Development Process Research Articles

In Situ Monitoring of Allylamine and 1,1,3,3-Tetramethyldisiloxane Reaction to Form 2,2,7,7-Tetramethyl-1-oxa-3-aza-2,7-disilacycloheptane Using Raman Spectroscopy

The cyclic siloxazane, i.e., 2,2,7,7-tetramethyl-1-oxa-3-aza-2,7-disilacycloheptane (1), is a useful industrial intermediate that is challenging to produce. One method to synthesize 1 is through concurrent dehydrocoupling and hydrosilylation reactions between 1 and allylamine. This chemistry is highly exothermic and also generates a significant amount of H2. Raman spectroscopy was demonstrated to be an effective analytical method to track both reactions. It enables a safe reaction scale-up by monitoring the consumption of allyl groups and the silicon hydride (SiH) groups. Both functional groups could be readily quantified by using a solvent as an internal standard. It is found that the observed SiH signal can be attributed to an intermediate species, which would undergo a relatively slower hydrosilylation reaction. Interesting kinetics behavior is observed that leads to a mechanistic understanding of the catalyst's role in catalyzing the two elementary steps. The ability to track these moieties is critical to the development of a safe process that avoids accumulation of SiH intermediates.

Spinal cord injury: pathogenetic principles of molecular and cellular therapy

Spinal cord injury: pathogenetic principles of molecular and cellular therapy

Adopting lean product development in new production system introduction process for sustainable operational performance

This research explores adopting the lean product development (LPD) concept in the new production system introduction process (NPSIP) to achieve both pre-launching and post-launching operational performance considering sustainability aspects. An empirical study was conducted in a multi-national pharmaceutical company, having lean practice for over a decade. Two case projects for launching the new production system were followed in retrospect, and data was collected by interviewing experts. In the case company, evidence were found regarding adoption of soft lean practices in the NPSIP, however, lack of adoption of hard lean practices. Several challenges were identified that hinder achieving both pre-launching and post-launching operational performance, which could be mitigated by adopting LPD practices. This paper contributes to the broad lean literature by expanding its implication within the NPSIP context. Additionally, a set of LPD principles and practices is proposed that could be adopted in the NPSIP context. Adopting the LPD principles and practices in the NPSIP, manufacturing companies can launch a new production system faster, and achieve target sustainable operational performance faster, resulting in additional competitive advantage.

Comparative analysis of mitochondrial genomes in Ceratocystis fimbriata complex across diverse hosts

The decline ofAcacia mangiumWilld. in Malaysia, especially in Sabah since 2010, is primarily due to Ceratocystiswilt and canker disease (CWCD) caused by theCeratocystis fimbriataEllis & Halst. complex. This study was aimed to investigate the mitochondrial genome architecture of two differentC. fimbriatacomplex isolates from Malaysia: one fromA. mangiumin Pahang (FRIM1162) and another fromEucalyptus pellitain Sarawak (FRIM1441). This research employed Next-Generation Sequencing (NGS) to contrast genomes from diverse hosts with nine additional mitochondrial sequences, identifying significant genetic diversity and mutational hotspots in the mitochondrial genome alignment. The mitochondrial genome-based phylogenetic analysis revealed a significant genetic relationship between the studied isolates and theC. fimbriatacomplex in the South American Subclade, indicating that theC. fimbriatacomplex discovered in Malaysia isC. manginecans. The comparative mitochondrial genome demonstrates the adaptability of the complex due to mobile genetic components and genomic rearrangements in the studiedfungal isolates. This research enhances our knowledge of the genetic diversity and evolutionary patterns within theC. fimbriatacomplex, aiding in a deeper understanding of fungal disease development and host adaption processes. The acquired insights are crucial for creating specific management strategies for CWCD, improving the overall understanding of fungal disease evolution and control.

