Skin cancer is the most common cancer in the United States. The The Behavioral Risk Factor Surveillance System (BRFSS) surveyed 438,693 US participants aged 18 and above in 2021, providing valuable insight into skin cancer patterns and associated risk factors. Among the participants, 427,883 did not have any missing values, 9.44% had skin cancer. Exploratory association analysis of skin cancer was performed using a dataset with complete values, including five covariates: age, sex, BMI, race/ethnicity, and smoking status. Single-variant association analysis on these variables revealed significant associations with skin cancer for all covariates. Subsequently, multi-variant logistic regression analysis showed significant associations between skin cancer and age (5 year, beta=0.33 CI= (0.33, 0.34)), sex (female, beta=-0.19, CI= (-0.21, -0.16)), race/ethnicity (Black, beta= -2.68, CI= (-2.82, -2.55); Asian, beta= -2.30, CI=(-2.53, -2.08); American Indian/Alaskan Native, beta=-1.00, CI= (-1.14, -8.87); Hispanic, beta= -1.61, CI=(-1.71, -1.52)), and smoking status (current smokers, beta= -0.18, CI=(-0.22, -0.13); former smoker, beta=0.05, CI=(0.02, 0.07)). Additionally, two-way interactions among some of these factors were explored, and the interactions of age by BMI, age by sex (Female), and race/ethnicity (Hispanics) by current smoking were significantly associated with skin cancer, with p-values of <1 10-6, <1 10-6, and 2.63 10-6 respectively. Overall, our data validated the conclusion that age, sex, and race/ethnicity were the three most significantly-associated factors to skin cancer. This finding hints at possible guidance on how to identify groups that are at a greater risk of developing skin cancer, though further research is needed to control for covariates not examined here.