Detraining Research Articles

Reducing impulsive choice: V. The role of timing in delay-exposure training

Impulsive decision-making is common in addiction-related disorders, with some research suggesting it plays a causal role in their development. Therefore, reducing impulsive decision-making may prevent or reduce addiction-related behaviors. Recent research shows that prolonged experience with response-contingent delayed reward (delay exposure [DE] training) reduces impulsive choice in rats, but it is unclear what behavioral mechanisms underlie this effect. The present study evaluated whether improvements in interval timing mediate the effects of DE training on impulsive choice. Thirty-nine Long-Evans rats were randomly assigned to groups completing DE, immediacy-, or no-exposure training, followed by impulsive-choice and timing tasks (temporal bisection). Despite replicating the DE effect on impulsive choice, timing accuracy and precision were unaffected by DE training and unrelated to impulsive choice. The present findings did not replicate previous reports that timing precision and impulsive choice are related, which may be due to between-laboratory differences in impulsive choice tasks. Continued research to identify candidate behavioral mechanisms of DE training may assist in improving training efficacy and facilitating translational efforts.

Concurrent Training Followed by Detraining: Does the Resistance Training Intensity Matter?

Sousa, AC, Marinho, DA, Gil, MH, Izquierdo, M, Rodríguez-Rosell, D, Neiva, HP, and Marques, MC. Concurrent training followed by detraining: does the resistance training intensity matter? J Strength Cond Res 32(3): 632-642, 2018-The aim of this study was to analyze the training and detraining (DT) effects of concurrent aerobic training and resistance training against 3 different external loads on strength and aerobic variables. Thirty-two men were randomly assigned to 4 groups: low-load (LLG, n = 9), moderate-load (MLG, n = 9), high-load (HLG, n = 8), and control group (CG, n = 6). Resistance training consisted of full squat (FS) with a low load (40-55% 1 repetition maximum [1RM]), a moderate load (55-70% 1RM), or a high load (70-85% 1RM) combined with jump and sprint exercises. Aerobic training was performed at 75% of the maximal aerobic speed for 15-20 minutes. The training period lasted for 8-week, followed by 4-week DT. Pretraining, post-training, and post-DT evaluations included 20-m running sprints (0-10 m: T10; 0-20 m: T20), shuttle run test, countermovement vertical jump (CMJ) test, and loading test (1RM) in FS. All the experimental groups showed improvements (p ≤ 0.05) in all the parameters assessed, except the LLG for T10 and the HLG for T20. The LLG, MLG, and HLG showed great changes in 1RM and V[Combining Dot Above]O2max compared with the CG (p ≤ 0.05), whereas the HLG and MLG showed a greater percentage change than the CG in T10 (p < 0.001) and CMJ (p ≤ 0.05). The 4-week DT period resulted in detrimental effects in all variables analyzed for all 3 experimental groups. In conclusion, our results suggest that strength training programs with low, moderate, or high external loads combined with low-intensity aerobic training could be effective for producing significant gains in strength and aerobic capacities. Moreover, the higher loads used increased gains in explosive efforts.

Wat levert een training voor voedselbankklanten op? Bevindingen uit een kwalitatieve studie

Wat levert een training voor voedselbankklanten op? Bevindingen uit een kwalitatieve studie

External load training does not alter balance performance in well-trained women

This study investigated the influence of external load training (ELT) on static and dynamic balance. Nineteen females stratified into two groups (ELT = 9, control = 10) completed three testing sessions over 6 weeks. The ELT group wore weighted vests (WV) of ~8% body mass for 32 h/week during daily living and three training sessions/week for 3 weeks. Following completion of ELT, a 3 week detraining (DET) phase was completed. Bilateral and unilateral static balance were assessed with eyes open and closed. Dynamic balance was assessed using the star excursion balance test (SEBT). Static and dynamic balance variables were analysed using a 2 (group) x 3 (time) between participants repeated measures ANOVA (p < 0.05). Results revealed significant reductions in average centre of pressure (COP) velocity in the control group on the non-dominant limb with eyes closed, and significantly greater reach distances in the ELT group on the SEBT for the posteromedial and medial directions on the dominant limb (p < 0.05). These findings suggest the ELT group did not significantly improve their balance in comparison to the control group. However, future research should further examine this unique, supplemental training method and the impact on balance performance.

