Human Development Research Articles

New Spain through the Lens of Spatial Humanities: The Case of the Bishopric of Michoacán

This article provides an overview of the development of spatial humanities in Mexico, focusing specifically on the Bishopric of Michoacán. This ecclesiastical and jurisdictional unit, established during the Viceroyalty of New Spain, has recently been examined through the lens of spatial humanities. Our review identifies that this approach, when combined with traditional historical methods, can be highly effective in advancing research on territorial reconfiguration processes involving both Spanish and Indigenous actors. Furthermore, we present two examples of geographical text analysis (GTA) applied to the Relaciones Geográficas of Michoacán. Building on this review and the examples, we aim to encourage researchers interested in Mexico's past to enhance the potential of early historical sources by extracting valuable information intertwined with the spatial data contained in these documents.

Manajemen Berbasis Sekolah dalam Meningkatkan Mutu Pendidikan di MA Unggulan KH. A. Wahab Hasbullah Jombang

Education is the main foundation in the development of individuals and communities, until now the quality of education is still a topic of discussion in the community. The main role of education is to improve the quality of human resources, one of the solutions is through school based management (MBS) as resourve management to improve the quality of education. The purpose of the research is: (1) knowing the school based management in MA Unggulan KH. A. Wahab Hasbullah. (2) knows efforts to improve the quality of education in MA Unggulan KH. A. Wahab Hasbullah. (3) knowing the obstacles and solutions to improve the quality of education in MA Unggulan KH. A. Wahab Hasbullah. The method used in this study is qualitative descriptive with interviewing, observation, and documentation techniques. The date sources used in this study are primary sources and secondary sources. Based on the results of research, it can be concluded that MA Unggulan KH. A. Wahab Hasbullah has succeeded in implementing MBS effectively to improve the quality of education. In an effort to improve the quality of education, MA Unggulan KH. A. Wahab Hasbullah has implemented various schools based management strategies that focus on human resource development, teacher quality improvement, and more effective curriculum development. The strong leadership of the principal and the full commitment of all school staff are major factors in the successful implementation of MBS. The implementation of MBS is also supported by the use of technology to facilitate school administration management, learning, and communication between stakeholders. It has also helped to improve efficiency and effectiveness in the educational process in schools. In improving the quality of education, it mus also be accompanied by several obstacles and accompanied by concrete solutions.

Togaram1 is expressed in the neural tube and its absence causes neural tube closure defects

Neural tube closure defect pathomechanisms in human embryonic development are poorly understood. Here we identified spina bifida patients expressing novel variants of TOGARAM gene family. TOGARAM1 has been associated with the ciliopathy Joubert syndrome, but its connection to spina bifida and role in neural development is unknown. We show that Togaram1 is expressed in the neural tube and Togaram1 knockout mice have abnormal cilia, reduced sonic hedgehog (Shh) signalling, abnormal neural tube patterning and display neural tube closure defects. Neural stem cells from Togaram1 knockout embryos showed reduced cilia and defects in Shh signalling. Overexpression in IMCD3 and HEK293 cell of TOGARAM1 carrying the variant found in the spina bifida patient resulted in cilia defect along with reduced pericentriolar material one (PCM1), a critical constituent of centriolar satellites involved in transporting proteins towards the centrosome and primary cilia. Our results demonstrate the role of TOGARAM1 in regulating Shh signalling during early neural development that is critical for neural tube closure and elucidates potential mechanisms whereby the ciliopathy associated gene TOGARAM1 gives rise to spina bifida aperta in humans.

Hierarchical Genomic Analysis of Susceptibility to Schizophrenia in Sudanese multi-case families

Background Schizophrenia, with its diverse and complex presentation, is a prime candidate for genetic investigation. Its heritability in both familial and sporadic cases, clinical overlap with other psychiatric conditions, and individual variations in response to treatment contribute to its complexity. Numerous genes and associated biochemical pathways show significant differences at the population, familial, and individual levels. Additionally, schizophrenia may represent an evolutionary trade-off for human brain development, creativity, and intellectual performance. Material and Methods This case pseudo-control study analyzed the whole genomes/exomes of seven Sudanese families with multiple siblings affected by schizophrenia. We examined shared variants among family members, including both cases and controls, and unique variants shared between patients but not controls. These variants were filtered based on their impact on protein function, expression levels, allele frequencies, ACMG classification for rare variants, and disease associations. Networks were created to identify central genes and common biological pathways. Results and Discussion The examination of this complex disorder in Sudanese families revealed numerous variants, both common and rare, showing differences between families and between our population and those reported in the literature. This highlights the challenge of accounting for the known heritability of the disease. Our hierarchical approach demonstrates that schizophrenia’s etiology involves the cumulative effect of various interacting variants in an ascending order of influence. Common variants are shared among all samples, while rare variants are shared among two or three families, most of which are associated with schizophrenia. In conclusion The significance lies not merely in the number of detected variants but in understanding their interactive roles, step by step, to reveal the complete picture of the disease’s phenotype.

