With a focus on a specific flood-prone community in Camden, NJ, this research utilizes a detailed hydraulic and hydrologic (H&H) model to assesses the impacts of climate change on Combined Sewer Overflows (CSOs) and localized flooding under two different infrastructure scenarios. In the US, the Clean Water Act compels regulated utilities to develop Long-Term Control Plans to reduce combined sewer overflows (CSOs), but there is no parallel mandate to simultaneously reduce flooding within the associated service areas. With different control measures in place, H&H models are frequently used to evaluate CSO volumes and frequencies under historical climate conditions. However, precipitation intensification and sea level rise (SLR) will also modify CSO volumes. This study uses a calibrated and validated 1D and 2D Personal Computer Stormwater Management Model (PCSWMM) simulation to predict both CSO discharges and flooding under different climate and infrastructure scenarios. A total of ten climate change scenarios comprising a range of plausible climate futures are considered. The infrastructure scenario that is tested would divert stormwater generated in an upstream municipality (Pennsauken, NJ) away from Camden’s combined sewer system. Without the disconnection, increases in precipitation will increase CSOs, whereas SLR primarily increases flooding. The proposed mitigation strategy can immediately reduce both CSOs and flooding, but with diminishing effectiveness over time, as climate change demonstrates the need for supplemental measures. Areas for further analysis regarding alternative mitigation methods and future research are outlined.