ABSTRACT Cracking is an essential intuitive indicator of damage in masonry structures. Evaluating the progression of fatigue cracks in ancient brick masonry structures is vital for the preservation and safety of ancient buildings. By conducting amplitude cyclic uniaxial compression tests on ancient brick masonry specimens, using the video image correlate-3d (VIC-3D) technology to collect images of the entire process from loading to failure, the development of fatigue cracks is analyzed and concluded. A reversed S-shaped function for fatigue crack evolution was established based on the fatigue damage mechanism. The model parameters’ physical significance, value range, and their impact on the model curve were discussed. The fatigue damage evolution equation was derived from the fatigue crack evolution model. The research results show that a reversed S-shaped function for fatigue crack evolution covers various types of fatigue crack evolution laws, with strong adaptability and high accuracy. The damage evolution curve established, based on the fatigue crack evolution model, has a reversed S-shaped change rule, and was divided into three stages: the first stage (0 N f ~ 0.1 N f ) fatigue damage grows faster; the second stage (0.1 N f ~ 0.9 N f ) fatigue damage growth is stable, close to linear change; when the cycle ratio exceeds 0.9, it enters the third stage, and fatigue damage increases rapidly.