Physicomathematical modeling of interaction of detonation waves in silane/hydrogen composite mixtures with clouds of inert micro- and nanoparticles ranging from 10 nm to 100 µm is performed. The normalized detonation velocity is calculated as a function of the volume concentration of particles. It is found that the efficiency of detonation suppression increases only as the particle diameter decreases to 1 µm. The influence of the thermodynamic parameters of particles on the detonation suppression efficiency is identified. The concentration limits of detonation are determined. It is demonstrated that a certain equilibrium asymptotic level of the concentration limits of detonation is reached as the particle diameter decreases below 1 µm. An approximation of the concentration limits of detonation is obtained in the form of an analytical dependence of the limiting volume concentration of particles on their diameter and fuel concentration in a composite two-fuel mixture of silane, hydrogen, and air.