Product Development Research Articles

Blocked force characterization and transposition at secondary connections of a compressor

Applications in sustainable energy systems, like heat pumps, are encountering emerging challenges, among which acoustic comfort stands out as a critical factor in shaping the end-user experience. Early integration of vibroacoustic into each industrial design phase ensures the prevention and prediction of potential noise issues, thus avoid costly design modification loops. BDR Thermea and CETIM, in a collaborative project, have implemented new methodologies for designing acoustically optimized products, highlighting the importance of considering vibroacoustic design at each design stage of new products developments. In this study, structure-borne noise characterization methods are applied to a heat pump compressor using the ISO 21955 and ISO 20270 standards. The forces transmitted at its suction and discharge ports were studied through component based TPA for the intrinsic characterization of the compressor. Once obtained, these forces were transposed to a new receiving structure. The results allowed a comparison of the outcomes from both approaches and highlighted the importance of considering the influence of the stiffness of the connections at the compressor ports.

Virtual validation of a Metro rolling-stock for exterior and interior noise in standard controlled conditions

Validation of rolling-stock is a time and cost expensive task during the development of train. Replacing type tests by simulation (virtual validation) that fits the need of the complete railway industry in terms of accuracy and uncertainty, is possible in some cases. Simulation is widely used by train manufacturers during development of new products with good accuracy of prediction in a controlled environment as free field and ballasted track. Methodologies available are able to predict correctly in controlled conditions (ISO 3095/3381) interior and exterior noise for different operating conditions. In this paper, simulation cases will be presented for a standard metro product operating in controlled conditions. Simulations will be compared with experimental data for interior and exterior noise. Exterior noise modelling and propagation is done with analytical tools while interior noise is modeled using an experimental-numerical (beam-tracing) approach. Input data for simulations corresponds to numerical models of rolling noise and measured sound power level of equipment. Validation of the models are discussed and analyzed to confirm the reliability of virtual validation for rolling stock operating at controlled conditions. A proposal of a virtual validation approach based on uncertainties of the simulation is also discussed.

The influence and mechanism of fish collagen peptide and egg yolk lecithin on proliferation and lipid composition in feline adipocytes.

The influences of fish collagen peptide (FCP) and egg yolk lecithin (EYL) on the proliferation, fat accumulation and triglyceride content in feline adipocytes were investigated in this work, aiming at unveiling the mechanism of fat accumulation for cheek of feline animals. The lipogenic changes of adipocytes in the presence of FCP and EYL were determined by high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS). The results demonstrated that FCP of 10mg/mL had the strongest cell activity, with a relative increment rate of 156 ± 0.23%, and the triglyceride content reached 215.9 ± 3.86 mmol/L. By comparison, it was observed that an EYL concentration of 5mg/mL elicited the highest cell activity, exhibiting a relative increment rate of 152 ± 0.60%, and the level of triglyceride content was noted to reached 256.56 ± 25.68 mmol/L. After the feline adipocytes were treated with different concentrations of two active substances, fat formation and lipid droplets were found by oil red O staining. Liposome analyses confirmed that the formation of lipid compounds was regulated by FCP and EYL through pathways involved in lipid metabolism, notably including inositol phosphate insulin resistance, and phosphatidylinositol signaling pathways. This regulation was found to enhance cell vitality and facilitate fat accumulation. These findings provide a new strategy for the development of nutritional and healthy products or foods that promote feline cheek.

Development and potential of robotisation and automation in Kazakhstan's automobile industry: a bibliographical and analytical review

