The results of human biological and cultural evolution are currently at odds. A prosperous consumer lifestyle as a result of cultural evolution does not provide enough of the adaptive stimuli that man claims as a result of natural biological evolution. The aim of this article is to define civilization dilemmas in relation to the quality of life of modern man. The chosen methods were the methods of analysis, synthesis, induction and deduction applied to the method of anchored theory in the sense of studying the concept as the main category, as well as causal and operational thinking. A synthesis of evidence and a critical and reproducible summary of the results of available publications on the subject were performed as well. The results of the study provide knowledge that quality longevity (delaying senescence) requires a certain degree of hormetic stress, especially in the area of caloric restriction, physical and mental exertion and hardening (salutogenetic quadrivium). The first dilemma analyzed is the autodeterministic discomfort self-limitation of the ascetic type. Within the framework of cognitive dissonance and causal attribution, it leads to the question of whether the advanced discomfort will be balanced by a subsequent comfortable life. The second dilemma analyzed is the use of technological possibilities of biotracking (BZV, biomonitoring), which will be increasingly, in accordance with the progress of knowledge, offered in deciding on the nature of necessary human activities, which can be interpreted as a restriction on freedom of decision. Conclusions: The analyzed dilemmas will increasingly affect a person's quality of life in their self-limiting form.