Product Development Research Articles

A small antimicrobial peptide derived from a Burkholderia bacterium exhibits a broad-spectrum and high inhibiting activities against crop diseases.

Crop diseases cause significant quality and yield losses to global crop products each year and are heavily controlled by chemicals along with very limited antibiotics composed of small molecules. However, these methods often result in environmental pollution and pest resistance, necessitating the development of new bio-controlling products to mitigate these hazards. To identify effective antimicrobial peptides (AMPs) considered as potential sources of future antibiotics, AMPs were screened from five bacterial strains showing antagonism against a representative phytopathogenic fungus (Rhizoctonia Solani) through the Bacillus subtilis expression system, which has been developed for identifying bacterial AMPs by displaying autolysis morphologies. A total of 5000 colonies were screened, and five displaying autolysis morphologies showed antagonism against R. solani. A novel AMP with the strongest antagonism efficiency was determined and tentatively named HR2-7, which is composed of 24 amino acids with an alpha-helical structure. HR2-7 has strong and broad-spectrum antimicrobial activity, tested against 10 g-positive and -negative bacteria and four phytopathogenic fungi by contact culture in plates with minimal lethal concentrations of 4.0 μM. When applied as purified peptide or in fermented B. subtilis culture solution, HR2-7 showed strong controlling efficiency on plants against diverse fungal and bacterial pathogens. Based on current understanding, HR2-7 is recognized as the first AMP derived from an agricultural antagonistic bacterium. It exhibits wide-ranging and notable antimicrobial efficacy, offering a supplementary approach for managing plant diseases, in addition to conventional chemical pesticides and antibiotics.

Chemical characterization of wheat-based waste derived from a pharmaceutical process for its potential valorization

IntroductionWe report the analysis and characterization and the preliminary biological evaluation, of both liquid and solid wastes obtained from the processing of wheat (Triticum vulgare) to produce the most iconic phytostimulin-based pharmaceutical products. The study aims to verify whether the waste can be reused in another process and not destined to its simple destructive disposal.MethodsIn this perspective, we first carried out an in-depth chemical-physical analysis of the waste together with a biocompatibility evaluation to plan the feasible final choice of waste destination. The liquid and solid waste derived from the processing of wheat extract were analyzed and characterized through ultra-high-performance liquid chromatography coupled with high-resolution Orbitrap mass spectrometry (UHPLC-Q-Orbitrap HRMS).ResultsResults highlight that ferulic acid represent the most abundant phenolic compound for solid waste with a content of 89.782 mg/kg and dihydroferulic acid is the predominant for liquid waste (6.24 mg/L). These concentrations represent 55.87% and 84.39% of the total concentration of bioactive compounds for liquid and solid waste, respectively. The antioxidant activity registered for the solid extract was 8.598 and 7.262 mmol trolox/kg, respectively for ABTS and FRAP assays. The total phenolic content (TPC) in the liquid extract undergoes a significant percentage reduction compared to the solid waste. As regards toxicity, both liquid and solid wastes were investigated in vitro preclinical models of human skin (HaCaT cells and HDFa) after 24, 48, and 72 h of exposure. No cytotoxic effect was noted even at the highest tested concentration (100 μg/mL) at 72 h.DiscussionOverall, considering its chemo-physical features and active ingredients, we believe that this waste is highly reusable as a starting material for the development of cosmeceutical products. Thus, this study allows us to motivate the destination of the waste of the production in a recyclable raw material for additional industrial processes, thereby promoting an eco-friendly circular economy operation.

2'-Fucosyllactose and 3'-Sialyllactose Reduce Mortality in Neonatal Enteroaggregative Escherichia coli Infection by Improving the Construction of Intestinal Mucosal Immunity.

Human milk oligosaccharides could prevent pathogenic bacterial infections in neonates; however, direct in vivo anti-infection evidence was still lacking. Here, we systematically evaluated the effects of 2'-fucosyllactose (2'-FL) and 3'-sialyllactose (3'-SL) on the structural development and functional maturation in neonates and their defense against enteroaggregative Escherichia coli infection. It was found that supplementation with 2'-FL and 3'-SL improved the resistance of weaned mice to enteroaggregative E. coli. The mechanism related to the promotion of 2'-FL and 3'-SL in the maturation of intestinal mucosal immunity by promoting stem cell differentiation, mucus layer integrity, and tight junction formation. 2'-FL and 3'-SL significantly increased the ratio of Th1 and Treg cells in the lamina propria, contents of short-chain fatty acids, as well as the serum content of IgA. This study lays a theoretical basis for the application of 2'-FL and 3'-SL in infant formula, as well as the development of intestinal health products.