The engineering sector, which includes automobile production, plays an important role in the national economy and industrial progress. It affects the development of production, scientific and technical progress, labor productivity, national security, quality of life. In order to increase productivity, reduce labor costs and improve product quality, industrial automation and robotization processes have been significantly developed in industrialized countries of the world. The global market for industrial robots is expected to grow 14.3% annually and reach $30.8 billion by 2027. However, Kazakhstan faces special difficulties in adopting these technologies due to the lack of development of automation infrastructure. This study aims to develop priorities and directions of advanced scientific and technological solutions for intelligent joint systems of robotics and automation, especially in the automotive industry of Kazakhstan. In this regard, the purpose of the study is to assess the current state of automation in the automotive industry of Kazakhstan, to identify challenges and opportunities associated with the introduction of robotics, and to provide a strategic basis for the advancement of these technologies. The research corresponds to the state programs of Kazakhstan on science, technology and digitization. The scientific and practical importance of this work is that it is aimed at providing solutions for increasing efficiency by adapting advanced robotic technologies to local production systems. Through the development of domestic innovations and the transfer of global technologies, research contributes to the field of industrial automation and helps Kazakhstan's industries to achieve global competitiveness. It is expected that the practical results of the research will contribute to the improvement of production quality, efficiency and productivity in the automotive sector of Kazakhstan, contributing to sustainable development in accordance with world trends. The value of the work lies in providing individual, technologically advanced solutions to meet the nation's urgent need for robotics automation and integration.

Enhancing Collaboration and Interdisciplinary Strategies for Navigating Innovative Technologies and Regulatory Approvals in the Cosmetic Industry

Abstract: The cosmetic industry, driven by innovation, constantly seeks safer, more effective, and sustainable products. However, regulatory hurdles often impede the introduction of innovative cosmetics. This paper explores the convergence of advanced technologies and regulatory conformity, emphasizing the need for collaborative, interdisciplinary approaches. Through an extensive review of literature and case studies, we reveal the multifaceted challenges within the industry. These encompass shifting consumer expectations, ingredient safety concerns, and intricate global regulations. Cross-functional collaborations, uniting researchers, regulators, industry experts, and consumers, are pivotal, driving innovation while ensuring product safety and compliance. Our research stresses the importance of a proactive, all-encompassing approach to product development. This approach should integrate cutting-edge technologies, rigorous safety assessments, and smart regulatory strategies from project inception. Additionally, it emphasizes engaging stakeholders, sharing knowledge, and practicing transparency to earn trust from consumers and regulators. This paper provides a comprehensive overview of the balance between innovation and regulation in the cosmetic industry, advocating for a paradigm shift characterized by collaboration and interdisciplinary efforts. By aligning innovation with regulatory compliance, the industry can effectively navigate the complex landscape of modern cosmetics, fostering the creation of safer, more sustainable, and consumer-centric products.

Implant dynamics, inner structure, and their impact on drug release of in situ forming implants uncovered through CT imaging

In situ forming implants (ISFIs) composed of biodegradable polymers and biocompatible solvents are generally designed for sustained drug release. In this study, a non-invasive computed tomography (CT) imaging approach is used to achieve real time imaging of ISFIs in vivo and in vitro using leuprolide acetate in situ forming implant as a model drug product. The process of implant formation, inner structure change and their impact on drug release were elucidated. Real-time drug distribution was unveiled by the CT contrast agent, iohexol, where it shows a core-shell structure of the deposition. The incorporation of leuprolide acetate (LA) led to a reduced extent of burst release, prolongated release profile, and extended implant size expansion. LA was found to interact with the solvent and slowed down the polymer phase inversion, thus significantly changed the drug distribution in the implant and reduced the drug release. The implant inner structure identified through SEM, implant size change, and polymer degradation along with the CT real time imaging all consistently support the implant formation differences and their implant on the drug release. Similar patterns of implant size expansion and iohexol distribution in the implants were observed both in vitro and in vivo for the implants with and without LA. The comprehensive understanding of the impact of implant formation on drug release through real time CT imaging facilitates the ISFI product development and evaluation.

Process and supplier capability, collaboration in new product development and competitive advantage: the moderating effect of research and development capability

The purpose of the study was to examine the influence of process and supplier capabilities on collaboration in new product development and competitive advantage and the extent to which research and development capabilities moderates. An explanatory research design was used and the study relied solely on the quantitative method. A primary source of data was used. Convenience and purposive sampling techniques were used to select the respondents for the study. The total sample size of the study was two hundred and fifty (250). The findings of the study indicate that Process capabilities have a positive and significant influence on collaboration in new product development. Supplier capabilities have a positive and insignificant influence on collaboration in new product development. Collaboration in new product development has a positive and significant influence on competitive advantage. Research and development capability positively and significantly moderates collaboration in new product development and competitive advantage. The research is embarked upon to provide insight on the influences of process and supplier capabilities, collaboration in new product development and competitive advantage and the moderating effect of research and development capabilities of the firms on the output of SMEs within the context of Ghana.

