Development Of Model Research Articles

Development and Validation of an Algorithm Model for Predicting Heat Sink Effects during Pulmonary Thermal Ablation

The aim of this study was to develop an algorithm model to predict the heat sink effect during thermal ablation of lung tumors and to assist doctors in the formulation and adjustment of surgical protocols. The heat sink effect is an important factor affecting the therapeutic effect of tumor thermal ablation. At present, there is no algorithm model to predict the intraoperative heat sink effect automatically, which needs to be measured manually, which lacks accuracy and consumes time. To construct a segmentation model based on a convolutional neural network that can automatically identify and segment pulmonary nodules and vascular structure and measure the distance between the nodule and vascular. First, the classical Faster RCNN model was used as the nodule detection network. After obtaining the bounding box of pulmonary nodules, the VSPP-NET model was used to segment nodules in the bounding box. The distance from the nodule to the vasculature was measured after the surrounding vasculature was segmented by the VSPP-NET model. The lung CT images of 392 patients with pulmonary nodules were used as the training data for the algorithm. 68 cases were used as algorithm validation data, 29 as nodule algorithm test data, and 80 as vascular algorithm test data. We compared the heat sink effect of 29 cases of data with the results of the algorithm model and expert segmentation and compared the difference between the two results. In pulmonary CT image vasculature segmentation, the recall and precision of the algorithm model reached >0.88 and >0.78, respectively. The average time for automatic segmentation of each image model is 29 seconds, and the average time for manual segmentation is 158 seconds. The output image of the model shows that the results of nodule segmentation and nodule distance measurement are satisfactory. In terms of heat sink effect prediction, the positive rate of the algorithm group was 28.3%, and that of the expert group was 32.1%, with no significant difference between the two groups (p=0.687). The algorithm model developed in this study shows good performance in predicting the heat sink effect during pulmonary thermal ablation. It can improve the speed and accuracy of nodule and vessel segmentation, save ablation planning time, reduce the interference of human factors, and provide more reference information for surgeons to make ablation plans to improve the ablation effect.

Predicting removal efficiency of organic pollutants by soil vapor extraction based on an optimized machine learning method

Soil vapor extraction (SVE) was a cost-effective technology for remediating volatile and semi-volatile organic contaminated soils. Many factors, including SVE parameters, soil properties, and contaminant characteristics, significantly influenced the remediation efficiency of SVE. The optimal conditions for organic pollutants removal efficiency were site-specific and varied among studies. Therefore, a generalized model was needed to predict the remediation efficiency of SVE in organic contaminated soils. This study employed machine learning to predict the removal efficiency of organic pollutants by SVE. The model's development was based on a trainset, and its predictive capabilities were evaluated using a testset. An XGBoost (XGB) model was derived from literature data (R2 = 0.9728). Time, pollutant type, and temperature were identified as the three most important features affecting SVE remediation efficiency. The accuracy (R2 = 0.9799) and universality of the model were enhanced through an optimization scheme. The developed XGB model demonstrated the ability to predict the removal efficiency of organic pollutants by considering all collected influential factors. The mechanism of multi-factor interaction on remediation efficiency was clarified. Overall, this study would contribute to evaluating the remediation potential of SVE for specific organic contaminated soils, aiding in maximizing the removal efficiency of organic pollutants under optimal conditions.

Exploiting Blockchain to Make AI Trustworthy: A Software Development Lifecycle View

Artificial intelligence (AI) is a very powerful technology and can be a potential disrupter and essential enabler. As AI expands into almost every aspect of our lives, people raise serious concerns about AI misbehaving and misuse. To address this concern, international organizations have put forward ethics guidelines for constructing trustworthy AI (TAI), including privacy, transparency, fairness, robustness, accountability, and so on. However, because of the black-box characteristics and complex models of AI systems, it is challenging to translate these guiding principles and aspirations into AI systems. Blockchain, an important decentralized technology, can provide the capabilities of transparency, traceability, immutability, and secure sharing and hence can be used to make AI trustworthy. In this paper, we survey studies on blockchain-based TAI (BTAI) from a software development lifecycle view. We classify the lifecycle of BTAI into four stages: Planning, data collection, model development, and system deployment/use. Particularly, we investigate and summarize the trustworthy issues that blockchain can achieve in the latter three stages, including (1) data transparency, privacy, and accountability; (2) model transparency, privacy, robustness, and fairness; and (3) robustness, privacy, transparency, and fairness of system deployment/use. Finally, we present essential open research issues and future work on developing BTAI systems.