Investigating the Dynamics of Workforce Stability: The Influence of Perceived Employability on Career Resilience, Task Performance, Learning Agility and Employee Retention

The main purpose of this study is to analyze the complex interrelationships among perceived employability, employee task performance, employee retention, career resilience, and learning agility to cover this knowledge gap and provide HR practices and policies supported by evidence that can increase service sector development and contribute to Saudi Arabia's economic goals. The study used a cross-sectional quantitative design and conducted an online survey of employees in the service sector of Saudi Arabia. Snowball sampling was used during the data collection, and 403 usable responses were collected and utilized for data analysis. Data analysis techniques included descriptive statistics, Pearson correlation, and composite assessment analyses were conducted through SPSS 28. For hypothesis testing, the PLS-SEM model was used through SmartPLS4. R2adj, standardized root means square residual, Normed fit index, and Q2predict were used for model evaluation. The research findings highlighted the importance of perceived employability which is positively related to task performance and retention and show the need for organizations to train their employees so that they are characterized by career resilience and learning agility, which relate positively on their task performance and their retention within the Saudi service industry. Acquiring knowledge and understanding regarding these relationships is essential to develop targeted practices and policies to improve employee outcomes and elevate the organization's competitiveness in an economy undergoing rapid transformations. This study's findings provide practical implications regarding human resource management and organizational development strategies in Saudi Arabia that will support future research by enhancing perceived employability, building career resilience, developing employee task performance, improving learning agility, and ensuring a higher rate of employee retention, realizing the significance of each element in developing organizational goals and success. Keywords: perceived employability, employee task performance, employee retention, career resilience, learning agility.

Neuronal splicing of the unmethylated histone H3K4 reader, PHF21A, prevents excessive synaptogenesis

PHF21A is a histone-binding protein that recognizes unmethylated histone H3K4, the reaction product of LSD1 histone demethylase. PHF21A and LSD1 form a complex, and both undergo neuron-specific microexon splicing. The PHF21A neuronal microexon interferes with nucleosome binding, whereas the LSD1 neuronal microexon weakens H3K4 demethylation activity and can alter the substrate specificity to H3K9 or H4K20. However, the temporal expression patterns of PHF21A and LSD1 splicing isoforms during brain development and their biological roles remain unknown. In this work, we report that neuronal PHF21A isoform expression precedes neuronal LSD1 expression during human neuron differentiation and mouse brain development. The asynchronous splicing events resulted in stepwise deactivation of the LSD1-PHF21A complex in reversing H3K4 methylation. An unbiased proteomics survey revealed that the enzymatically inactive LSD1-PHF21A complex interacts with neuron-specific binding partners, including MYT1-family transcription factors and post-transcriptional mRNA processing proteins such as VIRMA. The interaction with the neuron-specific components, however, did not require the PHF21A microexon, indicating that the neuronal proteomic milieu, rather than the microexon-encoded PHF21A segment, is responsible for neuron-specific complex formation. Finally, by using two Phf21a mutant mouse models, we found that Phf21a neuronal splicing prevents excess synapse formation that otherwise would occur when canonical PHF21A is expressed in neurons. These results suggest that the role of the PHF21A microexon is to dampen LSD1-mediated H3K4 demethylation, thereby containing aberrant synaptogenesis.

