Evolutionary Development Research Articles

Where Is the Son of Man Coming or Going?

Abstract In Daniel 7 the ‘Son of Man coming with the clouds’ appears to move toward (or within) heaven. In the apocalyptic discourses Jesus has the Son of Man moving in the opposite direction to earth, traditionally understood as the Second Coming. Resolutions of the discrepancy include arguing that Daniel 7 refers to Jesus’s ascension, that the Synoptics use Daniel’s language to refer to a coming in judgement against Jerusalem in A.D. 70, others suggest evolutionary developments in the early church or a mistaken Jesus. This article suggests Jesus’s use of Daniel reflects a close exegetical reading of the text. There is no discrepancy.

Эзотерический подход к экспликации понятий страдания, объективированной воли (эго) и имманентной целенаправленности с позиции концептуальной идеи об эволюционной каузальной финалистичности

This study endeavors to explicate and elucidate, from an esoteric perspective, the potential, prospective, and functional content of such phenomena as suffering, objectified will (with the ego representing the referent of the psychic structure of the subject), and immanent teleology. Drawing upon the philosophical perspectives on suffering and objectified will by German philosopher A. Schopenhauer, as well as referencing the esoteric teachings of American philosopher-mystic F. Merrell-Wolff, the philosophical views on human existence by J.-P. Sartre, the spiritual concepts of Canadian psychologist E. Tolle, and the arguments posited by Aristotle in favor of the existence of a final cause, the study aims to analyze these phenomena. An attempt is made to demonstrate the interconnectedness between the claims of the objectified will, as discussed in philosophical discourse, and the ideas of theoretical physicist S. Hawking in the field of physical sciences, particularly in the evolutionary development of the universe. Through the discourse, immanent teleology, manifested in life itself as an inclination towards eternal peace, is asserted as an a priori form of understanding the world of phenomenal spatiotemporal multiplicity. In contrast, the objectified will strives for the identity of infinite energy density through possession, sole proprietary ownership, and governance over the objects of the universe. These dual directions culminate in liberation through the overcoming or destruction of enslavement, ultimately leading to the annulment of time and space.

Analysis of pore-fracture structure evolution and permeability in tar-rich coal under high-temperature pyrolysis using μCT technology

To study the internal evolution characteristics of tar-rich coal under high-temperature pyrolysis and improve pyrolysis efficiency, three-dimensional reconstruction and analysis of tar-rich coal from northern Shaanxi after high-temperature pyrolysis were conducted using μCT technology. The evolutionary development of pore and fracture structure at different temperatures and the relationship between pore-fractures and permeability was studied and discussed. The results show that when tar-rich coal from 300 to 600 °C, it mainly undergoes two stages: in the first stage, the internal substance structure of the coal mainly undergoes thermal cracking, forming large fracture bands; in the second stage, the coal undergoes intense pyrolysis reactions, resulting in primarily circular or elliptical large pore structures within the coal, with a reduction in the number of fractures. Furthermore, a strong exponential relationship is exhibited between the porosity and permeability of tar-rich coal, and a predictive equation is provided. When the temperature exceeds 500 °C, the coupled effect of pores and fractures contributes more than 20% to permeability, and its impact cannot be ignored.

Region and layer-specific expression of GABAA receptor isoforms and KCC2 in developing cortex.

