Development Of Industrial Processes Research Articles

Challenges and opportunities to include patient-centric product design in industrial medicines development to improve therapeutic goals.

In the past, drug developers in industry chose approaches mainly focusing on the drug product's efficacy, safety and quality according to the level required by regulatory expectations stipulated in guidelines, pharmacopoeia and other regulatory provisions. By putting more focus on the patient perspective, regulatory authorities are currently raising their requirements regarding successful product submissions. The increasing involvement of patients in the product development process (e.g. conduction of human factor use tests, integration of feedback from patient and patient advisory groups into clinical programmes) requires adaptations to the existing and established industrial drug development processes without compromising fast patient access to innovative therapies. This review provides an expert opinion on the emerging challenges and opportunities to implement a patient-centric approach into new drug development programmes. The aim is to better understand the challenge of finding the right balance between bringing innovative drugs fast to the patients and to develop these in parallel in a patient-centric product form as well as why this is an opportunity and how stakeholder parties (e.g. patients, clinicians, pharmacists, caregivers, regulators) can provide support to achieve desired outcomes.

IDENTIFICATION OF PRIORITY DIRECTIONS FOR THE DEVELOPMENT OF AGRO-INDUSTRIAL CLUSTERS IN THE NORTHERN REGION

The arcile descuites the features of the development of the agro-industrial complex of the Komi Republic, including based on the SWOT analysis of its agro-food sector. The study identifies the strengths and weaknesses of integration in the conditions of the Northern region, identifies opportunities and threats, formed the principles for the formation and functioning of a product cluster. The algorithm determining the priority directions of development of clusters in the Northern region, allows to deepen the system displays the development of agricultural production in rural areas and includes the following areas: analysis of the status and dynamics of development of agricultural production in the region; the allocation of typological groups; assessment of the influence of the main values of the factors on agricultural production; analysis of the development of processing industries; matrix analysis definition of priority directions of development of the cluster; the formation of potential product clusters.

Viscosities of pure protic ionic liquids and their binary and ternary mixtures with water and ethanol

The knowledge of the viscosity of ionic liquids is crucial for the design and development of industrial processes that involve these fluids, as well as for the theoretical study of this property. In this study, viscosities of four protic ionic liquids (PILs) consisting of ethanolamine as cation and formate, acetate, butyrate and hexanoate as anions, have been measured at the temperature range from 293.15 to 393.15 K, at atmospheric pressure. Viscosities of binary and ternary mixtures of these ionic liquids with water and ethanol at 293.15, 298.15 and 303.15 K have been also measured. PILs were found to be highly viscous fluids, except for 2-hydroxyethylammonium formate, and their viscosity is affected to a great extent by the presence of water and/or ethanol. The temperature dependency of the viscosity for pure ionic liquids is analyzed by means of the Vogel-Tammann-Fulcher equation, while for ionic liquid mixtures a modified Grunberg-Nissan equation is developed in this work. Satisfactory agreement between the experimental data and the model was obtained in all cases. Finally, the glass transition temperature of the PILs was measured.

Current Situation of the Challenging Scale-Up Development of Hydroxymethylfurfural Production.

Hydroxymethylfurfural (HMF) is a high‐value platform chemical derived from renewable resources. In recent years, considerable efforts have been made to produce HMF also at industrial scale, which still faces some challenges regarding yield as well as sustainable and economic process designs. This critical Review evaluates the industrial process development of sustainable biomass conversion to HMF. Qualitative and quantitative guidelines are defined for the technological assessment of the processes described in patent literature. The formation of side products, difficulties in the separation and purification of HMF as well as catalyst regeneration were identified as major challenges in the HMF production. A first small‐scale, commercial HMF production plant with a capacity of 300 tHMF per year has been operating in Switzerland since 2014.