The Influence of Digital Economic Growth and Productive Work Force Toward Human Development Index in Indonesia Viewed from a Maqashid Sharia Perspective

Introduction: Community productivity is critical in maintaining quality of life to avoid disasters. The use of digital technology in the economic aspect has also provided opportunities for people far from the market to earn income to meet their living needs. Objective: The research problem is formulated as follows: What is the influence of digital economic growth and productive labor on the Human Development Index in Indonesia in 2018-2022, both partially and simultaneously, and how is this viewed from a maqasid syariah perspective?Method: This research is presented as five-year time series data and analyzed using quantitative descriptive methods and multiple linear regression analysis, using Eviews 10 as an analytical tool. The sampling technique used was purposive sampling, with sample criteria in the form of digital economic growth, productive workforce, and data during the 2018-2022 period. Result: The digital economic growth variable partially has a negative and insignificant effect on the Human Development Index. Meanwhile, the productive labor variable positively and significantly affects the Human Development Index. Simultaneously, the growth of the digital economy and productive workforce has had a positive and significant effect on the Human Development Index in Indonesia in 2018-2022. From a maqasid syariah perspective, digital economic activities are permitted if no arguments prohibit them. Implication: This research provides valuable insights that can influence how we view and approach digital economic growth and productive labor in Indonesia's human development context. By considering these impacts, various parties can optimize their strategies to advance people's quality of life more effectively.

Sustained Growth and Competitiveness SME´s Within the Context of Intellectual Property

Due to the exponential pace of technological innovation, intellectual property is an important support for SMEs in innovation, growth and competitiveness of work. Licensing and cooperation open ways for SMEs to access complementary resources, expand their market reach, and accelerate product development. Our research consists of an analysis of 43 Slovak companies in the field of intellectual property, its licensing and the impact of IP partnerships on competitiveness and business growth. The aim was to point out the possible causes of low cooperation of companies in the field of intellectual property. The survey results provide information on opportunities to enter new markets using partnerships. These partnerships can mean a competitive advantage for SMEs, which can be achieved mainly by reducing the barriers that SMEs face when engaging in licensing agreements and cooperation in the field of intellectual property. The results lead to recommendations for successfully finding and maintaining partnerships.

Engaging children and adolescents in the design and conduct of paediatric research

The importance of patient engagement in product development and clinical research is widely acknowledged. In pediatrics, parents and guardians are often vocal advocates for their children in the process, but investigators and sponsors rarely directly solicit children's or adolescents’ perspectives in clinical research planning or as patient partners during the conduct of research. Here, we provide compelling reasons and recommendations for investigators and sponsors to systematically engage young people in the design, conduct, and review of research, and the premise that input will be incorporated as a routine expectation. We consider the theoretical, ethical, and practical implications of this approach.

Live or Let Die: MILSTD 1472 Type Usability Checklists in an Agile Development World

Traditional Human System Integration (HSI) processes are at risk of being eliminated given the industry driven velocity and continuous delivery methods of Agile and Development to Operations Engineering. One such process at risk is usability standard checklists like MIL-STD 1472. The DoD Design Criteria Standard—Human Engineering, or MIL-STD 1472 is a military standard that provides guidelines for the ergonomic design of military systems and equipment. It is primarily focused on ensuring that military systems are designed to optimize human performance, safety, and comfort. However, it can be time-consuming to use given that it contains over 4,400 compliance items in its entirety. In an Agile DevOps environment, the typical delivery of products is 2 weeks with some software products boasting deployments every 11 min. Incorporation of usability and rigorous human factors checklists in the design of products using a DevOps environment is a challenge given the shorter timelines and smaller increments between product development and deployment combined with the expertise and hours needed to execute the checklists. The need for regression testing, the act of re-checking items to make sure new features have not created unforeseen usability issues, exacerbates the problem. Software quality testing for each release demands automatic methods to reduce the efforts of recursive testing. Industry standard methods in agile engineering utilize heuristics for quick turn low-cost usability inspections. This paper describes the derivation of a set of usability heuristics based on MIL-STD 1472 which can be used to identify potential human factors issues more quickly, with less cost, and reduced amount of expertise required. The paper also gives an example of a case study which incorporated automatic checking to support usability experts keeping pace with the high velocity pipelines of software development in an agile DevOps environment.