Measuring Perception of College Welcome Provided to Foreign-Born Students: Validation with Pilot Data

Immigrant and foreign-born students are one of the fastest growing populations in higher education across the US, and yet there is a dearth of research around their sense of belonging on campus and in the classroom. Therefore, this paper will cover the development and evaluation process for a scale designed to evaluate the perception of college welcome provided to immigrant students. Data from 94 college students was used to conduct a series of factor analyses to assess the survey questions and their utility for measuring college welcome. The scale is made up of four factors. The Cognitive awareness of college welcome factor showed a Cronbach's alpha of 0.72, the Emotional college welcome factor showed a Cronbach's alpha of 0.732 Behaviors of college welcome showed a Cronbach's alpha of 0.75 and the Relational college welcome showed a Cronbach's alpha 0.767. Overall, Cronbach's alpha is 0.864 for the perception of college welcome which is excellent. While the results are promising that this scale could indeed be measuring college welcome, it is important that more data be collected, reflect a higher percentage of immigrant students, and that future research be done to continue to assess the reliability and validity of this scale. This scale is the first step in better understanding the perception of welcome provided to foreign-born students, which is critical so that social workers can intervene and help improve the social and emotional well-being of students.

Социально ответственная коммуникация бизнеса: генезис и эволюция

Introduction. In the modern world, socially responsible communication and the social policy of business in relation to the state and society play a key role on which the growth of the company’s intangible assets and its financial well-being depends. The purpose of the article is to analyze the prerequisites for the emergence of socially responsible business communication in Russia and abroad, consider the stages of their development and draw up a periodization. Methodology and methods. The theoretical and methodological basis of the study was a systematic approach that promotes ordering and systematization of many historical events and facts of social business initiatives into an integral unity. Research methods: analysis of literary sources, retrospective analysis, comparative analysis of Russian and Western practices of socially responsible communication and social business initiatives, synthesis, generalization. Results. Using a systematic approach, an analysis of Russian and global methodology for socially responsible behavior of companies and a historiographical review of communication activities in the context of social responsibility of business were made, and a periodization of the process of development of socially responsible communication of business in Russia and abroad was compiled. Scientific novelty lies in the systematization and periodization of the prerequisites and facts of the origin and development of socially responsible communication in Russia and abroad. Practical significance. The results of the study may be useful for improving socially responsible business communication.

Individual and collaborative infographic design and cognitive strategies in visual literacy support process: a qualitative research perspective

This study examined the individual and collaborative infographic development processes of middle school students in a qualitative research context. In the first phase, individual and collaborative infographics were developed, a simultaneous think-aloud protocol and interviews were conducted. In the second phase, focus group interviews were conducted with 22 teachers. The findings of the study revealed that students who developed infographics individually and collaboratively completed their tasks at different stages. Protocol analysis data showed that individual and collaborative efforts were reflected in cognitive processes and that collaborative groups spent less time in testing and individual students spent less time in questioning. The findings showed that collaborative learning activities can support the learning process with components such as questioning, peer scaffolding, and sharing.

HISTORICAL EVOLUTION AND INNOVATIVE DESIGN OF QIANG COSTUMES

Рurpose. This paper analyzes the evolution process and cultural connotation of Qiang costume form, discusses the application form of Qiang costume elements in modern clothing design, and provides a theoretical basis for the innovative design of national costumes. Methodology. The field research method, literature analysis method, and case study method are used to analyze the evolution process, cultural connotation, and design application of Qiang costumes. Results. By studying the development process and style design changes of the Qiang costumes, it is concluded that its unique cultural connotation and design characteristics are closely related to the social characteristics, production methods and religious beliefs of the Qiang people. It is the materialized expression of the Qiang people's world outlook and national psychology. It reveals the reasons for the change of the Qiang costume modelling and proposes the method of using ethnic elements in modern costume design. Scientific novelty. This paper studies the development process of Qiang costume shape from the perspective of design, history, ethnology and anthropology, and puts forward that Qiang costume is the materialized expression form of local people 's world outlook, values and aesthetics, and clarifies that the change of Qiang costume shape is influenced by religious culture and Han-Tibetan culture. Suggestions are made in the form of integration of national costume elements with modern clothing design. Practical significance. The Qiang costume has been fused with other ethnic cultures in the course of historical changes, which is both inherited and changed, which is very inspiring to modern costume design. Digging deeper into the cultural connotation and design language of Qiang costume, so that it can innovate the design method and explore the design carrier while inheriting the national culture, so as to provide reference for the creation of a costume design that can embody both the traditional Chinese culture and the sense of the times.

