The “Current Trends in Peptide Science” reviews in this issue feature papers on a variety of peptide approaches to combating human diseases, including peptide antimicrobials, inhibitors of enzymes, anticancer agents, and vaccines. In the first paper, Bryant, Lazarus, and their colleagues describe advances in opioid peptide research made through the introduction of the 2′6′-dimethyl-L-tyrosine (Dmt) residue into opioidmimetics, particularly in the context of Dmt-Tic compounds. The authors review the ability of Dmt—when substituted for Tyr in opioid peptides—to enhance the interaction and accompanying biological activities of the resulting compounds with respect to δ and μ-opioid receptors. Structural data on these materials are presented which have facilitated the development of pharmacophores for both δ-opioid receptor agonists and antagonists. Through studies of mixture-based peptide synthetic combinatorial libraries, Blondelle and her colleagues then describe their advances in the development of antimicrobial and antiviral peptides, and their application to the control of infectious diseases. Noting that immunization with peptides can induce humoral and cellular immune responses mediated by antibody and T lymphocytes, respectively, the authors further describe their efforts in evaluating synthetic peptides as vaccines, including applications to HIV-1 proteins. In the following paper, Cooperman reviews research into class I ribonucleotide reductases (RR's), which are established targets for cancer chemotherapeutic and antiviral agents. Oligopeptides are described which specifically inhibit the RR's from which they are derived; structural work on these peptides is presented which has led to a model compatible with binding data, from which detailed knowledge could lead to peptide inhibitors selective for tumor cells. Focusing on the key role of the growth factor receptor-bound protein 2 (Grb2) in the Ras signaling pathway, which renders Grb2 a potential target for the design of antitumor agents, Lung and Tsai review current approaches to the development of Grb2 SH2 domain peptide inhibitors intended to interrupt Grb2 recognition. The authors delineate the classes of inhibitors used in this context, which range from those containing nonhydrolyzable mimetics of phosphates to nonphosphorylated cyclic peptide ligands for the Grb2 SH2 domain. Then, Cachia and Hodges provide a comprehensive discussion of synthetic peptide vaccines which may have utility in the prevention and treatment of Pseudomonas aeruginosa—an opportunistic pathogen that causes urinary tract and respiratory system infections, and which becomes extremely difficult to treat in cystic fibrosis patients. These authors describe their progress in development of anti-adhesin peptides targeted at the prevention of host cell attachment, and toward the elucidation of rules in consensus sequence design that can facilitate synthetic peptide vaccine development. These reviews highlight and re-state the emerging importance of the diverse roles of peptides in potential treatment of human disorders ranging from cancer to HIV to cystic fibrosis. We hope that readers discover, and share, the optimism inherent in these reports.