Developmental Background Research Articles

Torcular pseudomass: a potential diagnostic pitfall in infants and young children.

Incidental findings on brain MRI may constitute a diagnostic pitfall. We observed an incidental extra-axial midline rounded pseudomass between the torcular Herophili and the occipital squama, with spontaneous resolution, which we called "torcular pseudomass." We investigated the frequency, imaging features, natural history and developmental background of this finding in a large group of infants and young children. We conducted a single-center retrospective study by reviewing all brain MRIs performed in children younger than 3years between 2007 and 2013 in a specialized pediatric hospital. We looked for soft tissue (minimum 2mm thick) interposed between the torcula and the occipital squama on midsagittal T1 and T2 images; we recorded the maximal diameters and outcome. Of 2,283 the children who had brain MRIs during the study period, 291 (12.7%, 95% confidence interval [CI] 0.11, 0.14) presented with a torcular pseudomass (median age 4months, range 0days to 35months, 56% male). MRI features were the same in all of these children: T1 isointensity and T2 hyperintensity to the cerebral cortex, facilitated diffusion on diffusion-weighted imaging and apparent diffusion coefficient maps, and contrast enhancement. The median diameters were: anteroposterior, 5.8mm; transverse, 10.5mm; cranio-caudal, 20.6mm. Follow-up MRI was available in 34.7% (95% CI: 0.20, 0.40) of the children; median follow-up time was 18months. Among these children, 35.6% (95% CI: 0.26, 0.45) had total involution, 52.5% (95% CI: 0.26, 0.62) had partial involution and 4.1% (95% CI: 0.05, 0.18) showed stability. Redundant soft tissue in the torcular region, or torcular pseudomass, is not an infrequent finding in infants and young children. It should be considered a physiological tissue, reflecting the postnatal developmental process of the brain and cranial vault, without the need for further investigation or follow-up imaging studies.

Hepatitis Foundation International Biosimilars Issue Brief

Biosimilars are biological medical products highly similar to the original products manufactured by different pharmaceutical companies. Biosimilars inherit a critical role that addresses the growing need for mechanism-based drugs needed to treat diseases such as hepatitis, HIV and various cancers. In this issue brief, the developmental background, approval process, regulatory review and safety procedures and naming process will be discussed in detail. Benefits and cost to the patient population will also be examined, contrasting how biosimilars can be interchanged or substituted with other drugs to produce near identical health outcomes at affordable prices. Although biosimilar development appears promising, guidelines to proper labeling and surveillance of adverse effects are still being conducted. Patients tend to respond differently to drug therapies, making biosimilars the patient-specific treatment alternative. The Food and Drug Administration (FDA) continues to expand on its recommendations to improve regulation, safety precautions and transparency across all levels of health care for medical providers and their patients.

Unique pattern of dietary adaptation in the dentition of Carnivora: its advantage and developmental origin

Carnivora is a successful taxon in terms of dietary diversity. We investigated the dietary adaptations of carnivoran dentition and the developmental background of their dental diversity, which may have contributed to the success of the lineage. A developmental model was tested and extended to explain the unique variability and exceptional phenotypes observed in carnivoran dentition. Carnivorous mammalian orders exhibited two distinct patterns of dietary adaptation in molars and only Carnivora evolved novel variability, exhibiting a high correlation between relative molar size and the shape of the first molar. Studies of Bmp7-hetero-deficient mice, which may exhibit lower Bmp7 expression, suggested that Bmp7 has pleiotropic effects on these two dental traits. Its effects are consistent with the pattern of dietary adaptation observed in Carnivora, but not that observed in other carnivorous mammals. A molecular evolutionary analysis revealed that Bmp7 sequence evolved by natural selection during ursid evolution, suggesting that it plays an evolutionary role in the variation of carnivoran dentition. Using mouse experiments and a molecular evolutionary analysis, we extrapolated the causal mechanism of the hitherto enigmatic ursid dentition (larger M2 than M1 and M3). Our results demonstrate how carnivorans acquired novel dental variability that benefits their dietary divergence.