The Influence of Macroeconomic Variables on Asean- 5 Countries' Foreign Exchange Reserves Long-Term Relationship and Causality (Empirical Data Year 2014 to 2021)

The country's foreign exchange reserves are an important factor in supporting the economic development process in ASEAN-5 countries. The country's foreign exchange reserves are greatly influenced by macroeconomics so macroeconomic changes will have a large and rapid impact on foreign exchange reserves. So this research aims to determine the influence of macroeconomics, namely the rate of inflation, exchange rate, export value, and economic growth on the foreign exchange reserves of ASEAN-5 countries. The data processing was carried out using the multiple panel data regression method, empirical data from 2014 to 2021. The results of the data processing that has been carried out show that the model test, together with the inflation rate, exchange rate, export value, and economic growth, has an effect of 94.9867 percent. to the foreign exchange reserves of ASEAN-5 countries. Meanwhile, partially the export value and economic growth variables have a significant effect on ASEAN countries' foreign exchange reserves and are positively proportional, but the inflation rate and exchange rate have no effect on ASEAN countries' foreign exchange reserves and are negatively proportional. Apart from that, the role of the government is also very influential in maintaining the country's foreign exchange reserves because macroeconomics is determined by government policies.

Study of Celie's Portrayal in "The Color Purple" Under the Theory of Androgyny

The classic novel The Color Purple by black American author Alice Walker outlines the journey of Celie, a black woman in the Southern part of America in the early 20th century, as she grows up under the triple oppression of race, gender and class. Celie is abused by her stepfather and then forced to marry Mr. ____, a widower who already has four children, and lives in daily slave-like worry. However, with the help of other women, Celie gradually awakens from her numb and closed state, thinks about her gender and identity, and finally grows up to be an independent woman with individuality, dignity, and self-confidence. Therefore, based on the theory of androgyny, this paper analyzes in depth the development process of Celie's gender consciousness, revealing that her gender consciousness goes from clear boundaries to blurring, and finally achieves integration through self-awakening. In the novel, Celie experiences the questioning and redefinition of her own gender awareness, from the initial limitation of social expectations to the gradual escape from the traditional gender boundaries, and finally realizes the comprehensive awareness of gender. Through an in-depth analysis of the image of Celie and the evolution of her gender cognition in The Color Purple, the author hopes to better help readers understand the plurality of individual gender cognition, and to provide useful literary references for the promotion of gender harmony.

Development and comparison of machine learning models for in-vitro drug permeation prediction from microneedle patch

The field of machine learning (ML) is advancing to a larger extent and finding its applications across numerous fields. ML has the potential to optimize the development process of microneedle patch by predicting the drug release pattern prior to its fabrication and production. The early predictions could not only assist the in-vitro and in-vivo experimentation of drug release but also conserve materials, reduce cost, and save time. In this work, we have used a dataset gleaned from the literature to train and evaluate different ML models, such as stacking regressor, artificial neural network (ANN) model, and voting regressor model. In this study, models were developed to improve prediction accuracy of the in-vitro drug release amount from the hydrogel-type microneedle patch and the in-vitro drug permeation amount through the micropores created by solid microneedles on the skin. We compared the performance of these models using various metrics, including R-squared score (R2 score), root mean squared error (RMSE), and mean absolute error (MAE). Voting regressor model performed better with drug permeation percentage as an outcome feature having RMSE value of 3.24. In comparison, stacking regressor have a RMSE value of 16.54, and ANN model has shown a RMSE value of 14. The value of permeation amount calculated from the predicted percentage is found to be more accurate with RMSE of 654.94 than direct amount prediction, having a RMSE of 669.69. All our models have performed far better than the previously developed model before this research, which had a RMSE of 4447.23. We then optimized voting regressor model’s hyperparameter and cross validated its performance. Furthermore, it was deployed in a webapp using Flask framework, showing a way to develop an application to allow other users to easily predict drug permeation amount from the microneedle patch at a particular time period. This project demonstrates the potential of ML to facilitate the development of microneedle patch and other drug delivery systems.

