Since the emergence of microfluidic platforms sensors integration has been a major challenge. With the advances in miniaturization of these platforms, there is a need for solutions to integrate various optical components in order to build sensors, which will offer different detection characteristics such as several emission and sensing wavelengths. Moreover, the integration of an electrochemical sensor including a transparent electrode that will be compatible with the optical sensor represents an additional challenge. In this perspective, organic optoelectronic devices combined with silver nanowire electrodes could be a solution. The integration of a fluorescent sensor and an electrochemical oxygen sensor into a microfluidic platform and the different characteristics, advantages and disadvantages that offer organic light-emitting diodes (OLED), organic photodetectors (OPD) and silver nanowire electrodes are discussed. Finally, an example of the integration of an optical and an electrochemical sensor into a microfluidic chip for water pollution detection will be described.