Dextran-induced Paw Edema Research Articles

The effects of newly synthesized pyrazole derivatives on formaldehyde-, carrageenan-, and dextran-induced acute paw edema in rats.

The antiinflammatory effects of 10 newly synthesized pyrazole derivatives on formaldehyde-induced rat paw edema were investigated. The most effective of them (K-3) was investigated again in dextran- and carrageenan-induced paw edema. In formaldehyde-induced paw edema, K-3 50, 100, and 200 mg/kg p.o. inhibited the edema by 48.9% (p<0.002), 68.7% (p<0.001), and 79.1% (p<0.001), respectively, 3 h after administration. In dextran-induced paw edema, the same dose of K-3 produced 27.1% (p<0.05), 46.8% (p<0.01), and 63.8% (p<0.002) inhibition, respectively. In the carrageenan-induced paw edema test, K-3 100 mg/kg decreased the inflammatory response by 52.0% after 4 h. Acute toxicity studies revealed that K-3 was nontoxic up to an oral dose of 2500 mg/kg.

Evaluation of Anti-Inflammatory Effects of Cassia fistula (Leguminosae) Leaf Extract on Rats

ABSTRACT Cassia fistula Linn. is used by the people of Tripura, India as an anti-inflammatory, but the mode of activity is unknown. In this study, Cassia fistula leaves were tested for anti-inflammatory effects, as compared with phenylbutazone, using carrageenin, histamine, and dextran induced paw edema in rats. Potent anti-inflammatory activity against all phlogistic agents was noted.

Antinociceptive and antiedematogenic effects of the hydroalcoholic extract and coumarin from Torresea cearensis Fr. All.

This work studied the antinociceptive and antiedematogenic effects of the hydroalcoholic extract (HAE) and coumarin (Coum) from T. cearensis in experimental models of nociception in mice, and carrageenan- and dextran-induced paw edema in rats. HAE (100 and 200 mg/kg, p.o.) and Coum (5-20 mg/kg, p.o.) reduced in a dose - dependent manner the nociception produced by acetic acid and formalin. In the hot plate test, HAE (100-400 mg/kg, p.o.) and Coum (5 and 10 mg/kg, p.o.) increased the latency time to the thermal stimulus 90 min after administration. While naloxone partially reversed the antinociceptive effect of the HAE but not that of Coum, L-arginine reversed the antinociceptive effect of Coum in the formalin test. HAE (200 mg/kg, p.o.) and Coum (10 and 20 mg/kg, p.o.) significantly inhibited the carrageenan-induced edemas in rats but not the dextran-induced edema. This antiedematogenic effect on the carrageenan model was supported by histological studies performed in sections of the rat paw. In conclusion, the antinociceptive effects of HAE and Coum occur by a mechanism at least in part dependent on the opioid system. The nitric oxide system possibly has also a role in the Coum nociception. In addition, the antiedematogenic activity is manifested in inflammatory processes dependent on polimorphonuclear cells.

S17.3. Contribution of red cell aggregation to venous resistance in skeletal muscle

Riparin II (RipII), an alkamide isolated from the green fruit of Aniba riparia, was tested in the various animal models of inflammation to investigate its anti-inflammatory activity. Male Wistar rats (180–240 g) were treated with RipII by gavage at doses 25 or 50 mg/kg, before initiating the inflammatory responses. The tests used were paw edema induced by carrageenan, dextran, histamine or serotonin; peritonitis induced by carrageenan and fMLP, as well as the measurement of MPO activity, TNF-α and Il-1β amount in the peritoneal fluid. In the animal models of carrageenan and dextran-induced paw edema, the animals treated with RipII showed lower edema than those of the control group. Treatment with RipII also reduced the paw edema induced by histamine but not serotonin. In the carrageenan-induced peritonitis model, treatment with RipII reduced leukocyte migration, the MPO activity and the amount of TNF-α and IL-1β in the peritoneal fluid. In summary, these results indicate that RipII has an anti-inflammatory activity in chemical models of acute inflammation. RipII might be directly or indirectly inhibiting the activity, production or release of pro-inflammatory mediators involved in the generation of the pain associated with inflammation.

O-059 - Influence of guanabenz(GB) on dextran-induced paw edema and histamine release from isolated peritoneal mast cells in rats

O-059 - Influence of guanabenz(GB) on dextran-induced paw edema and histamine release from isolated peritoneal mast cells in rats

Effects of compound [formula omitted] on dextran-induced paw edema and histamine content of inflammatory exudate

Effects of compound [formula omitted] on dextran-induced paw edema and histamine content of inflammatory exudate

Dextran-induced paw edema and 5-hydroxytryptamine release

Dextran-induced paw edema and 5-hydroxytryptamine release

ANTI‐INFLAMMATORY AND IRRITANT EFFECTS OF A FRACTION FROM NORMAL HUMAN PLASMA

1 By the use of carrageenan-induced rat paw oedema assay the anti-inflammatory activity of a fraction isolated from normal human plasma has been measured after its intravenous, intraperitoneal and oral administration. Its effects in the dextran-induced rat paw oedema and the systemic dextran anaphylactoid reaction in the rat were also studied.2 The fraction showed marked anti-inflammatory activity in the carrageenan test after intravenous administration and a smaller but still significant activity when given intraperitoneally, but was inactive orally after the administration of a larger dose. It was active in the dextran-induced paw oedema test but not against the anaphylactoid reaction.3 A comparison between its anti-inflammatory and irritant properties revealed no correlation when each parameter was determined in relation to dose. The fraction did not affect the blood pressure of the anaesthetized rat.4 These findings are discussed in relation to the existence of a natural anti-inflammatory substance or substances in human plasma.