Neurology| August 01 2004 Prevalence, Symptoms, and Prognosis of Intracerebral Abscess AAP Grand Rounds (2004) 12 (2): 15. https://doi.org/10.1542/gr.12-2-15 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Prevalence, Symptoms, and Prognosis of Intracerebral Abscess. AAP Grand Rounds August 2004; 12 (2): 15. https://doi.org/10.1542/gr.12-2-15 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search toolbar search search input Search input auto suggest filter your search All PublicationsAll JournalsAAP Grand RoundsPediatricsHospital PediatricsPediatrics In ReviewNeoReviewsAAP NewsAll AAP Sites Search Advanced Search Topics: abscess Source: Goodkin HP, Harper MB, Pomeroy SL. Intracerebral abscess in children: historical trends at Children’s Hospital Boston. Pediatrics. 2004;113:1765–1770. Of the 386 patients identified by databases as having been treated for intracerebral abscess at Children’s Hospital, Boston, Mass, between 1981 and 2000, 55 had the diagnosis confirmed by cranial imaging or autopsy reports. A retrospective review of the records of these 55 patients was performed. The age of patients ranged from 5 days to 34 years; 7 were younger than 8 weeks at presentation and 5 were younger than 1 month. Nine children were classified as immunosuppressed, 6 had organ transplantations, 2 were treated for acute lymphoblastic leukemia, and 1 had hyperimmunoglobulin M syndrome. Abscesses were single in 37 and multiple noncontiguous in 18. Cultures obtained by aspiration, resection, or biopsy on 42 occasions identified pathogens in 36 (86%), with 2 or more organisms in 14. Streptococcus milleri was the most frequent isolate. Of the 9 patients with fungal infections, 7 were immunosuppressed, and all died. Presenting symptoms included headache in 27 (50%), vomiting in 12 (22%), photophobia in 5 (9%), fever in 16 (29%), seizures in 15 (27%), changes in mental status (lethargy to coma) in 17 (31%), paresthesias in 4 (7%), hemiparesis in 4 (6%), and increasing head circumference in 3 (6%). All but 1 patient received antimicrobial therapy, either alone or in combination with surgery. Surgical treatment (aspiration in 39 and resection in 3) was performed in 42 (76%) cases, with 20 patients requiring 2 or more procedures. Thirteen (24%) patients died, with the most common cause of death being multisystem failure. Of the 24 patients followed after discharge (16 lost to follow-up), 7 recovered, 10 had developmental delay or learning disorders, 6 had epilepsy, and 3 developed hydrocephalus requiring a ventriculoperitoneal shunt. The 55 patients in this 1981–2000 series were compared to a similar study of the natural history of intracerebral abscess in 94 patients treated between 1945 and 1980.1 Congenital heart disease was the most common predisposing factor during both time periods, with the rate of cerebral abscess similar in both time periods (2.75 per year for 1981–2000 versus 2.68 per year for 1945–1980). When compared to the earlier era, the more recent case series revealed a decrease in the frequency of abscesses associated with sinus or otitic infection (11% in 1981–2000 versus 26% in 1945–1980), an increase in infants affected (18% versus 7%), an increased number associated with acute immunosuppressive diseases (16% versus 1%), an increase in cases treated with antibiotics alone (22% versus 1%), no significant change in mortality (24% versus 27%), previously unrecognized Citrobacter causative organism (only in 3 neonatal cases), and fungus infection (predominantly in immunosuppressed patients) not encountered in the 1945–1980 era. Despite improvements in diagnosis due to neuroimaging, brain abscess continues to result in high rates of neurologic impairment and death. A brain abscess consists of localized pus within the brain substance. Organisms enter the brain via the blood stream from a distant... You do not currently have access to this content.