Malaysia's Niche in International Higher Education: Targeting Muslim-majority, Commonwealth, and Less-developed Countries

AbstractIn 2010, more than 87,000 international students were studying in Malaysia. The Malaysian government wants to increase the number of international students to more than 200,000 by 2020. The case of Malaysia as an emerging player in international education is particularly interesting as it is not only one of the first former colonies of a European country to achieve such high international attractiveness, but also one of the first Muslim-majority countries to become a hub of international education. This article analyses both the supply and demand side of this remarkable trend. The historical and political circumstances for the institutional buildup of Malaysian higher education are discussed, followed by an analysis of the religious, linguistic, and developmental background of the international students coming to Malaysia. Lastly, factors affecting other prominent destinations of international student migration, such as the implications of the terrorist attacks of September 11, 2001, are taken into account.

Development of Desktop Machine Tool with Pipe Frame Structure

While many components used in automobiles, household electric appliances, etc., are becoming more compact, the size of most machine tools used to work on such components remains unchanged. Therefore, to improve the efficient use of factory space and economical use of energy, machine tools that are comparable in size to workpieces are required. Thus far, we have focused our developmental efforts on the miniaturization of machine tools, e.g., a lathe with a width ten times the machining diameter of a workpiece and a lathe with a bed made of a pipe frame truss structure. Based on these past study results, we have newly developed a desktop machine tool with a pipe frame structure. This paper reports on the developmental background and overview of the developed machine tool, its characteristics, its evaluation results, and our future plans.

To divide or not to divide: An alternative behavior for teratocytes in Encarsia pergandiella (Hymenoptera: Aphelinidae)

Encarsia pergandiella (Hymenoptera: Aphelinidae) is an endoparasitoid with an unusual embryonic development compared to most of congeneric species and all other members of the superfamily Chalcidoidea. The developmental background of this wasp is based on an alecithal hydropic egg, with the embryo developing inside an extra-embryonic membrane which dissociates at hatching into special larva-assisting cells, the teratocytes. In E. pergandiella many teratocytes at hatching were multinucleated syncytial cells with no evidence of a cellular membrane separating the nuclei. These teratocytes during larval development produced smaller uninucleated teratocytes, through successive divisions obtained by progressive ingrowth of the plasmatic membrane, accompanied by appearance of degeneration symptoms, such as protrusions and blebs. As a consequence of this divisional process teratocytes showed a size reduction and an increase in number of about four times during the second day of larval development. Only on the third day of larval life teratocytes started to decrease in number, until total disappearance at larval maturation. This behaviour is in striking contrast with all other studied systems in which teratocytes do not divide and progressively decrease in number as the parasitoid larva develops.

Asthma.

Asthma is the most common inflammatory disease of the lungs. The prevalence of asthma is increasing in many parts of the world that have adopted aspects of the Western lifestyle, and the disease poses a substantial global health and economic burden. Asthma involves both the large-conducting and the small-conducting airways, and is characterized by a combination of inflammation and structural remodelling that might begin in utero. Disease progression occurs in the context of a developmental background in which the postnatal acquisition of asthma is strongly linked with allergic sensitization. Most asthma cases follow a variable course, involving viral-induced wheezing and allergen sensitization, that is associated with various underlying mechanisms (or endotypes) that can differ between individuals. Each set of endotypes, in turn, produces specific asthma characteristics that evolve across the lifecourse of the patient. Strong genetic and environmental drivers of asthma interconnect through novel epigenetic mechanisms that operate prenatally and throughout childhood. Asthma can spontaneously remit or begin de novo in adulthood, and the factors that lead to the emergence and regression of asthma, irrespective of age, are poorly understood. Nonetheless, there is mounting evidence that supports a primary role for structural changes in the airways with asthma acquisition, on which altered innate immune mechanisms and microbiota interactions are superimposed. On the basis of the identification of new causative pathways, the subphenotyping of asthma across the lifecourse of patients is paving the way for more-personalized and precise pathway-specific approaches for the prevention and treatment of asthma, creating the real possibility of total prevention and cure for this chronic inflammatory disease.Supplementary informationThe online version of this article (doi:10.1038/nrdp.2015.25) contains supplementary material, which is available to authorized users.

Use of fructosyl peptide oxidase for HbA1c assay.

