Development Of Health Interventions Research Articles

Behavior changes influence mpox transmission in the United States, 2022–2023: Insights from homogeneous and heterogeneous models

Abstract In 2022, an unprecedented mpox epidemic rapidly swept the globe, primarily transmitted through sexual contact among men who have sex with men (MSM). However, our understanding of how changes in human behavior influence this outbreak remains incomplete. In this study, we introduce a novel two-layer network model to investigate the impact of human behavior on mpox transmission within the United States (US) during 2022-2023, leveraging surveillance data. We theoretically explore mpox transmission under behavioral changes using homogeneous and heterogeneous mean-field approximations. While the heterogeneous model captures differences in individual behavior, its variations do not significantly affect the overall spread, validating the feasibility of using only homogeneous models to study behavioral changes. Utilizing infection data, we exhibit the influence of behavior changes across varying transmission levels of mpox, emphasize the significant role of sexual behavior among MSM, and recommend enhancing surveillance of non-sexual cases to enable timely control of spread. Utilizing vaccination data, we demonstrate the critical impact of behavior changes on the transmission capacity of monkeypox virus (MPXV), contrasting the limited effectiveness of vaccine campaigns. This study highlights the importance of human behavior in controlling the spread of future outbreaks, offering valuable insights for the strategic development of public health interventions aimed at mitigating such occurrences.

Association between exposure to environmental pollutants and increased oral health risks, a comprehensive review.

The burden of disease and death attributable to environmental pollution is a growing public health challenge worldwide, particularly in developing countries. While the adverse effects of environmental pollution on oral health have garnered increasing attention, a comprehensive and systematic assessment remains lacking. This article delves into the intricate relationship between environmental pollution and oral health, highlighting significant impacts on various aspects such as dental caries, periodontal diseases, oral facial clefts, cancer, as well as other oral diseases. Our results suggested that secondhand smoke, particulate matters (PM) and heavy metals are the most important risk factors affecting oral health. Additional contributors, such as radiation pollutants, electronic cigarette, phthalates, gaseous air pollutants, pesticides, solvents, wood dust, formaldehyde and excessive fluoride were investigated, though evidence for their impacts remains limited and often inconclusive. The review also explores potential mechanisms underlying these impacts, including microorganism, inflammation, oxidative stress, genetic influences, and toxicant exposures from heavy metals and other pollutants. For instance, PM2.5 may contribute to dental caries by disrupting oral pH balance and absorbing heavy metals such as lead and cadmium which have been considered as caries promoting elements. It is also associated with adverse inflammatory responses and tissue damage in periodontal tissues by causing oxidative stress, potentially leading to periodontitis. Drawing on current evidence, it provides a comprehensive analysis of these associations, offering critical insights to guide the development of preventive strategies and public health interventions. The findings highlight the pressing need for future research to validate the causal links between environmental pollution and oral diseases and to unravel the underlying biological mechanisms. Ultimately, greater attention must be directed toward addressing the relationship between environmental pollution and oral diseases, with a focus on pollution control and the reduction of preventable environmental risks to safeguard oral health on a broader scale.

Factors Associated with HIV Testing Uptake in Cameroon: Data from the 2018 Cameroon Demographic and Health Survey.

HIV represents a significant public health challenge, contributing to increased mortality and morbidity within the population. Despite the implementation of various HIV testing strategies, the uptake rate of HIV testing remains low. This study aims to assess the factors associated with HIV testing uptake among women and men in Cameroon. A secondary analysis of the 2018 Cameroon demographic and health survey (DHS) was conducted using data of sexually active men and women aged 15-64. Multivariate logistic regression was employed to identify the key factors associated with HIV testing in Cameroon. We included a total of 18,112 participants (12563 women and 5549 men). The study found that 47.8% (95% CI 46.9-48.7) of women and 45% (95% CI 43.7-46.3) of men were tested for HIV in the past 12 months. Among women and men, age above 20-24 years (AOR= 1.3, p<0.01 vs AOR= 2.3, p<0.001), a high level of education (AOR= 2.1, p<0.001 vs AOR= 2.3, p<0.001) and high wealth (AOR= 1.9, p<0.001 AOR= 2.0, p<0.001) were positively associated with HIV testing uptake. Conversely,residing in the northern regions (AOR= 0.5, p<0.001 vs AOR= 0.4, p<0.001), was negatively associated. Among men, no independent significant association was found between HIV testing uptake and never being married. This study, utilizing data from the Cameroon DHS, provides valuable insights into HIV testing in Cameroon. To achieve UNAIDS targets of "zero new infections and zero deaths" by 2030, interventions must prioritize less educated individuals, younger age groups and low income earners. The findings from this research can inform recommendations for decision-makers and contribute to the development of effective public health interventions to combat HIV in Cameroon.