Model-based assembly process planning for flexible aircraft cabin architectures

AbstractThe configuration and equipment of an aircraft cabin has a significant impact on the passenger’s flight experience. To meet the needs of passengers and improve the flight experience, airlines repeatedly demand customised adaptations to the cabin design. The implementation of these changes requires a high degree of flexibility in production and can lead to difficulties in setting up a fixed final assembly line. In addition, unforeseen events and changes in the OEMs’ supply chain require a rapid response in aircraft production to be able to deliver on time. Digitalisation in product development and production planning makes it possible to overcome these challenges and makes an important contribution to flexibility, time and cost efficiency. This paper presents a digital approach to modelling and flexible planning of assembly processes of the cabin. To this end, aircraft design data is automatically linked to the assembly system to react quickly to design changes in the assembly planning process. The integration is realised in a system architecture model depicted with the systems modelling language (SysML). The architecture model follows the formal process description defined in VDI3682. A planning algorithm then uses the production architecture parameters to optimise the assembly processes, e.g. in terms of time. The approach presented is demonstrated using the example of scheduling the pre-assembly processes of the "crown module". The latter includes all structural and functional components above the window panels, such as overhead bins, electrics and air conditioning. The results show how changes in aircraft and cabin design or in the production plant and resources can be flexibly evaluated. This allows conceptual changes to be evaluated and traded before the cabin design is frozen and transferred to real production. These advantages contribute to the time and cost optimisation of aircraft production. This work thus makes a valuable contribution to the further development of digital solutions in aircraft production.

A novel isolation technique for sweetpotato starch and its application in thermal property characterization.

The utilization of sweetpotato starch in the food industry is significantly influenced by the granule size of the starch. To isolate sweetpotato starch fractions with different sizes, an efficient isolation method is in demand. The differences in thermal properties of starch fractions with different sizes from various sweetpotato varieties were revealed insufficiently. In this study, we devised a time-saving isolation technique to effectively isolate sweetpotato starch fractions based on granule sizes. The new technique was proved applicable for sweetpotato varieties with different flesh colors. The amylose contents of the isolated starch fractions were in the range 16.49-23.27%. A positive association was observed between amylose content, relative crystallinity of starch fractions and their granule size. Conversely, both the swelling power and water solubility at 95 °C displayed a consistent decline from more than 30 g g-1 to lower than 20 g g-1 as the granule size increased. Tp, To and Tc decreased gradually with an increase of starch granule size, while the medium- or small-sized starch fractions showed higher ΔH. In the first stage of thermogravimetric analysis curves, the weight of the small-sized starch fractions decreased the slowest, but no definite pattern was detected in the second or third stage. Therefore, the newly established technique and the results of this study will help better understand the properties of sweetpotato starch fractions with different sizes and certainly provide guidelines for the utilization of sweetpotato starch in food processing and product development. © 2024 Society of Chemical Industry.

Study of the protective efficacy of CombiMab-2 against human immunodeficiency virus type 1 in mice humanised with CD4<sup>+</sup> T-lymphocytes

