Developmental Cascade Research Articles

Reciprocal relationship between interpersonal communication and depressive symptoms and the mediating role of resilience across two years: Three-wave cross-lagged panel model

BackgroundDepression among children has been a growing public health concern. It is generally recognized that individuals with depression are likely to have interpersonal malfunctioning. However, there remains a limited scientific understanding of the reciprocal relationship between interpersonal communication and depressive symptoms among rural Chinese children in a longitudinal approach. MethodsTherefore, guided by the interpersonal model of depression and the developmental cascade model, the present study conducted a cross-lagged panel analysis study to explore the bidirectional relationship between interpersonal communication and depressive symptoms across three waves among 2188 elementary school students in rural areas of one county of Gansu Province, China. We also examined the mediating effect of resilience and sex differences of the models. ResultsOur results showed that depressive symptoms negatively predicted interpersonal communication from T1 to T2 and T2 to T3. Interpersonal communication negatively predicted depressive symptoms from T1 to T2, but not T2 to T3. Furthermore, resilience showed significant partial mediating effects in the reciprocal relationship between interpersonal communication and depressive symptoms. In terms of sex differences, the significant relationship between depressive symptoms at T1 and interpersonal communication at T2 was found to be significant among male students and marginally significant among female students. The full mediating effect of resilience at T1 was found only among male students, whereas resilience at T2 functioned as a full mediator between depressive symptoms at T2 and interpersonal communication at T3 only among female students. LimitationsFirst, the present sample consisted of only third and fourth grade (i.e., in T1) students from one county in rural China. Second, the present study examined depressive symptoms instead of depression as a clinical diagnosis. Third, the third wave of the data was collected during COVID-19. The impact of the COVID-19 pandemic could unexpectedly pose on child mental health. ConclusionsThe finding underlined the importance of providing comprehensive depression prevention and intervention from fostering children's inner resilience and promoting their ability to navigate interpersonal resources.

Developmental and homeostatic signaling transmitted by the G-protein coupled receptor FPR2.

Formyl peptide receptor 2 (FPR2) and its mouse counterpart Fpr2 are the members of the G protein-coupled receptor (GPCR) family. FPR2 is the only member of the FPRs that interacts with ligands from different sources. FPR2 is expressed in myeloid cells as well as epithelial cells, endothelial cells, neurons, and hepatocytes. During the past years, some unusual properties of FPR2 have attracted intense attention because FPR2 appears to possess dual functions by activating or inhibiting intracellular signal pathways based on the nature, concentration of the ligands, and the temporal and spatial settings of the microenvironment in vivo, the cell types it interacts with. Therefore, FPR2 controls an abundant array of developmental and homeostatic signaling cascades, in addition to its "classical" capacity to mediate the migration of hematopoietic and non-hematopoietic cells including malignant cells. In this review, we summarize recent development in FPR2 research, particularly in its role in diseases, therefore helping to establish FPR2 as a potential target for therapeutic intervention.

Vocabulary and automatic attention: The relation between novel words and gaze dynamics in noun generalization.

Words direct visual attention in infants, children, and adults, presumably by activating representations of referents that then direct attention to matching stimuli in the visual scene. Novel, unknown, words have also been shown to direct attention, likely via the activation of more general representations of naming events. To examine the critical issue of how novel words and visual attention interact to support word learning we coded frame-by-frame the gaze of 17- to 31-month-old children (n = 66, 38 females) while generalizing novel nouns. We replicate prior findings of more attention to shape when generalizing novel nouns, and a relation to vocabulary development. However, we also find that following a naming event, children who produce fewer nouns take longer to look at the objects they eventually select and make more transitions between objects before making a generalization decision. Children who produce more nouns look to the objects they eventually select more quickly following the naming event and make fewer looking transitions. We discuss these findings in the context of prior proposals regarding children's few-shot category learning, and a developmental cascade of multiple perceptual, cognitive, and word-learning processes that may operate in cases of both typical development and language delay. RESEARCH HIGHLIGHTS: Examined how novel words guide visual attention by coding frame-by-frame where children look when asked to generalize novel names. Gaze patterns differed with vocabulary size: children with smaller vocabularies attended to generalization targets more slowly and did more comparison than those with larger vocabularies. Demonstrates a relationship between vocabulary size and attention to object properties during naming. This work has implications for looking-based tests of early cognition, and our understanding of children's few-shot category learning.

A Developmental Cascade Analysis of Peer Rejection, Depression, Anxiety, and Externalizing Problems from Childhood through Young Adulthood.