Recurrent Neural Networks for Image Captioning: A Case Study with LSTM

This research investigates the viability of Long Short-Term Memory (LSTM) systems, a subtype of Recurrent Neural Networks (RNNs), for picture captioning. Leveraging the MS COCO dataset, the study compares the execution of LSTM-based RNNs with Vanilla RNN, Gated Recurrent Unit (GRU), consideration components, and transformer-based models. Experimental comes about to illustrate that the LSTM-based RNN shows competitive execution, accomplishing a BLEU-4 score of 0.72, a METEOR score of 0.68, and a CIDEr score of 2.1. The comparative investigation uncovers its prevalence over Vanilla RNN and GRU, highlighting its capability to capture long-range conditions inside successive picture information. Moreover, the study investigates the effect of consideration instruments and transformer designs, exhibiting their potential improvements in the context-aware caption era. The transformer-based show outflanks all other models, accomplishing a BLEU-4 score of 0.78, a METEOR score of 0.72, and a CIDEr score of 2.5. The findings give important bits of knowledge toward the creating scene of picture captioning strategy, which makes LSTM-based RNNs solid and productive approaches for capturing worldly groupings in visual substance. In achieving these, the study provides a framework for future developments in hybrid models and manufacturing processes that push boundaries of smart image perception and understanding

Developing Biogas Digital Comic for Improving Renewable Energy Literacy

The use of renewable energy as a substitute for fossil energy must continue to be promoted to achieve sustainability. This study aimed to reveal the development of digital comics on the topic of biogas energy as a learning medium. The method used is research and development with the DDDE model (Decide, Design, Develop, and Evaluate). The results showed that biogas digital comics were very good to be used as learning media. This study recommends the use of comics as a medium of learning on other topics.
 Keywords: Biogas Digital Comic, Improving, Renewable Energy Literacy

Understanding vote transfers in two-round elections without resorting to declared data. The contribution of ecological inference, consolidated with factual information from a case study of the 2014 municipal elections in Montpellier

In electoral sociology, the analysis of vote transfers has traditionally depended on individual data obtained from surveys. Because such data suffer from a significant amount of declaration and memory bias, replacing them with the electoral statistics available down to polling station level may be advantageous. Recent developments in models of ecological inference allow us to use these aggregated data to establish estimates of vote transfers while minimising the risk of ecological error. Nonetheless, the reliability of ecological inference models for estimating vote transfers has thus far received little attention in the form of empirical evaluations. The purpose of the present article is to cast light on this blind spot by analysing a model for predicting electoral volatility in a two-round election, namely the municipal election held in Montpellier in 2014. What makes this approach original is its use of observed information – the proportion of non-voters in both rounds – first to compare this data with the estimates produced by the model and then to integrate it as a modelling parameter to measure its impact on estimated vote allocation. This analysis reveals that the initial model's results are relatively reliable regarding the known parameter, although they slightly overestimate its amplitude and underestimate its variability. The model that integrates information regarding the proportion of consistent non-voters yields estimates close to those obtained using the “raw” model. In terms of interpretative capacity, the value added by integrating this additional information is, therefore, slight. However, integrating the information does make it possible to establish narrower density intervals, reducing the uncertainty associated with the interpretation of the other parameters, particularly proportions associated with candidates who received few votes in the first round.

