Aim: This systematic review examines potential connections between dark matter and chemical processes, focusing on weak interactions similar to neutrinos and a proposed experimental design for detecting dark matter interactions at the nuclear level. Neutrinos, though weakly interacting, may cluster under extreme conditions, providing new insights into dark matter detection (Friedland & Giannotti 2008) [8]. Background: Dark matter, constituting 85% of the universe’s mass, is invisible to direct detection methods (Bertone & Hooper, 2018; Peebles, 1982) [4, 12]. While its gravitational influence shapes cosmic structures and environments for chemical reactions, this review emphasizes potential interactions between dark matter and atomic nuclei, applying neutrino detection methods as a framework (Liddle & Lyth, 2000) [11]. Although neutrinos generally do not interact strongly with matter, under specific extreme or hypothetical conditions, they might cluster into larger structures. These conditions could include increased neutrino mass, stronger gravitational interactions, or the presence of a new force (Garrett & Duda 2011) [9]. Such scenarios might occur near black holes or in the early universe (Bahcall et al. 1999) [3]. This idea adds an intriguing dimension to the potential behaviors of neutrinos and could influence how we approach dark matter detection. Method: To maintain consistency: A comprehensive review of astrophysics, chemistry, and particle physics literature was conducted to explore detection techniques used in neutrino research and apply them to dark matter interactions (Cirelli, 2009) [5]. A hypothetical experiment involving nuclear resonance and weak nuclear interactions was proposed. Results: Neutrino detection technologies offer a valuable model for experiments aimed at capturing dark matter interactions. (Friedland & Giannotti, 2008) [8]. This could lead to breakthroughs in understanding dark matter's role in nuclear chemistry. Conclusion: Dark matter's elusive nature remains a significant challenge for detection, but its potential weak interactions with nuclei, akin to those of neutrinos, offer a promising experimental pathway. This review highlights the importance of experimental designs targeting these subtle interactions and suggests that discovering dark matter's chemical-like properties could revolutionize the field of chemistry (Garrett & Duda, 2011; Bahcall et al., 1999) [9, 3].