The need to belong with peers is an essential component of development, and when individuals face peer rejection they often experience a host of negative outcomes, including internalizing and externalizing problems. There exists conflicting evidence whether peer rejection precedes, succeeds, or reciprocally influences psychopathology. This study used two longitudinal community samples recruited from Portuguese schools with data from middle childhood through early adulthood. The obtained data measured mean levels and assessed stability of peer rejection, and peer rejection's association with demographic and psychopathology variables concurrently across development. Analyses fit developmental cascade models of peer rejection, depression, anxiety, and externalizing problems. Mean peer rejection levels remained relatively stable over time, and peer rejection scores were mildly to moderately correlated at measurement points closer together but attenuated at timepoints that were further apart in time. At some timepoints, age, and parental SES and education were associated with peer rejection. Peer rejection was associated with depression, anxiety, and externalizing problems concurrently at each time point (r = ~0.3-0.5). Developmental cascade models supported depression and anxiety temporally preceding peer rejection and some reciprocal relationships between depression and peer rejection. Anxiety was a robust temporal precedent of psychopathology and peer rejection.

Functional characterization of five developmental signaling network genes in the white-backed planthopper: Potential application for pest management.

The white-backed planthopper (WBPH, Sogatella furcifera) is a major rice pest that exhibits condition dependent wing dimorphisms - a macropterous (long wing) form and a brachypterous (short wing) form. Although, the gene cascade that regulates wing development and dimorphic differentiation has been largely defined, the utility of these genes as targets for pest control has yet to be fully explored. Five genes typically associated with the developmental signaling network, armadillo (arm), apterous A (apA), scalloped (sd), dachs (d), and yorkie (yki) were identified from the WBPH genome and their roles in wing development assessed following RNA interference (RNAi)-mediated knockdown. At 5 days-post injection, transcript levels for all five targets were substantially decreased compared with the dsGFP control group. Among the treatment groups, those injected with dsSfarm had the most pronounced effects on transcript reduction, mortality (95 ± 3%), and incidence (45 ± 3%) of wing deformities, whereas those injected with dsSfyki had the lowest incidence (6.7 ± 4%). To assess the utility of topical RNAi for Sfarm, we used a spray-based approach that complexed a large-scale, bacteria-based double-stranded RNA (dsRNA) expression pipeline with star polycation (SPc) nanoparticles. Rice seedlings infested with third and fourth instar nymphs were sprayed with SPc-dsRNA formulations and RNAi phenotypic effects were assessed over time. At 2 days post-spray, Sfarm transcript levels decreased by 86 ± 9.5% compared with dsGFP groups, and the subsequent incidences of mortality and wing defects were elevated in the treatment group. This study characterized five genes in the WBPH developmental signaling cascade, assessed their impact on survival and wing development via RNAi, and developed a nanoparticle-dsRNA spray approach for potential field control of WBPH. © 2023 Society of Chemical Industry.

A gene-environment cascade theoretical framework of developmental psychopathology.

Previous theories have emphasized genetic effects "inside the skin" via endophenotypes within the broader developmental psychopathology theory. Expanding on the mechanisms of gene-environment correlation, we propose a new integrative framework emphasizing how genetic effects "outside the skin" (Reiss & Leve, 2007) accumulate due to individual variation in social information processing in negative environments and sociocultural contexts as part of developmental cascades to psychopathology. In this gene-environment cascade theoretical framework, genetic predisposition for psychopathology, as well as stable traits and behaviors, can lead to negative environments via gene-environment correlations that can be exacerbated or buffered by an individual's social information processing. Moreover, these "environments" range from dyadic social relationships to broader sociocultural contexts. Over time, these processes exacerbate one another as part of developmental cascades, resulting in accumulating risk for psychopathology. By focusing on gene-environment correlations and integrating disparate social-emotional, cognitive, and sociocultural research domains, this framework delineates key processes by which early genetic predisposition can contribute to developmentally distinct and accumulating risk for psychopathology over the life course. Implications for intervention and methodological advances that facilitate testing models are presented. This new framework moves the field further away from genetic determinism by informing targets of early psychosocial prevention. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Understanding developmental cascades and experience: Diversity matters.