Emotions perceived by Mayan women during the perinatal period

Attention to emotional disorders during the perinatal stage is a crucial aspect; during this period, the mother experiences a series of significant changes that can influence her well-being and, therefore, that of the newborn. Appropriate detection and treatment of emotional disorders, such as perinatal depression and anxiety, are essential to ensure a healthy environment. The objective of this study was to describe the emotions perceived during the perinatal period by women of the Mayan ethnic group. This analysis is essential to better understand emotional experiences and provide a solid foundation for the development of mental health interventions. We sought to identify the predominant feelings, when faced with questions related to their emotions and actions in certain situations. Finally, it was possible to obtain proposals from the Mayan community, which reflected their main needs for the well-being of their mental health.

Digital health interventions for adolescents living with HIV in low- and middle-income countries: A narrative review and logic model

The development of digital health interventions for adolescents living with HIV (ALHIV) in low- and middle-income countries (LMICs) remains poorly understood due to limited research. This narrative review applies a logic model to synthesize evidence on the development and adaptation of digital health interventions for ALHIV in LMICs. The review identifies studies involving interventions such as mobile apps or online support groups from databases including MEDLINE, PubMed, SCOPUS and gray literature. Grounded in the WHO framework for Youth-centered Digital Health Interventions, the model addresses health system challenges and links intervention components to process and health outcomes. Individual, family and environmental contextual factors are incorporated to enhance the model's relevance. This model serves as a guide for stakeholders, including designers, developers, implementers, researchers, and funders, in designing and evaluating digital interventions for ALHIV in resource-constrained settings, while highlighting key areas for future research and policy action. Registration N/A. Tweetable abstract A logic model for guiding the design of digital health interventions for adolescents living with HIV in low- &amp; middle-income countries.

Patient Perspectives on a Digital Assistant for Medication Reconciliation: An Interview Study Comparing Socioeconomic Groups.

Medication reconciliation, the process of documenting a patient's medication, is currently a time-consuming and labor-intensive process. To make medication reconciliation more efficient, digital assistants (DAs) offer a promising solution. Especially since human-like digital interfaces tend to be appreciated by more vulnerable populations such as patients in a low socioeconomic position (SEP). Despite the potential of DAs for low-SEP populations in particular, these groups are often not involved during the development and design phase of such digital health interventions. This exclusion may explain the lower adoption rates of digital interventions among low-SEP patients and exacerbate the so-called digital divide. We explored the perceptions and needs of patients across the SEP gradient using a participatory design approach. Patients of low-, middle-, and high-SEP backgrounds were asked to interact with a DA developed for this study and were interviewed afterward. A thematic analysis revealed seven themes regarding design, input method, comprehensibility, privacy concerns, benefits, the intention to use, and reassurance. Overall, patients were afraid to make mistakes in their medication entries and therefore valued feedback from the system or caregivers. Low-SEP patients specifically seemed to value more structured input methods when using the DA, while high-SEP patients emphasized the importance of a secure environment for the DA and sought clarity about its functionalities. Our study demonstrates the importance of involving patients across the socioeconomic gradient when developing a digital health tool and offers concrete recommendations for inclusive DA design for researchers and developers.

Benefits for peer educators in delivering wellbeing education to agricultural students

Background: Effectively supporting and promoting mental health education for at-risk populations is crucial. In New Zealand, risks in relation to the suicide for young farm labourers, alongside the stress associated with the transition to university and the vulnerability of rural communities, place agricultural students in a vulnerable position. The use of peer educators has been identified as an important way of building connections in health and wellbeing education and increasing engagement and mental health knowledge. This article reports on the experiences of peer educators in delivering a mental health and wellbeing programme to agricultural students at two universities in New Zealand. Design: As part of evaluating a mental health and wellbeing programme, researchers sought to learn more about the experiences and learnings of peer educators. Drawn on findings from a wider mixed-methods study, this article reports on qualitative findings related to the use of peer educators. These findings emerged from semi-structured interviews with the peer educators involved in the delivery of the programme. Findings: Peer-led mental health and wellbeing programmes have benefits not only for the students participating but also for the peer educators leading them. These benefits include increased mental health knowledge, confidence and skills. In addition, the peer educators found value in delivering important mental health and wellbeing messages. Conclusions: Peer educators can benefit from the experience of delivering mental health and wellbeing programmes. Furthermore, they can be utilised to deliver these programmes with little prior knowledge of the topics they are delivering provided they have support from professionals with teaching and clinical expertise. These findings are important for informing the development and delivery of mental health interventions for at-risk communities looking to increase connectedness and build resilience.

