Urban schools in the United States are struggling. In this era of highstakes testing, teacher accountability, and standards-based curriculum, there is more and more research showing that an achievement gap exists between White students and students of color (Darling-Hammond, 2007). In large part, students of color attend urban schools where underfunding, low teacher retention, and the forces of community poverty pose signifi cant challenges to effective, sustained classroom instruction (Borrero & Bird, 2009; Duncan-Andrade, 2007; Nieto, 2002). Urban schools, and urban school teachers, are left to bear the brunt of the criticism from policy-makers, the media, and the public. More importantly, classroom teachers are left to bear the brunt of the tremendous challenge to serve the diverse needs of all of their students. Schooling in urban areas places added pressure on Catholic schools as well, as declining enrollment is forcing schools to close (Carpenter, 2008; Gragnani, 2006; McDonald & Schultz, 2009). Schools and classroom teachers cannot be alone in the quest to improve classroom instruction for students of color in urban contexts. Universities, and particularly universities in urban areas, are in prime position to provide support to K-12 schools. Fundamentally, most universities in urban centers promote mission statements that declare their commitment to the local community. Practically, universities possess tremendous resources in the form of faculty and students that can provide direct support to local schools. This paper describes a partnership between an alliance of nine urban Catholic schools and an urban university in San Francisco, California. The development of the partnership is described in part, but the details of the actual collaboration and involvement of university faculty with school leaders and teachers are the central foci. This collaboration is outlined to show how university community involvement can provide direct support to urban K-12 schools. Specifi cally, the development of professional learning communities (PLCs) is presented as a foundation upon which university-K-12 partnerships can be built. PLCs in schools are groups of teachers and staff members with a shared vision for improving student learning. PLC members