Community Service: Tea from Sukun Leaves as a Traditional Beverage with a Modern Approach

This community service activity aims to introduce and develop the potential of sukun (breadfruit) as a raw material for tea production, emphasising the aspects of health, economy, and cultural preservation. Sukun, which has long been known as a traditional food plant, has various benefits that are not widely acknowledged, especially in the form of tea. The program involved the local community in training focused on processing sukun into high-value tea products. In addition, education was provided on packaging and marketing techniques, to enhance the competitiveness of sukun tea products in modern markets. The results of this activity show an increase in community awareness regarding the economic value of sukun, as well as the development of innovative and high-quality sukun tea products, which can be an alternative healthy beverage and support local economic sustainability. Through an integrative approach, this program succeeded in exploring local potential and combining it with modern innovation, thereby revitalizing traditional culinary heritage in a form that aligns with today’s needs.

Chromatographic analysis of ponatinib and its impurities: method development, validation, and identification of new degradation product

BackgroundPonatinib, a third-generation tyrosine kinase inhibitor, is employed in the management of adult chronic myeloid leukemia. Nevertheless, the presence of process impurities and degradation impurities linked to ponatinib may potentially influence its effectiveness and safety. Therefore, the objective of this research was to establish a robust liquid chromatography method and systematically validate it for the detection of substances related to ponatinib.MethodsThe separation of ponatinib and its impurities was conducted using an Agilent 5HC-C18 chromatographic column (4.6 mm × 250 mm, 5 μm). The mobile phase A comprised a mixture of water and acetonitrile in a 9:1 ratio, with an aqueous solution of pH 2.4 containing 2 mM potassium dihydrogen phosphate and 0.4% triethylamine. Mobile phase B, consisting of acetonitrile, was eluted in a gradient fashion. The flow rate was set at 1.0 mL/min, detection wavelength at 250 nm, column temperature at 40°C, and injection volume at 10 μL.ResultsThe method demonstrated high specificity, sensitivity, solution stability, linearity, precision, accuracy, and robustness. Additionally, this research unveiled a novel compound, imp-B, generated via the oxidative degradation of ponatinib. The molecular structure of the newly discovered product was elucidated through the utilization of nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HRMS).ConclusionIn conclusion, the chromatographic method developed in this study has the potential to be utilized for the detection of ponatinib and its impurities, thereby offering significant insights for quality assessment in ponatinib research.

Calcium Transport and Enrichment in Microorganisms: A Review

Calcium is a vital trace element for the human body, and its deficiency can result in a range of pathological conditions, including rickets and osteoporosis. Despite the numerous types of calcium supplements currently available on the market, these products are afflicted with a number of inherent deficiencies, such as low calcium content, poor aqueous solubility, and low human absorption rate. Many microorganisms, particularly beneficial microorganisms, including edible fungi, lactic acid bacteria, and yeast, are capable of absorbing and enriching calcium, a phenomenon that has been widely documented. This opens the door to the potential utilization of microorganisms as novel calcium enrichment carriers. However, the investigation of calcium-rich foods from microorganisms still faces many obstacles, including a poor understanding of calcium metabolic pathways in microorganisms, a relatively low calcium enrichment rate, and the slow growth of strains. Therefore, in order to promote the development of calcium-rich products from microorganisms, this paper provides an overview of the impacts of calcium addition on strain growth, calcium enrichment rate, antioxidant system, and secondary metabolite production. Additionally, it highlights calcium transport and enrichment mechanisms in microorganism cells and offers a detailed account of the progress made on calcium-binding proteins, calcium transport pathways, and calcium storage and release. This paper offers insights for further research on the relevant calcium enrichment in microorganism cells.

Geoparks Twinning Agreements, A Vision from Formality and Territorial Links. Mixteca Alta (Mexico) and Napo Sumaco (Ecuador) Geoparks as Comparative Cases