Indoor radon exposure: A systematic review of radon-induced health risks and evidence quality using GRADE approach

BackgroundRadon (Rn) is a radioactive gas with well-established carcinogenic properties. It is a significant contributor to natural background ionizing radiation exposure, accounting for over 50 % of human exposure. Prolonged exposure to radon gas has been conclusively linked to various health issues such as lung cancer, leukemia, and Chronic Obstructive Pulmonary Diseases (COPD). Despite this, there is a scarcity of comprehensive studies examining the quality of evidence establishing an association between indoor radon exposure and these health problems. ObjectiveWe performed a systematic review of peer-reviewed research articles to explore the current evidence on the potential association between residential radon exposure and human health, specifically focusing on lung cancer, COPD, and leukemia. MethodsA comprehensive search was conducted on PubMed and Google Scholar using MeSH terms and keywords (residential radon, radon AND lung cancer, radon AND COPD, radon AND leukemia). The inclusion criteria focused on studies that analyzed the link between residential radon exposure and lung cancer, leukemia and COPD. We searched for peer-reviewed studies published from 2010 to 2024. Studies carried out in occupational settings were not considered. The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework to select relevant studies. Reviewers independently collected data, resolving disagreements through discussion. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to evaluate evidence quality, and the study was registered with PROSPERO, CRD42024550735. ResultsThe evidence indicating an associative or causal link between indoor radon and lung cancer was found to be of high quality or conclusive, particularly with stronger support from case-control studies. The findings for COPD and leukemia were inconclusive, indicating that additional research is necessary to establish a definitive link between residential radon exposure and these health outcomes. These associations was deemed moderate or inconclusive primarily due to methodological shortcomings, conflicting findings and the prevalence of weak study designs and poor exposure data. The existing evidence on the potential connection between residential radon exposure and the risk of COPD and leukemia is currently limited. In order to definitively confirm or disprove this association, more studies are needed. Further research is crucial to elucidate these relationships and to guide the development of effective public health interventions. ConclusionThe review found that the association between radon exposure and lung cancer was consistent with existing scientific knowledge. However, the evidence for association between indoor radon exposure and COPD was inconclusive. Additionally, evidence linking indoor radon exposure to leukemia was uncertain. Future research should use more robust study designs (cohort and case control studies) and directly measure long-term radon levels to investigate the potential association between residential radon exposure and COPD and leukemia.

Exploring the Importance of Cultural Sensitivity in Arts-Based Health Interventions

Arts-based health interventions have emerged as valuable tools for improving community health and well-being by integrating creative practices such as music, visual arts, and performance into healthcare settings. These interventions provide a unique way to address health disparities and engage communities. However, the success of such interventions hinges on cultural sensitivity, as they are implemented in diverse communities with different values, beliefs, and health practices. This paper examines the role of cultural sensitivity in the development and implementation of arts-based health interventions. It emphasizes the need for cultural competence to ensure that these interventions are relevant, respectful, and effective across various cultural contexts. Case studies of successful culturally sensitive arts-based initiatives are examined, highlighting best practices for collaboration with communities and the importance of adapting interventions to local needs. Keywords: Arts-based health interventions, Cultural sensitivity, Community health, Cultural competence, Public health.

Psychosocial Needs of People Living With Pleural Mesothelioma and Family Carers: A Mixed Methods Study.