This Presidential Address is aimed at considering how infant development can be understood in terms of developmental cascades. Adopting a developmental cascades approach may be especially useful for understanding development in infancy, when changes occur in multiple domains over relatively short time spans. Thinking about change in terms of developmental cascades highlights the role of the input in development, both in terms of how the input changes with development and in terms of how differences in the input lead to different developmental pathways. I reflect on how a developmental cascade perspective can help us understand the role of input and how development builds as the emergence and refinement of abilities changes the input and shapes the developmental pathways. Further, I emphasize that infants develop despite differences in the input, and that when studying infant development we should seriously consider the diversity of experience that infants encounter and how differences in experience (and input) shape the developmental cascade.

Cascades linking school achievement and engagement to the acculturation of immigrant-origin youth

ABSTRACT Low academic achievement has been shown to lead to higher disengagement from school, the main acculturative arena for immigrant-origin youth. Therefore, we tested the hypothesis that their disengagement from school will lead over time to lower involvement with the national culture and higher involvement with the ethnic culture. To test this hypothesis, we examined developmental cascades linking academic achievement to school engagement and spreading to national and ethnic acculturation, in a three-wave longitudinal study of immigrant adolescents in Greece. Cross-lagged analyses revealed that lower academic achievement cascaded over time to decreases in school engagement, which in turn cascaded to decreases in national, and increases in ethnic, involvement. School engagement fully longitudinally mediated the effects of academic achievement on both national and ethnic involvement. All cross-lagged effects in the reverse direction were non-significant. The results highlight the importance of schools in immigrant-origin youth’s involvement with the national culture.

Perceived neighbourhood collective efficacy and adolescent health determinants: Investigating outdoor play as a mediator.

Research demonstrates that play is promotive of health and development in children across multiple domains. Outdoor play may be especially beneficial as environmental elements are conducive to recreation and relaxation. Maternal perception of neighbourhood collective efficacy (NCE), or sense of cohesion among residents, may be a form of social capital especially effective in promoting outdoor play, and thus healthy development. Yet little research has examined the long-term benefits of play beyond childhood. We utilized longitudinal data from the Fragile Families and Child Wellbeing Study (N = 4441) to evaluate outdoor play during middle childhood as a mediator between perceived NCE in early childhood and adolescent health determinants. Maternal self-reported perceived NCE at age 5, children's outdoor play was assessed at age 9 and adolescents' self-reported height, weight, physical activity and depressive and anxiety symptoms at age 15. Total play served as mediator between NCE and later adolescent health determinants. Perceived NCE in early childhood (age 5) significantly predicted more total play in middle childhood (age 9), which in turn predicted more physical activity and lower anxiety symptoms in adolescence (age 15). Consistent with a developmental cascades approach, maternal perceptions of NCE shaped children's engagement in outdoor play that may serve as a foundation for later emerging health behaviours.

Understanding the link between anxious parental overprotection and academic confidence in emerging adults: Mediation through interpersonal and intrapersonal processes

Some parents may engage in overparenting, often characterized as overprotection, to ensure their college student’s academic success, yet, findings show that such parental efforts undermine performance. In the present study, we propose that there are interpersonal (parental hostility) and intrapersonal factors (depression and self-regulation) that act as mechanisms through which anxious overprotective parenting leads to diminished emerging adult academic confidence. Emerging adults ( N = 967; 75.6% women; M age = 18.71, SD = .94) who were primarily in their first (60.5%) or second (35.7%) year of college completed measures of academic confidence (academic adjustment, academic efficacy, confidence in graduating), reports of mothers’ and fathers’ anxious overprotective parenting, perceptions of maternal and paternal hostility, depression, and self-regulation. Employing a double mediation structural equation model, results revealed that anxious maternal and paternal overprotective parenting operated through perceived parental hostility to intrapersonal processes (depression, self-regulation) in predicting academic confidence. Maternal and paternal hostility, in particular, was paramount as an interpersonal mediator through which overprotective parenting led to emerging adult intrapersonal and academic outcomes. Although cross-sectional, the current findings are suggestive of the developmental cascade model (Masten & Cicchetti, 2010), whereby diminished family dynamics are associated with internalizing symptoms and self-regulatory issues, which, in turn, are linked with lower academic achievement in children.

Relations among parenting, academic performance, and psychopathology: An investigation of developmental cascades and their interplay with maternal and paternal parenting.