Resistance Training–Induced Elevations in Muscular Strength in Trained Men Are Maintained After 2 Weeks of Detraining and Not Differentially Affected by Whey Protein Supplementation

Hwang, PS, Andre, TL, McKinley-Barnard, SK, Morales Marroquín, FE, Gann, JJ, Song, JJ, and Willoughby, DS. Resistance training-induced elevations in muscular strength in trained men are maintained after 2 weeks of detraining and not differentially affected by whey protein supplementation. J Strength Cond Res 31(4): 869-881, 2017-Resistance training (RT) with nutritional strategies incorporating whey protein intake postexercise can stimulate muscle protein synthesis and elicit hypertrophy. The early phases of training-induced anabolic responses can be attenuated with longer-term training. It is currently unknown if short-term detraining (DT) can restore these blunted anabolic responses during a subsequent retraining (ReT) period. Twenty resistance-trained men (age 20.95 ± 1.23 years; n = 20) were randomized into one of 2 groups (PRO or CHO; 25 g) in a double-blind manner. Participants followed a 4-day per week RT program (4-week RT; 2-week DT; 4-week ReT) while consuming their respective supplement only on workout days during RT and ReT, but every day during DT. At baseline, 4 weeks after RT (post-RT), 2 weeks after DT (post-2-week DT), and after 4 weeks of ReT after DT (post-ReT), leg press strength (LPS) was assessed and rectus femoris cross-sectional area and lean mass changes were assessed by ultrasonography and dual-energy x-ray absorptiometry, respectively. A factorial 2 × 4 (group by time) analyses of variance with repeated measures were used with a probability level at ≤0.05. LPS was elevated throughout the 10-week training study (p = 0.003) with no decrease in LPS after DT in both groups. Although not statistically significant, both groups retained lean mass after DT. A 2-week period of DT appeared to retain muscular strength in resistance-trained men. Therefore, a short-term period of DT can potentially retain lower-body strength in young resistance-trained men irrespective of supplementing with 25 g of whey protein postexercise.

Effect of previous strength training episode and retraining on facilitation of skeletal muscle hypertrophy and contractile properties after long-term detraining in rats.

In the present study, we investigated the effects of previous strength training and retraining following long-term cessation of exercise on muscle mass and contractile properties. Female Sprague-Dawley rats (n=24) aged eight weeks were randomly assigned one of the four groups: control (CON), detraining (DT), training (TR), and retraining (RT). The training regimen consisted of climbing ladder 5×3 sets, once every third day for eight weeks with weight attached to the tail. The weight carried during each training session was initially 50% of body weight and progressively increased by 10% per session. The rats in DT were detained for 20 weeks followed by eight weeks strength training. The rats in the both TR and RT groups underwent eight weeks training. DT was age matched new training group while RT was retraining group after 20 weeks of detraining. Soleus, gastrocnemius, tibialis anterior, and flexor hallucis longus (FHL) muscles were harvested in order to measure the weight, and in situ contractile properties of FHL were measured including specific twitch tension (Spt) and specific tetanic tension (Spo). TR showed significant increase in muscle mass compared to CON (P<0.05). DT and RT showed significant increase in muscle mass when compared to all other groups (P<0.05). There was no statistical difference in Spt and Spo among the groups. The present study showed that previous strength training facilitates retraining-induced muscle hypertrophy following long-term cessation of exercise.

Role of training and detraining on inflammatory and metabolic profile in infarcted rats: influences of cardiovascular autonomic nervous system.