γ-Aminobutyric acid (GABA) type A receptors (GABAARs) are ligand-gated Cl-channels that mediate the bulk of inhibitory neurotransmission in the mature CNS and are targets of many drugs. During cortical development, GABAAR-mediated signals are significantly modulated by changing subunit composition and expression of Cl-transporters as part of developmental processes and early network activity. To date, this developmental evolution has remained understudied, particularly at the level of cortical layer-specific changes. In this study, we characterized the expression of nine major GABAAR subunits and K-Cl transporter 2 (KCC2) in mouse somatosensory cortex from embryonic development to postweaning maturity. We evaluated expression of α1-5, β2-3, γ2, and δ GABAAR subunits using immunohistochemistry and Western blot techniques, and expression of KCC2 using immunohistochemistry in cortices from E13.5 to P25 mice. We found that embryonic cortex expresses mainly α3, α5, β3, and γ2, while expression of α1, α2, α4, β2, δ, and KCC2 begins at later points in development; however, many patterns of nuanced expression can be found in specific lamina, cortical regions, and cells and structures. While the general pattern of expression of each subunit and KCC2 is similar to previous studies, we found a number of unique temporal, regional, and laminar patterns that were previously unknown. These findings provide much needed knowledge of the intricate developmental evolution in GABAAR composition and KCC2 expression to accommodate developmental signals that transition to mature neurotransmission.

A comparative plastome approach enhances the assessment of genetic variation in the Melilotus genus

BackgroundMelilotus, a member of the Fabaceae family, is a pivotal forage crop that is extensively cultivated in livestock regions globally due to its notable productivity and ability to withstand abiotic stress. However, the genetic attributes of the chloroplast genome and the evolutionary connections among different Melilotus species remain unresolved.ResultsIn this study, we compiled the chloroplast genomes of 18 Melilotus species and performed a comprehensive comparative analysis. Through the examination of protein-coding genes, we successfully established a robust phylogenetic tree for these species. This conclusion is further supported by the phylogeny derived from single-nucleotide polymorphisms (SNPs) across the entire chloroplast genome. Notably, our findings revealed that M. infestus, M. siculus, M. sulcatus, and M. speciosus formed a distinct subgroup within the phylogenetic tree. Additionally, the chloroplast genomes of these four species exhibit two shared inversions. Moreover, inverted repeats were observed to have reemerged in six species within the IRLC. The distribution patterns of single-nucleotide polymorphisms (SNPs) and insertions/deletions (InDels) within protein-coding genes indicated that ycf1 and ycf2 accumulated nonconservative alterations during evolutionary development. Furthermore, an examination of the evolutionary rate of protein-coding genes revealed that rps18, rps7, and rpl16 underwent positive selection specifically in Melilotus.ConclusionsWe present a comparative analysis of the complete chloroplast genomes of Melilotus species. This study represents the most thorough and detailed exploration of the evolution and variability within the genus Melilotus to date. Our study provides valuable chloroplast genomic information for improving phylogenetic reconstructions and making biogeographic inferences about Melilotus and other Papilionoideae species.

Death from Failed Protection? An Evolutionary-Developmental Theory of Sudden Infant Death Syndrome

Sudden infant death syndrome (SIDS) has been mainly described from a risk perspective, with a focus on endogenous, exogenous, and temporal risk factors that can interact to facilitate lethal outcomes. Here we discuss the limitations that this risk-based paradigm may have, using two of the major risk factors for SIDS, prone sleep position and bed-sharing, as examples. Based on a multipronged theoretical model encompassing evolutionary theory, developmental biology, and cultural mismatch theory, we conceptualize the vulnerability to SIDS as an imbalance between current physiologic-regulatory demands and current protective abilities on the part of the infant. From this understanding, SIDS appears as a developmental condition in which competencies relevant to self-protection fail to develop appropriately in the future victims. Since all of the protective resources in question are bound to emerge during normal infant development, we contend that SIDS may reflect an evolutionary mismatch situation—a constellation in which certain modern developmental influences may overextend the child’s adaptive (evolutionary) repertoire. We thus argue that SIDS may be better understood if the focus on risk factors is complemented by a deeper appreciation of the protective resources that human infants acquire during their normal development. We extensively analyze this evolutionary-developmental theory against the body of epidemiological and experimental evidence in SIDS research and thereby also address the as-of-yet unresolved question of why breastfeeding may be protective against SIDS.