Detecting and resolving feature envy through automated machine learning and move method refactoring

Efficiently identifying and resolving code smells enhances software project quality. This paper presents a novel solution, utilizing automated machine learning (AutoML) techniques, to detect code smells and apply move method refactoring. By evaluating code metrics before and after refactoring, we assessed its impact on coupling, complexity, and cohesion. Key contributions of this research include a unique dataset for code smell classification and the development of models using AutoGluon for optimal performance. Furthermore, the study identifies the top 20 influential features in classifying feature envy, a well-known code smell, stemming from excessive reliance on external classes. We also explored how move method refactoring addresses feature envy, revealing reduced coupling and complexity, and improved cohesion, ultimately enhancing code quality. In summary, this research offers an empirical, data-driven approach, integrating AutoML and move method refactoring to optimize software project quality. Insights gained shed light on the benefits of refactoring on code quality and the significance of specific features in detecting feature envy. Future research can expand to explore additional refactoring techniques and a broader range of code metrics, advancing software engineering practices and standards.

Enhancing Thai student-teacher problem-solving skills and academic achievement through a blended problem-based learning approach in online flipped classrooms

The study aimed to develop a learning model that enhances Thai student-teacher problem-solving skills (PSS) and academic achievement (AA) through a blended problem-based learning (PBL) approach in online flipped classrooms. Phase 1 consisted of the design of the Flipped PARSER (problem-attempt-research-solutions-evaluation-reflect) Model (FPM) through the study of documentation and research. Phase 2 involved using nine experts to assist with the model's development and evaluation using in-depth interviews and content analysis. Phase 3 involved the application and use of the FPM by 30 student-teachers, from which their AA, PSS, and satisfaction were evaluated against the control group of 31 participants. The results from the nine experts' input on the FPM design were significant. Instructor activities included selecting content, media, materials, and their design and development. Other components included learning activities, tools, lesson delivery, and evaluation. Also, PBL methods were again confirmed as an instrumental pedagogy in teaching PSS. When combined with online learning and flipped classrooms, the study's results were higher than those using traditional classroom methods. The study contributes to the literature by determining that online teaching models effectively teach PSS and raise AA scores.

Development of Nusselt number and friction factor models for rough rod bundles based on wall functions

The fuel assembly in the reactor undergo surface roughening due to fouling deposits and material corrosion, which significantly impact the pressure drop and convective heat transfer performance of the fuel assembly. In this study, new models were developed based on the wall velocity and temperature distribution functions. The Nusselt number and friction factor are obtained by integrating these functions over the flow cross-section. The findings demonstrate the accuracy of the method in predicting the friction factor and Nusselt number for both rough tube and smooth rod bundles. The models developed in this study can be utilized to predict the friction factor and Nusselt number in rod bundles with different relative roughness under turbulent flow states, considering square and hexagonal arrangements with P/D<1.5. The present study reveals that the roughness promotes convective heat transfer to a slightly less extent as the pressure drop.

Precise photoionisation treatment and hydrodynamic effects in atmospheric modelling of warm and hot Neptunes

Context. Observational breakthroughs in the field of exoplanets in the last decade have motivated the development of numerous theoretical models, such as those describing atmospheres and mass loss, which is believed to be one of the main drivers of planetary evolution. Aims. We outline for which types of close-in planets in the Neptune-mass range the accurate treatment of photoionisation effects is most relevant, particularly with respect to atmospheric mass loss and the parameters relevant for interpreting observations, such as temperature and ion fraction. Methods. We developed the Cloudy e Hydro Ancora INsieme (CHAIN) model, which combines our 1D hydrodynamic upper atmosphere model with the non-local thermodynamical equilibrium (NLTE) photoionisation and radiative transfer code Cloudy accounting for ionisation, dissociation, detailed atomic level populations, and chemical reactions for all chemical elements up to zinc. The hydro-dynamic code is responsible for describing the outflow, while Cloudy solves the photoionisation and heating of planetary atmospheres. We applied CHAIN to model the upper atmospheres of a range of Neptune-like planets with masses between 1 and 50 M⊕, also varying the orbital parameters. Results. For the majority of warm and hot Neptunes, we find slower and denser outflows, with lower ion fractions, compared to the predictions of the hydrodynamic model alone. Furthermore, we find significantly different temperature profiles between CHAIN and the hydrodynamic model alone, though the peak values are similar for similar atmospheric compositions. The mass-loss rates predicted by CHAIN are higher for hot strongly irradiated planets and lower for more moderate planets. All differences between the two models are strongly correlated with the amount of high-energy irradiation. Finally, we find that the hydrodynamic effects significantly impact ionisation and heating. Conclusions. The impact of the precise photoionisation treatment provided by Cloudy strongly depends on the system parameters. This suggests that some of the simplifications typically employed in hydrodynamic modelling might lead to systematic errors when studying planetary atmospheres, even at a population-wide level.

