Diabetes In Chinese Population Research Articles

A genetic variation in the fat mass‐ and obesity‐associated gene is associated with obesity and newly diagnosed type 2 diabetes in a Chinese population

Recently, a genome-wide association study identified a strong association between the fat mass- and obesity-associated rs9939609 single nucleotide polymorphism (SNP) and the risk of obesity in European population. However, the results in Chinese population were reported to be contradictory. Therefore, our aim was to examine whether this SNP is associated with obesity and newly diagnosed type 2 diabetes (T2D) in Chinese population. We genotyped rs9939609 in 2587 subjects [obesity 243, overweight 976, normal weight 1368 or newly diagnosed T2D 877, impaired glucose regulation 305, normal glucose tolerance (NGT) 1405] using an allelic discrimination assay-by-design TaqMan method on ABI7900HT. We analysed associations of the rs9939609 SNP with obesity and newly diagnosed T2D through Logistic regression analysis. In obesity case-control study, we found that the A allele was strongly associated with obesity and overweight. The odds ratios for the allele A versus T were 1.447 for Obesity versus normal weight (95% CI 1.104-1.896, p = 0.007) and 1.363 for Overweight versus normal weight (95% CI 1.149-1.617, p < 0.0001). In T2D case-control study, the odds ratios for the allele A versus T were 1.305 for T2D versus NGT (95% CI 1.097-1.552, p = 0.003) and 1.280 for combined T2D and impaired glucose regulation (IGR) versus NGT (95% CI 1.089-1.503, p = 0.003). The associations of the A allele with T2D and combined T2D and IGR remained significant with adjustment for age, sex and body mass index (BMI). The fat mass- and obesity-associated gene rs9939609 SNP is strongly associated with risk of obesity and newly diagnosed T2D in the Chinese population.

Glycated haemoglobin A1c for diagnosing diabetes in Chinese population: cross sectional epidemiological survey

Objectives To evaluate haemoglobin A1c (HbA1c) in diagnosing diabetes and identify the optimal HbA1c threshold to be used in Chinese adults.Design Multistage stratified cross sectional epidemiological survey.Setting Shanghai, China, 2007-8.Participants...

Low plasma adiponectin level, white blood cell count and Helicobacter pylori titre independently predict abnormal pancreatic β-cell function

Adiponectin is an adipocytokine with insulin sensitizing effect while chronic inflammation damages pancreatic β-cells leading to reduced insulin response. We aimed to prove the hypothesis that adiponectin levels and inflammatory markers (white blood cell counts [WCC], Helicobacter pylori [HP] titers, high sensitivity C-reactive protein [hs-CRP]) may interact to affect risk of diabetes. We studied 288 Chinese men (age-median: 41.0 years, IQR: 35.3–46.0 years) being recruited from the community in Hong Kong. The mean adiponectin level was 5.39 ± 2.81 μg/ml and 40.9% ( n = 107) had low adiponectin level (<4 μg/ml). On multiple regression analysis, adiponectin was negatively associated with diabetes, HOMA insulin resistance top quartile, plasma glucose (PG) and 2 h insulin; and positively associated with HOMA insulin sensitivity index. WCC was independently associated with PG and 15′ insulin, and negatively associated with HOMA insulin sensitivity top quartile. HP titre was associated with 30′ PG level and diabetes. hs-CRP did not enter the multivariable model. In conclusion, adiponectin, WCC and HP titer are independent predictors for hyperglycemia and reduced insulin sensitivity in Chinese men. These findings may explain the high risk for diabetes in Chinese population despite their relatively low adiposity.

A single nucleotide polymorphism (SNP) rs2072907 in the adiponutrin gene (ADPN) was not associated with obesity and type 2 diabetes in Chinese Population

We aimed to assess the association between adiponutrin gene (ADPN) SNPrs2072907 and obesity or type 2 diabetes mellitus (T2DM) in Chinese population. 500 T2DM and 331 nondiabetic subjects were recruited. No association was found between SNPrs2072907 and obesity or T2DM. ADPN was not an obesity/T2DM susceptibility gene in Chinese population.