The aim of this study was to evaluate the effects of exercise training (ET, 50–70% of VO2 max, 5 days/week) and detraining (DT) on inflammatory and metabolic profile after myocardial infarction (MI) in rats. Male Wistar rats were divided into control (C, n = 8), sedentary infarcted (SI, n = 9), trained infarcted (TI, n = 10; 3 months of ET), and detrained infarcted (DI, n = 11; 2 months of ET + 1 month of DT). After ET and DT protocols, ventricular function and inflammation, cardiovascular autonomic modulation (spectral analysis), and adipose tissue inflammation and lipolytic pathway were evaluated. ET after MI improved cardiac and vascular autonomic modulation, and these benefits were correlated with reduced inflammatory cytokines on the heart and adipose tissue. These positive changes were sustained even after 1 month of detraining. No expressive changes were observed in oxidative stress and lipolytic pathway in experimental groups. In conclusion, our results strongly suggest that the autonomic improvement promoted by ET, and maintained even after the detraining period, was associated with reduced inflammatory profile in the left ventricle and adipose tissue of rats subjected to MI. These data encourage enhancing cardiovascular autonomic function as a therapeutic strategy for the treatment of inflammatory process triggered by MI.

Training and Detraining Effects on Satellite Cell Response after Exhaustive Exercise in Thoroughbred Horses

We investigate the effects of training and detraining on the satellite cell activation in thoroughbred horse muscles after an exhaustive exercise. Six horses were subjected to con- ventional training for 18 weeks and detraining for 6 weeks. Before training (Pre), after 10-week and 18-week training (10Tr and 18Tr), and after 6-week detraining (DTr), an incremental ex- ercise test (IET) was performed on inclined treadmill to measure V 4

MTOR signaling response to resistance exercise is altered by chronic resistance training and detraining in skeletal muscle

Resistance training-induced muscle anabolism and subsequent hypertrophy occur most rapidly during the early phase of training and become progressively slower over time. Currently, little is known about the intracellular signaling mechanisms underlying changes in the sensitivity of muscles to training stimuli. We investigated the changes in the exercise-induced phosphorylation of hypertrophic signaling proteins during chronic resistance training and subsequent detraining. Male rats were divided into four groups: 1 bout (1B), 12 bouts (12B), 18 bouts (18B), and detraining (DT). In the DT group, rats were subjected to 12 exercise sessions, detrained for 12 days, and then were subjected to 1 exercise session before being killed. Isometric training consisted of maximum isometric contraction, which was produced by percutaneous electrical stimulation of the gastrocnemius muscle every other day. Muscles were removed 24 h after the final exercise session. Levels of total and phosphorylated p70S6K, 4E-BP1, rpS6, and p90RSK levels were measured, and phosphorylation of p70S6K, rpS6, and p90RSK was elevated in the 1B group compared with control muscle (CON) after acute resistance exercise, whereas repeated bouts of exercise suppressed those phosphorylation in both 12B and 18B groups. Interestingly, these phosphorylation levels were restored after 12 days of detraining in the DT group. On the contrary, phosphorylation of 4E-BP1 was not altered with chronic training and detraining, indicating that, with chronic resistance training, anabolic signaling becomes less sensitive to resistance exercise stimuli but is restored after a short detraining period.

Detraining Increases Body Fat and Weight and Decreases V[Combining Dot Above]O2peak and Metabolic Rate