Little effort has been made to integrate developmental cascades with maternal/paternal parenting in a single investigation. The present study seeks to test cascading effects among academic and internalizing/externalizing symptoms and their associations with maternal/paternal parenting across three time points from 8 to 10 years. Data for this investigation came from a nationally representative prospective cohort study of children born in April through July of 2008 in South Korea who were followed up annually. The sample included 1,598 families (48.5% girls). Parents rated their parenting and teachers rated children's internalizing/externalizing problems and academic performance. Structural equation modeling showed that externalizing problems were negatively related to academic performance. Academic performance was negatively related to internalizing problems and positively related to maternal/paternal authoritative parenting, which in turn led to children's higher academic performance. Bidirectional relations were found between academic performance and externalizing problems and between paternal authoritative parenting and children's internalizing problems. Findings suggested cascading effects and their associations with parenting were not attributable to child gender, intelligence, or socioeconomic differences. These findings lend support to adjustment erosion and academic incompetence models and underscore the need for greater attention to the role that fathering may play in children's development and mothering.

Developmental cascades of behavior problems and cognitive ability from toddlerhood to middle childhood: A 9-year longitudinal study

Little is known about the direction, ordering, and uniqueness of longitudinal associations between behavior problems and cognitive ability, from toddlerhood to middle childhood. A developmental cascade model was tested in the present study to examine the transactional processes in 103 Chinese children at the ages of 1, 2, 7, and 9 years. Behavior problems were assessed using the maternal reported Infant-Toddler Social and Emotional Assessment at the ages of 1, 2 and parental reported Children Behavior Checklist at the ages of 7, 9. Cognitive ability was measured using Bayley Scales of Infant and Toddler Development at the ages of 1, 2 and Wechsler Intelligence Scale for Children at the ages of 7, 9. The results revealed the stability of behavior problems and cognitive ability from age 1 to age 9 years and concurrent associations between externalizing and internalizing problems. Unique longitudinal associations were identified between (1) age 1 cognitive ability and age 2 internalizing problems, (2) age 2 externalizing problems and age 7 internalizing problems, (3) age 2 externalizing problems and age 7 cognitive ability, (4) age 7 cognitive ability and age 9 externalizing problems. The results indicated essential targets for future interventions aimed at reducing children's behavior problems at 2 years old and promoting cognitive ability at 1 year old and 7 years old.

Carroll's Three-Stratum (3S) Cognitive Ability Theory at 30 Years: Impact, 3S-CHC Theory Clarification, Structural Replication, and Cognitive-Achievement Psychometric Network Analysis Extension.

Carroll's treatise on the structure of human cognitive abilities is a milestone in psychometric intelligence research. Thirty years later, Carroll's work continues to influence research on intelligence theories and the development and interpretation of intelligence tests. A historical review of the relations between the 3S and CHC theories necessitates the recommendation that the theories of Cattell, Horn, and Carroll be reframed as a family of obliquely correlated CHC theories-not a single CHC theory. Next, a previously unpublished Carroll exploratory factor analysis of 46 cognitive and achievement tests is presented. A complimentary bifactor analysis is presented that reinforces Carroll's conclusion that his 3S model more accurately represents the structure of human intelligence than two prominent alternative models. Finally, a Carroll-recommended higher-stratum psychometric network analysis (PNA) of CHC cognitive, reading, and math variables is presented. The PNA results demonstrate how PNA can complement factor analysis and serve as a framework for identifying and empirically evaluating cognitive-achievement causal relations and mechanisms (e.g., developmental cascade and investment theories), with an eye toward improved cognitive-achievement intervention research. It is believed that Carroll, given his long-standing interest in school learning, would welcome the integration of theory-driven factor and PNA research.

Longitudinal relationships across emotional distress, perceived emotion regulation, and social connections during early adolescence: A developmental cascades investigation.

Early adolescence is a vulnerable period for emotional distress. Both emotion regulation and social connection to peers and family adults are understood to be associated with distress. However, existing longitudinal work has not explored these constructs jointly in a way that estimates their reciprocal relationships over adolescence. We present a three-wave random-intercepts cross-lagged panel model of reciprocal relationships between emotional distress, perceived emotion regulation, and social connections during early adolescence, among 15,864 participants from education settings in disadvantaged areas of England, over three annual waves (at ages 11/12, 12/13, and 13/14 years). Findings showed that emotional distress and perceived emotion regulation share a negative relationship over time, and that higher perceived emotion regulation predicts greater family connection in the initial stages of early adolescence (from age 11-12 to 12-13 years). Findings also indicated that connection to peers is positively associated with family connection, but also positively predicts slightly greater distress in the later stages of early adolescence (from age 12-13 to 13-14 years). Findings indicate a risk of negative spiral between emotional distress and perceived emotion regulation in early adolescence, and that social connection may not necessarily play the role we might expect in reducing distress.

Associations between responsive parental behaviours in infancy and toddlerhood, and language outcomes at age 7 years in a population-based sample.

