<p>The extent of unemployment constitutes one of the most basic indicators of sustainable development and particularly in the field of socioeconomic development, given that the extended unemployment, especially of the youth, cannot be considered to be compromising with the concept of sustainable development, as it restricts the possibilities of an important part of society to satisfy its needs, in the present and in the future too. Labor, when using the linear regression analysis, defines the relations between regional and national employment and unemployment in Greece, in order to reveal the reactions of each of the 13 regions of the country to the national trends for a period of 16 years, between 1998 and 2013. The differentiations that are revealed are considered crucial in the implementation of a regional strategy against unemployment, in order to achieve better prospects of economic development, to reduce the unemployment rate of each particular area and to implement an integrated strategy of sustainable development of the country.</p>