Exploring the role of regional capacity in human resource development in Indonesia

The role of local government in regional development planning is an essential topic in the context of sustainable local development. This study aimed to analyze the role of local governments in regional development planning and their impact on the effectiveness and sustainability of development at the local level. The research method used is a qualitative approach with data collection techniques through in-depth interviews, participatory observation, and document analysis related to regional development policies and regulations. This research was conducted in several districts/cities in certain regions, considering diverse geographical, social, and economic contexts. The results showed that the role of local governments in regional development planning is vital in coordinating various interests, resources, and related actors. Local governments act as regulators, facilitators, and implementers in determining the direction, policies, and allocation of development resources. In addition, community and private-sector involvement is also recognized as an integral part of democratic and inclusive planning processes. The impact of the role of local governments in regional development planning can be seen in increasing the effectiveness of development programs, increasing community participation, reducing regional disparities, and improving the community’s quality of life. Nevertheless, challenges such as corruption, lack of interagency coordination, and political uncertainty remain obstacles that must be overcome. This study concludes that the role of local governments in regional development planning is a critical factor in achieving sustainable regional development. Therefore, measures are needed to strengthen institutional capacity, increase transparency, and strengthen public participation to ensure sustainable and inclusive development planning at the local level.

NMNAT1 Is Essential for Human iPS Cell Differentiation to the Retinal Lineage.

The gene encoding nicotinamide mononucleotide adenylyltransferase 1 (NMNAT1), a nicotinamide adenine dinucleotide synthetase localized in the cell nucleus, is a causative factor in Leber's congenital amaurosis, which is the earliest onset type of inherited retinal degeneration. We sought to investigate the roles of NMNAT1 in early retinal development. We used human induced pluripotent stem cells (hiPSCs) and established NMNAT1-knockout (KO) hiPSCs using CRISPR/cas9 technology to reveal the roles of NMNAT1 in human retinal development. NMNAT1 was not essential for the survival and proliferation of immature hiPSCs; therefore, we subjected NMNAT1-KO hiPSCs to retinal organoid (RO) differentiation culture. The expression levels of immature hiPSC-specific genes decreased in a similar manner after organoid culture initiation up to 2 weeks in the control and NMNAT1-KO. Neuroectoderm-specific genes were induced in the control and NMNAT1-KO organoids within a few days after starting the organoid culture; PAX6 and TUBB3 were higher in NMNAT1-KO organoids up to 7days than in the control organoids. However, the induction of genes involving retinal early development, such as RAX, which was induced at around day 10 in this culture, was considerably reduced in NMNAT1-KO organoids. Morphological examination also showed failure of retinal primordial structure formation, which became visible at around 2 weeks of the control culture, in the NMNAT1-KO organoids. Decreased intracellular NAD levels and poly(ADP-ribosyl)ation were observed in NMNAT1-KO organoids at 7 to 10days of the culture. Mass spectrometry analysis of inhibited proteins in the poly(ADP-ribosyl)ation pathway identified poly(ADP-ribosyl)ation of poly(ADP-ribose) polymerase 1 (PARP1) as a major protein. These results indicate that NMNAT1 was dispensable for neural lineage differentiation but essential for the commitment of retinal fate differentiation in hiPSCs. The NMNAT1-NAD-PARP1 axis may play a critical role in the appropriate development of human retinal lineage differentiation.

Contamination Levels and Distribution of Pesticides in Crops and Its Hazardous Effects on Living Beings

AbstractFarmers heavily treat crops with fertilizers and pesticides in an effort to maximize production. It causes a great deal of ecological destruction in addition to poor soil health. Crop poisoning can occasionally arise from the overuse of insecticides. Some well‐known pesticides, such as chlorpyrifos, carbofuran, and endrin, are members of the organophosphate, organochlorine, and carbamates families and remain in crops for extended periods of time. Remaining organochlorine pesticides (OCPs) are thought to be endocrine disruptors and carcinogenic. A person's risk of developing endometriosis, hypopadias, cryptorchidism, and malignancies of the breast, lung, cervix, and prostate may increase if there is an accumulation of OCP in their body. Reports have also linked the effects of OCP exposure to human growth, cerebral development, and psychomotor development. Since they are no longer allowed to be manufactured or used, organochlorine insecticides have raised a great deal of concern because they can still be found in large quantities, even in remote locations. Living things become harmful over an extended period of time when exposed to such chemical residues. Pesticide overuse can have detrimental effects on the food chain and the ecosystem. It entirely changes the pH of the soil and lowers its fertility. Food products can become hazardous to humans if they are consumed soon after a pesticide application. This review study raises important concerns about crops treated with excessive pesticides that endanger human health.