Penyelesaian Sengketa di Luar Pengadilan sebagai Upaya Pemulihan Dampak Kerusakan Lingkungan

This article aims to review the resolution of environmental disputes outside the court based on Law Number 32 of 2009 concerning Environmental Protection and Management (UUPPLH). The problem is focused on efforts to protect and restore environmental damage. The method used in this research is normative or doctrinal legal research. Data is collected through a literature approach and analyzed qualitatively. The rapid development of the industry, requires natural resources in the form of raw materials and energy sources that are very large as well. The consequence of the industrial development process is the increase in waste produced by the industry. This is very possible for friction between the surrounding communities, which in turn can lead to conflict or dispute. This study concludes that resolving environmental disputes outside the court is considered more beneficial because if it takes a case in court it takes a long time. By shortening the process the impact of environmental damage can be more quickly addressed so that the ecosystem can soon recover and social, economic and cultural life can proceed as it should.

Lanthanothermic Reduction of TiO2

The development of a new titanium (Ti) smelting process is highly desired to decrease the cost of Ti metal. In this study, a new method to produce a low-oxygen-concentration Ti directly from TiO2 using La as the reductant was developed. First, deoxidation experiments of metallic Ti using La as the deoxidant were conducted, and the ability of La to deoxidize metallic Ti was demonstrated. The oxygen concentrations in Ti were approximately 3900 ± 400 mass ppm O and 120 ± 50 mass ppm O at La/La2O3 and La/LaOCl/LaCl3 equilibria, respectively, at 1200 K (927 °C). Then, TiO2 reduction experiments utilizing La as the reductant were conducted to produce low-oxygen-concentration Ti directly. TiO2 pellets and Ti pieces were held in LaCl3 molten salt with a sufficient amount of La at 1200 K (927 °C) for 86 ks. After the reaction, the TiO2 pellets were reduced to metallic Ti without reaction inhibition by the formation of intermediate products. The oxygen concentration of the Ti pieces, which were placed in the molten salt with the TiO2 pellets, was 100 ± 50 mass ppm O. These results indicate that low-oxygen-concentration Ti containing less than 200 mass ppm O could be produced directly from TiO2 by utilizing La as the reductant in LaCl3 molten salt at 1200 K (927 °C). This new method is expected to lead to the development of a new industrial process for the production of ultra-low-oxygen-content Ti from Ti ore without a chlorination process.

Sustainability of food waste biorefinery: A review on valorisation pathways, techno-economic constraints, and environmental assessment

The need to increase circularity of industrial systems to address limited resources availability and climate change has triggered the development of the food waste biorefinery concept. However, for the development of future sustainable industrial processes focused on the valorisation of food waste, critical aspects such as (i) the technical feasibility of the processes at industrial scale, (ii) the analysis of their techno-economic potential, including available quantities of waste, and (iii) a life cycle-based environmental assessment of benefits and burdens need to be considered. The goal of this review is to provide an overview of food waste valorisation pathways and to analyse to which extent these aspects have been considered in the literature. Although a plethora of food waste valorisation pathways exist, they are mainly developed at lab-scale. Further research is necessary to assess upscaled performance, feedstock security, and economic and environmental assessment of food waste valorisation processes.

SIMULATION OF GRADIENT-BASED INDIVIDUAL DESIGN BEHAVIOUR IN DISTRIBUTED DEVELOPMENT PROCESSES

AbstractAs current vehicle development processes in the automotive industry are highly distributed, the interaction between design teams is limited. In this paper we use a simulation in order to investigate how the rate of design team interaction affects the solution quality and development cost. Results show, that in case of no limiting constraints, a low rate of interaction yields the best results regarding solution quality and development cost. If design activities are affected by constraints, however, the rate of interaction is subject to a conflict between solution quality and development cost.

ТЕХНІКО-ТЕХНОЛОГІЧНІ РІШЕННЯ ПРОЦЕСУ ОДЕРЖАННЯ ВОЛОКНА З ЛУБ’ЯНИХ КУЛЬТУР

The paper is devoted to solving problems related to developing scientific bases for resource-saving technologies in bast crops complex processing. The work contains theoretical and experimental research in processing flax and hemp raw materials. The work objective is to find ways to improve the production conditions for processing bast fibre plants and to solve the problems of ameliorating the qualitative and quantitative bast fibre characteristics by improving the technological features of stem material processing and structural design application to the joint connections of the devices for processing bast-fibre raw materials. The paper also analyses current trends in the flax and hemp processing industry development, investigates the technical and technological features of processing bast-fibre crop stems and assesses the directions for increasing their processing efficiency.