Auxiliary diagnosis and prognosis evaluation of KIF4A, RAD51AP1 and CDKN3 in esophageal cancer

To investigate the expression of mRNA in esophageal cancer (ESCA) tissues and its potential and diagnostic and prognostic value by high-throughput sequencing data. Using the Cancer Genome Atlas Program (TCGA) database in USA by integrative bioinformatics analysis methods, the gene expression profiles and clinical data of 173 patients with ECSA were collected. The mRNA expression levels in ESCA tissue and para-cancerous tissue samples were analyzed using DESeq2, edgeR and limma to screen the differentially expressed genes (DEGs). DEGs-related protein network diagrams were drawn. GO and KEGG function enrichment analysis were performed and the hub genes were screened and the survival analysis of hub genes was analyzed. Genes related to the prognosis of ESCA were selected and their prognostic value in ESCA was analyzed. Finally, the receiver operating characteristic curve was drawn to evaluate its diagnostic value. The results showed that using TCGA cancer data, a total of 620 up-regulated DEGs and 668 down-regulated DEGs with significant differential expression between ESCA and para-cancerous tissues were screened. DEGs were mainly involved in receptor complexes, ubiquitin ligase complexes, etc., playing GTPase activity, phospholipid binding, and other molecular functions, and participating in the regulation of intracellular substance transport, small molecule metabolism, and other biological processes. Protein functional enrichment analysis showed that these proteins were mainly enriched in the IL-17 signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Epstein-Barr virus infection, neutrophil extracellular trap formation, and other pathways involved in the formation and development process of ESCA. Survival analysis showed that the overall survival rate of ESCA patients with high expression of KIF4A, RAD51AP1, and CDKN3 was significantly shortened, and the difference was statistically significant (P<0.05). Furthermore, the areas under the curve (AUC) of KIF4A, RAD51AP1, and CDKN3 for diagnosing esophageal cancer were 0.956, 0.951 and 0.979, respectively, with sensitivities and specificities both exceeding 80%. Additionally, ROC results of the combined diagnostic model of these three genes showed an AUC of 0.979, with sensitivities and specificities of 0.914 and 1, respectively. This indicates that KIF4A, RAD51AP1 and CDKN3 have individual or combined auxiliary diagnostic value for ESCA. In conclusion, KIF4A, RAD51AP1 and CDKN3 have high diagnostic efficiency for ESCA, and their increased expression is closely related to the prognosis, suggesting that these three genes could be used as auxiliary diagnostic and prognostic factors for ESCA.

Larval Development of the Blue Dolphin Cichlid (Cyrtocara moorii Boulenger, 1902): Morphological Changes

In this study, the larval development of Cyrtocara moorii was examined morphologically and compared with other Cichlidae species. The important morphological changes and critical developmental stages that C. moorii larvae undergo were determined during the process from hatching up to 20 days. It was observed that the larvae had a large yolk sac, transparent bodies, and undeveloped fins in the first days. Important developmental events such as eye development, mouth opening, onset of free swimming behavior, fin formation, and increased pigmentation were recorded. It was determined that the larvae started free swimming between 6-9 days, the yolk sac was completely depleted on the 10th day, and the larval development was completed, reaching the juvenile form on the 15-20th days. When the larval development of C. moorii was compared with other Cichlidae species, species-specific differences were observed as well as some similarities. It is thought that these differences may be related to the ecological adaptations, reproductive strategies, and evolutionary history of the species. It is suggested that future research should comparatively examine the larval development processes of more Cichlidae species and elucidate the mechanisms underlying this diversity.

Integrity assessment of shale gas wells in Changning Block based on hierarchical analysis method

AbstractThe integrity of shale gas wells is crucial in ensuring safety and efficiency throughout the development process. Such integrity spans the entire process of drilling and fracturing horizontal wells and is an essential indicator for ensuring safe and stable production throughout the lifespan of the well. This study investigates methods for assessing the integrity of shale gas wells by employing the analytic hierarchy process combined with experimental data to establish evaluation criteria and weights. The assessment is carried out specifically on shale gas wells in Changning Block. Results indicate that the integrity of these shale gas wells is influenced by various factors, such as drilling and fracturing processes. Moreover, the integrity assessment of indicators such as oil layer casing/technical casing, liquid carrying capacity, and tube column deformation is relatively low, indicating a need for enhanced monitoring and management. The comprehensive evaluation results indicate that, overall, the integrity rating of shale gas wells is generally considered “common,” but some potential safety hazards still remain that require timely attention and resolution. Case analysis reveals varying levels of integrity risks in shale gas wells. Case 1’s score of 93.51 warrants attention but is still deemed generally safe. However, Case 2’s score of 73.89 indicates a disaster level, emphasizing urgent intervention needs. Critical factors such as pressure, cementation quality, and corrosion demand proactive management for safe, sustainable operations.