Diabetic nephropathy and risk factors for peripheral artery disease in Chinese with type 2 diabetes mellitus

The risk for peripheral arterial disease (PAD) is increased in patients with chronic kidney disease. We investigated the effects of renal function on PAD in Chinese with type 2 diabetes mellitus. This study enrolled a total of 2983 (1342 men and 1641 women) Chinese adults with diabetes. The mean age was 63.2 ± 11.9 years. Peripheral arterial disease was diagnosed by an ankle-brachial index less than 0.9. Renal function was evaluated by serum creatinine (SCr), estimated glomerular filtration rate, and urinary albumin-creatinine ratio (ACR). Risk factors for PAD were evaluated using multiple logistic regression analysis. Age, cholesterol, and high-density lipoprotein cholesterol (HDL-C) (inverse association) were significant risk factors in men, whereas age, body mass index (inverse association), low-density lipoprotein cholesterol, and HDL-C (inverse association) were significant risk factors for diabetic women. After adjustment for age, body mass index, blood pressure, glycosylated hemoglobin, cholesterol, HDL-C, low-density lipoprotein cholesterol, and triglyceride levels, we found that SCr levels greater than 1.5 mg/dL, estimated glomerular filtration rate less than 60 mL/min, and urinary ACR greater than 30 mg/g were independent risk factors for PAD in diabetic men and that SCr levels greater than 1.4 mg/dL and urinary ACR greater than 30 mg/g were independently associated with PAD in diabetic women. The risk factors for PAD are somewhat different between men and women with diabetes in Chinese population in Taiwan. Diabetic nephropathy is significantly associated with PAD in this patient population.

Zinc Transporter-8 Gene (SLC30A8) Is Associated with Type 2 Diabetes in Chinese

Several genome-wide association studies identified a strong association of SLC30A8 with type 2 diabetes in individuals of European ancestry. The effect of the association of rs13266634 with type 2 diabetes or related glycemic traits has not been fully extended to non-European populations, and a comprehensive examination of common variants in the gene has not yet been carried out in Han Chinese. The objective of the study was to investigate the association of SLC30A8 with type 2 diabetes in Chinese. A comprehensive gene-based association study was performed using 14 tagging single-nucleotide polymorphism (SNPs) of SLC30A8 in Han Chinese subjects with normal glucose tolerance (NGT; n = 721), impaired glucose regulation (IGR; n = 375), and type 2 diabetes (n = 521). A significant association for SNP rs13266634 was observed between patients with type 2 diabetes and NGT controls (P = 0.016). The association was also observed between combined type 2 diabetes/IGR and NGT subjects (P = 0.002). The adjusted odds ratios for homozygote CC vs. TT at this locus were 1.71 for type 2 diabetes (95% confidence interval 1.19-2.45, P = 0.002) and 1.77 for type 2 diabetes and IGR (95% confidence interval 1.29-2.42, P = 0.0001). We further studied the genotype-phenotype correlation in 70 Han Chinese using iv glucose tolerance test and found an association between SNP rs13266634 and acute insulin response to glucose and disposition index (adjusted P = 0.012 and 0.004, respectively). Our results provide evidence that SLC30A8 is a susceptible locus for type 2 diabetes in Chinese population, and its variant can influence insulin secretion.

Prevalence and Associated Factors of Refractive Errors Among Type 2 Diabetics in Kinmen, Taiwan