Prospects for the Development of Advanced Grain Processing in Russia

Purpose: The article is devoted to the identifying and evaluating promising areas of advanced grain and legumes processing development as a strategically important area for import substitution and food security of the agribusiness complex. Methodology/Approach: To achieve this goal, it is necessary to solve the following tasks: the analysis of advanced grain and legumes processing products; the evaluation of the current Russian market for advanced grain processing products; the identification of promising products and directions of the advanced grain processing industry development. Findings: According to the analysis in this article, this industry is in its infancy, despite the fact that in most developed countries of the world, advanced grain processing is widely elaborated. The key reasons for the Russia's lag there involve the lack of domestic techniques and highly qualified specialists in this field. Processing grain into flour, starches, glucose syrups, biofuels and organic acids makes possible manufacturing plastic and other products. To realize the Russia's potential in manufacturing high-value-added agricultural products, it is necessary to provide state support for investment projects for wheat deep processing through preferential lending and taxation, and co-financing of projects. The strategic goal of the Russian agribusiness in the medium and long term should be changing the structure of manufacturing and export in order to export finished products, but not raw materials. Practical implications: The results of this research could be introduced in the process of strategic planning of the agribusiness development and import substitution policy in Russia. Originality/Value: The key contribution of this study lies in the findings of the advanced grain processing industries’ analysis in Russia with the regional aspects taken into account.

Compositional variability of food wastes and its effects on acetone-butanol-ethanol fermentation

Converting food waste into butanol via acetone, butanol, and ethanol (ABE) fermentation provides the potential to recover energy and value-added chemicals from food waste. However, the high variability of food waste compositions has hindered the consistency and predictability of butanol production, impeding the development of a robust industrial fermentation process. This study characterized the compositional variation of collected food wastes and determined correlations between food waste compositional attributes and butanol yields for a better prediction of food waste fermentation with Clostridium. The total sugar, starch, fiber, crude protein, fat and ash contents (on dry basis) in the food waste samples were in a range of 0.5–53.5%, 0–25.2%, 0.6–26.9%, 5.5–21.5%, 0.1–37.9%, and 1.4–13.7%, respectively. The high variability of food waste composition resulted in a wide range (3.5–11.5 g/L) of butanol concentrations with an average of 8.2 g/L. Pearson’s correlation analysis revealed that the butanol concentrations were strongly and positively correlated with equivalent glucose and starch contents in food waste, strongly and negatively correlated with fiber content, and weakly correlated with total sugar, protein, fat, and ash contents. The regression models constructed based on equivalent glucose and fiber contents reasonably predicted the butanol concentration, with the R2 of 0.80. Our study investigated the variability of food waste composition and, for the first time, unveiled relationships between food waste compositional attributes and fermentation yields, contributing to a greater understanding of food waste fermentation, which, in turn, assists in developing new strategies for increased consistency and predictability of food waste fermentation.

