Determination Of Iodine Content Research Articles

Heavy atom-induced quenching of fluorescent organosilicon nanoparticles for iodide sensing and total antioxidant capacity assessment.

We present a novel approach for iodide sensing based on the heavy-atom effect to quench the green fluorescent emission of organosilicon nanoparticles (OSiNPs). The fluorescence of OSiNPs was significantly quenched (up to 97.4% quenching efficiency) in the presence of iodide ions (I-) through oxidation by hydrogen peroxide. Therefore, OSiNPs can serve as a fluorescent probe to detect I- with high selectivity and sensitivity. The highly selective response is attributed to the hydrophilic surface enabling good dispersion in aqueous solutions and the lipophilic core allowing the generated liposoluble I2 to approach and quench the fluorescence of OSiNPs. The linear working range for I- was from 0 to 50 μM, with a detection limit of 0.1 μM. We successfully applied this nanosensor to determine iodine content in edible salt. Furthermore, the fluorescent OSiNPs can be utilized for the determination of total antioxidant capacity (TAC). Antioxidants reduce I2 to I-, and the extent of quenching by the remaining I2 on the OSiNPs indicates the TAC level. The responses to ascorbic acid, pyrogallic acid, and glutathione were investigated, and the detection limit for ascorbic acid was as low as 0.03 μM. It was applied to the determination of TAC in ascorbic acid tablets and fruit juices, indicating the potential application of the OSiNP-based I2 sensing technique in the field of food analysis.

Methods for determining iodine in urine

Iodine deficiency remains a serious threat to public health worldwide, especially in children and pregnant women. Despite the apparent ease of iodine deficiency elimination with the help of a simple and highly effective strategy of compulsory salt iodization, the problem of iodine deficiency and iodine deficiency disorders remains urgent for public health in the Russian Federation. The most effective and informative way to study iodine status at population level is determination of iodine concentration in urine in epidemiological studies. This article presents a review of urinary iodine determination methods, as well as methodological recommendations for iodine determination, developed and adopted in National Medical Research Center for Endocrinology.

Effects of oral iodine supplementation in very low birth weight preterm infants for the prevention of thyroid function alterations during the neonatal period: results of a randomised assessor-blinded pilot trial and neurodevelopmental outcomes at 24months.

The trace element iodine (I) is essential for the synthesis of thyroid hormones. Parenteral nutrition solutions, formula milk, and human breast milk contain insufficient iodine to meet recommended intake for preterm infants. Iodine deficiency may affect thyroid function and may be associated with morbidity or neurological outcomes. The primary objective is to assess the evidence that dietary supplementation with iodine affects thyroid function during the neonatal period. The design was a randomised controlled pilot trial. Infants who met the inclusion criteria were enrolled through consecutive sampling and assigned to two different groups. The setting was a Spanish university hospital. Ninety-four patients with very low birth weight (under 1500g) were included. Intervention group: 30µg I/kg/day of iodine in oral drops given to 47 infants from their first day of life until hospital discharge. Control group: 47 infants without supplements. Formula and maternal milk samples for the determination of iodine content were collected at 1, 7, 15, 21, 30days, and at discharge. Blood samples were collected for thyroid hormones. Neurological development was assessed at 2years of age (Bayley III Test). Infants in the supplemented group reached the recommended levels from the first days of life. The researchers detected the effects of iodine balance on the plasma levels of thyroid hormones measured during the first 12weeks of age. The trial assessed the impact of the intervention on neurodevelopmental morbidity.Conclusion: Thyroid function is related to iodine intake in preterm infants. Therefore, supplements should be added if iodine intake is found to be inadequate. The analyses found no effects of iodine supplementation on the composite scores for Bayley-III assessments in all major domains. The study results indicate potentially important effects on language development related to low iodine excretion during the first 4weeks of life What is Known: • Thyroid function is related to iodine intake in preterm infants. • Preterm babies on formula preparations and with exclusive parenteral nutrition are at high risk of iodine deficiency. What is New: • Iodine intake should be monitored during the neonatal period. • Iodine supplements should be added if iodine intake is found to be inadequate.