ARKRAY, Inc developed the world's first automatic glycohemoglobin analyzer based on HPLC (1981). After that, ARKRAY developed enzymatic HbA1c assay "CinQ HbA1c" with the spread and diversification of HbA1c measurement (2007). CinQ HbA1c is the kit of Clinical Chemistry Analyzer, which uses fructosyl peptide oxidase (FPOX) for a measurement reaction. This report mainly indicates the developmental background, measurement principle, and future of the enzymatic method HbA1c reagent.

Maternal and Paternal Filicide: Case Studies from the Australian Homicide Project

Data drawn from the Australian Homicide Project were used to examine whether and how maternal and paternal filicide perpetrators differ in terms of motivations for filicide and childhood and adulthood adversities. In addition, key differences between filicide and non‐filicide perpetrators were examined. Data were collected across a number of states and territories in Australia between 2010 and 2013 through interviews with 231 men and women convicted of murder or manslaughter. Of these participants, 14 had perpetrated filicide. Detailed information on the developmental background of the perpetrators, as well as motives and situational contexts of the homicide incidents, was gathered through the interviews. Findings from the current study reveal some important gender differences among filicide perpetrators. For example, filicidal fathers are more likely to perpetrate accidental filicide, and to report unemployment, alcohol and drug problems and previous engagement in child abuse, while filicidal mothers are more likely to perpetrate altruistic or neglectful filicide, and to report mental health problems. In addition, male filicide perpetrators report a greater number of adversities compared to male non‐filicide perpetrators, while female filicide perpetrators display fewer adversities compared to their non‐filicide counterparts.‘Findings from the current study reveal some important gender differences among filicide perpetrators’Key Practitioner Messages Practitioners are uniquely placed to assist in filicide prevention. Opportunities for service providers to raise awareness of key risk factors for filicide are crucial. Health and social service providers are ideally placed to screen parents seeking support to uncover early warning risks. Mental health service support is crucial, particularly for mothers, as is screening parents for severe depression or suicidal ideations. Provision of parenting support skills to help parents cope with extreme stress appears salient. ‘Health and social service providers are ideally placed to screen parents seeking support to uncover early warning risks’

Evaluation of Environmental Conditions in Two Cities of East Siberia Using Bio-indication Methods (Fluctuating Asymmetry Value and Mutagenic Activity of Soils)

Bioindicational evaluation of environmental quality on the territory of Yakutsk and Mirny (East Siberia, Yakutia) has been performed. Fluctuating asymmetry (FA) value of leaves of the Japanese White Birch Betula platyphylla Sukacz. was examined and soil condition was assessed by occurrence of Mitosis Pathologies (MP) in germinating Japanese leek Allium fistulosum L. cultivated on samples of lawn soils. About 18,000 leaves and 37 soil samples (over 20,000 anaphase and telophase cells) was examined. In most samples from city territories statistically significant increase in FA and MP in comparison to unimpaired habitats was registered. Positive correlation between FA value and traffic load as well as total content of heavy metals in soil was found. On the territory of the administrative center (Yakutsk), motor transport was found to be the main source of the pollution. Consequently major streets, especially in the immediate vicinity of roadways, and crossroads with heavy traffic load suffer from pollution most. On the territory of the industrial center (Mirny) pollution spreads from technogenically impaired areas to the residential area. Developmental stability abnormalities and total mutagenic background indicate deterioration of environmental conditions as a consequence of combined impact of negative factors arising from anthropogenically transformed environment.

Cycle of coercion: experiences of maltreatment and disciplinary measures in Canadian inmates.

In spite of past and current efforts at implementing effective rehabilitative interventions in carceral settings, institutions of confinement are primarily concerned with the maintenance of order within their walls. The purpose of this paper is to better understand associations between inmates' developmental background and the experience of institutional discipline, to collect information on childhood maltreatment and disciplinary measures for a sample of Canadian prisoners. Information relative to socio-economic background, childhood maltreatment and experience of discipline while in custody was obtained using face-to-face interviews and institutional file review for a sample of 416 male and 106 female offenders in Canadian provincial institutions. Results from logistic regression analyses provided support for the association between childhood maltreatment and the experience of discipline, specifically in the form of increased monitoring from correctional staff. Furthermore, this association was found to be more pronounced for female offenders. The findings highlight the need to incorporate a developmental perspective to current understanding of the use of disciplinary interventions in a prison environment. Such an approach may allow for preventing the enactment of a cycle of coercion, with negative consequences for the inmates. This study is original in its use of latent variable analytic methods to uncover the structure underlying the construct of childhood maltreatment in adult offenders. In addition, it provides valuable data of interest to researchers, corrections personnel and policy makers on the possible links between earlier developmental experiences and adjustment to the prison environment.