INTRODUCTION. Despite existing treatment methods, complete eradication of human immunodeficiency virus (HIV) infection remains an unattainable goal due to the high variability of HIV type 1 (HIV-1). HIV infection necessitates life-long administration of antiretroviral medicinal products, which cause serious adverse drug reactions. The development of gene therapy products based on adeno-associated virus (AAV) vectors encoding broadly neutralising antibodies represents a promising direction for creating long-term therapies capable of countering a wide range of viral variants.AIM. This study aimed to evaluate the protective efficacy of CombiMab-2, a medicinal product consisting of a combination of three AAV vectors (AAV9-VRC07-523, AAV9-10-1074, and AAV9-PGDM1400) encoding broadly neutralising antibodies against HIV-1, in a humanised mouse model.MATERIALS AND METHODS. The study used an HIV infection model based on immunodeficient B-NDG mice humanised with human CD4+ lymphocytes (1.5×107 cells per animal) from a leukoconcentrate of a healthy donor. The experiment used two groups of mice, including a control group (3 animals) receiving saline solution and an experimental group (5 animals) receiving CombiMab-2. The medicinal product was administered into different muscles as three separate components six weeks prior to infection. The CCR5-tropic HIV-1 strain was obtained by transfecting HEK293FT cells with the pNL4-3(AD8) plasmid encoding the full-length virus. The authors monitored viral loads in the plasma of animals by reverse transcription polymerase chain reaction and CD4+ lymphocyte counts in the peripheral blood of animals by flow cytometry for four weeks after infection.RESULTS. Six weeks after CombiMab-2 administration, the levels of broadly neutralising antibodies in the serum of humanised mice ranged from 0.17 μg/mL to 4.0 μg/mL. In the control group, the viral load reached 105 copies/mL one week after HIV-1 infection and continued to rise over the next three weeks. In the treatment group, infection developed only in one mouse, which had the lowest antibody titre before infection. No viral load was detected in the remaining mice of the treatment group, which indicated that the medicinal product was effective if serum concentrations of broadly neutralising antibodies reached 0.5 μg/mL or higher.CONCLUSIONS. The tested medicinal product based on three AAV vectors (AAV9-VRC07-523, AAV9-10-1074, and AAV9-PGDM1400) exhibits protective activity against HIV-1 in humanised mice. The presented data allow the authors to consider CombiMab-2 as a promising antiviral agent that can serve as a basis for further pharmaceutical development.

Biosynthesis and potential application of sustainable lignocellulolytic enzymes cocktail for the development of eco-friendly multifunctional cellulosic products

Biosynthesis and potential application of sustainable lignocellulolytic enzymes cocktail for the development of eco-friendly multifunctional cellulosic products

Labeled and Label-Free Target Identifications of Natural Products.

Target identification, employing chemical proteomics, constitutes a continuous challenging endeavor in the drug development of natural products (NPs). Understanding their targets is crucial for deciphering their mechanisms and developing potential probes or drugs. Identifications fall into two main categories: labeled and label-free techniques. Labeled methods use the molecules tagged with markers such as biotin or fluorescent labels to easily detect interactions with target proteins. Thorough structure-activity relationships are essential before labeling to avoid changes in the biological activity or binding specificity. In contrast, label-free technologies identify target proteins without modifying natural products, relying on changes in the stability, thermal properties, or precipitation in the presence or absence of these products. Each approach has its advantages and disadvantages, offering a comprehensive understanding of the mechanisms and therapeutic potential of the NPs. Here, we summarize target identification techniques for natural molecules, highlight case studies of notable NPs, and explore future applications and directions.

Distribution of Non-Structural Carbohydrates and Root Structure of Plantago lanceolata L. under Different Defoliation Frequencies and Intensities.

Plantago lanceolata L. (plantain) increases herbage dry matter (DM) production and quality during warm and dry conditions due to its deep roots and drought tolerance and reduces nitrogen losses in grazing systems compared to traditional pastures. However, plantain density usually declines after the third growing season, mainly due to defoliation management. The effects of defoliation frequency and intensity on water-soluble carbohydrate (WSC) reserves and below-ground plant responses need further research to optimize grazing strategies for improved productivity and sustainability of grazing systems. Our study investigated the effects of defoliation frequencies (15, 25, and 35 cm of extended leaf length, ELL) and intensities (5 and 8 cm of residual heights) on morphological traits and WSC concentrations in plantain biomass under controlled environmental conditions. Defoliation frequency significantly influenced morphological and chemical characteristics and biomass distribution more than residual height. Less frequent defoliations promoted above-ground herbage DM production, reproductive stems, and root biomass. Root architecture showed adaptations in response to defoliation frequency, optimizing resource acquisition efficiency. Frequent defoliation reduced high molecular weight WSC concentrations in leaves, affecting regrowth capacity and DM mass. A defoliation frequency of 25 cm ELL (~15 days) balances herbage production and root development, promoting long-term pasture sustainability.