Self-Development in Islam: Ways and Methods

The development concept is a broad and widely understood term and philosophy. Its active presence is ever-present in the multidimensional process of life cycle. The continuous process of development leads to the pinnacle of development. The development of the material side of man is visible and recognized, likewise, the development of its immaterial aspect (souls) is essential. A person is composed of body and soul. Balanced development of both sides of the human being gives recognition to a complete and fulfilled human being. The soul is the main director of the body. The effectiveness and success of his material development depends to a large extent on the development of the soul. The best of creation is seated in the best seat of mankind through the proper development of the soul. Philosophy and principles that play an important role in the development of the soul, it will undoubtedly be identified as a role model for building a developed and ideal human society for generations to come.

THE EVOLUTION OF STANDARDIZATION OF SUSTAINABLE DEVELOPMENT REPORTING

Accountability for sustainable development process is currently in high demand. Partners of business activities are interested not only in the financial condition and business activity of organizations, but also in the attitude towards environmental protection, implementation of social programs, fulfillment of public obligations. To this end, the problem arises of organizations preparing and publishing reports on sustainable development with international standards. The article presents the evolution of sustainability reporting standardization, which includes the GRI-SAAB-IFRS-S process chain and analyzing opportunities for financial and non-financial information reporting.

Enhancing agile product development with scrum methodologies: A detailed exploration of implementation practices and benefits

This study conducts a systematic literature review to examine the implementation, challenges, and ongoing evolution of Scrum methodologies within Agile product development frameworks. Aimed at understanding how Scrum can be effectively tailored to meet the needs of diverse organizational contexts, especially in scenarios involving remote and distributed teams, the research also seeks to uncover the trajectory of Agile practices' continuous evolution. Employing a rigorous methodology, the review analyzed peer-reviewed articles and conference papers from key academic databases, including IEEE Xplore, ACM Digital Library, and Scopus, published between 2013 and 2024. The selection was based on relevance to Scrum practices, empirical evidence, and theoretical contributions to the field of Agile development. Key insights from the study underscore the critical role of Scrum in enhancing collaboration, flexibility, and responsiveness in product development processes. Challenges identified include the necessity of overcoming organizational resistance and the importance of customizing Scrum practices to align with specific project and team dynamics. Notably, the research highlights Scrum's adaptability in supporting distributed teams through strategic communication and trust-building measures. Furthermore, the study points to the integration of Scrum with DevOps and its application beyond software development as indicators of its evolutionary potential within Agile methodologies. Finally, the study offers strategic recommendations for organizations adopting Scrum, emphasizing cultural adaptation, continuous training, and practice customization. It also suggests avenues for future research, particularly in exploring Scrum's integration with emerging technologies and broader industry applications, contributing valuable insights into enhancing Agile product development efficacy through Scrum methodologies. Keywords: Scrum Methodologies, Agile Product Development, Distributed Teams, Continuous Evolution.

Кількісне оцінювання функціональної ефективності мережевих структур за аналізом чутливості оптимізаційної моделі до зовнішніх впливів

The real network organizational structure is constantly under the influence of external influences, which can cause unexpected consequences due to the cascading spread of relevant disturbances directed at critically important parameters. Parametric sensitivity analysis is the latest computational procedure, the results of which provide the researcher with an idea and quantitative assessment of the appropriate response of the structure in the form of an analytical platform as a composition and interaction of scenario analysis, cascade process development and optimization modeling technology. The main task is timely adaptation to expected changes in business analytics, oriented to optimal resources distribution. The generalized minimum cost problem is a typical example of widespread problems of optimal distribution and use of limited, in particular, energy resources, of any nature and purpose, using the scientific management and analysis of decisions, in its network model attention is paid to the potentials of nodes. The maximum flow problem is an example of the active and effective application of methods and models of flows optimization, where the processes and objects used a network organization, the energy systems and complexes investigated, where arc parameters are critical in its model. In the article, for these classic optimization problems, mathematical and spreadsheet models were built on concrete examples. Direct and dual mathematical programming problems were solved, the following stages were carried out - the organization of a computer experiment and the construction of an analytical platform for evaluating the behavior of the network structure under the influence of external influences and disturbances as their consequences. To take into account the specific conditions of real objects with a network structure at the stage of modification, the model supplemented with appropriate restrictions and correction of input data sets. The obtained results should be useful for planning and management personnel and top-management for discussion and decision-making regarding, for example, the optimal placement of energy equipment, the weighted distribution of energy flows in the "source-sink" system or the appointment of executors for work, automated project management using project networks, etc. Keywords: optimization modeling, maximum network flow, minimum cost flows, network organizational structures, decision making, spreadsheet modeling and analytics.