Iodine Deficiency Disorders: Current State of the Problem in the Bryansk Region

The Bryansk region is one of the regions of the Russian Federation most affected by the accident at the Chernobyl nuclear power plant on April 26, 1986.In the conditions of a chronic uncompensated deficiency of iodine in the diet in the first months after the accident, an active seizure of radioactive iodine by the thyroid tissue took place, which inevitably resulted in an increase in thyroid diseases from the population in the future. The article presents the results of a control and epidemiological study carried out in May 2021 by specialists of the National Medical Research Center of Endocrinology of the Ministry of Health of Russia, aimed at assessing the current state of iodine provision in the population of the Bryansk region. Assessment of iodine supply of the population of the Bryansk region. The research was carried out in secondary schools of three districts of the Bryansk region (Bryansk, Novozybkov and Klintsy).The study included 337 schoolchildren of pre-pubertal age (8-10 years), all children underwent: measurement of height and weight immediately before the doctor's examination, which included palpation of the thyroid gland (thyroid gland); Thyroid ultrasound using a portable device LOGIQe (China) with a multi-frequency linear transducer 10-15 MHz; determination of iodine concentration in single portions of urine. A qualitative study for the presence of potassium iodate in samples of table salt (n = 344) obtained from households and school canteens was carried out on the spot using the express method. According to the results of a survey of 337 pre-pubertal children, the median urinary iodine concentration (mCIM) is 98.3 μg / L (range from 91.5 to 111.5 μg / L, the proportion of urine samples with a reduced iodine concentration was 50.1%). According to the ultrasound of the thyroid gland, 17% of the examined children had diffuse goiter, the frequency of which varied from 9.4 to 29% in the areas of study. The share of iodized salt consumed in the families of schoolchildren in the study areas was 17.8% (values range from 15.6 to 19%), which indicates an extremely low level of iodized salt consumption by the population. All salt used for cooking in school canteen areas of the study was iodized, which confirms compliance with the requirements of SanPiN 2.4.5.2409-08. Despite the active implementation in the Bryansk region of various preventive programs of IDD and social activities to promote the use of iodized salt, in the absence of mass prevention with the help of iodized salt to date, their unsatisfactory results should be noted.

Assesment of Iodine Deficiency in Patients with Nodular Goiter Living in the Precarpatian Region

The objective of the research was to assess the state of iodine supply of patients with nodular goiter living in the Precarpathian region.
 Materials and methods: 56 patients with nodular goiter were examined (38 women and 18 men), the average age of patients was 48 years. WHO / UNICEF / ICCIDD guidelines were used to assess the severity of iodine deficiency: goiter frequency according to palpation and ultrasound examinations, median of iodine excretion in urine, thyroid-stimulating hormone (TSH) and thyroglobulin levels. Determination of iodine concentration in urine was conducted by the method of “blind”, closed randomized study in single portions of urine according to the Sandell-Kolthoff reaction by the method of Dunn et al. in the laboratory of epidemiology of endocrine diseases at the State Institution “V.P. Komisarenko Institute of Endocrinology and Metabolism” (supervisor – Professor VI Kravchenko).
 Results. According to the results of the study of iodine in the urine, the data with an average value of 85.9 μg/l were obtained. The median of thyroglobulin serum was in the range of 12.27 ng/L. Levels of thyroid-stimulating hormone were average in patients with nodular goiter of I and II grades constituting 3.13 mU/l (table 2). The level of thyroglobulin median was noted to be the highest in patients with thyroid size corresponding to grade II.
 Conclusions. The results of the study of iodine in the urine of patients with nodular goiter of grades I and II living in the Precarpathian region indicated a mild level of iodine deficiency. The presence of iodine deficiency necessitated both mass (the use of iodized salt by the population) and individual iodine prevention (prescribing potassium iodide).

