Intervention studies have been explored to identify actions to effectively remediate indoor environmental quality (IEQ) problems and to improve people's health, well-being, comfort, and productivity. This study assessed a comprehensive set of IEQ indicators related to ventilation, air pollution, thermal comfort, illuminance, and noise for the first time in Portuguese office buildings. The purpose was to derive evidence-based corrective measures for a further environmental intervention program. The study monitored and surveyed 15 open-space offices from six modern office buildings in Porto (Portugal) during a workday between September and December 2022. Illuminance was of most concern among the assessed IEQ indicators since the measured levels were below the minimum limit required in 27% of the evaluated workplaces. For CO2, although mean concentrations were below 1000 ppm, absolute values exceeding that level were consistently registered in 20% of the offices during the afternoon period. Mean levels of PM2.5, PM10, and ultrafine particles exceeding the WHO guidelines were found in 13%, 7%, and 7% of the offices, respectively. The assessed thermal comfort levels were typically neutral, corresponding to an estimated mean of 6% of dissatisfied people. Based on the findings, an intervention plan was designed to be implemented in the further stages of this work. The priority interventions to test include relocation of printers (PM source removal), optimisation of ventilation rates (using real-time data from CO2 sensors), adjustment of desk positions to improve illuminance, and introduction of indoor plants.