Wound dressings play a significant part in the treatment of diabetic foot ulcer (DFU). Modern wound dressing which is commonly known as the moist wound dressing can be better optional than the conservative one for the DFU. Aim: This study aimed to review the available articles on modern wound dressing for diabetes mellitus wound. Method: A total of six articles were reviewed and explained under the findings and discussion part of this study. The published articles from the year 2008 onwards are included in this narrative review. Result: Overall, it is evident that using of modern wound dressing can make sure excellent wound surroundings, avoid complications, improvement of quality of life of patients and aid the healing of DFU providing that the patient’s glycemic level is controlled. Conclusion: The process of wound healing in DFU is not static and it requires an appropriate environment at each stage of the healing process. And also a reasonable approach to the selection of dressing for certain types of wounds should be clarified. However, further study needs to be carried out to prove the current finding.

Effect of photobiomodulation on CCC-ESF reactive oxygen species steady-state in high glucose mediums.

Delayed wound healing is one of the most challenging complications of diabetes mellitus (DM) in clinical medicine, and it is related to the excessive generation of reactive oxygen species (ROS). Photobiomodulation (PBM) can promote wound healing in many ways, so it can be used as a method for the treatment of delayed healing of DM wounds. In this study, we investigated the effect of PBM on ROS homeostasis in human embryonic skin fibroblast cells (CCC-ESFs) cultured in high glucose concentrations. The CCC-ESFs were cultured in vitro and divided into two groups, including the control group and the 635 nm laser irradiation group. After 2 days of high glucose treatment, the experimental group was irradiated with different doses of laser for 3 days. First, we measured the cellular proliferation, and the results showed that laser irradiation could promote cellular proliferation. Then, we measured the generation of ROS, the activities of total superoxide dismutase (SOD), and total antioxidant capacity (TAC) of the cells; the results showed that high glucose destroyed cells by inducing high concentration of ROS, the balance of oxidation, and antioxidation cause oxidative stress damage to cells. PBM can increase the antioxidant capacity of cells, reducing the high concentration of ROS induced by high glucose. Finally, we measured the levels of mitochondrial membrane potential (∆ψm) and the secretion of nuclear factor kappa-B (NF-κB), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β); the results showed that PBM can reduce apoptosis and regulate the inflammatory state. We conclude that PBM can maintain the ROS homeostasis, increase the TAC of cells, and trigger the cellular proliferation, and the response of CCC-ESFs to PBM was dose-dependent.

Clinical Analysis of Channa micropeltes for Treating Wound of Diabetes Mellitus

Abstract: Toman fish contains albumin and omega-6 fatty acid that are instrumental in the healing process of diabetes mellitus (DM) wound. People with DM usually have a prolonged wound healing process. Albumin controls the osmotic pressure, the development of granulation tissue, gives the energy to re-epithelialisation process and collagen base material. Omega-6 fatty acid interrupts phagocytosis induced by neutrophil cells. It increases the action of machropage cell, so that Toman fish can be used as an alternative in accelerating the DM wound healing process. The purpose of this research is to prove the effect of Toman fish extract at 16 mL/ KgBW rat dosage per oral on wound length and contraction on the back of wistar rat (Rattus novergiucs) with DM for 14 days. It was the experimental with a posttest only with control group design used 12 wistar rat that were divided into 3 groups; the group of Toman fish extract with dose 16 mL/ Kg BW rat, positive control group using Haruan extract with dose 13,54 mL/ Kg BW rat and negative control group using Comfeed BR2 feed. One-way ANOVA test result for wound length and contraction (p= 0,000). The result Post-hoc Least Significant Difference test for wound length and contraction shows that there are significant differences between the group of Toman fish extract and Haruan fish extract (p= 0,000). There is also significant difference between the group of Toman fish extract and Comfeed BR2 feed (p= 0,000). There is no significant difference between the group of Haruan fish extract and Comfeed BR2 feed (p= 0,930). The research concluded that Toman fish extract at 16 mL/ Kg BW rat dosage affects the length and contraction of diabetic mellitus wound. Keywords: Channa micropeltes, clinical analysis, diabetes mellitus, wound

Polyethylene‐glycol chitosan hydrogel accelerates traumatic wound healing in diabetic mice

Wounds are considered a public health problem worldwide; it represents a significant economic impact on health systems. Diabetic lesions, microvascular dysfunction, trauma and burns, are some factors related to poor repair. Nowadays in regenerative medicine, biocompatible biomaterials (e.g., hydrogels) have proven been effective in regenerative processes. Therefore, preformed synthetic matrices could be a therapeutic alternative to accelerate wound repair.Objectiveto evaluate the Polyethylene‐glycol chitosan hydrogel (hg‐PEGDA‐Q) effect on traumatic wounds. Two CD1 mice (10 weeks, n = 5) were used: healthy control (CT) and with alloxan‐induced Diabetes Mellitus (DM) (200 mg / kg). Under anaesthesia, two traumatic dorsal wounds separated by 1 cm (diameter (⌀) 5 mm, area 19.63mm2) were caused to each mouse: a) without treatment (WT) (proximal wound) and b) with hydrogel PEGDA‐Q (⌀ 5 mm, thickness 2 mm, distal wound). The macro and microscopic evolution were evaluated on 12 postoperative day. For analyse the macroscopic images were rescaled through a vernier and ImageJ software (1: 1 mm scale). hg‐PEGDA‐Q matrix was synthesized by sequential method and photopolymerization.Resultsin CT group, hg‐PEGDA‐Q decreased the diameter and area with respect to untreated wound (hg‐PEGDA‐Q vs. WT) (⌀ 2.71 ± 0.64 mm vs. 3.71 ± 0.27 mm; area 5.79 ± 1.67 mm2 vs. 9.23 ± 1.97 mm2). In DM group, the same behaviour was observed with hydrogel (DM hg‐PEGDA vs. DM‐WT) (⌀ 3.04 ± 0.64 mm vs. 3.90 ± 0.29mm; area 6.29 ± 2.35 mm2 vs. 12.01 ± 3.66 mm2). Regarding initial diameter (5 mm, day 0), in control group, wound retraction (WR) was (hg‐PEGDA‐Q 45% vs. WT 25%), while in diabetic group WR was (hg‐PEGDA‐Q 39% vs. WT 21%). Comparing the initial area (19.63 mm2 at day 0), in control group the WR was (hg‐PEGDA‐Q 70% vs. WT 52%), while in DM group the WR was (hg‐PEGDA‐Q 67 % vs. WT 38%). Histomorphological analysis: hg‐PEGDA‐Q generated complete reepithelialization and dermo‐epidermal changes suggesting an advanced wound healing process compared to control group without treatment. DM group treated with hg‐PEGDA‐Q changes were similar, however consolidation was lower. In contrast DM WT group, reepithelialization and wound consolidation were deficient. Results indicate PEGDA‐Q hydrogel scaffolding network could be a therapeutic alternative to accelerate healing processes in normal and diabetic conditions