Competitive collegiate swimmers commonly take a month off from swim training after their last major competition. This abrupt cessation of intense physical training has not been well studied and may lead to physiopsychological decline. The purpose of this investigation was to examine the effects of swim detraining (DT) on body composition, aerobic fitness, resting metabolism, mood state, and blood lipids in collegiate swimmers. Eight healthy endurance-trained swimmers (V(O2)peak, 46.7 ± 10.8 ml · kg(-1) · min(-1)) performed 2 identical test days, 1 in the trained (TR) state and 1 in the detrained (~5 weeks) state (DT). Body composition and circumferences, maximal oxygen consumption (V(O2)peak), resting metabolism (RMR), blood lipids, and mood state were measured. After DT, body weight (TR, 68.9 ± 9.7 vs. DT, 69.8 ± 9.8 kg; p = 0.03), fat mass (TR, 14.7 ± 7.6 vs. DT, 16.5 ± 7.4 kg; p = 0.001), and waist circumference (TR, 72.7 ± 3.1 vs. DT, 73.8 ± 3.6 cm; p = 0.03) increased, whereas V(O2)peak (TR, 46.7 ± 10.8 vs. DT, 43.1 ± 10.3 ml · kg(-1) · min(-1); p = 0.02) and RMR (TR, 1.34 ± 0.2 vs. DT, 1.25 ± 0.17 kcal · min(-1); p = 0.008) decreased, and plasma triglycerides showed a trend to increase (p = 0.065). Our data suggest that DT after a competitive collegiate swim season adversely affects body composition, fitness, and metabolism. Athletes and coaches need to be aware of the negative consequences of detraining from swimming, and plan off-season training schedules accordingly to allow for adequate rest/recovery and prevent overuse injuries. It's equally important to mitigate the negative effects on body composition, aerobic fitness and metabolism so performance may continue to improve over the long term.

The Effects of Concurrent Resistance and Endurance Training Follow a Detraining Period in Elementary School Students

The purpose of this study was to compare the effects of an 8-week training period of resistance training alone (GR), or combined resistance and endurance training (GCOM), followed by 12 weeks of detraining (DT) on body composition, explosive strength, and ·VO₂max adaptations in a large sample of adolescent school boys. Forty-two healthy boys recruited from a Portuguese public high school (age: 13.3 ± 1.04 years) were assigned to 2 experimental groups to train twice a week for 8 weeks: GR (n = 15), GCOM (n = 15), and a control group (GC: n = 12; no training program). Significant training-induced differences were observed in 1- and 3-kg medicine ball throw gains (GR: +10.3 and +9.8%, respectively; GCOM: +14.4 and +7%, respectively), whereas no significant changes were observed after a DT period in both the experimental groups. Significant training-induced gains in the height and length of the countermovement (vertical-and-horizontal) jumps were observed in both the experimental groups. No differences were perceived after a DT period in lower limb power. Time at 20 m decreased significantly for both intervention programs (GR: -11.5% and GCOM: -12.4%, <0.00), but either GR or GCOM groups kept the running speed after a DT period of 12 weeks. After training, the ·VO₂max increased only significantly for GCOM (4.6%, p = 0.01). A significant loss was observed after a DT period in GR but not in GCOM. Performing resistance and endurance training in the same workout does not impair strength development in young school boys. As expected, strength training by itself does not improve aerobic capacity. Our results also suggest that training program effects even persist at the end of the DT period.

Muscle performance and functional capacity retention in older women after high-speed power training cessation

Power declines more steeply than strength with advancing age and training cessation among older women and is associated with the loss of functional ability. We tested the hypothesis that the impact of 6weeks of detraining (DT) subsequent to 12weeks of high-speed power training on maximal strength (1RM) of the arm and leg muscles, power performance (counter movement jump and ball throwing) and functional task (sit-to-stand test) would decrease physical performance, and specifically power performance.Thirty-seven older women were divided into an experimental group and a control group [EG, n=20, 65.8 (2.5) years; CG: n=17, 64.8 (2.8) years]. Muscular strength, power and functional testings were conducted before the initiation of training (T1), after 12weeks (T2) and after 6weeks of DT (T3).During the 12weeks of training, EG significantly increased their dynamic strength performance (range from 41.9 to 64.1%), muscle power output (range from 18.2 to 33.6%) (p<0.05) and function (15.8%) (p<0.05). No significant differences were observed in the magnitude of the increases in CG. Short-term DT led to larger effects on maximal strength (18.1–23.8%) (p<0.05) of both upper and lower extremity muscles than in muscle power (2–4.5%) and function (2.8%) (p<0.05). However, all measurements remained higher (12.6–36.4%; p<0.05) than in pre-training levels.These data indicated that DT may induce larger declines in muscle strength than in power output and preserved physical independence, mediated in part, by the effectiveness of high-speed power training particularly developed for older women.