AbstractCurrently, geoparks represent territories with great potential for the generation of educational and conservation processes, with productive and community development strategies through geotourism, using their natural and unique attributes, in a coordinated effort to improve the quality of life of their communities, based on the sustainable use of sites of geological interest of global importance. On the way to the construction of geoparks, territories find elements in common with other territories pursuing similar objectives, which leads to the creation of synergies and commonwealths. Working together in a network represents one of the most solid pillars of the geoparks, being a fundamental contribution to society. Geopark twinning is an alternative to promote micro-partnerships between geoparks with similar conditions and characteristics, which allow strengthening internal processes, as well as the exchange of knowledge, strategies and experiences, and the strengthening of institutional and management capacities. In addition, twinning arrangements are management tools that also serve as instruments to merge and unite identities in territories that are compatible in several areas, beyond geological heritage. In this sense, the present work shows the case studies of Mixteca Alta UNESCO Global Geopark (MAUGG) and Napo Sumaco Aspiring UNESCO Global Geopark (NSAUGG), where twinning arises from aspects such as community management, traditions, cultural approaches, worldview towards the land and its use. In both territories there is a high population of local indigenous groups: Mixtecos (Mexico) and Napo Runa (Ecuador), with agricultural customs based on their limitations or environmental conditions, such as the development of lamabordos and chacras; moreover, the decision-making systems are based on the competence and trust that the population has in their leaders, and not in political or partisan conflicts (election by uses and customs). Finally, their vision of the territory is based on respect for the environment and the beings that are part of it, and on giving a sacred conception to what provides them with food and life.

Water quality assessment for aquacultivation in Quang Ngai city, Quang Ngai province

Aquatic product development and growth are significantly influenced by the water supply used for aquaculture. Evaluating the water quality available for this activity is vital since Quang Ngai city has been a major hub for the growth of aquaculture in Quang Ngai province. Twelve surface water quality parameters were monitored and analyzed at eight sampling points in the river basins of An Nghia and Tinh Khe communes from May to September 2023. The Water Quality Index (WQI) was calculated, and methods including Principal Component Analysis (PCA), calculation of environmental variable weights based on principal components (PC), and Pearson correlation were used to assess the correlation of the investigated factors. In the river basin of An Nghia and Tinh Khe communes, 12 criteria for the assessment of surface water quality were tracked and examined using 8 sampling locations between May and September in 2023. The degree of linkage was assessed using principal component analysis (PCA), weighting environmental factors based on principal components (PC), and Pearson correlation. The water quality index (WQI) was calculated between the factors of the research. The findings show that: (1) The parameters exceeded the permitted limit: DO, Alkalinity, NH4+, TP, Vibrio SPP, Coliform, TOC, and TN. The two metrics with the greatest levels of pollution among them are Vibrio SPP and NH4+. The WQI index ranges from 52-74 and is within the average water quality range (51-75); (2) PCA analysis reveals that only the first two principal components, PC1 and PC2 can account for 74.39% of the variance, with NH4+ (0.089) having the highest weight; (3) NH4+ and Vibrio SPP content have a strong correlation (r = 0.95), indicating that both of these parameters can be used to evaluate water quality in the study area in general.

A combined approach of design for Six Sigma, generic product development process and ergonomics-safety philosophy to reduce musculoskeletal disorder problems

Purpose The purpose of this paper is to decrease musculoskeletal disorder (MSD) problems using a combined approach including design for Six Sigma, generic product development process, and ergonomic-safety philosophies. Design/methodology/approach A total of 550 students voluntarily participated in this study. Kolmogorov–Smirnov and t-tests were used to analyze the collected anthropometry. A cause-and-effect diagram, Pareto’s chart, a brainstorming session, and a priority matrix were also used to extract the 22 design parameters of the product. Moreover, Cronbach’s alpha values were determined to verify the validity of qualitative and quantitative data. Findings Results showed that students are at a high risk of developing MSD issues. The most serious MSD problems among the students were neck pain (74%), back pain (73%), muscle and joint pain (67%), knee pain (57%), leg pain (54%), etc. Besides, all anthropometrics of males are higher than females except Hip Breadth. Among 12 anthropometries, two measurements and one measurement showed statistical significance at p < 0.01 and p < 0.05, respectively. Six design parameters of the mounted desktop (Seat Height, Desk Height, Seat to Desk Clearance, Seat Width, Seat Depth, and Backrest Height) are the most crucial design parameters to design and develop the product. Practical implications The proposed design of the mounted desktop can be used in different tertiary educational institutes to reduce MSDs among students. Originality/value To the best of the authors’ knowledge, this is the first attempt that introduces a combined approach to reduce MSD issues by applying Six Sigma, a generic product development process, and ergonomics-safety philosophy to design and measurement of 22 design parameters of mounted desktop for university students.