The Kinetics of Iodine Content Decreasein Fortified Rice During Storage

Iodine Deficiency Disorders (IDD) is a major public health problem in several areas of the world, especially in developing countries. Iodine deficiency can cause goitre, cretinism, decrease of intelligence, mental retardation, brain damage, deaf-mutism, and cause miscarriage in pregnant women and stillbirth as well. The purpose of this research was to determine the stability of the iodine content and determine the kinetics of reaction rate of iodine content decrease in fortified rice during storage. The research was carried out in several steps, i.e. preparation of microcapsules containing iodine, fortification of microencapsulated iodine into rice, determination of iodine content in fortified riceand determination of the kinetics of iodine content decrease in fortified rice during storage. The determination of the kinetics of iodine content decrease in fortified rice was carried out using accelerated self-life test (ASLT) by Arrhenius equation methods.Theresultsshowed that the average of kineticsrateofiodine content decrease in fortified rice (k) was 0.0141 mg kg−1hour−1 and 1.692 kcal mol−1K−1 of activation energy (Ea), which indicated that iodine content (as KIO3) in fortified rice was fairly stable during storage, although there was still a decrease in iodine content caused by several factors (i.e. temperature, atmosphere, humidity, oxygen and moisture content). The results showed also that the increase in storage temperature can cause the increment of the kinetics value (rate constant) of iodine content decrease. The longest shelf life of fortified rice was 92 days at storage temperature of 25°C.

Analisis Kandungan Yodium Dalam Garam Beryodium Pada Wadah Penyimpanan Plastik Dan Kaca Selama 6 Hari Penyimpanan

Setiap tahun terdapat 39 juta bayi baru lahir beresiko memiliki kapasitas intelektual rendah akibat defisiensi yodium. Terdapat 5% ibu hamil yang kadar TSH dan TPO-Abnya meningkat. Konsekuensi defisiensi yodium dapat dihindari jika pada saat hamil ibu sejak awal mengkonsumsi yodium secara adekuat. Sumber yodium yang tersedia dan cukup murah adalah garam yang difortifikasi yodium. Namun, waktu penyimpanan, kondisi penyimpanan, dan jenis garam berpengaruh terhadap penurunan kandungan yodium dalam garam beryodium. Tujuan penelitian untuk mengetahui kandungan iodium pada garam beryodium dengan berbagai wadah penyimpanan selama penyimpanan 6 hari. Jenis penelitian ini merupakan penelitian deskriptif. Sampel garam diambil secara acak di toko kelontong dengan merk dagang yang paling banyak digunakan konsumen di kota Palu dan sekitarnya. Wadah yang digunakan adalah wadah plastik dan wadah kaca. Setiap wadah dibagi dua, ada wadah transparan dan ada wadah yang tidak transparan (dibungkus). Penyimpanan dilakukan selama 6 hari dengan analisa kandungan yodium garam dilakukan pada hari ke 0, hari ke-2, hari ke-4 dan hari ke-6. Hasil penelitian menunjukan bahwa baik wadah plastik maupun wadah kaca, terdapat penurunan kandungan yodium. Rata-rata persentase penurunan kandungan yodium terbesar terjadi pada penyimpanan dalam wadah plastik dan kaca yang transparan (9,49% dan 4,75%). Sedangkan pada wadah yang tidak transparan rata-rata penurunan kandungan yodiumnya sebesar 4,99% pada wadah plastik dan 3,18 % pada wadah kaca. Persentase penurunan kandungan yodium terbesar setiap dua hari penyimpanan terdapat pada garam yang disimpan dalam wadah plastik transparan yakni rata-rata sebesar 4,77%. Kesimpulan; Penyimpanan garam beryodium yang terbaik adalah dalam wadah kaca yang tidak transparan

Determination of iodine content in laminaria and enriched berry sauce

Determination of iodine content in laminaria and enriched berry sauce

Evaluation of Iodine Content in Portuguese Primary School Meals After Mandatory Iodization Program (P22-004-19)

ObjectivesIodine is an essential trace element in the human and animal diets. The major role of thyroid hormones is related to the growth and development of the body. Iodine deficiency is the most common cause of preventable mental impairment. There are, in Portugal, a widespread deficiency of iodine of pregnant women and school-age children [1 - 3]. The aim of this study was monitored the real content of iodine in school meals. MethodsCollection of foods from schools was designed to represent school meal program based on three hundred samples organized into three groups. Group I contained one hundred and forty-four samples cooked with iodized salt from primary schools across the Lisbon metropolitan area. Group II had twelve samples from a pilot school. This school was used as a reference for real iodine content. Group III was constituted by one hundred and forty-four samples used as a standard for minimum iodine value. These samples were collected based on consumption patterns from national food consumption surveys.Based on ISO/EN 17,025:2005 and EN 15,111:2007, the determination of iodine content was performed using inductively coupled plasma-mass spectrometry (ICP-MS) after alkaline extraction with TMAH (tetramethylammonium hydroxide) in a graphite block system during 3 hours at 90 °C. ResultsThe concentration of iodine in samples showed a wide range of levels, e.g., Group I from 5.3 μg/100 g in pasta to 52 μg/100 g in cod and Group II the highest value (32 μg/100 g) in soup. The lowest value (<1.9) was found in the meat of Group III. The ratio between Group I and Group III was used to estimate the effectiveness of the program, and the biggest difference was found in fish and lowest was determined in soup. The difference between iodine content in Group I and Group II was used to monitoring the use of iodized salt in the other schools from Lisbon metropolitan area. The cooking procedure, iodization salt absorption, and operator performance were identified as the main factors contributing to the differences between real and prescribed content. ConclusionsThis study demonstrates that the determination of iodine content in foods cooked with and without iodized salt is an appropriate approach to evaluate fortification program and risks of both inadequate and excess iodine intake. Funding SourcesN/A.