Hemodynamic and autonomic benefits of exercise training in myocardial infarction persists after 30 days of detraining

Male Wistar rats were divided in randomized groups: control (C), myocardial infarction (MI)+sedentary (SI), MI+exercise training (ET) (TI), MI+detraining (DI). After 12 weeks of ET, MI size although similar at the begining (~40±3%) was reduced at the end of the protocol in trained and detraining groups (TI: 19±6% and DI: 22±4%) when compared to SI (38±3%). TI group displayed increased maximum speed of running in comparison with C, SI, and DI; however, DI remained increased in relation to SI (C: 2.0±0.1; SI: 1.4±0.08; TI: 2.6±0.1 and DI: 1.9±0.1 Km/h). Basal lactate that was reduced by ET in TI, remained lower in DI as compared to SI animals. ET induced resting bradycardia and increase of mean arterial pressure in TI rats as compared to SI, and these adaptations remained after detraining in DI rats. Baroreflex sensitivity that was normalized by ET, persisted after detraining period, as evidenced by tachycardic (C: 3.2±0.1; SI: 1.9±0.4; TI: 3.0±0.1; DI: 2.9±0.4 bpm/mmHg) and bradycardic (C: 2.0±0.1; SI: 1.4±0.08; TI: 2.0±0.1; DI: 1.9±0.2 bpm/mmHg) responses. These &amp;#64257;ndings indicate that ET is not only an effective tool in the management of MI derangements but also that these changes were kept working even after 30 days of detraining.

The effects of concurrent resistance and endurance training follow a specific detraining cycle in young school girls.

The purpose of this study was to compare the effects of an 8-week training period of strength training alone (GR), or combined strength and endurance training (GCOM), followed by 12-weeks of de-training (DT) on body composition, power strength and VO2max adaptations in a schooled group of adolescent girls. Methods: Sixty-seven healthy girls recruited from a Portuguese public high school (age: 13.5+1.03 years, from 7th and 9th grade) were divided into three experimental groups to train twice a week for 8 wks: GR (n=21), GCOM (n=25) and a control group (GC: n=21; no training program). Anthropometric parameters variables as well as performance variables (strength and aerobic fitness) were assessed. Results: No significant training-induced differences were observed in 1kg and 3kg medicine ball throw gains (2.7 to 10.8%) between GR and GCOM groups, whereas no significant changes were observed after a DT period in any of the experimental groups. Significant training-induced gains in CMVJ (8 to 12%) and CMSLJ (0.8 to 5.4%) were observed in the experimental groups. Time of 20m significantly decreased (GR: −11.5% and GCOM: −10%) after both treatment periods, whereas only the GR group kept the running speed after a DT period of 12 weeks. After training VO2max increased only slightly for GCOM (4.0%). No significant changes were observed after the DT period in all groups, except to GCOM in CMVJ and CMSLJ. Conclusion: Performing simultaneous strength and endurance training in the same workout does not appear to negatively influence power strength and aerobic fitness development in adolescent girls. Indeed, concurrent strength and endurance training seems to be an effective, well-rounded exercise program that can be prescribed as a means to improve initial or general strength in healthy school girls. De-training period was not sufficient to reduce the overall training effects.

Efeitos do treino e do destreino sobre indicadores de força em jovens voleibolistas: implicações da distribuição do volume

This study aimed to compare the effects of strength training (ST) and detraining (DT) of two volume periodization models (linear - LM; non linear - NLM) in young male volleyball players. 12 volleyball players (17.1±0.5 years old) were randomly divided into two groups. The results of the present study suggest that 8 weeks of ST induce changes in the indicators of increased maximal strength and explosive strength, regardless of models used. However, the NLM seems less effective in the development of explosive strength in specific motor skills (vertical jump). As for DT, this study suggests that 4 weeks is sufficient to cause significant losses as an indicator of release between the two models of training. The LM induces significant losses in the explosive strength of the upper (medicine ball throwing) and lower body (vertical jump), while the NLM suggests higher losses in the maximum strength (train top) besides the jumping ability.