Rethinking Justice: Unraveling the Tapestry of Justice in Islamic and Western Philosophies

Throughout human civilization, justice has been an enduring value, evolving through continuous advocacy. Fueled by human reason, individuals consistently elevate their standards, leading to the transformation of justice derived from natural law, societal changes, and religious doctrines. This dynamic process signifies that humanity, along with its cultures, laws, and justice perceptions, progresses rather than regresses—growing more intricate, sophisticated, and advanced. This article delves into the development of justice concepts in Islamic and Western cultures across classical, modern, postmodern, and contemporary eras. Utilizing a philosophical approach, it argues that justice undergoes a developmental evolution in both cultures—from discussions in the context of natural law to exploring religious justice and culminating in discussions of social justice. Despite epistemological differences, both Islamic and Western cultures remain inseparable from justice principles: enforcing justice, presupposing equality, aligning with truth, embodying equilibrium, and positioning things rightly.

Metabolic Allometric Scaling of Multicellular Organisms as a Product of Evolutionary Development and Optimization of Food Chains

Production of energy is a foundation of life. The metabolic rate of organisms (amount of energy produced per unit time) generally increases slower than organisms’ mass, which has important implications for life organization. This phenomenon, when considered across different taxa, is called interspecific allometric scaling. Its origin has puzzled scientists for many decades, and still is considered unknown. In this paper, we posit that natural selection, as determined by evolutionary pressures, leads to distribution of resources, and accordingly energy, within a food chain, which is optimal from the perspective of stability of the food chain, when each species has sufficient amount of resources for continuous reproduction, but not too much to jeopardize existence of other species. Metabolic allometric scaling (MAS) is then a quantitative representation of this optimal distribution. Taking locomotion and the primary mechanism for distribution of energy, we developed a biomechanical model to find energy expenditures, considering limb length, skeleton mass and speed. Using the interspecific allometric exponents for these three measures and substituting them into the locomotion-derived model for energy expenditure, we calculated allometric exponents for mammals, reptiles, fish, and birds, and compared these values with allometric exponents derived from experimental observations. The calculated allometric exponents were nearly identical to experimentally observed exponents for mammals, and very close for fish, reptiles and the basal metabolic rate (BMR) of birds. The main result of the study is that the MAS is a function of a mechanism of optimal energy distribution between the species of a food chain. This optimized sharing of common resources provides stability of a food chain for a given habitat and is guided by evolutionary pressures and natural selection.

EVOLUTION OF SAZ SOILS OF CENTRAL FERGHANA GRASSLAND

In article addresses the role of the anthropogenic factor in the process of modern evolutionary development of irrigated meadow saz soils in Central Fergana.

Asymmetry between the dorsal and ventral digging valves of the female locust: function and mechanics

BackgroundThe female locust is equipped with unique digging tools, namely two pairs of valves—a dorsal and a ventral—utilized for excavating an underground hole in which she lays her eggs. This apparatus ensures that the eggs are protected from potential predators and provides optimal conditions for successful hatching. The dorsal and the ventral valves are assigned distinct roles in the digging process. Specifically, the ventral valves primarily function as anchors during propagation, while the dorsal valves displace soil and shape the underground tunnel.ResultsIn this study, we investigated the noticeable asymmetry and distinct shapes of the valves, using a geometrical model and a finite element method. Our analysis revealed that although the two pairs of valves share morphological similarities, they exhibit different 3D characteristics in terms of absolute size and structure. We introduced a structural characteristic, the skew of the valve cross-section, to quantify the differences between the two pairs of valves. Our findings indicate that these structural variations do not significantly contribute to the valves’ load-bearing capabilities under external forces.ConclusionsThe evolutionary development of the form of the female locust digging valves is more aligned with fitting their respective functions rather than solely responding to biomechanical support needs. By understanding the intricate features of these locust valves, and using our geometrical model, valuable insights can be obtained for creating more efficient and specialized tools for various digging applications.