682P Differential splicing of OBSCN throughout human cardiac and skeletal muscle development

682P Differential splicing of OBSCN throughout human cardiac and skeletal muscle development

A Hybrid 2D-to-3D in vitro Differentiation Platform Improves Outcomes of Cerebral Cortical Organoid Generation in hiPSCs.

Three-dimensional (3D) cerebral cortical organoids are popular in vitro cellular model systems widely used to study human brain development and disease, compared to traditional stem cell-derived methods that use two-dimensional (2D) monolayer cultures. Despite the advancements made in protocol development for cerebral cortical organoid derivation over the past decade, limitations due to biological, mechanistic, and technical variables remain in generating these complex 3D cellular systems. Building from our previously established differentiation system, we have made modifications to our existing 3D cerebral cortical organoid protocol that resolve several of these technical and biological challenges when working with diverse groups of human induced pluripotent stem cell (hiPSC) lines. This improved protocol blends a 2D monolayer culture format for the specification of neural stem cells and expansion of neuroepithelial progenitor cells with a 3D system for improved self-aggregation and subsequent organoid development. Furthermore, this "hybrid" approach is amenable to both an accelerated cerebral cortical organoid protocol as well as an alternative long-term differentiation protocol. In addition to establishing a hybrid technical format, this protocol also offers phenotypic and morphological characterization of stage-specific cellular profiles using antibodies and fluorescent-based dyes for live cell imaging. © 2024 Wiley Periodicals LLC. Basic Protocol 1: hiPSC-based 2D monolayer specification into neural stem cells (NSCs) Basic Protocol 2: Serial passaging and 2D monolayer expansion of neuroepithelial progenitor cells (NPCs) Support Protocol 1: Direct cryopreservation and rapid thawing of NSCs and NPCs Basic Protocol 3: Bulk aggregation of 3D neurospheres and accelerated cerebral cortical organoid differentiation Alternate Protocol 1: Bulk aggregation of 3D neurospheres and long-term cerebral cortical organoid differentiation Support Protocol 2: High-throughput 3D neurosphere formation and 2D neurosphere migration assay Support Protocol 3: LIVE/DEAD stain cell imaging assay of 3D neurospheres Support Protocol 4: NeuroFluor NeuO live cell dye for 3D cerebral cortical organoids.

Air quality historical correlation model based on time series

Air quality is closely linked to human health and social development, making accurate air quality prediction highly significant. The Air Quality Index (AQI) is inherently a time series. However, most previous studies have overlooked its temporal features and have not thoroughly explored the relationship between pollutant emissions and air quality. To address this issue, this study establishes a historical correlation model for air quality based on a time series model—the Gaussian Hidden Markov Model (GHMM)—using industrial exhaust emissions and historical air quality data. Firstly, a traversal method is used to select the optimal number of hidden states for the GHMM. To optimize the traditional GHMM and reduce error accumulation in the prediction process, the Multi-day Weighted Matching method and the Fixed Training Set Length method are utilized. Both direct and indirect prediction modes are then used to predict the AQI in the Zhangdian District. Experimental results indicate that the improved GHMM with the indirect mode provides higher accuracy and more stable state estimation results (MAE = 13.59, RMSE = 17.59, mean forecasted value = 117.94). Finally, the air quality historical correlation model is integrated with the air quality meteorological correlation model from a previous study, further improving prediction accuracy (MAE = 11.59, RMSE = 14.87, mean forecasted value = 120.88). This study demonstrates that the GHMM’s strong ability to analyze temporal features significantly enhances the accuracy and stability of air quality predictions. The integration of the air quality historical correlation model with the air quality meteorological correlation model from a previous study leverages the strengths of each sub-model in handling different feature groups, leading to even more accurate predictions.

The use of community-engagement approaches to identify strategies for increasing workplace well-being among LGBTQ+ adults

