Objective: This study aimed to investigate the effectiveness of cognitive behavioral stress management (CBSM) on health-related quality of life (HRQOL), self-efficacy of diabetes management, and adherence to treatment of patients with type 2 diabetes.
 Materials and Methods: The present study was a semi-experimental study with a control group. The research samples included 30 patients with type 2 diabetes. Data collection tools in this study included the Boyer & Earp quality of life (QOL) scale for patients with diabetes (D-39), the diabetes management self-efficacy scale (DMSES), and treatment adherence questionnaire in patients with chronic diseases. The CBSM therapy was performed in 8 sessions for the experimental group. To analyze the data, a univariate analysis of covariance was used with SPSS-23 software.
 Results: The results showed that the CBSM had a significant effect on the overall health-based QOL (F=8.620; P=0.007), diabetes management self-efficacy (F=12.021; P=0.002), and treatment adherence (F=83.253; P=0.0001). In addition, the CBSM has a significant effect on diabetes control (F=8.932; P=0.007), anxiety and worry (F=5.023; P=0.035), and sexual functioning (F=7.611; P=0.011), diet (F=10.041; P=0.004), therapeutic regimen (F=24.250; P=0.0001), making effort for treatment (F=22.987; P=0.0001), intention to take the treatment (F=108.001; P=0.0001), adaptability (F=28.704; P=0.0001), and integrating illness into life (F=38.263; P=0.0001).
 Conclusion: The CBSM intervention can be used to improve health-based QOL, diabetes management self-efficacy, and treatment adherence in type 2 diabetes patients.
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