ANALISIS KANDUNGAN YODIUM DALAM GARAM BERYODIUM PADA WADAH PENYIMPANAN PLASTIK DAN KACA SELAMA 6 HARI PENYIMPANAN

ABSTRACT Every year there are 39 million of infant newborn at risk of being born with low intellectual capacity due to iodine deficiency. Meanwhile, there are 5 percen of pregnant women who have increased TSH and TPO-Ab level.The consequences of Iodine deficiency can be prevented if pregnant women in adequate iodine intake early. Abundant and inexpensive source of iodine is salt iodization. Unfortunatelly, iodine concentration in salt iodization can be decreased due to time and conditions of storage, and type of salt. The aim of this study is to determine iodine content in Salt iodization that stored in different containers for six days of storage. The type of study was descriptive study. Sample is salt iodization were obtained from the grocery store by taking randomly and brands that are widely used in Palu city and its surroundings. Storage container of salt iodization consist of two namely plastic and glass jar. Each container consist of transparent and non transparent jars. Storage of sample is carried out for six days and analysis of iodine content was carried out on day 0, day 2, day 4 and day 6 of storage. The result of study showed that both glass and plastic container decreased iodium content in salt. The largest median of percentage reduction in iodine content occurred in transparent plastic and glass container, in 9,49 and 4,74% respectively. However, median of percentage reduction in non-transparent plastic and glass container, in 4,99 and 3,18%, respectively. For 2 days of storage, the largest median of percentage reduction in iodine content found in transparent plastic container which is 4,77%. Conclusion: The best storage of iodization salt is it in non-transparent container.

Determination of iodine content in Fijian foods using spectrophotometric kinetic method

The spectrophotometric kinetic method was validated for the determination of iodine in different food samples. The method is based on the iodide catalysed reduction of Ce4+ to Ce3+ by As3+. The absorbance of the kinetic indicator reaction was measured at 370 nm for exactly 1 min at 37 °C. The change in absorbance per min, as a measure of initial rate, was plotted against the different iodine concentrations to achieve a linear calibration equation with the R2 value of 0.9998 which showed excellent reproducibility. The limit of detection (LOD) was 1.54 ng/mL and the limit of quantification (LOQ) was 4.90 ng/mL. The incineration of the food organic matter was achieved by ashing the food samples at 600 °C using KOH and ZnSO4 in steps for 3 h. Trace levels of iodine (ng) were determined successfully using the validated spectrophotometric kinetic method for the 9 food samples (36 sub-samples). The Fiji seaweeds, lumiwawa (brown seaweed) showed the highest iodine content being 6373.30 ± 0.39 ng/g followed by sea grapes (green seaweed) 1162.81 ± 0.61 ng/g, lettuce 114.81 ± 0.08 ng/g, English cabbage 108.40 ± 0.06 ng/g, Chinese cabbage 104.01 ± 0.06 ng/g, pumpkin 101.24 ± 0.08 ng/g, long bean 97.61 ± 0.10 ng/g, banana 76.18 ± 0.10 ng/g and tomato 40.32 ± 0.04 ng/g. The coefficient of variation for the sample analysis was <5.31% with a mean and standard deviation of 2.55 ± 0.17% for the food samples analysed. The recovery analysis of iodine from standard samples ranged from 99.84 ± 0.91% to 100.24 ± 5.92% with an excellent average recovery of 100.06 ± 3.16%. The analytical coefficient of variation was calculated to be 0.34% for the food samples analysed. This shows exceptional system analytical stability of the method used in this study.