Novel Types of Phyllobilins in a Fern - Molecular Reporters of the Evolution of Chlorophyll Breakdown in the Paleozoic Era.

Breakdown of chlorophyll (Chl), as studied in angiosperms, follows the pheophorbide a oxygenase/phyllobilin (PaO/PB) pathway, furnishing linear tetrapyrroles, named phyllobilins (PBs). In an investigation with fern leaves we have discovered iso-phyllobilanones (iPBs) with an intriguingly rearranged and oxidized carbon skeleton. We report here a key second group of iPBs from the fern and on their structure analysis. Previously, these additional Chl-catabolites escaped their characterization, since they exist in aqueous media as mixtures of equilibrating isomers. However, their chemical dehydration furnished stable iPB-derivatives that allowed the delineation of the enigmatic structures and chemistry of the original natural catabolites. The structures of all fern-iPBs reflect the early core steps of a PaO/PB-type pathway and the PB-to-iPB carbon skeleton rearrangement. A striking further degradative chemical ring-cleavage was observed, proposed to consume singlet molecular oxygen (1O2). Hence, Chl-catabolites may play a novel active role in detoxifying cellular 1O2. The critical deviations from the PaO/PB pathway, found in the fern, reflect evolutionary developments of Chl-breakdown in the green plants in the Paleozoic era.

АНАЛИЗ УСТОЙЧИВОСТИ В МОДЕЛИРОВАНИИ ЭВОЛЮЦИОННЫХ ПРОЦЕССОВ

The paper considers mathematical models of the evolution of new biological species from a common ancestor, depending on the adaptability to the environment in the presence of a particular trait in the genotype. Equations describing the change in the number of individuals with dominant and recessive traits, taking into account their fertility, are presented. The calculation of the time for which the population of the species consumes vital environmental resources has also been made. Within the framework of this model, the growth rate of the population in conditions of a shortage of a food source is investigated. A mathematical model of the population growth of the species, the limits of applicability and methods of its continuation using equations describing the factor of population decline due to sudden changes in the environment are presented and described. The article presents criteria for the applicability of critical points of one mathematical model as initial conditions for another. The results of the calculations can be used in the framework of population genetics, as well as for environmental studies. On their basis, it is possible to make assumptions about the possibility of further evolutionary development of a biological species.

Anterior-posterior Wnt signaling network conservation between indirect developing sea urchin and hemichordate embryos.

How animal body plans evolved and diversified is a major question in evolutionary developmental biology. To address this question, it is important to characterize the exact molecular mechanisms that establish the major embryonic axes which give rise to the adult animal body plan. The anterior-posterior (AP) axis is the first axis to be established in most animal embryos, and in echinoderm sea urchin embryos its formation is governed by an integrated network of three different Wnt signaling pathways: Wnt/β-catenin, Wnt/JNK, and Wnt/PKC pathway. The extent to which this embryonic patterning mechanism is conserved among deuterostomes, or more broadly in metazoans, is an important open question whose answers could lead to a deeper appreciation of the evolution of the AP axis. Because Ambulacrarians (echinoderms and hemichordates) reside in a key phylogenetic position as the sister group to chordates, studies in these animals can help inform on how chordate body plans may have evolved. Here, we assayed the spatiotemporal gene expression of a subset of sea urchin AP Wnt patterning gene orthologs in the hemichordate, Schizocardium californicum. Our results show that positioning of the anterior neuroectoderm (ANE) to a territory around the anterior pole during early AP formation is spatially and temporally similar between indirect developing hemichordates and sea urchins. Furthermore, we show that the expression of wnt8 and frizzled5/8, two known drivers of ANE patterning in sea urchins, is similar in hemichordate embryos. Lastly, our results highlight divergence in embryonic expression of several early expressed Wnt genes (wnt1, wnt2 and wnt4). These results suggest that expression of the sea urchin AP Wnt signaling network is largely conserved in indirect developing hemichordates setting the foundation for future functional studies in S. californicum.

