The development of anthelmintic resistance and the high cost of traditional anthelmintic drugs have led to the evaluation of medicinal plants as an alternative source of anthelmintic drugs. Parasitic roundworms (nematodes) cause significant morbidity and mortality in livestock and cause significant loss of productivity in farmers around the world. Control of these nematodes has relied heavily on the use of a limited number of anthelmintic drugs. However, resistance to many of these anthelmintic is now widespread, and new drugs need to be found to ensure sustainable and effective treatment and management in the future. In present study aimed to evaluate the anthelmintic activity of PEE, EAE, MEE & AEE extracts of Cleome viscose Linn seeds. The result revealed that ethyl acetate extract at 50 mg/mL was the most active against Pheretima posthuma.