Co-simulation can bring improvements to the development of cyber-physical perceptive systems (CPPS) in critical fields, allowing uninterrupted system operation and flexibility to use both real-time sensor data and non-real-time data. This paper proposes a co-simulation approach that integrates physical systems and communication systems, including both hardware and software components. This study demonstrates how systems of different natures with discrete or continuous events can be simulated using three methods: time stepped, global event driven, and variable stepped. Through two case studies from the medical and energy fields, CPPS and co-simulation reveal their importance for the future by improving precision and efficiency, which leads to more accurate diagnoses and personalized treatments in the medical field and increases the stability of energy networks.
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