The study's main goal was to compare several data mining and machine learning algorithms to estimate body weight based on body measurements at a different share of Polish Merino in the genotype of crossbreds (share of Suffolk and Polish Merino genotypes). The study estimated the capabilities of CART, support vector regression and random forest regression algorithms. To compare the estimation performances of the evaluated algorithms and determine the best model for estimating body weight, various body measurements and sex and birth type characteristics were assessed. Data from 344 sheep were used to estimate the body weights. The root means square error, standard deviation ratio, Pearson's correlation coefficient, mean absolute percentage error, coefficient of determination and Akaike's information criterion were used to assess the algorithms. A random forest regression algorithm may help breeders obtain a unique Polish Merino Suffolk cross population that would increase meat production.