The Rise of Global Health Emergency Governance

AbstractIn this paper I shed new light on contemporary developments in global health governance, policymaking, and knowledge production. Specifically, by investigating the historical roots and emergence of global health emergency governance. Drawing on the Foucauldian notion of “problematisation” and on Science and Technology Studies of disaster, I trace, examine, and elucidate three main axes through which, I argue, health emergencies became a problem of global governance. I show, first, the formation of emergency management as a distinct professional field. Second, the migration of emergency management into global health governance and its proliferation within it. And third, the move from global health emergency management to the global governance of health emergencies. Overall, I suggest the rise of global health emergency governance provides crucial context for understanding social, political, and epistemic tensions and controversies in health emergencies such as COVID-19. Through the analysis, I identify a particular rationale that is rooted in emergency management and had become embedded in global health emergency governance. A rationale that involves “temporal compression” and “structural plasticity.” I discuss possible implications of this rationale for global health governance, policy, and knowledge.

'From women for women': A citizen science approach engaging women in the isolation and application of the vaginal health-associated bacterium Lactobacillus crispatus.

A vaginal microbiome rich in Lactobacillus crispatus is associated with good reproductive and sexual health outcomes. Dysbiosis, indicated by the loss of Lactobacillus crispatus, is a risk factor for urogenital infections, such as the clinical diagnosis of bacterial vaginosis (BV) or urinary tract infections. While many scientists have explored probiotics using a conventional pharmaceutical approach, concerns about accessibility and affordability prompt an investigation into a preventive approach using this naturally occurring bacterium. Our study aimed to explore a potential woman-friendly vaginal probiotic product using the naturally occurring bacterium, Lactobacillus crispatus. Citizen scientists actively participated in a two-day practicum and successfully performed the procedures using self-collected vaginal swabs. The practicum received positive responses from participants who demonstrated notable engagement and enthusiasm. With expert guidance, participants without a laboratory background were able to execute assigned tasks successfully. From the Dutch crispatus Citizen Science Collective of 48 women, 22 succeeded in isolating their own Lactobacillus crispatus strains using a Loop-Mediated Isothermal Amplification (LAMP) protocol for identification. Additionally, 48 metagenomes and 54 whole genomes from 22 individuals were sequenced for comparative analysis. This project effectively engaged a community of women in the isolation of Lactobacillus crispatus strains from their vaginal microbiota, followed by in vitro characterization experiments and a hackathon for the development of a probiotic product. Our citizen science approach opens up collaboration possibilities and new avenues for exploration of vaginal health, facilitating community involvement and the development of targeted interventions to enhance women's well-being.

SOCIALIZATION OF COUNSELING AND INNOVATION IN THE DEVELOPMENT OF SLAM TEA PRODUCTS

Counseling on bay leaf tea bag MSME products is expected so that the residents of Salam Hamlet can understand and understand the benefits of bay leaves for health, especially in overcoming hypertension. And can set an example to make similar herbal tea products that can be used as a product that can be sold by residents. The place where community service activities are carried out is Salam Hamlet, Sarewu Village, RW 03, Pancalang District, Kuningan Regency has high-quality knowledge and health degrees so that a healthy community and environment are created. Community service activities are in the form of counseling, tea making, and the design and packaging of bay leaf tea. The participants of this counseling activity were very enthusiastic and were conducive. Many people ask in terms of its use in the manufacturing process. However, the testers of bay leaf tea bags and bay leaf tea bags distributed to participants were very limited because there were obstacles in the manufacturing process, namely in the drying because it always rained every day, so it hindered the drying process because we dried with sunlight (not using an oven) due to the limitations of the tools at the post. In the next development and innovation process, we have also made logo and packaging designs for bay leaf tea.

The Theoretical Logic, Challenges and Countermeasures of Vocational Education Enabling the Development of New Quality Productive Forces

New quality productive forces are the advanced productive forces that conform to the needs of new economic development and accord with the new development concept. Vocational education has become one of the research hotspots of the development of new quality productivity, and the two two-way empowerments. However, vocational education is faced with problems such as lagging education concept, mismatch of education system, and poor degree of integration of industry and education. Therefore, vocational education needs to change the concept of education, optimize the professional structure, improve the level of teachers, deepen the integration of industry and education.