A wealth of evidence supports the important role high-quality parent-child interactions play in children's early language acquisition. However, the impact on later language outcomes remains unclear. To examine the associations between responsive parental behaviours across the early years and child language outcomes at age 7 years with families from an Australian longitudinal cohort study (N = 1148, 50% female). At child ages 12, 24 and 36 months, parents completed a self-report measure of responsive parental behaviours. Child language was directly assessed at age 7 using the Clinical Evaluation of Language Fundamentals, 4th edition (CELF-4), Australian Standardisation. Linear regression was used to examine associations between responsive parental behaviours from 12 to 36 months (consistently high, inconsistent and consistently low responsive parental behaviours at the three time points) and language scores at age 7 years. Adjusted models were run, including the following potential confounders: child sex; birth weight; birth order; maternal education; socio-economic disadvantage; non-English-speaking background; family history of speech-language problems; mother's vocabulary score; maternal mental health score; and mother's age at birth of child. A final adjusted model was run, including the potential confounder variables as well as adjusting for children's earlier language skills. Linear regression results showed children with parents who rated high on responsive parental behaviours at all three time points had higher mean language scores at age 7 than children whose parents reported low responsive parental behaviours across early childhood. This association attenuated after adjusting for earlier child language skills. Findings support the consistent use of responsive parental behaviours across the very early years of childhood to support long-term language outcomes. Findings also suggest that models of surveillance and support which monitor and assist families at multiple time-points over the early years are likely to be most effective for preventing ongoing language difficulties. What is already known on this subject There is extensive evidence consistently demonstrating the important contribution of aspects of parent-child interaction, specifically responsive parental behaviours, to children's language development. What this paper adds to the existing knowledge Understanding the cumulative benefit of responsive parent-child interactions across the very early years may help to inform preventive interventions and service delivery models for supporting young children's language development. This study demonstrates in a large, population-based cohort the contribution of consistency of responsive parental behaviours during infancy and toddlerhood to school-age language outcomes, accounting for other child, family and environmental factors. Capturing regular parent behaviours via self-report during the early years may be a more efficient and less costly method than parent-child interaction observations to monitor the home language-learning environment during routine developmental checks. What are the potential or actual clinical implications of this work? Findings support the need for surveillance of children and families in the early years, ensuring that intervention occurs when families need it most, that is, support is responsive to changing needs and that nuanced advice and support strategies are provided to activate positive developmental cascades. Capturing both parent behaviours and child language may assist clinicians to identify those families who may benefit from parent-child interaction intervention.

A developmental cascade model of adolescent peer relationships, substance use, and psychopathological symptoms from child maltreatment

IntroductionAlthough previous studies have demonstrated high intercorrelations among deviant peer affiliation, substance use, externalizing and internalizing symptoms in adolescence, these studies have been limited because they did not examine 1) the associations over time by assuming one particular sequence; and 2) child maltreatment effects. MethodsThis study included 617 adolescents (54.3 % girls, 55.6 % Black) at-risk of maltreatment living in the U.S and primarily low-income. Deviant peer affiliation was assessed at ages 12, 14, and 16 using 13 items from the modified version of the Youth Risk Behavior and Monitoring the Future Survey. Externalizing and internalizing symptoms were measured at ages 12, 14, and 16 using the Child Behavior Checklist. The number of substances used (ages 12, 14, 16, and 18) were created by summing the self-reported alcohol, tobacco, and marijuana use. Each type of maltreatment (birth to age 12) was assessed using the self-report. ResultsAutoregressive cross-lagged structural equation modeling explained the stability effects within each domain, as well as how different maltreatment types affect diverse developmental processes. Cross-lagged results showed the socialization effects of peers on substance use, whereas the peer selection effects on externalizing symptoms. Physical abuse was only associated with externalizing symptoms, while sexual abuse was associated with both externalizing and internalizing symptoms. Additionally, emotional abuse was associated with deviant peer affiliation and substance use. ConclusionsIdentifying the underlying reciprocal processes offers a deeper understanding of peer relationships in the substance use and externalizing symptoms among at-risk of maltreatment sample.

The role of working memory updating and capacity in children's mathematical abilities: A developmental cascade model.