Behind the scenes: facilitators and barriers to developing state scarce resource allocation plans for the COVID-19 pandemic.

In response to COVID-19, many states revised, developed, or attempted to develop plans to allocate scarce critical care resources in the event crisis standards of care were triggered. No prior analysis has assessed this plan development process, including whether plans were successfully adopted. How did states develop or revise scarce resource allocation plans during the COVID-19 pandemic and what were the barriers and facilitators to their development and adoption at the state level? Plan authors and state leaders completed a semi-structured interview February to September 2022. Interview transcripts were qualitatively analyzed for themes related to plan development and adoption according to the principles of grounded theory. Thirty-six participants from 34 states completed an interview, from states distributed across all U.S. regions. Among participants' states with plans that existed prior to 2020 (n=24), 17 were revised and adopted in response to COVID-19. Six states wrote a plan de novo, with the remaining states failing to develop or adopt a plan. Thirteen states continued to revise their plans in response to disability or aging bias complaints or to respond to evolving needs. Many participants expressed that urgency in the early days of the pandemic prevented an ideal development process. Facilitators of successful plan development and adoption include: coordination or support from the state department of health and existing relationships with key community partners, including aging and disability rights groups and minoritized communities. Barriers include: lack of perceived political interest in a plan and development during a public health emergency. To avoid repeating mistakes from the early days of the COVID response, states should develop or revise plans with community engagement and consider maintaining a standing committee with diverse membership and content expertise to periodically review plans and advise state officials on pandemic preparedness.

Pengaruh Kombinasi Stimulasi Pijat bayi dan Esensial Oil Lavender Terhadap Motorik Kasar dan Motorik Halus Pada Bayi Usia 3-12 Bulan di Kota Bengkulu

Background: The growth and development period of infants needs special attention because the process is very fast. There are still toddlers who experience gross motor and fine motor disorders. World Health Organization (WHO) 2016 globally states that around 20-40% of infants aged 0-2 years experience problems with delays in the development process, 5-25% of toddlers who experience gross motor and fine motor disorders. The impact of delays in infant gross motor development causes a decrease in creativity in the adaptation period while the impact of delays in fine motor development causes obstacles in the child's learning process. Efforts that can be made in optimizing the growth and development of fine motor and gross motor in infants in addition to nutrition provided by the mother and one of the other ways needs stimulation. The combination of stimulation of baby massage and lavender essential oil is one of the stimulations to improve gross motor and fine motor in infants aged 3-12 months.  Objective: Proving the effect of a combination of baby massage stimulation and lavender essential oil on improving gross motor and fine motor in infants aged 3-12 months. Methods: Pre-experimental quantitative research design with one group pretest-postest design. Sample 40 infants aged 3-12 months. Analysis used to assess the effect on the improvement of gross motor and fine motor in 2 PMB using t test.  Results: Hypothesis testing in this study using the Wilcoxon test. Obtained a probability value (p value) of (p value) 0.02 or &lt; 0.05, which means that there is a combined effect of baby massage stimulation and lavender essential oil on improving gross motor and fine motor in infants aged 3-12 months. The intervention was given for 4 weeks, twice a week the intervention was given a combination of baby massage and lavender essential oil, then an evaluation was carried out using the Pre-Developmental Screening Questionnaire (KPSP), consisting of 10 assessment items, starting from gross motor, fine motor, socialization and independence assessments. as well as speech and language skills. Conclusion: The combination of baby massage stimulation and lavender essential oil has an effect on improving gross motor and fine motor in infants aged 3-12 months. Suggestion: parents who have babies are expected to routinely provide baby massage stimulation.