Systematic Review and Meta-Analysis Investigating the Diagnostic Yield of Dual-Energy CT for Renal Mass Assessment.

OBJECTIVE. The objective of our study was to perform a systematic review and meta-analysis to evaluate the diagnostic accuracy of dual-energy CT (DECT) for renal mass evaluation. MATERIALS AND METHODS. In March 2018, we searched MEDLINE, Cochrane Database of Systematic Reviews, Embase, and Web of Science databases. Analytic methods were based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Pooled estimates for sensitivity, specificity, and diagnostic odds ratios were calculated for DECT-based virtual monochromatic imaging (VMI) and iodine quantification techniques as well as for conventional attenuation measurements from renal mass CT protocols. I2 was used to evaluate heterogeneity. The methodologic quality of the included studies and potential bias were assessed using items from the Quality Assessment Tool for Diagnostic Accuracy Studies 2 (QUADAS-2). RESULTS. Of the 1043 articles initially identified, 13 were selected for inclusion (969 patients, 1193 renal masses). Cumulative data of sensitivity, specificity, and summary diagnostic odds ratio for VMI were 87% (95% CI, 80-92%; I2, 92.0%), 93% (95% CI, 90-96%; I2, 18.0%), and 183.4 (95% CI, 30.7-1093.4; I2, 61.6%), respectively. Cumulative data of sensitivity, specificity, and summary diagnostic odds ratio for iodine quantification were 99% (95% CI, 97-100%; I2, 17.6%), 91% (95% CI, 89-94%; I2, 84.2%), and 511.5 (95% CI, 217-1201; I2, 0%). No significant differences in AUCs were found when comparing iodine quantification to conventional attenuation measurements (p = 0.79). CONCLUSION. DECT yields high accuracy for renal mass evaluation. Determination of iodine content with the iodine quantification technique shows diagnostic accuracy similar to conventional attenuation measurements from renal mass CT protocols. The iodine quantification technique may be used to characterize incidental renal masses when a dedicated renal mass protocol is not available.

Determination of iodine content in milk and food supplements by inductively coupled plasma mass spectrometry (ICP-MS)

The determination of iodine in milk and food supplements by inductively coupled plasma&amp;nbsp;mass spectrometry (ICP-MS) was investigated. Several parameters of the equipment were&amp;nbsp;optimized automatically such as power of radio frequency, nebulizer gas, and voltage of ion&amp;nbsp;lens. Iodine was extracted from samples by using 2% HNO3 with ultrasonic at 80&amp;ordm;C. Sample&amp;nbsp;solutions were adjusted to the pH of 9&amp;divide;10 by using ammonium hydroxide, and then filtered&amp;nbsp;by using a 0.45 &amp;micro;m membrane before being analyzed by means of ICP-MS. The method has&amp;nbsp;good repeatability and high recovery efficiency that are suitable for the determination of iodine&amp;nbsp;in milk and food supplements.

Effects of Iodine Agronomic Bio- fortification on selected Physiological Characteristics of Cassava in Calabar, Southeastern Nigeria

Field experiments were conducted between November 2011 and May 2014 at the Crop Science Teaching and Research Farm of the University of Calabar, (Southeastern rainforest agro-ecological zone of Nigeria) to determine the effectiveness of Iodine agronomic fortification of cassava. The field experiment was a 2x3x4 factorial experiment arranged in randomized complete block design replicated three times, conducted using two cassava varieties,( TME 419 and TMS 30555); four iodine rates( 0, 2.5, 5.0 and 10.0) kg/ha KI; applied at 8, 10 and 12 WAP. Physiological data were obtained by determination of Iodine content [in cassava tuber]; tuber cyanide content (HCN); Carbohydrate content of tuber; starch content of tuber and tuber protein contents. Iodine absorption and retention in cassava tuber flesh was significantly positively correlated with Iodine doses at the times of application (p0.05 and 0.01). TME 419 retained more Iodine in tissues than TMS 30555 and recorded highest correlation co-efficient at 10WAP. Iodine doses and time of application did not significantly control (P≥0.05) contents of cyanide, carbohydrate and starch in cassava tubers. Protein content was significantly varied in cassava varieties and rate and time of Iodine application influenced tuber protein content. TME 419 produced more tuber protein, Iodine doses of 2.5kg/ha KI and 0kg/ha KI had higher protein content than 5kg and 10kg/ha KI. Application at 8WAP and 10WAP were not significantly different. For favourable physiological cassava characteristics, 2.5kg/ha KI is recommended applied 10 weeks after planting (WAP).

