A systematic review was carried out on the scientific production related to neonatal resuscitation protocols and their impact on infant mortality, using the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) methodology. The main purpose of this analysis was to identify and characterize the relevant publications registered in the Scopus and WoS databases, evaluating their scope and contribution to the study of these critical variables in neonatal health. During the review process, 28 publications were initially identified that addressed the topic, which were refined through the use of specific keywords, such as Neonatal Resuscitation Protocols and Infant Mortality. After excluding duplicates and documents that did not meet the inclusion criteria, a total of 17 studies were selected for detailed analysis. The identification and evaluation of these publications made it possible to observe global trends in research on the effectiveness of neonatal resuscitation protocols. A key finding was that, although standardized protocols have proven to be fundamental tools for reducing infant mortality, their effectiveness is conditioned by contextual factors such as the training of health personnel, the availability of technological resources, and inequalities in access to neonatal health services. This analysis confirmed that, in low- and middle-income countries, structural barriers limit the effective implementation of these protocols, highlighting the need to adapt them to local realities. In addition, one of the most relevant aspects identified in the review was the increasing incorporation of technological advances in resuscitation protocols, such as the use of monitoring devices and innovative tools that optimize interventions in critically ill neonates. However, these technological developments are mostly concentrated in developed country contexts, posing a global challenge to ensure that these innovations are accessible and applicable in resource-limited regions. This approach underscores the importance of advancing equity in neonatal care through public health policies that promote universal access to essential technologies. In summary, this systematic analysis not only made it possible to identify the main characteristics of recent research, but also evidenced the need to strengthen the strategies for the implementation of neonatal resuscitation protocols to maximize their impact on the reduction of infant mortality. This work provides a solid foundation for future research and highlights priority areas for improvement, including training of medical personnel, optimization of resource use, and technological innovation adapted to diverse socio-economic contexts.
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