Development of a Comprehensive Dynamic Model for Giant Magnetostrictive Transducers Considering Bias Magnetic Field

Development of a Comprehensive Dynamic Model for Giant Magnetostrictive Transducers Considering Bias Magnetic Field

Considering the Secondary Use of Clinical and Educational Data to Facilitate the Development of Artificial Intelligence Models.

Medical training programs and health care systems collect ever-increasing amounts of educational and clinical data. These data are collected with the primary purpose of supporting either trainee learning or patient care. Well-established principles guide the secondary use of these data for program evaluation and quality improvement initiatives. More recently, however, these clinical and educational data are also increasingly being used to train artificial intelligence (AI) models. The implications of this relatively unique secondary use of data have not been well explored. These models can support the development of sophisticated AI products that can be commercialized. While these products have the potential to support and improve the educational system, there are challenges related to validity, patient and learner consent, and biased or discriminatory outputs. The authors consider the implications of developing AI models and products using educational and clinical data from learners, discuss the uses of these products within medical education, and outline considerations that should guide the appropriate use of data for this purpose. These issues are further explored by examining how they have been navigated in an educational collaborative.

From Finite Element Simulations to Equivalent Circuit Models of Extracellular Neuronal Recording Systems Based on Planar and Mushroom Electrodes.

define a new methodology to build multi-compartment lumped-elements equivalent circuit models for neuron/electrode systems. the equivalent circuit topology is derived by careful scrutiny of accurate and validated multiphysics finite-elements method (FEM) simulations that couple ion transport in the intra- and extracellular fluids, activation of the neuron membrane ion channels, and signal acquisition by the electronic readout. robust and accurate circuit models are systematically derived, suited to represent the dynamics of the sensed extracellular signals over a wide range of geometrical/physical parameters (neuron and electrode sizes, electrolytic cleft thicknesses, readout input impedance, non-uniform ion channel distributions). FEM simulations point out phenomena that escape an accurate description by equivalent circuits; notably: steric effects in the thin electrolytic cleft and the impact of extracellular ion transport on the reversal potentials of the Hodgkin-Huxley neuron model. our multi-compartment equivalent circuits match accurately the FEM simulations. They unveil the existence of an optimum number of compartments for accurate circuit simulation. FEM simulations suggest that while steric effects are in most instances negligible, the extracellular ion transport affects the reversal potentials and consequently the recorded signal if the electrolytic cleft becomes thinner than approximately 100 nm. the proposed methodology and circuit models improve upon the existing area and point contact models. The coupling between the extracellular concentrations and reversal potential highlighted by FEM simulations emerges as a challenge for future developments in lumped-element modeling of the neuron/sensor interface.

Development and Validation of MRI Radiomics Models to Differentiate HER2-Zero, -Low, and -Positive Breast Cancer.