BackgroundLGBTQ+ individuals often face social stigma and workplace discrimination, negatively impacting their well-being. However, limited research exists on the factors and strategies that enhance their positive workplace experiences. This study was a sequential qualitative mixed-method design conducted in three phases. The study had the following objectives: identifying factors associated with workplace well-being, generating strategies for improving workplace well-being, and obtaining feedback on the identified strategies' acceptability. MethodsIn Phase 1, in-depth interviews were conducted with 10 LGBTQ+ who described factors that improved their satisfaction at work. In Phase 2, two focus group discussions were held with 13 participants, including LGBTQ+ adults, scholars in positive psychology, human resource development, and civil rights advocates, to develop strategies for improving workplace well-being based on Phase 1 data. In Phase 3, a survey was sent to a subset of the focus group participants (N = 7) to ascertain the acceptability of the developed strategies. Data analysis was performed using deductive and inductive approaches. ResultsThe study's first phase identified the factors contributing to workplace well-being. These factors were categorized into intrapersonal, interpersonal, and social-ecological. In the second phase and third phase, 11 strategies were developed to improve workplace well-being. These strategies were divided into two sections. The first section includes strategies organizations and agencies can implement to promote employee well-being (such as emphasizing diversity and equity as core values). The second section outlines strategies for government and civil society sectors (such as establishing laws addressing LGBTQ+ equal rights). The Index of Congruence (IOC) assessed the relationship between strategies and workplace well-being improvement. Results showed IOC values from 0.8 to 1 for 11 strategies, indicating high content validity. ConclusionsStrategies to enhance LGBTQ+ workplace well-being were identified through community engagement, but further research is needed for implementation and evaluation.

A 3D Bioprinted Cortical Organoid Platform for Modeling Human Brain Development (Adv. Healthcare Mater. 27/2024)

A 3D Bioprinted Cortical Organoid Platform for Modeling Human Brain Development (Adv. Healthcare Mater. 27/2024)

Synaptic neoteny of human cortical neurons requires species-specific balancing of SRGAP2-SYNGAP1 cross-inhibition

Human-specific (HS) genes have been implicated in brain evolution, but their impact on human neuron development and diseases remains unclear. Here, we study SRGAP2B/C, two HS gene duplications of the ancestral synaptic gene SRGAP2A, in human cortical pyramidal neurons (CPNs) xenotransplanted in the mouse cortex. Downregulation of SRGAP2B/C in human CPNs led to strongly accelerated synaptic development, indicating their requirement for the neoteny that distinguishes human synaptogenesis. SRGAP2B/C genes promoted neoteny by reducing the synaptic levels of SRGAP2A,thereby increasing the postsynaptic accumulation of the SYNGAP1 protein, encoded by a major intellectual disability/autism spectrum disorder (ID/ASD) gene. Combinatorial loss-of-function experiments invivo revealed that the tempo of synaptogenesis is set by the reciprocal antagonism between SRGAP2A and SYNGAP1, which in human CPNs is tipped toward neoteny by SRGAP2B/C. Thus, HS genes can modify the phenotypic expression of genetic mutations leading to ID/ASD through the regulation of human synaptic neoteny.

Regional development through innovation: a proposal for a technological hub framework

Brazil has made progress in innovation, although unevenly across its regions, with the state of Acre still facing challenges in this sector. The creation of an innovation and technology hub at Senai/AC aims to promote regional development by bringing together government, companies, and academia to stimulate local economic growth. This article proposes a strategic framework for the implementation of the Senai/AC Innovation and Technology Hub, with the goal of strengthening the regional economy and increasing industrial competitiveness. Based on a Systematic Literature Review, the best global and regional practices for the creation of innovation ecosystems were identified. The qualitative analysis of 40 articles resulted in strategic guidelines adapted to local needs, highlighting the importance of effective governance, resource mobilization, collaborative environments, human capital development, and a culture of innovation. The Senai/AC Hub has the potential to act as a catalyst for the state's socioeconomic development and strengthen local industries. Future studies can assess the effectiveness of the guidelines and the hub's impact on regional production chains, comparing it with other hubs to identify synergies and best practices.

The role of cerebellar FOXP1 in the development of motor and communicative behaviors in mice.

The gene FOXP2 is well established for a role in human speech and language; far less is known about FOXP1. However, this related gene has also been implicated in human language development as well as disorders associated with features of autism spectrum disorder (ASD). FOXP1 protein expression has also recently been identified in the cerebellum-a neural structure previously shown to express FOXP2 protein. The current study sought to elucidate the behavioral implications of a conditional knock-out of Foxp1 using an En1-Cre driver, which is active in the entirety of the cerebellum and a subset of neurons in the midbrain and spinal cord, in mice using a test battery including motor tasks associated with cerebellar dysfunction, as well as communicative and autistic-relevant behaviors. Male and female mice with a conditional knock-out (cKO, n = 31) and wildtype littermate controls (WT, n = 34) were assessed for gross and orofacial motor control, motor-coordination learning, locomotion, social behavior, anxiety, auditory processing and expressive vocalizations. Overall results suggest Foxp1 plays a specific role in the development of communicative systems, and phenotypic expression of disruptions may interact with sex. Robust motor deficits associated with Foxp1 protein loss may particularly affect vocalizations based on significant orofacial motor deficits in cKO subjects could also contribute to vocalization anomalies. In summary, the current study provides key insights into the role of Foxp1 in cerebellar function and associated behaviors in mice, with implications for an improved understanding of communicative and motor-based neurodevelopmental disabilities in humans.