Man and embryo: Historicizing ideas about humanity in the study of reproduction, 18th–19th centuries

AbstractThis article is concerned with historicizing the idea that all people belong to a single collective of biological human beings. It analyzes implications and changes in the concept of “Man” over the 18th and 19th centuries, particularly in the study of reproduction and embryos. Examining gendered assumptions in 18th‐century generation systems shows how these theories described the formation of male more than female embryos. This asymmetry matched the idea that only rational males, standing above nature, were determinant for the concept of Man. In the 19th century, new studies pushed Man closer to the rest of the natural world, provoking a readjustment in definitions of Man and understandings of the human embryo. However, far from equalizing humanity, the 19th‐century concept of Man introduced a hierarchy in the human species based on different levels of embryonic and evolutionary development.

New Generation Nebulizers.

Standard nebulizers are intended for general purpose use and typically are continuously operated jet or ultrasonic nebulizers. Evolutionary developments such as breath-enhanced and breath-triggered devices have improved delivery efficiency and ease of use, yet are still suitable for delivery of nebulized medications approved in this category. However, recent developments of vibrating membrane or mesh nebulizers have given rise to a significant increase in delivery efficiency requiring reformulation of former drug products or development of new formulations to match the enhanced delivery characteristics of these new devices. In addition, the electronic nature of the new devices enables tailoring to specific applications and patient groups, such as guiding or facilitating optimal breathing and improving adherence to the therapeutic regimen. Addressing these patient needs leads to new nebulization technologies being embedded in devices with fundamentally distinct functionality, modes of operation and patient interfaces. Therefore, new generation nebulizers can no longer be regarded as one category with fairly similar performance characteristics but must be clinically tested and approved as drug/device combinations together with the specific drug formulation, similar to the approval of pressurized metered-dose inhalers and dry powder inhalers. From a regulatory viewpoint, it is required that drug and device are associated with each other as combinations by clear, mutually conforming labels or, even more desirably, by distinct container-closure systems (closed system nebulizer).

Horizontal Gaze Assessment: An Extensive Narrative Review

Bipedalism was a significant milestone in the evolutionary development of Homo sapiens sapiens, influencing neocortical evolution and subsequent behavioral changes. Coordinated visual and sensory inputs are crucial for posture, environmental interaction, and surgical planning, with horizontal gaze being a pivotal parameter. This narrative review aims to explore various geometric measures used to assess horizontal gaze in patients, highlighting their applications in surgical planning. A literature review was conducted in indexed databases using Mesh terms like "Cervical Vertebrae" and "Visual Fields" along with keywords such as "horizontal gaze" and "sagittal spine parameters." Among 477 initially identified articles, 41 were selected for inclusion after rigorous filtering. The most recognized method for assessing horizontal gaze is the Chin Brow Vertical Angle (CBVA), initially described in patients with ankylosing spondylitis. Clinical photography is employed as a tool for CBVA calculation, while other measures like McGregor slope and Slope of the Line of Sight have been considered as alternatives to CBVA. Each method presents its unique advantages and limitations. This review highlights the need for further research into horizontal gaze measurement methods. Developing novel approaches to determine horizontal gaze can significantly enhance surgical planning and, consequently, improve patient outcomes. The ongoing exploration of these geometric measures offers promising prospects for advancing the field and optimizing patient care.

Eye development influences horn size but not patterning in horned beetles.

Understanding the origin of novel morphological traits is a long-standing objective in evolutionary developmental biology. We explored the developmental genetic mechanisms that underpin the formation of a textbook example of evolutionary novelties, the cephalic horns of beetles. Previous work has implicated the gene regulatory networks associated with compound eye and ocellar development in horn formation and suggested that horns and compound eyes may influence each other's sizes. Therefore, we investigated the functional significance of genes central to visual system formation in the initiation, patterning, and size determination of head horns across three horned beetle species. We find that while the downregulation of canonical eye patterning genes reliably reduces or eliminates compound eye formation, it does not alter the position or shape of head horns yet does result in an increase in relative horn length. We discuss the implications of our results for our understanding of the genesis of cephalic horns in particular and evolutionary novelties in general.

