Recent data from the National Center for Education Statistics (2002) noted that students with disabilities make up 13.2% of the student population in public schools. Due to recent federal government legislation that includes the Individuals with Disabilities Education Act (1997) and No Child Left Behind Act (2001), more school districts are moving students out of self-contained classrooms (a classroom containing only students with disabilities where they often receive little or no science instruction) and into inclusive science classroom settings (a classroom setting where all students regardless of the type of disability are educated with their same-age peers). This represents a 30% increase in the last decade. This steady increase of inclusion may be beneficial to students, but it creates special challenges for teachers of biology, many of whom were not trained in special education. In inclusive biology classrooms, all students are expected to meet standards for biology education. These standards include developing understanding of science content knowledge and scientific thinking skills (National Research Council, 1996). A variety of instructional strategies used to promote science learning for students with learning disabilities has been described in the literature. These include: providing learning tasks that engage students in actively doing science (Champagne, Newell & Goodnough, 1996; Mastropieri & Scruggs, 1992), adapting available science activities to address the needs of diverse learners (Finson, Ormsbee, Jensen & Powers, 1997), using alternate assessments (Finson & Ormsbee, 1998), delivering instruction through integrated themes (Champagne et al., 1996), and implementing appropriately-developed computer applications to promote science learning (Mastropieri & Scruggs, 1996). Science education professionals generally agree that a hands-on, inquiry-based approach to learning science potentially benefits all students. In addition, advocates of science reform initiatives suggest that reformed-based classrooms will produce learning environments that are supportive of all students (Anderson & Fetters, 1996). However, there is a concern that students with disabilities will be unable to develop inquiry skills since accommodating these learners is likely to prove complicated and time consuming for many mainstream classroom teachers (Scruggs & Mastropieri, 1992). In this article, we describe how to best assist inclusive high school students in learning biology with inquiry-based activities using a Web-integrated biology program. An aim of this study was to determine optimal ways of implementing materials with inclusive learners. We describe experiences trying to support the development of students' science skills during an investigative laboratory. We also discuss classroom adaptations and instructional strategies teachers may use to assist in promoting biology learning with inclusive learners. Context This design-based study was conducted in collaboration with two university faculty members (a science educator/ researcher and a special education educator/researcher) partnered with a classroom biology teacher, and a special education teacher who co-instructed in an inclusive ninth grade biology classroom. Design-based studies combine inductive qualitative approaches with quantitative and quasi-experimental approaches, varying the method to suit investigative questions that present themselves over the life of the collaboration (Cobb, Confrey, diSessa, Lehrer & Schauble, 2003). In these investigations, researchers establish a regular presence in the classroom to support the use of an innovation and work as essential partners to promote effective learning strategies. In part, this serves to temporarily establish conditions that are favorable to the innovation's success. Without these conditions, it would not be possible to study the phenomena or ideas of interest. …