BACKGROUND. Breast cancer HER2 expression has been redefined using a three-tiered system, with HER2-zero cancers considered ineligible for HER2-targeted therapy, HER2-low cancers considered candidates for novel HER2-targeted drugs, and HER2-positive cancers treated with traditional HER2-targeted medications. OBJECTIVE. The purpose of this study was to assess MRI radiomics models for a three-tiered classification of HER2 expression of breast cancer. METHODS. This retrospective study included 592 patients with pathologically confirmed breast cancer (mean age, 47.0 ± 18.0 [SD] years) who underwent breast MRI at either of a health system's two hospitals from April 2016 through June 2022. Three-tiered HER2 status was pathologically determined. Radiologists assessed the conventional MRI features of tumors and manually segmented the tumors on multiparametric sequences (T2-weighted images, DWI, ADC maps, and T1-weighted delayed contrast-enhanced images) to extract radiomics features. Least absolute shrinkage and selection operator analysis was used to develop two radiomics signatures, to differentiate HER2-zero cancers from HER2-low or HER2-positive cancers (task 1) as well as to differentiate HER2-low cancers from HER2-positive cancers (task 2). Patients from hospital 1 were randomly assigned to a discovery set (task 1: n = 376; task 2: n = 335) or an internal validation set (task 1: n = 161; task 2: n = 143); patients from hospital 2 formed an external validation set (task 1: n = 55; task 2: n = 50). Multivariable logistic regression analysis was used to create nomograms combining radiomics signatures with clinicopathologic and conventional MRI features. RESULTS. AUC, sensitivity, and specificity in the discovery, internal validation, and external validation sets were as follows: for task 1, 0.89, 99.4%, and 69.0%; 0.86, 98.6%, and 76.5%; and 0.78, 100.0%, and 0.0%, respectively; for task 2, 0.77, 93.8%, and 32.3%; 0.75, 92.9%, and 6.8%; and 0.77, 97.0%, and 29.4%, respectively. For task 1, no nomogram was created because no clinicopathologic or conventional MRI feature was associated with HER2 status independent of the MRI radiomics signature. For task 2, a nomogram including an MRI radiomics signature and three pathologic features (histologic grade of III, high Ki-67 index, and positive progesterone receptor status) that were independently associated with HER2-low expression had an AUC of 0.87, 0.83, and 0.80 in the three sets. CONCLUSION. MRI radiomics features were used to differentiate HER2-zero from HER2-low cancers or HER2-positives cancers as well as to differentiate HER2-low cancers from HER2-positive cancers. CLINICAL IMPACT. MRI radiomics may help select patients for novel or traditional HER2-targeted therapies, particularly those patients with ambiguous results of immunohistochemical staining results or limited access to fluorescence in situ hybridization.

A signal detection-based confidence-similarity model of face matching.

Face matching consists of the ability to decide whether two face images (or more) belong to the same person or to different identities. Face matching is crucial for efficient face recognition and plays an important role in applied settings such as passport control and eyewitness memory. However, despite extensive research, the mechanisms that govern face-matching performance are still not well understood. Moreover, to date, many researchers hold on to the belief that match and mismatch conditions are governed by two separate systems, an assumption that likely thwarted the development of a unified model of face matching. The present study outlines a unified unequal variance confidence-similarity signal detection-based model of face-matching performance, one that facilitates the use of receiver operating characteristics (ROC) and confidence-accuracy plots to better understand the relations between match and mismatch conditions, and their relations to factors of confidence and similarity. A binomial feature-matching mechanism is developed to support this signal detection model. The model can account for the presence of both within-identities and between-identities sources of variation in face recognition and explains a myriad of face-matching phenomena, including the match-mismatch dissociation. The model is also capable of generating new predictions concerning the role of confidence and similarity and their intricate relations with accuracy. The new model was tested against six alternative competing models (some postulate discrete rather than continuous representations) in three experiments. Data analyses consisted of hierarchically nested model fitting, ROC curve analyses, and confidence-accuracy plots analyses. All of these provided substantial support in the signal detection-based confidence-similarity model. The model suggests that the accuracy of face-matching performance can be predicted by the degree of similarity/dissimilarity of the depicted faces and the level of confidence in the decision. Moreover, according to the model, confidence and similarity ratings are strongly correlated. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

A structural equation modeling approach for modeling variability as a latent variable.