The sanctions’ resistance analysis of economic sectors: Priorities of sovereign development and technological modernization

The purpose of the study is to develop analytical tools and methodological support for assessing the stability and vulnerability of sectors of the national economy to the effects of external sanctions. The study of the problem was based on the general scientific methods of generalization, analysis and classification. Methods of logical, economic, content, statistical, investment and expert analysis were used, as well as methods of econometric and mathematical modeling to achieve the research goal. A system of indicators for assessing the operational (technological and commercial) and investment dependence of the economic sector on imports is proposed. Methodological methods for assessing the sanctions dependence of the industry in the formation of production and investment development programs are substantiated. Examples of calculations of dependence indicators by levels and aspects of the industry description in the operating and investment areas are given. Recommendations are given on the use of the proposed indicators in the process of strategic and programming development in the conditions of ensuring technological independence and structural adaptation of the Russian economy.

The Design and Development of Dabujiang Patchwork Embroidery for Modern Bags

Background and Aim: Dabujiang patchwork embroidery, an intangible cultural handicraft with the longest heritage in southern Hunan, has garnered increasing attention in recent years due to its unique characteristics. However, these products are facing a situation of decline because they cannot meet the needs of modern people. The objective of this research article is to design and develop modern bags featuring Dabujiang patchwork embroidery patterns for women in contemporary society. Materials and Methods: This research is a combination of qualitative research and quantitative research. The qualitative research method was used to study the color, pattern, and meaning of characteristics from 54 pieces of 6 theme categories of Dabujiang product pictures. Interview intangible cultural inheritors, designers, bag shop owners, and women consumers to understand modern women's design needs for women's bags. Combining the characteristics of the Dabujiang pattern characteristics with the needs of modern women, the design and development of six new Dabujiang women's bags based on 6 theme categories. Through 424 questionnaires for women to assess the women's favorite new bags and analyze the reasons women like and find out the future trend of women's bag development. Results: The results of the research revealed: 1) The patterns based on the six categories have different symbolic meanings respectively and they are mainly bionic and geometric patterns. The lines are curves, and the layout is generally symmetrical and balanced. 2) There are 11 kinds of common colors and mainly based on the five orthodox colors of Chinese tradition. The main colors are red, blue, yellow, black, and white, representing the five traditional Chinese elements, which extend different meanings. 3) Through interviews find out young women prefer large bags of bag 1 style, the Morandi color scheme, and meanings of happiness, love, career success, luck, wealth, and beauty. Consequently, the researcher designed six bag styles based on bag 1 style and six theme categories to meet the needs of modern women associated with these six meanings. Questionnaire responses from 424 young women showed that 23.58% favored the Phoenix pattern bag style, making it the most preferred among the six new bag designs. This style showcases a phoenix motif in blue, white, and black colors, symbolizing career success. Conclusion: The findings indicate that modern women highly value career success and self-worth, prioritizing independence over traditional roles. This conclusion mainly stems from the transformation of modern women's roles and the awakening of self-awareness. In addition to assuming the role of mother in the family, modern women also play the role of professional women in society, and more and more women regard career success as their pursuit goal. In the context of the changing identity and goals of modern women, the products should be designed that meet the needs of modern women based on their needs, combined with the symbolic meaning of cultural patterns. For future product development, incorporating symbolic patterns that align with the career aspirations of modern young women is recommended.

Design and Development of Souvenir Jewelry using Hexi Pictograph

Background and Aim: Hexi rock paintings show what life was like for our ancestors in the early days. This paper looks at how Hexi rock paintings can inspire jewelry souvenirs, how rock paintings are used in jewelry, and where further research could be done. Materials and Methods: The researchers used a mixed methods approach to the study, examining the location, significance, and design applications of the petroglyphs, designing souvenirs using the art of jewelry and the content of the petroglyphs, conducting in-depth consultation on the content of the petroglyphs through a survey of the staff involved, and interviews with the experts, critiquing the products of the designs and incorporating the experts' views into the research process. Results: The result showed that the protective nature of petroglyphs makes fieldwork and the extraction of petroglyph content more challenging. However, during the design and development of products, we identified a market gap for Hexi petroglyphs. In light of market demand and consumer psychology, the study employs Hexi petroglyphs to produce jewelry souvenirs through the collation and extraction of their content, thereby promoting the protection of local culture, the development of the tourism industry, and the creative industry. This study examines the potential of Hexi rock paintings to be used as a source of inspiration for the creation of jewelry souvenirs. This study is closely related to the future development of Hexi rock paintings and contributes to the promotion of tourism around them and the development of local cultural tourism. Conclusion: This study examines the potential of Hexi rock paintings to be used as a source of inspiration for the creation of jewelry souvenirs. This study is closely related to the future development of Hexi rock paintings and contributes to the promotion of tourism around them and the development of local cultural tourism.