Determination of Iodine Content in Dairy Products by Inductively Coupled Plasma Mass Spectrometry

A probing study to establish a reliable and robust method for determining the iodine concentration using the ELAN® DRC™ II ICP-MS was performed in combination with a sample digestion and filtration step. Dairy products from locally available sources were evaluated to help determine the possibility and need for further evaluations in relation to the U.S. population's iodine intake. Prior to analysis, the samples were aliquoted and digested for 3 hours at 90±3 °C. Dilution and filtration were performed, following the digestion. The sample extract was analyzed, and the results were confirmed with NIST SRM 1549a Whole Milk Powder. Further experimentation will need to be performed to optimize the method for projected sample concentration and throughput.

GW28-e0015 Determination of iodine content in the left ventricular myocardial of healthy subjects using dual-source dual-energy CT

GW28-e0015 Determination of iodine content in the left ventricular myocardial of healthy subjects using dual-source dual-energy CT

Determination of iodine content in the left ventricular myocardium of healthy subjects using dual-source dual-energy CT myocardial first perfusion imaging: a preliminary study

Objective: To analyze the normal value of the iodine content in the left ventricular myocardium of healthy subjects and to observe if there is a segmental differences on iodine distribution by using the second generation dual-source dual-energy computed tomography myocardial first perfusion imaging. Methods: In this retrospective study, 42 healthy subjects, who admitted to our department between January to June 2016, with normal second generation dual-source dual-energy computed tomography and coronary CT angioghphy (CTA), electrocardiogram (ECG) results, normal cardiac, hepatic, renal function, normal myocardial enzymes results were enrolled, data from 38 out of 42 subjects with satisfactory image quality were analyzed using Siemens Dual Energy-Heart PBV image processing software.In accordance with the standards of the American Heart Association myocardial 17 fractionation method, content of iodine was measured at different segmental left ventricular myocardium and aorta (left coronary artery from the opening level). The standardized containing iodine value (nIC) was calculated. Results: The iodine content of left ventricular myocardium in normal subjects was 3.1-7.8 mg/ml.The nIC of myocardium from 1st to 17th segments was 0.28±0.06, 0.31±0.07, 0.30±0.07, 0.30±0.04, 0.28±0.04, 0.29±0.05, 0.29±0.01, 0.30±0.07, 0.31±0.07, 0.27±0.06, 0.28±0.08, 0.28±0.07, 0.29±0.08, 0.31±0.07, 0.27±0.06, 0.29±0.06 and 0.21±0.07, respectively.The nIC of the 17th segment was the lowest and was significantly lower than in other segments (all P<0.05), the nIC was similar among the rest 16 segments (all P>0.05). Conclusion: The normal iodine content range in left ventricle myocardium is 3.1-7.8 mg/ml, and the lowest iodine content is detected in the apex and which is significantly lower than the other left ventricular segments.

Quantitative iodine content threshold for discrimination of renal cell carcinomas using rapid kV-switching dual-energy CT.

Determine iodine content threshold discriminating papillary renal cell carcinomas (pRCC) from complex cysts (CCs) using rapid kV-switching dual-energy CT (rsDECT). IRB-approved retrospective study of 72 consecutive patients with pathologic diagnosis of renal cell carcinoma, who underwent rsDECT from 2011 to 2015. Controls included consecutive patients with CC during same period. Iodine content of each pRCC (n=27) was measured on rsDECT workstation for arterial (n=15) or nephrographic phase (n=12), and compared to iodine content for clear cell renal cell carcinomas (ccRCC, n=46) and complex cysts (n=54). An optimal iodine content threshold was estimated using logistic regressions and Youden's J based on maximum specificity and sensitivity. Iodine threshold of 1.28mg/cc was optimal to discriminate between pRCCs and CCs for nephrographic phase (sens 1.0, spec 0.96, PPV 0.92, and NPV 1.0, AUC 0.997, acc 0.97, p<0.0001). Iodine threshold of 1.22mg/cc was the optimal cutoff value to discriminate between pRCCs and CCs in the arterial phase (sens 0.67, spec 0.97, PPV 0.91, NPV 0.85, AUC 0.76, and acc 0.84, p=0.006). The optimal threshold to discriminate between ccRCCs and pRCCs was 1.85mg/cc in the arterial phase (sens 0.87, spec 0.92, PPV 0.87, NPV 0.92, p<0001) and 2.71mg/cc in the nephrographic phase (sens 1.0, spec 1.0, PPV 1.0, NPV 1.0, p<0.0001). Quantitative iodine values on rsDECT discriminate between papillary RCC and complex cysts, and between papillary RCC and clear cell RCC, the former addressing an important clinical challenge particularly when an unenhanced series has not been performed. These rsDECT thresholds differ from values derived from dual-source DECT technology.