Drawing upon recent developments in structural equation modeling, the current study presents an analytical framework for addressing research questions in which, rather than focusing on means, it is intraindividual (or intragroup) variability that is of direct research interest. Beyond merely serving as an alternative to existing multilevel modeling approaches, this framework allows for extensions to accommodate a variety of complex research scenarios by parameterizing variability as a latent variable that can in turn be embedded within a broader covariance and mean structure involving other observed and/or latent variables. The estimation procedures and parameter interpretation for the latent random variability models are discussed. The versatility of the proposed methods is demonstrated through four empirical examples. The Mplus, BUGS, and Stan model syntax for the illustrative examples are supplied to facilitate the application of the methods. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Optimal scheduling and demand response implementation for home energy management

The optimal scheduling of the loads based on dynamic tariffs and implementation of a direct load control (DLC) based demand response program for the domestic consumer is proposed in this work. The load scheduling is carried out using binary particle swarm optimization and a newly prefaced nature-inspired discrete elephant herd optimization technique, and their effectiveness in minimization of cost and the peak-to-average ratio is analyzed. The discrete elephant herd optimization algorithm has acceptable characteristics compared to the conventional algorithms and has determined better exploring properties for multi-objective problems. A prototype hardware model for a home energy management system is developed to demonstrate and analyze the optimal load scheduling and DLC-based demand response program. The controller effectively schedules and implements DLC on consumer devices. The load scheduling optimization helps to improve PAR by a value of 2.504 and results in energy cost savings of ₹ 12.05 on the scheduled day. Implementation of DLC by 15% results in monthly savings of ₹ 204.18. The novelty of the work is the implementation of discrete elephant herd optimization for load scheduling and the development of the prototype hardware model to show effects of both optimal load scheduling and the DLC-based demand response program implementation.

758 An Appraisal of the Quality of Development and Reporting of Predictive Models in Neurosurgery

INTRODUCTION: Overwhelming evidence indicates that the quality of reporting of predictive models is poor, often being confounded by small datasets, inappropriate statistical methods, a lack of validation, and reproducibility. METHODS: Articles reporting prediction models published in the top five neurosurgery journals by SJR2-rank (Neurosurgery, Journal of Neurosurgery, Journal of Neurosurgery: Spine, Journal of NeuroInterventional Surgery, and Journal of Neurology, Neurosurgery, and Psychiatry) between January 1st, 2018, and January 1st, 2023, were identified via a PubMed search strategy that combined terms related to machine learning and prediction models. The identified original research articles were analyzed against the TRIPOD criteria. RESULTS: 110 articles were included and analyzed against the TRIPOD checklist. Among the articles screened, the median compliance was 57.4% (50.0-66.7%). Models utilizing machine learning-based models exhibited lower compliance on average compared to conventional learning-based models (57.1%, 50.0-66.7% vs. 68.1%, 50.2-68.1%, p = 0.472). Among the TRIPOD criteria, the lowest compliance was observed in blinding the assessment of predictors and outcomes (n = 7, 12.7% and n = 10, 16.9%, respectively), including an informative title (n = 17, 15.6%) and reporting model performance measures including confidence intervals (n = 27, 24.8%). Few studies provided sufficient information to allow for the external validation of results (n = 26, 25.7%). CONCLUSIONS: Published machine learning models predicting outcomes in neurosurgery often fall short of meeting the established guidelines laid out by TRIPOD for their development, validation, and reporting. This lack of compliance may indicate the extent to which these models have been subjected to external validation or adopted into routine clinical practice in neurosurgery.

Predicting effects of a digital stress intervention for patients with depressive symptoms: Development and validation of meta-analytic prognostic models using individual participant data.