Consuming placelessness: a geographic critique of current Antarctic tourism development

This paper explores the ongoing development of products, activities, and experiences in the rapidly expanding Antarctic tourism industry and their potential implications for the production of Antarctic places. Informed by theories of place and placelessness, the paper identifies three particular place framings informed by tourism diversification: the compression of time and space, the detachment of Antarctica from Earth, and the progressive consumption of wilderness through luxury and comfort. The paper argues that these dynamics may contribute to a detachment from the ways in which Antarctic places are situationally and materially assembled, leading to the abstraction, simplification, and obfuscation of socio-material relations making for a place. The possible consequence is the transformation of the Antarctic into a placeless space of consumption. By emphasizing the detachment facilitated by certain prominent activities and infrastructure, the paper contributes to debates about tourism destination development, urging consideration of how tourism can be shaped to foster an appreciation of places in their own right.

Enhancing Patient Safety Through an Integrated Internet of Things Patient Care System: Large Quasi-Experimental Study on Fall Prevention.

The challenge of preventing in-patient falls remains one of the most critical concerns in health care. This study aims to investigate the effect of an integrated Internet of Things (IoT) smart patient care system on fall prevention. A quasi-experimental study design is used. The smart patient care system is an integrated IoT system combining a motion-sensing mattress for bed-exit detection, specifying different types of patient calls, integrating a health care staff scheduling system, and allowing health care staff to receive and respond to alarms via mobile devices. Unadjusted and adjusted logistic regression models were used to investigate the relationship between the use of the IoT system and bedside falls compared with a traditional patient care system. In total, 1300 patients were recruited from a medical center in Taiwan. The IoT patient care system detected an average of 13.5 potential falls per day without any false alarms, whereas the traditional system issued about 11 bed-exit alarms daily, with approximately 4 being false, effectively identifying 7 potential falls. The bedside fall incidence during hospitalization was 1.2% (n=8) in the traditional patient care system ward and 0.1% (n=1) in the smart ward. We found that the likelihood of bedside falls in wards with the IoT system was reduced by 88% (odds ratio 0.12, 95% CI 0.01-0.97; P=.047). The integrated IoT smart patient care system might prevent falls by assisting health care staff with efficient and resilient responses to bed-exit detection. Future product development and research are recommended to introduce IoT into patient care systems combining bed-exit alerts to prevent inpatient falls and address challenges in patient safety.

Consumer Perception of Palm Sugar Products in Rokan Hulu District, Indonesia: A Prospective Analysis Approach

The demand for palm sugar has been consistently increasing each year, particularly due to the growing public awareness of health benefits. Palm sugar is considered a safer sweetener option due to its low glycemic index and absence of side effects. The primary objective of this research is to analyze consumer perceptions regarding the attributes of palm sugar. This analysis is crucial in assessing consumer satisfaction and loyalty toward palm sugar consumption. Consequently, the findings will contribute to enhancing the marketing mix strategies for palm sugar. The survey method was employed to conduct this research, with a sample size of 30 consumer respondents selected through random sampling. Additionally, an opinion poll was conducted with key individuals to gather insights on the development of palm sugar products. The collected data were then analyzed using a prospective analysis approach. The research results indicate that specific attributes significantly influence consumer perceptions when purchasing palm sugar. Consumer perceptions in purchasing palm sugar are based on details of the marketing mix attributes which are the determining attributes, namely: taste, quality, palm sugar color, texture, popularity of craftsmen, and price. The marketing development implications of this research are improvements to three attribute components, namely raw material composition information, product standards, hygiene, partnerships, and technology. This serves as a consideration for craftsmen to improve consumer perceptions of palm sugar. Keywords: marketing of palm sugar, perception, prospective

Directly mining and identifying a cellobiose 2-epimerase with isomerization activity by phylogenetic analysis

The isomerization activity of cellobiose 2-epimerase (CE) offers the potential for conversion of lactose into lactulose. However, the isomerization activity of reported CEs is low and identifying CE with isomerization activity is still challenging and time consuming. Here, we developed a strategy for directly mining CE with isomerization activity through phylogeny analysis and a novel CE from Dictyoglomus sp (XVH1-CE) was identified which has isomerization activity as expected. The isomerization activity of XVH1-CE could reach 4.3 U mg−1 at 85 °C and pH 7.5, which is highest among all reported CEs. Moreover, Molecular Dynamics (MD) simulation further revealed that XVH1-CE presents a significant region change influenced by lactulose, and statistic special binding pose seen as important for lactulose catalysis performed a high frequency. Our research demonstrated enzyme-mining strategy based on phylogeny analysis can offers new opportunities for the development of lactulose production by CE.