Previous studies indicated that working memory (WM) updating and WM capacity play essential roles in mathematical ability. However, it is unclear whether WM capacity mediates the effect of WM updating on mathematics, and whether the cascading effects vary with different mathematical domains. The current study aims to explore the longitudinal mediating role of WM capacity between WM updating and mathematical performance, and how the relations change with the age and domains. A total of 131 Chinese first-graders participated the study. Participants were required to complete tasks on WM updating and WM capacity in Grade 1 and Grade 2, as well as paper-and-pencil tests on mathematics achievement in Grade 3. The role of WM updating and capacity in the development of pupil's mathematical achievement was examined. Results revealed that verbal WM updating in Grade 1 predicted basic arithmetic and logical-visuospatial ability in Grade 3 via its cascading effect on verbal WM capacity in Grade 2. Moreover, visuospatial WM updating in Grade 1 predicted visuospatial WM capacity in Grade 2. Visuospatial WM capacity in Grade 1 predicted logical-visuospatial ability in Grade 3 instead of basic arithmetic ability in Grade 3. The findings suggested that WM updating exerts effect on pupil's mathematical performance via WM capacity, meanwhile, this effect depends on children's mathematics domain.

Autistic symptoms, social anxiety symptoms, and depressive symptoms among Chinese college students: A longitudinal study

BackgroundThere was a high degree of co-occurrence between autistic symptoms, social anxiety symptoms, and depressive symptoms, but their longitudinal associations have not been adequately studied. MethodThree hundred and ninety-seven Chinese college students (68.51% female; 21.43 ± 2.22 years) from mainland China were assessed via self-reported questionnaires multiple times over the course of a year. A developmental cascade model was used to investigate the longitudinal linkages among autistic symptoms, social anxiety symptoms, and depressive symptoms. ResultsResults indicated that (1) autistic symptoms at each time point reliably predicted depressive symptoms at the next time point, whereas only depressive symptoms at Time 1 predicted autistic symptoms at Time 2; (2) social anxiety symptoms did not predict subsequent depressive symptoms significantly, whereas depressive symptoms at Time 1 predicted social anxiety symptoms at Time 2; (3) the relationship between autistic symptoms and social anxiety symptoms showed a spiral pattern, i.e., social anxiety symptoms of Time 1 predicted autistic symptoms at Time 2, which in turn predicted social anxiety symptoms at Time 3; and (4) social anxiety symptoms at Time 1 predicted depressive symptoms at Time 3 indirectly through autistic symptoms at Time 2. ConclusionsThese results clarify the longitudinal predictive relationship between autistic symptoms and two typical emotional symptoms, suggesting in practice that we should adopt intervention strategies targeting emotional symptoms combined with social skills for college students with high autism symptoms and individuals with autism spectrum disorders.

Developmental cascades and educational attainment.

Developmental cascades describe how systems of development interact and influence one another to shape human development across the lifespan. Despite its popularity, developmental cascades are commonly used to understand the developmental course of psychopathology, typically in the context of risk and resilience. Whether this framework can be useful for studying children's educational outcomes remains underexplored. Therefore, in this chapter, we provide an overview of how developmental cascades can be used to study children's academic development, with a particular focus on the biological, cognitive, and contextual pathways to educational attainment. We also provide a summary of contemporary statistical methods and highlight existing data sets that can be used to test developmental cascade models of educational attainment from birth through adulthood. We conclude the chapter by discussing the challenges of this research and explore important future directions of using developmental cascades to understand educational attainment.

Motor-language links in children with Down syndrome: a scoping review to revisit the literature with a developmental cascades lens.

Children with Down syndrome (DS) typically have motor and language needs. Improving function is a shared goal for the rehabilitation therapy team, however physical therapy, occupational therapy, and speech-language pathology professionals treat patients differently. This difference in care may mask developmental cascades whereby changes in one domain (e.g., motor) can have seemingly unexpected effects on another domain (e.g., language). This scoping review identified papers where motor and language data have been reported together in children with DS and reinterpreted findings from a developmental cascades lens. Online databases were used to identify 413 papers published before October 2021 from which 33 papers were retained that reported both motor (gross and/or fine) and language (expressive and/or receptive) data in individuals with DS with a chronological age of 0-18 years. The majority of papers (79%) that reported motor and language data in children with DS did not examine their link, while 12% analyzed motor-language links, but using a cross-sectional or retrospective design. Only three papers (9%) utilized a longitudinal design to examine predictive links. Motor functioning and language functioning have often been reported together, but not analyzed together, in studies of children with DS. The few studies that did analyze motor-language links largely replicated findings from other developmental populations where motor gains were positively linked to language gains. Analyzing links between domains when such data is available is needed to fully characterize developmental cascades in DS and may have broad clinical implications.