STATE AND DEVELOPMENT PROSPECTS OF THE OILSEED-PRODUCT SUBCOMPLEX OF THE AGRO-INDUSTRIAL COMPLEX OF UKRAINE

Introduction. The main oilseeds of Ukraine are sunflower, soybean and rapeseed (winter and spring) - in 2019, their share in the structure of oilseeds is 99.3% of the sown area. In different years, the profitability of their production ranges from 25 to 50%, providing one of the highest levels of cost recovery in domestic agricultural production. This is the main reason for the stable growth of sown areas under oilseeds. Purpose. The purpose of the study is to assess the state and development prospects of the oil and food subcomplex of the agro-industrial complex of Ukraine in terms of the national economy increasing openness. Results. The article examines the state of agricultural production and industrial processing of seeds and oilseeds in Ukraine. There is a rapid growth of sown areas under the respective crops. Significant reserves of increase in production of sunflower, soybean and rapeseed due to increased yield are substantiated. The redundancy of the share of sunflower crops in the structure of sown areas is noted. It is assumed that a serious shortcoming in the development of the oil and food subcomplex is the excessive export volume of rapeseed, which is more appropriate to use for domestic processing to meet the needs of domestic consumers in scarce motor fuel. Conclusions. The main type of raw material in the field of industrial processing of oilseeds are sunflower seeds. Excessive sales of sunflower seeds abroad were redirected for domestic processing due to the introduction of export duties. Among the factors hindering the full development of the domestic oil market is its non-competitive structure. For the development of industrial processing of rapeseed, it is necessary to introduce an appropriate export duty of 10% and not to reimburse VAT on rapeseed exports. For the development of domestic biodiesel production, it is necessary to create clear and transparent legislation that establishes a long-term model of the industry, defining the basic rules of market participants, requirements for marketable products, creating conditions for the formation of logistics and infrastructure for collecting biological raw materials, transportation, production of second-generation biofuels. Keywords: sunflower, soybean, rapeseed, area, yield, oil, monopoly, export, raw materials, biodiesel.

The development of industrial (thermal) processes in the context of sustainability: The case for microwave heating

AbstractThe volumetric, uniform, and selective heating of microwaves is a novel technique with the potential to be established in a wide range of applications. The individual interaction of each phase/component of multiphase/multicomponent systems with microwaves creates more than a temperature in the system. Having a high local temperature on an active site that is a strong microwave receptor promotes catalytic and non‐catalytic reactions. The relatively low temperature of the bulk material(s) restricts the undesirable secondary reactions correspondingly. This finding has already led to several applications. In this work, the fundamentals of microwave heating and their prospective applications are debated. Select lab‐scale results of metal and sulphur removal from petroleum oil, pyrolysis of lignin, and dry reforming of methane are demonstrated. The expected impacts of microwaves on other multiphase reactions are proposed.

How is the Pharmaceutical Industry Structured to Optimize Pediatric Drug Development? Existing Pediatric Structure Models and Proposed Recommendations for Structural Enhancement

BackgroundPediatric regulations enacted in both Europe and the USA have disrupted the pharmaceutical industry, challenging business and drug development processes, and organizational structures. Over the last decade, with science and innovation evolving, industry has moved from a reactive to a proactive mode, investing in building appropriate structures and capabilities as part of their business strategy to better tackle the challenges and opportunities of pediatric drug development.MethodsThe EFGCP Children’s Medicines Working Party and the IQ Pediatric working group have joined their efforts to survey their member company representatives to understand how pharmaceutical companies are organized to fulfill their regulatory obligations and optimize their pediatric drug development programs.ResultsKey success factors and recommendations for a fit-for-purpose Pediatric Expert Group (PEG) were identified.ConclusionPediatric structures and expert groups were shown to be important to support optimization of the development of pediatric medicines.

Macro-Factors in the Development of Industrial Concentration Processes

Russia seeks to occupy its position in the international division of labor, corresponding to its intellectual, industrial and scientific potential, to become a full participant in world economic processes, to use the advantages of international exchange for economic growth and effective reform of the structure of the national economy. This implies the creation of a developed system of international cooperation institutions and the formation of a complex of effective management tools both by the process of integration of the Russian economy into the world economic system in the context of globalization and its consequences, the development of a well-thought-out state strategy in the regional economy. Planning the processes of concentration, managing these processes on a scientific basis and choosing the optimal size of enterprises occupies an important place in the planning system of industrial production.

The History of the German Association for Crystal Growth

The History of the German Association for Crystal Growth

Convective Drying at Fish Chips Technology

The article presents the overview of the main technological processes in fish structured products dehydration. The rational modes of the technological process of minced fish raw materials with various initial moisture and fat content heat treatment are determined. One of the main tasks of the fish processing industry development which allows increasing the profitability of products and their quality is improving technological processes. The scientifically substantiated choice of resource and energy-saving modes of processing food materials is highly important in this case. It will reduce not only production costs but also emissions of harmful substances into the environment and increase the efficiency of using equipment. It must be taken into consideration that the optimization of dehydration technological processes without identifying their patterns is extremely difficult. Increasing efficiency and controlling technological processes makes sense only on the basis of patterns. The effectiveness of the hydrobionts processing determines the quality and cost of finished products manufacturing while fish processing enterprises working. The development and implementation of highly efficient technologies with the use of resource-saving technical systems, for example, using heat pumps, makes it possible to produce cost-effective high-quality products.