Purpose: A community-based study was conducted to identify the extent of prevalence of refractive errors and their associated factors from among the Chinese type 2 diabetic population in Kinmen. Methods: A total of 547 patients (> 40 years old) with type 2 diabetes were examined with a complete eye screening tests including objective autorefraction. Spherical equivalent refractions of right eyes were reported. Data collected include age, gender, general medical information and serum biochemistry. Results: The mean refraction was −0.83 ± 2.49 D. Prevalence rates were determined for myopia (44.1%), hyperopia (24.1%), high myopia (13.0%), and astigmatism (87.8%). Age is an important factor for all of the refractive errors. After adjustment for age, male gender and > 3 grade nuclear opacity appeared to be statistically significant factors for myopia. For hyperopia, ≥7% HbA1c was a significant associated factor, and for astigmatism, ≥200 mg/dl total cholesterol was the risk factor. Multiple linear regression showed that every increase of one year of age and one percent of HbA1c is associated with 0.04 D (p = 0.003) and 0.13D (p = 0.04) shift in hyperopia, respectively. Nuclear opacity with grade 3-4 and grade 5-6 will shift toward myopia of −0.72D (p = 0.02) and −5.34D (p < 0.0001) after adjustment for other risk factors. Conclusions: This study provides epidemiological data on refractive errors in a Chinese diabetic population in Kinmen, Taiwan. The myopia prevalence is higher than the reported rates in the general population. This survey further confirmed that myopia is more prevalent than hyperopia in the diabetic population. Age and blood sugar shift the refraction toward hyperopia while nuclear cataract reverses it. Correction of refractive errors in the diabetics remained a challenge as not only spectacles but medical intervention is mandatory.

Development and validation of the Chinese version of the Diabetes Management Self-efficacy Scale

Objective The purpose of this study was to translate the Diabetes Management Self-Efficacy Scale (DMSES) into Chinese and test the validity and reliability of the instrument within a Taiwanese population. Research design and methods A two-stage design was used for this study. Stage I consisted of a multi-stepped process of forward and backward translation, using focus groups and consensus meetings to translate the 20-item Australia/English version DMSES to Chinese and test content validity. Stage II established the psychometric properties of the Chinese version DMSES (C-DMSES) by examining the criterion, convergent and construct validity, internal consistency and stability testing. The sample for Stage II comprised 230 patients with type 2 diabetes aged 30 years or more from a diabetes outpatient clinic in Taiwan. Results Three items were modified to better reflect Chinese practice. The C-DMSES obtained a total average CVI score of .86.The convergent validity of the C-DMSES correlated well with the validated measure of the General Self-Efficacy Scale in measuring self-efficacy ( r=.55; p<.01). Criterion-related validity showed that the C-DMSES was a significant predictor of the Summary of Diabetes Self-Care Activities scores (Beta=.58; t=10.75, p<.01). Factor analysis supported the C-DMSES being composed of four subscales. Good internal consistency (Cronbach's alpha=.77 to .93) and test–retest reliability (Pearson correlation coefficient r=.86, p<.01) were found. Conclusions The C-DMSES is a brief and psychometrically sound measure for evaluation of self-efficacy towards management of diabetes by persons with type 2 diabetes in Chinese populations.

Contribution of MODY6 gene in the pathogenesis of familial type 2 diabetes in Chinese population

To investigate the contribution of MODY6 gene in the pathogenesis of familiar type 2 diabetes in Chinese population. PCR and single strand configuration polymorphism (PCR-SSCP) technique was used to screen the coding sequence of NeuroD1/BETA2 gene for DNA variants in 188 probands in the pedigrees of familiar type 2 diabetes and 130 normal persons as controls in Beijing, China. The discovered variants were confirmed by sequencing. A4T5 polymorphism and a novel Gly12Arg mutation were found. The frequency of A4T5 of the patients was 19.7%, significantly higher than that of the controls (10.0%, P < 0.05). In the control group, the Homa-beta of the 13 subjects with T allele was 4.6 +/- 04, significantly lower than that of the 117 subjects without T allele (4.9 +/- 0.5, P < 0.05). Co-segregating with diabetes, Gly12Arg mutation was found in only one pedigree and in none normal subjects. A4T5 polymorphism of NeuroD1/BETA2 gene is correlated with familiar type 2 diabetes in Chinese population. NeuroD1/BETA2 gene or its nearby gene may play a role in the pathogenesis of familiar type 2 diabetes. The novel GlyArg mutation may be a genetic cause of some diabetic pedigrees.