Emerging New Trends in Neurosurgical Technologies

There has been tremendous progress in the modern day technologies causing a rapid evolution in the field of neurosurgery. The neurosurgeons have been equipped with the latest advancements such as the use of robotics in surgery, the image-guided neurosurgical procedures, and the stereotactic neurosurgery. In addition, the preoperative screening techniques have drastically improved the success of the surgical procedure. Neuronavigation has allowed the precise localization of the deep-seated brain structures thereby helping in the accurate operation of the affected regions without stirring the normal brain tissues. Such preciseness has helped in the improvement of the patient outcome. All these aspects have been discussed in detail in this review with a focus on their developmental background.

What is Counterintuitive? Religious Cognition and Natural Expectation

What is ‘counterintuitive’? There is general agreement that it refers to a violation of previously held knowledge, but the precise definition seems to vary with every author and study. The aim of this paper is to deconstruct the notion of ‘counterintuitive’ and provide a more philosophically rigorous definition congruent with the history of psychology, recent experimental work in ‘minimally counterintuitive’ concepts, the science vs. religion debate, and the developmental and evolutionary background of human beings. We conclude that previous definitions of counterintuitiveness have been flawed and did not resolve the conflict between a believer’s conception of the supernatural entity (an atypical “real kind”) and the non-believer’s conception (empty name/fictional). Furthermore, too much emphasis has been placed on the universality and (presumed) innateness of intuitive concepts (and hence the criteria for what is counterintuitive)—and far too little attention paid to learning and expertise. We argue that many putatively universal concepts are not innate, but mostly learned and defeasible—part of a religious believer’s repertoire of expert knowledge. Nonetheless, the results from empirical studies about the memorability of counterintuitive concepts have been convincing and it is difficult to improve on existing designs and methodologies. However, future studies in counterintuitive concepts need to embed their work in research about context effects, typicality, the psychology of learning and expertise (for example, the formation of expert templates and range defaults), with more attention to the sources of knowledge (direct and indirect knowledge) and a better idea of what ‘default’ knowledge really is.

Embryology of the heart and its impact on understanding fetal and neonatal heart disease

Heart development is a complex process during which the heart needs to transform from a single tube towards a fully septated heart with four chambers and a separated outflow tract. Several major events contribute to this process, that largely overlap in time. Abnormal heart development results in congenital heart disease, which has an estimated incidence of 1% of liveborn children. Eighty percent of cases of congenital heart disease are considered to have a multifactoral developmental background, whereas knowledge of monogenetic causes for congenital heart disease is still limited. This review focuses on several novel findings in cardiac development that might enhance our knowledge of aetiology and support refinement of prenatal diagnosis of congenital heart disease.

Design Languages of Contemporary Neo-Vernacular Architecture in China

The paper states the developmental background of neo-vernacular architecture in China, and introduces the concepts of vernacular architecture and neo-vernacular architecture. From the four aspects, form language, material language, technology language and space language, the paper expounds the design methods and ideas of contemporary neo-vernacular architecture of China with some building examples. In the end of the paper, the author points out that we should encourage the development of the neo-vernacular architecture in China.

Introducing the new GRASS module g.infer for data-driven rule-based applications

This paper introduces the new GRASS GIS add-on module g.infer. The module enables rule-based analysis and workflow management in GRASS GIS, via data-driven inference processes based on the expert system shell CLIPS. The paper discusses the theoretical and developmental background that will help prepare the reader to use the module for Knowledge Engineering applications. In addition, potential application scenarios are sketched out, ranging from the rule-driven formulation of nontrivial GIS-classification tasks and GIS workflows to ontology management and intelligent software agents.