Exercise training and detraining modify the morphological and mechanical properties of single cardiac myocytes obtained from spontaneously hypertensive rats

We determined the effects of exercise training and detraining on the morphological and mechanical properties of left ventricular myocytes in 4-month-old spontaneously hypertensive rats (SHR) randomly divided into the following groups: sedentary for 8 weeks (SED-8), sedentary for 12 weeks (SED-12), treadmill-running trained for 8 weeks (TRA, 16 m/min, 60 min/day, 5 days/week), and treadmill-running trained for 8 weeks followed by 4 weeks of detraining (DET). At sacrifice, left ventricular myocytes were isolated enzymatically, and resting cell length, width, and cell shortening after stimulation at a frequency of 1 Hz (~25°C) were measured. Cell length was greater in TRA than in SED-8 (161.30 ± 1.01 vs 156.10 ± 1.02 μm, P < 0.05, 667 vs 618 cells, respectively) and remained larger after detraining. Cell width and volume were unaffected by either exercise training or detraining. Cell length to width ratio was higher in TRA than in SED-8 (8.50 ± 0.08 vs 8.22 ± 0.10, P < 0.05) and was maintained after detraining. Exercise training did not affect cell shortening, which was unchanged with detraining. TRA cells exhibited higher maximum velocity of shortening than SED-8 (102.01 ± 4.50 vs 82.01 ± 5.30 μm/s, P < 0.05, 70 cells per group), with almost complete regression after detraining. The maximum velocity of relengthening was higher in TRA cells than in SED-8 (88.20 ± 4.01 vs70.01 ± 4.80 μm/s, P < 0.05), returning to sedentary values with detraining. Therefore, exercise training affected left ventricle remodeling in SHR towards eccentric hypertrophy, which remained after detraining. It also improved single left ventricular myocyte contractile function, which was reversed by detraining.

Neural drive preservation after detraining following neuromuscular electrical stimulation training

The purpose of the study was to investigate the behaviour of the central nervous system when 5 weeks of neuromuscular electrical stimulation (NMES) training was followed by 5 weeks of detraining. Nineteen males were divided into the neuromuscular electrostimulated group (EG, n = 12) and the control group (CG, n = 7). The training program consisted of 15 sessions of isometric NMES over a 5-week period. The EG subjects were tested before training (PRE), after 5 weeks of NMES training (POST) and after 5 weeks of detraining (DE) while CG subjects were only tested at PRE and at POST. Soleus (SOL) and gastrocnemii (GAS) maximal H-reflex and M-wave potentials were evoked at rest (i.e., H max and M max, respectively) and during maximal voluntary contraction (MVC) (i.e., H sup and M sup, respectively). SOL and GAS V-wave were recorded by supramaximal stimulation delivered during MVC. SOL and GAS electromyographic (EMG) activity as well as muscle activation were also assessed during MVC. After training, plantar flexor MVC increased significantly by 22% ( P < 0.001). Torque gains were associated with an increase in muscle activation ( P < 0.05), SOL and GAS normalized EMG activity ( P < 0.01 and P < 0.05, respectively) and V/ M sup ratios ( P < 0.01 and P < 0.05, respectively). No significant changes occurred in any of these parameters between POST and DE. H max/ M max and H sup/ M sup ratios for both muscles were unchanged after both the training and detraining periods. In conclusion, the NMES training-induced neural adaptations were maintained after detraining, suggesting that neural changes are long-lasting and did not affect the elements of H-reflex pathways.