Mesothelioma is a cancer of growing global incidence, especially in developing countries, with unique complex psychosocial impacts on patients and their carers. To provide a comprehensive understanding of the psychosocial needs of people living with pleural mesothelioma and family carers. A mixed methods design with 61 semi-structured interviews and psychometrically validated questionnaires to assess pleural mesothelioma patients' (n=36) quality of life and frailty and carers' (n=25) caregiving experiences, quality of life, and pre-loss prolonged grief symptoms. People with mesothelioma (29 men, 7 women, aged 46-89years) indicated moderate quality of life; 18 (50%) met criteria for frailty. Current carers (21 women, 4 men; aged 41-79years) generally reported positive caregiving experiences and high quality of life; 5 (20%) scored in the range indicative of risk for prolonged grief disorder. Four themes were generated: a desire for tailored information with bespoke detail, assistance to coordinate tasks of treatment, improved social and peer support, and effective psychological services. Needs varied, with main concerns being about breaking the news to spouses/children, the impact of the disease and death on family, loss of personal future, managing psychological symptoms, and avoiding burden. These specific and unmet psychosocial needs provide a strong basis for individualised care pathways to address these needs via the integration of psychology into the multidisciplinary care team and the development and evaluation of mental health and wellbeing interventions for mesothelioma patients and carers. Doing so will reduce psychosocial distress and improve residual vitality.

The role of digital health interventions in supporting family caregivers for people with dementia to improve quality of life.

Dementia is a chronic progressive terminal condition. Most care is provided by family caregivers (including close friends); their wellbeing is a public health priority. Caregivers manage increasingly complex needs with disease progression, and declining cognitive and physical function. This can impact the well-being of caregivers, and meaningful support is essential. This review article aims to understand what the benefits and challenges of digital health interventions are and provide considerations for future development of digital health interventions for family caregivers for people with dementia, to improve quality of life. Benefits include the valuable source of support from connective platforms; 24/7 accessibility; and opportunity for remote monitoring. However, this needs to balance with challenges, including the privacy of data concerns; and the digital divide driving inequalities in care provision for family caregivers with no access to internet devices. Digital health interventions can positively impact the overall well-being of family caregivers for people with dementia. If challenges are addressed and digital health interventions are designed to meet priorities for family caregivers, this can help improve the quality of life for family caregivers of people with dementia.

Provision of Digital Primary Health Care Services: Overview of Reviews.

Digital health is a growing field, and many digital interventions have been implemented on a large scale since the COVID-19 pandemic, mainly in primary health care (PHC). The development of digital health interventions and their application in PHC are encouraged by the World Health Organization. The increased number of published scientific papers on this topic has resulted in an overwhelming amount of information, but there is no overview of reviews to summarize this evidence. This study aims to provide policy makers, health managers, and researchers with a summary of evidence on digital interventions used in PHC. This overview of reviews searched the Web of Science and MEDLINE databases for systematic and scoping reviews on assessments of digital technologies implemented in PHC published from January 2007 to March 2023. Only reviews that addressed digital interventions whose targets were real patients or health care providers (HCPs) were included. A total of 236 records were identified from the search strategy, of which 42 (17.8%) full-text papers were selected for analysis, and 18 (7.6%) reviews met the eligibility criteria. In total, 61% (11/18) of the reviews focused their analysis on specific digital health interventions (client-to-provider telemedicine, provider-to-provider telemedicine, health worker decision support systems, systems for tracking patients' health status, client participation and self-care platforms, and provision of education and training to health workers), and 39% (7/18) of the reviews focused on specific topics related to PHC (preventive care, chronic disease management, behavioral health disorders, the COVID-19 pandemic, multicomponent PHC interventions, and care coordination). Most studies in the included reviews agreed on barriers to implementation, such as software and apps developed without involving end users, the lack of training of HCPs and patients in digital technology use, and the lack of reimbursement and billing strategies for remote consultations. However, they showed several mixed results related to health service quality and patients' clinical conditions and behavior changes. Research in digital health applied to PHC is still concentrated in high-income countries, mainly in North America and Europe. The mixed results related to health service quality and patients' clinical conditions or behavior changes may have been caused by deficiencies in the process of implementing digital interventions. It is necessary to examine the entire impact pathway and the causal relationship among implementation, health service quality, and clinical condition outcomes to support the spread of digital health in PHC settings.