Recruited vs. nonrecruited molecular signatures of brown, “brite,” and white adipose tissues

Mainly from cell culture studies, a series of genes that have been suggested to be characteristic of different types of adipocytes have been identified. Here we have examined gene expression patterns in nine defined adipose depots: interscapular BAT, cervical BAT, axillary BAT, mediastinic BAT, cardiac WAT, inguinal WAT, retroperitoneal WAT, mesenteric WAT, and epididymal WAT. We found that each depot displayed a distinct gene expression fingerprint but that three major types of depots were identifiable: the brown, the brite, and the white. Although differences in gene expression pattern were generally quantitative, some gene markers showed, even in vivo, remarkable depot specificities: Zic1 for the classical BAT depots, Hoxc9 for the brite depots, Hoxc8 for the brite and white in contrast to the brown, and Tcf21 for the white depots. The effect of physiologically induced recruitment of thermogenic function (cold acclimation) on the expression pattern of the genes was quantified; in general, the depot pattern dominated over the recruitment effects. The significance of the gene expression patterns for classifying the depots and for understanding the developmental background of the depots is discussed, as are the possible regulatory functions of the genes.

Development of Ultra Slim Utility Type CNC Lathe Adapted to Automation - An Approach to Energy Conservation from Machine Shops -

In the manufacturing field, high-precision and miniaturization have aggressively been pursued as pressing requirements for many components of automobiles and electric appliances, but machine tools used to machine such components remain large in size. There is a growing demand for “miniaturization of machine tools to fit the sizes of workpieces with a view to maximize energy and space efficiency used in machine shop. In response to the market requirements of major manufacturers of automobile components for “machine tools of width ten times machining diameters of object workpieces,” we have developed ultra slim CNC lathes which can machine object workpieces to an equivalent degree to conventional types of machine tools, and can also be adapted to automatically carry-in-and-out of workpieces. The intent of this paper is to describe the developmental background, overview the characteristics, space-saving and energy saving effects, and future plans of the newly developed lathe.

The Outflow Tract in Transposition of the Great Arteries: An Anatomic and Morphologic Study

Neoaortic root dilatation is observed after the arterial switch operation for transposition of the great arteries. Although structural differences in the vessel wall of these patients may be of influence, we hypothesize that a histomorphologic difference in composition and embedding of the fibrous annulus in transposition of the great arteries may play a role in neoaortic root dilatation. Two normal human hearts and two unoperated human hearts with transposition of the great arteries, 1 day postnatal, were studied. Histologic sections stained for collagen, myocardium, and elastin were prepared, and three-dimensional reconstructions of the outflow tracts were made to enable comparison of the morphologic structures between the normal hearts and those with transposition of the great arteries. The amount of collagen in the arterial roots was diminished in hearts with transposition of the great arteries compared with the normal hearts. In addition, the anchorage and embedding of both arterial roots in the myocardium was less extensive in transposition of the great arteries. The changed position of the arteries in the malformed hearts results in less support for the roots from the surrounding atrioventricular myocardium. The combination of the observed histomorphologic differences in amount of collagen and myocardial support may be an explanation for the neoaortic root dilatation observed after the arterial switch operation. The developmental background of the observed deficient fibrous annulus formation may originate from an epicardial problem.

Offenders' Perceptions of the Sentencing Process: A Study of Deterrence and Stigmatisation in the New South Wales Children's Court

The criminal court system remains society's pre-eminent response to criminal activity, despite recent innovations such as youth justice conferences. Little is known, however, about the impact of an appearance before court and, in particular, whether subjective reactions to the court process have any impact on recidivism. The current article reports the results of a longitudinal study conducted in the New South Wales (NSW) Children's Court. Two hundred and six young offenders were interviewed immediately after the conclusion of their sentencing hearing using a questionnaire designed to measure the extent to which they perceived the court hearing to be a deterrent, and the extent to which they felt either stigmatised or reintegrated by the experience of being sentenced. Other factors measured included the developmental background of the young person, their academic record, peer influence, and licit and illicit drug use. Participants with previous convictions and who felt stigmatised by the hearing were more likely to reoffend, while participants rating their likelihood of arrest in the event of future offending as high, and who reported that the sentence they received would prevent future offending, were less likely to reoffend. Some evidence was obtained, therefore, to support both deterrence and labelling theory.