Combination of Structural Analysis and Proteomics Strategy Revealed the Mechanism of Ultrasound-Assisted Cold Plasma Regulating Shrimp Allergy.

Allergic incidents of crustacean aquatic products occur frequently, and tropomyosin (TM) is the main allergen. Therefore, it is worthwhile to develop technologies to efficiently reduce the allergenicity of TM. In this study, ultrasound-assisted cold plasma (UCP) treatment was used to regulate shrimp allergy. The remarkable changes in TM structure were substantiated by alteration in secondary structure, reduction in sulfhydryl content, change in surface hydrophobicity, and disparity in surface morphology. The IgE and IgG binding ability of TM significantly decreased by 52.40% and 46.51% due to UCP treatment. In the Balb/c mouse model, mice in the UCP group showed most prominent mitigation of allergic symptoms, proved by lower allergy score, changes in levels of TM-specific antibodies, and restoration of Th1/Th2 cytokine imbalance. Using a proteomics approach, 439 differentially expressed proteins (DEPs) in the TM group (vs phosphate-buffered saline group) and 170 DEPs in the UCP group (vs TM group) were determined. Subsequent analysis demonstrated that Col6a5, Col6a6, and Epx were potential biomarkers of TM allergy. Moreover, Col6a5, Col6a6, Dcn, and Kng1 might be the target proteins of UCP treatment, while PI3K/Akt/mTOR might be the regulated signaling pathway. These findings proved that UCP treatment has great potential in reducing TM allergenicity and provide new insights into the development of hypoallergenic shrimp products.

Оценка обеспеченности человеческим капиталом аграрного сектора экономики

Abstract. The formation and use of human capital in the agricultural economy must meet modern economic requirements and the level of development of agricultural production. The assessment of the efficiency of the use of human resources and the quality of products plays a key role in adapting to changing market conditions. Therefore, it is important to constantly strengthen human resources to ensure a prompt response to market challenges. At the same time, agricultural production is currently undergoing changes in all key areas. This article analyzes the availability and efficiency of the use of agricultural enterprises' labor resources, based on statistical data for the Russian Federation. In this regard, the purpose of this scientific study is to analyze the availability of human capital in agriculture. The objectives of the study include carrying out a qualitative and quantitative assessment of labor resources. Methods. The methodological basis is based on the general scientific principles of a systematic approach. The analysis uses logical, factorial, comparative and strategic methods, as well as methods of qualitative research of the main trends in the presence and use of human capital in agriculture. Results. The analysis of the formation and use of human capital in agriculture in its quantitative and qualitative assessment in the Russian Federation is carried out: the dynamics of rural population density and the number of workers, the growth rate of wages of agricultural workers, the grouping of those employed in agriculture by level of education, gender and age is given. Scientific novelty. As a result of the research, new theoretical and practical conclusions were obtained, including: 1) identification and classification of socio-economic conditions that promote or, conversely, hinder the effective use and preservation of human capital in the agricultural sector; 2) comprehensive schemes for the formation of human capital in the agricultural sector are proposed, taking into account internal and external factors; 3) the need for the formation of a comfortable socio-economic environment in rural areas is justified; 4) confirmed the need to provide special support measures to attract highly qualified specialists to rural areas.

Decision-making strategies for organizational processes

This research aims to explore decision-making strategies in organizational processes and their relevance in today's business environment, using a comprehensive methodology based on a review of the scientific literature. Different approaches and methodologies used for decision making are presented, such as data-driven decision making, multi-criteria decision making, collaborative decision making and decision making based on artificial intelligence and machine learning. In addition, recent applications of these strategies in various organizational contexts, such as manufacturing, logistics and supply chain, project management, and product innovation and development, are discussed.