Iodine concentration in cooking salt consumed in Lubumbashi and the iodine status of vulnerable people: case study of pregnant women living in underprivileged areas

IntroductionLa consommation du sel faiblement iodé peut engendrer des troubles divers liés à la carence iodée Ce travail a pour objectif d’évaluer la teneur en iode du sel consommé à Lubumbashi et de déterminer le statut iodé des femmes enceintes, cible privilégiée de la carence iodée.MéthodesUne étude transversale descriptive a été consacrée à une analyse iodométrique d'iode dans 739 échantillons de sel collectés dans les ménages et marchés de Lubumbashi en 2014. Précédemment, l'iode urinaire a été déterminé par la technique de minéralisation au persulfate d'ammonium chez 225 femmes enceintes reçues en consultation du 15 mars 2009 au 25 avril 2011.RésultatsNotre enquête a révélé 47,5% des échantillons de sels de cuisine adéquatement iodés (15 à 40 ppm), 36,9% d’échantillons faiblement iodés, 7,4% d’échantillons trop riches en iode et 8,1% des échantillons non iodés. La disponibilité en iode du sel de cuisine analysé était globalement de 54,9%, se trouvant nettement en dessous des normes OMS (90%). En mesurant l'iode urinaire chez la femme enceinte, la carence iodée (iode urinaire <150 µg/l) a été observée dans une proportion de 52%.ConclusionLa faible disponibilité en iode du sel consommé à Lubumbashi pourrait être responsable d'une grande proportion de la carence iodée observée chez la femme enceinte, ce qui expose celle-ci aux risques majeurs des troubles dus à la carence en iode.

Correlation of Iodine content of mother’s milk and urine with their child’s TSH level

Background: Iodine deficiency is still a significant public health problem. In the rural plains of Nepal, it remains a mild-to-moderate public health problem among pregnant and lactating women despite the availability of iodized salt. To date, only limited attention has been paid to breast-milk iodine content despite its importance in the intellectual development of infants.Objectives: (i) To determine iodine content in mother’s urine, mother’s milk and to measure their respective child’s TSH level. (ii) To correlate iodine content of mother’s urine with child’s TSH level and also mother’s milk content with child’s TSH level.Setting and Design: cross sectional study in human using consecutive sampling techniqueMaterials and Methods: Mother’s urinary and milk iodine level was measured by Ammonium Persulfate Digestion Microplate method using Sandell-Kolthoff reaction in a sealing cassette (Hitachi, Japan) and child’s TSH by ELISA commercial Kit from Eliscan (RFCL, India) based on classical sandwich technique.Statistical analysis used: Spearman’s correlation was performed in quantitative variables. A p-value less than 0.05 and 0.001 were considered statistically significant and highly significant respectivelyResults: The median mother’s urine was 174.96 µg/L(97.39-215.43) and their respective median child TSH level was 3.86 mIU/L(2.66-4.80). Median mother’s milk iodine was 129.90 µg/L (94.14-165.94).There was significant negative correlation between mothers’ urinary iodine content and their child’s TSH (r2= -0.391, p = 0.005) and between mother’s urinary iodine and their child’s TSH (r2= -0.471, p = 0.001). There was positive correlation between mother’s milk iodine and mother urinary iodine but not statistically significant ((r2= 0.261, p = 0.067).Conclusion: Mothers urinary iodine, mother’s milk iodine and child TSH are interrelated with each other.Asian Journal of Medical Sciences Vol.7(1) 2015 40-48