Effect of detraining on cardiorespiratory variables in young Thoroughbred horses

Thoroughbred racehorses often experience interruptions to their training. Identifying the effects of these changes and how they alter athletic performance might provide an insight on to how to prevent these changes from occurring. Training and detraining young Thoroughbreds alters their aerobic capacities with correlated changes in circulatory capacities; if horses remained spontaneously active in a pasture during their detraining period, their decreases in aerobic capacity during detraining would be reduced. We trained 6 Thoroughbred yearlings for 6 months using a conventional yearling race training programme. They were then detrained for 10 weeks with free range on pasture for 8 h/day and stall rest at night. Treadmill measurements of O2 transport variables were made before training (PRE), after training (TR) and after detraining (DT). A step-test protocol identified each horse's aerobic capacity (VO2max) and speed to attain it, and a steady-state run at VO2max was used to quantify 02 transport variables at each time period. The mass-specific and whole-body VO2max, cardiac output (Q) and stroke volume (Vs) increased from PRE to TR. All mass-specific values decreased significantly from TR to DT; however, because body mass increased by 8.3% from TR to DT, none of the variables changed significantly from TR to DT on a whole-body basis. Changes in aerobic capacity are highly correlated with changes in Vs and circulatory capacity during training and detraining. Exercise activity of trained young horses free at pasture for 8 h/day is sufficient to maintain VO2max, (Q and Vs during 10 weeks of DT. Aerobic and cardiovascular fitness may be maintained in young Thoroughbred horses during at least 10 weeks of detraining by maintaining modest spontaneous exercise activity.

The effects of training and detraining on memory, neurotrophins and oxidative stress markers in rat brain

In the current investigation we tested how swimming training (T) (8 week, 5 times/week, 2 h/day), and detraining (DT) affects brain functions and oxidative stress markers in rat brain. The free radical concentration, measured by electron paramagnetic resonance, decreased in brain of T and DT rats compared to controls (C). The level of brain-derived neurotrophic factor (BDNF) increased as a result of training, but decreased below the control level after 6 weeks of detraining. In addition, the concentration of nerve growth factor (NGF) also declined with DT. The passive avoidance test was used to assess the memory of rats, and training-induced improvement was observed but the enhancement disappeared with detraining. When the content of mitochondrial electron transport complexes, as a potent free radical generator, was evaluated by the blue native gel method, no significant alterations were observed. The repair of nuclear and mitochondrial 8-oxodeoxyguanosine, as measured by the activity of OGG1, showed no significant difference. Therefore, the results suggest that regular exercise training improves memory, decreases the level of reactive oxygen species, and increase the production of BDNF and NGF. On the other hand, it appears that the beneficial effects of training are reversible in the brain, since detraining down-regulates the neurotrophin level, and memory. It is suggested that exercise training is more likely to beneficially effect the production of reactive oxygen species and the related oxidative damage.

Impact of physical training and detraining on endothelium-dependent vasodilation in patients with recent acute myocardial infarction

Background There is evidence that aerobic exercise improves endothelial function in healthy subjects as well as in patients with chronic heart failure. However, it is unknown whether this effect occurs in patients with recent myocardial infarction (AMI). Methods Fifty-two patients with a recent first uncomplicated AMI underwent endothelial function evaluation before and after 3 months of moderate aerobic exercise training. We measured brachial artery vasomotor reactivity using flow-mediated dilation (FMD), a cold pressor (CP) test, and sublingual nitroglycerin. Patients were randomized into 2 groups: 28 patients (G1) underwent training, while 24 patients (G2) served as controls. Brachial artery vasomotor reactivity was reassessed after 1 month of detraining (DT). Results At baseline the FMD was 1.66% ± 4.11% in G1 and 2.04% ± 3.4% in G2 ( P = NS) and vasoconstriction was evident after a CP test. The diameter reduction was −4.1% ± 3.89% in G1 and −4.39% ± 5.67% in G2 ( P = NS). At follow-up the FMD had increased to 9.39% ± 4.87% in G1 ( P < .01) and to 4.4% ± 3.9% in G2 ( P < .01 vs G1). Vasoconstriction during a CP test was observed only in G2. Endothelium-independent vasodilation was unchanged in both groups. Effort tolerance increased by 32% in G1 patients ( P < .01 versus G2) and was correlated with FMD change ( R = 0.51, P < .01). After detraining the FMD was significantly reduced in G1 ( P < .01) and a further vasoconstriction was evident after CP testing. Conclusions Exercise training improves endothelium-dependent vasodilation in post-AMI patients. This improvement is associated with a significant increase in exercise tolerance. These benefits disappeared after detraining.