A holistic review on artificial intelligence techniques for well placement optimization problem

Well placement optimization is one of the major challenging factors in the field development process of oil and gas industry. The objective function of well placement optimization is considered as high dimensional, discontinuous and multi-model. Over the last decade, both gradient-based and gradient-free optimization methods have been implemented to tackle this problem. Nature-inspired gradient-free optimization algorithms like particle swarm optimization, genetic algorithm, covariance matrix adaptation evolution strategy and differential evolution have been utilized in this area. These optimization techniques are implemented as stand-alone or as hybrid form to maximize the economic factors. In this paper, several nature-inspired metaheuristic optimization techniques and their application to maximize the economic factors are reviewed. Newly developed optimization algorithms are very efficient and favorable when compared to other established optimization algorithms and in all cases, it has been noticed that hybridization of two or more algorithms works better than stand-alone algorithms. Furthermore, none of the single optimization techniques can be established as being universally superior which aligns with no free lunch theorem. For future endeavor, combining optimization methods and exploiting multiple optimization processes for faster convergence and developing efficient proxy model is expected.

Assessment of Antibody Self-Interaction by Bio-Layer-Interferometry as a Tool for Early Stage Formulation Development.

To speed up the drug development process in the biopharmaceutical industry, high throughput methods are indispensable for assessing drug candidates and potential lead formulations, in particular during late stages of discovery and early phases of development. This study aimed to establish a bio-layer-interferometry based high throughput assay for assessing formulation dependent mAb self-interaction (SI-BLI) and to compare the results with kD values obtained by dynamic light scattering (DLS). Self-interaction of proprietary and commercially available mAbs was analyzed by SI-BLI and dynamic light scattering (DLS). We found significant correlations of the SI-BLI results and kD-values obtained by DLS for both, different mAbs in one platform formulation and for mAbs formulated in several buffer compositions. In total, we assessed self-interaction propensity of different mAbs in 58 formulations and found significant Pearson correlation (p < 0.05) between kD and results of SI-BLI. The SI-BLI results correlate with kD and enable fast ranking of both different drug candidates and potential lead formulations. Thus, SI-BLI might decrease the risk to lose potent mAb candidates during transition from discovery to development, and help to accelerate the development of high concentration liquid formulations.

Effect of agitation speed on freezing process of ice cream using a batch freezer

AbstractThis study investigates the effect of agitation speed on the freezing process of ice cream using a batch freezer. The temporal change in apparent viscosity during freezing is measured by the Metzner–Otto method. It was found that the apparent viscosity of ice cream after freezing decreased with an increase in the agitation speed. In addition, the number of bubbles incorporated into the ice cream also increased with the increase in the agitation speed. The bubbles were broken down into smaller bubbles by the higher shear force, that is, the higher agitation speed. Furthermore, a narrower distribution of the bubble size was obtained at higher agitation speeds. This indicated that the rheological properties and the microstructure of ice cream can be controlled by the agitation operation.Practical applicationsThis study clarified the effect of agitation speed on ice cream properties such as the apparent viscosity, the overrun and the size distribution of contained bubbles. Especially, the apparent viscosity is important for both industries and consumers. The Metzner–Otto method was used to directly measure the temporal change in the apparent viscosity during freezing. This temporal change has not been investigated so far. It was found that the apparent viscosity decreased with the increase in the agitation speed. In other words, the rheological properties can be controlled by the agitation operation. In industries, the continuous freezer is more preferable than the batch freezer used in this study. Nevertheless, the knowledge would be quite useful for the development of industrial processes of ice cream.