Purpose: To determine college students’ intentions to be Human Papillomavirus (HPV) vaccinated. Methods: The study was comprised of college students aged 18–45 years. A survey was developed based on the Theory of Planned Behavior (TPB). The significance of the TPB constructs—attitude, subjective norms, and perceived behavioral control—and an additional construct—knowledge—in predicting intention were assessed. Results: The regression model containing attitude, subjective norms and perceived behavioral control accounted for 40% of the variance in intention. Attitude and subjective norms were significant predictors, while perceived behavioral control was not. Provider recommendation was the only significant covariate. Knowledge did not significantly contribute to the model. Discussion: The TPB was useful in predicting HPV vaccination intentions. A focus on attitude, subjective norms and provider recommendation may be useful in creating new or enhancing existing interventions.