Prevalence of high neonatal thyroid stimulating hormone levels as an indicator of iodine deficiency in the province of La Pampa: An epidemiological analysis.

Introduction. Iodine plays a key role in human metabolism, growth, and development. During pregnancy and childhood, the demand for this micronutrient increases notably. Increased neonatal thyroid stimulating hormone (nTSH) levels, defined as nTSH ≥ 5 mIU/L, are a marker of iodine deficiency in a population if its prevalence is higher than 3%. Objective. To establish the prevalence of nTSH ≥ 5 in La Pampa in the 2021-2022 period, analyze its correlation with different variables, and compare it with data from a historical cohort. Population and methods. Cross-sectional, descriptive-analytical study in a population of newborn infants born in the 5 health regions of the province of La Pampa in 2021 and 2022. Results. Of the 5778 assessed newborn infants, 9.6% had nTSH levels ≥ 5 mIU/L. It was reported that 70.4% of these measurements were done after the third day of life. No significant differences were observed in the frequency of high nTSH levels by year of birth, birth weight, or days until sample collection. A higher prevalence was observed among male infants (10.6% versus 8.5%; p = 0.007) and term infants (9.8% versus 6.6%; p = 0.02). The prevalence of high TSH levels was superior to that observed in the 2001-2002 cohort. Conclusions. The prevalence of high nTSH levels in La Pampa during 2021 and 2022 was 9.6%, suggesting the presence of mild iodine deficiency in the population of this province, higher that what had been reported 2 decades ago.

Can employee training facilitate production repurposing in crises? An ability-motivation-opportunity perspective

Production repurposing is an initiative for firms to alter their manufacturing capabilities and outputs to meet new demands, particularly during times of crisis. This initiative is crucial for businesses to remain resilient to unexpected changes in the market. Despite its importance, the specific factors that drive production repurposing during crises, especially from the perspective of human capital development, are not well understood. Drawing upon the ability, motivation, and opportunity (AMO) framework, this study aims to examine the impact of pre-pandemic employee training, an ability-enhancing practice, on production repurposing during the pandemic. Based on a dataset of 4,679 firm-year observations from 32 countries sourced from the World Bank, our regression results indicate that firms that engaged in pre-pandemic employee training are more likely to initiate production repurposing during the pandemic. Furthermore, we delve into the moderating roles of government wage subsides, a motivation factor, and labor shortages, an opportunity constraint. The results reveal that government wage subsidies amplify the positive effect of pre-pandemic training on production repurposing, whereas labor shortages dampen this impact. Our heterogeneity analysis further suggests that national socioeconomic features can influence these relationships. This study underscores the role of employee training in preparing firms to actively adapt during crises. It also highlights the necessity of providing adequate motivations and creating conducive opportunities to facilitate human capital. These insights are valuable for managers and policymakers aiming to enhance firm adaptability and ensure resilient operations during crises.

Social Work's Role in Sustainable Agriculture: Driving Economic Self-Sufficiency and Social Integration

In the context of the social challenges of the global space for implementing projects to promote sustainable agriculture in rural areas, agriculture represents significant potential due to its multifunctionality (economic, social, ecological). In the context of agricultural projects - farms - this type of assistance can increase the labour market potential of disadvantaged populations. This is mainly through employment or social activation activities, which help improve the quality of life of socially disadvantaged people, their economic self-sufficiency, and their integration into society. In the context of sustainable development, agricultural projects play an essential role in maintaining social stability and reliability at the macro level. This paper aims to highlight the importance of social work and its position in projects promoting sustainable development. On the one hand, social work represents the position of a "transfer mechanism" between the management of economic and ecological processes with an agricultural orientation and the disadvantaged clients of social projects on the other hand. Keywords: sustainable agriculture, disadvantaged groups, client-family, human capital development, global space