Digital stress interventions could be helpful as an "indirect" treatment for depression, but it remains unclear for whom this is a viable option. In this study, we developed models predicting individualized benefits of a digital stress intervention on depressive symptoms at 6-month follow-up. Data of N = 1,525 patients with depressive symptoms (Center for Epidemiological Studies' Depression Scale, CES-D ≥ 16) from k = 6 randomized trials (digital stress intervention vs. waitlist) were collected. Prognostic models were developed using multilevel least absolute shrinkage and selection operator and boosting algorithms, and were validated using bootstrap bias correction and internal-external cross-validation. Subsequently, expected effects among those with and without a treatment recommendation were estimated based on clinically derived treatment assignment cut points. Performances ranged from R² = 21.0%-23.4%, decreasing only slightly after model optimism correction (R² = 17.0%-19.6%). Predictions were greatly improved by including an interim assessment of depressive symptoms (optimism-corrected R2 = 32.6%-35.6%). Using a minimally important difference of d = -0.24 as assignment cut point, approximately 84.6%-93.3% of patients are helped by this type of intervention, while the remaining 6.7%-15.4% would experience clinically negligible benefits (δ^ = -0.02 to -0.19). Using reliable change as cut point, a smaller subset (39.3%-46.2%) with substantial expected benefits (δ^ = -0.68) receives a treatment recommendation. Meta-analytic prognostic models applied to individual participant data can be used to predict differential benefits of a digital stress intervention as an indirect treatment for depression. While most patients seem to benefit, the developed models could be helpful as a screening tool to identify those for whom a more intensive depression treatment is needed. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Sensitivity of HAFS-B Tropical Cyclone Forecasts to Planetary Boundary Layer and Microphysics Parameterizations

Abstract Understanding how model physics impact tropical cyclone (TC) structure, motion, and evolution is critical for the development of TC forecast models. This study examines the impacts of microphysics and planetary boundary layer (PBL) physics on forecasts using the Hurricane Analysis and Forecast System (HAFS), which is newly operational in 2023. The “HAFS-B” version is specifically evaluated, and three sensitivity tests (for over 400 cases in 15 Atlantic TCs) are compared with retrospective HAFS-B runs. Sensitivity tests are generated by 1) changing the microphysics in HAFS-B from Thompson to GFDL, 2) turning off the TC-specific PBL modifications that have been implemented in operational HAFS-B, and 3) combining the PBL and microphysics modifications. The forecasts are compared through standard verification metrics, and also examination of composite structure. Verification results show that Thompson microphysics slightly degrades the days 3–4 forecast track in HAFS-B, but improves forecasts of long-term intensity. The TC-specific PBL changes lead to a reduction in a negative intensity bias and improvement in RI skill, but cause some degradation in prediction of 34-kt (1 kt ≈ 0.51 m s−1) wind radii. Composites illustrate slightly deeper vortices in runs with the Thompson microphysics, and stronger PBL inflow with the TC-specific PBL modifications. These combined results demonstrate the critical role of model physics in regulating TC structure and intensity, and point to the need to continue to develop improvements to HAFS physics. The study also shows that the combination of both PBL and microphysics modifications (which are both included in one of the two versions of HAFS in the first operational implementation) leads to the best overall results. Significance Statement A new hurricane model, the Hurricane Analysis and Forecast System (HAFS), is being introduced for operational prediction during the 2023 hurricane season. One of the most important parts of any forecast model are the “physics parameterizations,” or approximations of physical processes that govern things like turbulence, cloud formation, etc. In this study, we tested these approximations in one configuration of HAFS, HAFS-B. Specifically, we looked at two different versions of the microphysics (modeling the growth of water and ice in clouds) and boundary layer physics (the approximations for turbulence in the lowest level of the atmosphere). We found that both of these sets of model physics had important effects on the forecasts from HAFS. The microphysics had notable impacts on the track forecasts, and also changed the vertical depth of the model hurricanes. The boundary layer physics, including some of our changes based on observed hurricanes and turbulence-resolving models, helped the model better predict rapid intensification (periods where the wind speed increases quickly). Work is ongoing to improve the model physics for better forecasts of rapid intensification and overall storm structure, including storm size. The study also shows the combination of both PBL and microphysics modifications overall leads to the best results and thus was used as one of the two first operational implementations of HAFS.