Mothers to Babies &amp; Art of Creation: Canadian stakeholder engagement during intervention development

Abstract Background The 2021 British Medical Research Council framework, outline that effective development of interventions requires engagement of diverse stakeholders. In practice, however, engaging stakeholders in health intervention development often receives insufficient investment. The Mothers to Babies (M2B) Study and its linked Art of Creation (AoC) Intervention Project comprise a joint case study in prioritizing stakeholder engagement. Methods From 2016 to 2019, our M2B team dedicated its financial and personnel resources to assessing community health priorities for preventing non-communicable diseases (NCDs) in Hamilton, Canada. Motivated by a “first 1000 days” approach (i.e. health environments through pregnancy and infancy have outsized impacts on NCD risks across a child’s life), we worked with stakeholders to identify acceptable, feasible complex intervention strategies supportive of health behaviours among pregnant Hamiltonians. To this end, we surveyed 434 pregnant people of diverse backgrounds and ran focus groups, interviews, and meetings with 69 stakeholders with diverse orientations to pregnancy and family health provision. Results M2B’s work indicated two areas actionable through a complex, behavioural intervention: 1) lack of knowledge about the first 1000 days, and 2) need for platforms for peer support and empowerment. These themes were centred in the development and the stakeholder-engaged implementation/evaluation of the ongoing AoC intervention study. AoC uses outreach through local cultural institutions and arts-based workshops to facilitate understanding of the first 1000 days. AoC increases participants’ knowledge of the first 1000 days, supports social relationships among participants and is enjoyable and empowering. Conclusions Investing three years and dedicated personnel to stakeholder engagement by M2B yielded the development of AoC, a complex health promotion intervention that fits the diverse priorities of Hamilton communities.

11.D. Scientific session: Participatory approaches and co-creation in complex interventions to reduce inequity in health

Abstract Health disparities are linked to social inequalities, necessitating health researchers to address the health gaps that exist between different social groups, particularly in the realm of health interventions. This workshop delves into the significance of co-creation processes and participatory approaches in complex health interventions to reduce social inequities in health outcomes. Through empirical cases illustrating co-creation processes in intervention research, the workshop aims to enlighten the audience on the continuum of participatory approaches. The MRC/NIH framework of complex interventions highlights the importance of engagement with relevant stakeholders throughout the research phases to enhance the likelihood of developing or identifying interventions that can positively impact health outcomes. However, the extent and nature of stakeholder involvement may vary depending on the specific context and stage of the research. While stakeholder involvement has been a longstanding focus, the concept of co-creation, where stakeholders actively participate in the entire process of intervention development, implementation, and evaluation, has emerged more recently. This shift from creating interventions for the target population to collaborating with them in the intervention’s creation has led to the emergence of more inclusive health interventions that are contextually relevant and tailored to the local settings where they are intended to create change. Yet, introducing participatory approaches in intervention research may raise new questions about decision-making and power dynamics. While interventions led solely by experts and researchers may overlook the empowerment and capacity-building potential among stakeholders and intervention sites, co-creation processes have the capacity to empower stakeholders and address health inequities effectively. However, challenges persist in ensuring equal collaboration between researchers and participants, especially in disadvantaged groups. This workshop aims to prompt reflection on ethical issues arising from traditional health intervention approaches and approaches to ensure participants’ ownership of interventions when they are adapted in new contexts. Moreover, this workshop will discuss the design of participatory interventions: What methods can we use to co-create? What stakeholders to involve? At what stages of the intervention should co-creation occur? The workshop program begins with an introductory presentation of participatory approaches and co-creation in health intervention research, with examples from a school-based intervention. Next, three empirical cases of co-creation processes introduced in interventions in different contexts are presented. Finally, the audience is invited to a take part in a discussion focusing on how participatory approaches among disadvantaged populations can potentially contribute to reduced social inequity in health. Key messages • The involvement of stakeholders in the development, implementation and evaluation of health interventions can take many forms, and what is meaningful for the specific context needs to be considered. • Co-creation approaches in health interventions empower participants and address unequal power dynamics between those who deliver and those who receive health interventions.

Enhancing Health Literacy Among Disadvantaged Youth: A Participatory Approach in School Settings

Abstract Background School-based health literacy interventions have the potential to significantly impact the health of disadvantaged youth. However, the effectiveness of such interventions varies. The aim of the ‘health literacy among youth’-intervention was to improve the health literacy of disadvantaged youth in two school settings in Denmark. Methods The intervention began with identifying the health literacy needs of 128 students. Groups of teachers from each school participated in workshops facilitated by the research team to develop activities to address the specific needs of the students. Over the course of one school year (August 2023 to May 2024), these activities were implemented. Questionnaires were administered to students before, during, and after the intervention, and semi-structured interviews were conducted among teachers and students. Results Teachers at each school created activities aligned with the organizational structure and the needs of the students, focusing on occupational diseases and injuries, and physical activity and mental well-being, respectively. However, contextual factors such as time constraints, students’ characteristics, and teachers’ professional backgrounds and varying levels of motivation, influenced the implementation. Conclusions The intervention design offered flexibility in tailoring health literacy activities and their implementation to suit the unique contexts of the two schools. While the participatory approach facilitated targeted and organizationally aligned health interventions, its feasibility varied across contexts. Our findings highlight the importance of involving participants in developing health interventions to ensure relevance and alignment with specific needs of the target group. Key messages • Despite contextual similarities, the outcome of participatory intervention approaches may vary across contexts. • Co-creation contribute to health literacy interventions that are tailored the needs of the target group.

