A novel composite electrode was developed based on graphene oxide (GO) / MnO <sub>2</sub>:h‐MoO <sub>3</sub> nanocomposite for sensitive and selective voltammetric detection of acetaminophen (ACP). The composite electrode materials were characterized using X‐Ray photoelectron spectroscopy (XPS), X‐Ray Diffraction (XRD), scanning electron microcopy (SEM), electrochemical impedance spectroscopy (EIS) and cyclic voltammetric (CV) techniques. In the optimum conditions, the oxidation peak current ( <i>I<sub>pa</sub></i>) of ACP was increased linearly with its concentration over two linear ranges from 0.06 to 10.0 µmol L <sup>−1</sup> and 20.0 to 80.0 µmol L <sup>−1</sup> with a detection limit of 0.0133 μmol L <sup>−1</sup>. Due to its higher selectivity and long term stability, the composite electrode was applied to the detection of ACP in pharmaceutical formulations.