A framework for the integration of development and evolution: The forgotten legacy of James Meadows Rendel

The historical challenges to bridge the gaps between developmental biology and population or statistical genetics under the explanatory dominance of the Modern Evolutionary Synthesis during the 20th century have been thoroughly documented. However, although several attempts to integrate these fields have been made, most have been deemed unsuccessful. As an example of those efforts, in this paper I discuss the work of James Meadows Rendel, a student of J. B. S. Haldane and disciple of Conrad Hal Waddington. I present his largely forgotten or unrecognized, but innovative, ideas about canalization and the role of development in phylogeny as a valuable piece to connect these fields that could still have important ramifications for today's evolutionary biology. In fact, it is expected that the legacy of J. M. Rendel will be rediscovered, and more importantly, incorporated and extended by future researchers, in light of the growth of evolutionary developmental biology in the last decades. What is more, this case offers a chance to critically revisit standard historiographies about the dichotomy between developmental and population genetics research frameworks in 20th century biology.

Genomic surveillance strategy. Problems and perspectives

The topic of epidemiologic surveillance is one of the basic concepts in the theory and practice of epidemiologic science. In Russia, generalization of the accumulated factual material and theoretical developments have allowed us to formulate a number of provisions on the nature of the epidemic process. The pandemic of a new coronavirus infection has forced adjustments in all spheres of society, including the activities of the infectious disease epidemiological surveillance system, requiring the development and implementation of innovative solutions. Based on the experience of prompt response to the tasks set by the COVID-19 pandemic, the authors raised the problem of development and implementation of a system of molecular genetic monitoring for pathogens of emerging and re-emerging infections as a priority vector of epidemiological surveillance development. The introduction of modern molecular biological technologies for the identification of pathogens with epidemic potential, taking into account their genetic diversity, into the system of epidemiologic surveillance has been substantiated based on the experience of using platform solutions created by the Central Research Institute of Epidemiology of Rospotrebnadzor. The strategy of genomic epidemiologic surveillance as a powerful tool to ensure readiness for response measures and management of the epidemic process by implementing and adjusting preventive and anti-epidemic measures was developed. The Russian platform for aggregation of information on virus genomes (VGARus) developed at the Central Research Institute of Epidemiology of Rospotrebnadzor as a technological, scientific, organizational and infrastructural base of genomic epidemiological surveillance, acting as an interdepartmental consortium, has been introduced into practice. The efficiency of VGARus was shown to assess the mutational variability of SARS-CoV-2, the influence of evolutionary development of circulating pathogens on the characteristics of the epidemic process, the implementation of operational and retrospective analysis of morbidity and prediction of the spread of genetic variants of pathogens.

Exploration of Sustainable Agro-Pastoral Integration Development Models in the Qinghai-Tibet Plateau

The high-altitude geographical characteristics and unique climate types of the Qinghai-Tibet Plateau have dictated an agricultural and pastoral development path for the region, which, after a series of evolutionary developments, has culminated in the current model of agro-pastoral integration. However, the economic and ecological benefits brought by the development of agriculture and animal husbandry are accompanied by serious issues such as land degradation and overgrazing, making the exploration and practice of sustainable agro-pastoral integration models for the Qinghai-Tibet Plateau an urgent task. This article utilizes CiteSpace to review recent literature on agro-pastoral development models in the Qinghai-Tibet Plateau. Starting from the agro-pastoral processes, spatial layout, and economic development of the Qinghai-Tibet Plateau, this paper aims to provide a macroscopic understanding of the agro-pastoral integration model, propose new strategies and ideas for development, and offer scientific theoretical and practical guidance for sustainable development, achieving a win-win situation for economic growth and ecological protection.