Leveraging Trauma Informed Care for Digital Health Intervention Development in Opioid Use Disorder.

Digital health refers to the use of information and communication technologies in medicine (including smartphone apps, wearables, other non-invasive sensors, informatics and telehealth platforms) to prevent illness, deliver treatment, and promote wellness. This rapidly proliferating group of technologies has the potential to reduce harm for people with opioid use disorder (OUD) and facilitate the recovery process; however, development in this space for OUD has been slower compared to that for other medical conditions. Unique issues with OUD management surrounding patient provider relationships, interaction with the healthcare system, autonomy and trust sometimes hinder care approaches, including those in digital health. The trauma informed care framework (TIC), developed for use by organizations to support individuals who have experienced trauma, has particular applicability for digital health interventions in OUD care. This manuscript will serve as a review of TIC principles and how they can be applied to digital health interventions to increase access, equity, and empowerment for people with OUD. We will highlight representative current and pipeline digital technologies for OUD, challenges with these technologies, TIC models for OUD, and the integration of TIC principles into digital technology development to better serve people with OUD. Finally, we will posit strategies to incorporate the aforementioned principles into future research efforts. We ultimately aim to use TIC as a lens through which to develop digital technologies to help individuals with OUD while minimizing harm.

Children’s involvement in the development and evaluation of parent-focused mental health interventions: a scoping review protocol

Objective: This review will (i) describe methods used to involve children in the development and/or evaluation of parent-focused interventions to prevent or treat child mental health problems; (ii) summarize the perspectives of children or adults about these methods; (iii) highlight any reported enablers and barriers; and (iv) identify guidance and make recommendations for further research. Introduction: Parent-focused interventions (where children are not primarily involved or are excluded) have been implemented to address various child mental health outcomes. However, it is unclear to what extent, and to what end, children have been involved in developing and evaluating such interventions. Engaging children in formative research activities, with or without their parents, has the potential to improve quality and implementation. Inclusion criteria: Eligible studies will involve children (5–12 years) in the development and/or evaluation of parent-focused interventions aimed at preventing or treating common child mental health problems (eg, anxiety, depression, ADHD, disruptive behavior) delivered in any setting (eg, school, community, home, health facility). Eligible interventions may include one or more psychosocial practice elements targeting behavioral, cognitive, emotional, interpersonal, social, and/or environmental factors implicated in the onset and maintenance of child mental health problems. Methods: Comprehensive searches will be conducted in five electronic databases (PsycINFO, Medline, CINAHL, Embase, and SCOPUS). Gray literature will be sourced using Google as well as through searches of key organization websites and via notifications on social media. Only English language primary studies will be considered. Findings across a range of methodologies will be charted and combined into a narrative synthesis. Details of this rereview project are available: Open Science Framework: https:osf.io/x9376/

Effects of activity participation and cognitive levels on depression in middle-aged and older adults with chronic illness: a national cross-sectional study.

The world population is rapidly aging, and depression mainly affects middle-aged and older adults with chronic diseases and cognitive impairments. The sample for this study was obtained from the China Health and Retirement Longitudinal Study (CHARLS) public database. The sample size for inclusion was 12,767. There were 6,773 females and 5,994 males, with an overall low level of education. This study aims to provide a theoretical and practical reference basis for the clinical non-pharmacological treatment of depression in middle-aged and older adults (age ≥ 50 years) with chronic diseases. Additionally, the study seeks to promote the development of mental health interventions for middle-aged and older adults (age ≥ 50 years) with chronic diseases, ultimately enhancing the sense of well-being and quality of life for this demographic. Cognitive functioning and depressive symptoms of the study participants were assessed using the Mini-Mental State Examination Scale (MMSE) and the short version of the Center for Epidemiological Studies Depression Scale (CESD-10). Binary logistic regression results showed that among middle-aged and older adults (age ≥ 50 years) with chronic diseases, participation in physical activity [OR = 1.397; 95% CI (1.181-1.651); p < 0.05] was more effective than participation in social activities [OR = 0.997; 95% CI (0.924-1.076); p < 0.05] for preventing depression. Those with cognitive impairment [OR = 1.206; 95% CI (1.089-1.335); p < 0.05] were more likely to experience depression than those without cognitive impairment. Activity participation (physical activity and social activity) had a more significant effect on mild and moderate depression compared to no depression, and cognitive level had a more pronounced effect on moderate depression [OR = 1.491; 95% CI (1.278-1.740); p < 0.05] and major depression [OR = 2.231; 95% CI (1.282-3.884); p < 0.05]. Within the specific cohort of middle-aged and older adults (age ≥ 50 years) with chronic diseases, both activity participation and cognitive level exert a significant influence on the prevention and intervention of depression. Engagement in physical activity, participation in social activities, and enhanced cognitive functioning emerged as protective factors against depression. Therefore, the policy-maker should strengthen the prevention and treatment of depression in a comprehensive manner through the promotion of physical and social activities and the enhancement of cognitive level, so as to safeguard the mental health of middle-aged and older adults with chronic diseases.

Ai-powered Drug Discovery and Mental Health Therapy: Uniting Technologies for Holistic Healthcare

AI is making its way into health, especially in manners of approach toward this complex challenge. This paper looks at how AI-powered drug discovery and personalized mental health therapy merge into one holistic approach. AI analyzes large datasets for the identification of novel drug candidates, thereby accelerating drug discovery with the aim of reducing the cost and time-to-market for new treatments. Meanwhile, the development of AI-driven mental health interventions, such as natural language processing and machine learning algorithms, speaks to personalized therapeutic solutions fit for individual needs. This unitedly brings into view a synergistic model wherein AI works not only in optimizing drug discovery but also in the enhancement of care in mental health by way of individualized treatment. This paper, therefore, emphasizes key methodologies including deep learning, reinforcement learning for drug discovery, and RNNs for mental health interventions; with major emphasis on the use of AI to develop targeted treatments for ailments such as depression, anxiety, and neuropsychiatric disorders. An approach of that nature will not only provide much more depth in terms of health solutions but will also help bridge the mind-body gap, furthering both the concept and reality of personalized medicine and improving patient outcomes.

Recent trends and disparities in screen-based sedentary behavior and physical activity among U.S. overweight youth, 2018–2022

BackgroundSedentary behavior (SB) and physical activity (PA) are crucial factors influencing health outcomes in overweight children and adolescents. However, recent changes in SB and PA trends among U.S. overweight youth have not been well described, limiting the development of evidence-based clinical and public health interventions. MethodsSerial, cross-sectional analyses were conducted using data from the National Survey of Children's Health (NSCH) on U.S. overweight youth aged 6–17 years, spanning from 2018 to 2022. Linear regression models were employed to analyze time trends, with survey year as the exposure and recreational screen time (ST), adherence to the ≤2 h/day ST guideline, and adherence to the ≥1 h/day PA guideline as the outcomes. Multivariable-adjusted logistic and linear regressions were used to evaluate trends, adjusting for age group, sex, race/ethnicity, household income, and the highest education level of primary caregivers. ResultsData from 11,865 individuals (mean age 12.3 years [SD 2.9]; 6417 [52.3 %] girls) were analyzed. From 2018 to 2022, the average ST duration among overweight youth increased from 3.7 h to 4.1 h per day, a statistically significant increase (p = 0.07). The estimated prevalence of overweight youth meeting the ≤2 h/day ST guideline decreased from 44.6 % to 30.0 % (p = 0.007). Additionally, the prevalence of meeting the ≥1 h/day PA guideline remained low and stable, ranging from 8.4 % to 12.3 % during the analysis period (p = 0.6). DiscussionIn this nationally representative sample of U.S. overweight youth, ST increased by nearly 0.4 h/day over the five-year observation period, while adherence to the ≤2 h/day ST guideline decreased. Adherence to the ≥1 h/day PA guideline remained consistently low. These patterns were consistent across sociodemographic subgroups (age group, sex, ethnicity, and household income). These findings underscore the need for enhanced public health initiatives targeting U.S. youth to reduce recreational screen time and promote a physically active lifestyle.