Destructive Processes Research Articles

Targeted Treatment of Kidney using Intravenous and Intraarterial delivery of Whey Protein Isolate-Based Microgels

Here we report a promising whey protein isolate (WPI)-stabilized emulsion microgels for targeted drug delivery into the kidney. Investigation of stability revealed time-dependent degradation of the microgels starting at 72 h. Cytotoxicity studies showing increased sensitivity in Hek239 and Jurkat cells. A biodegradation assay underscored the role of macrophages in the destruction process of microgel particles. The efficiency of targeting the microgels for the kidney was assessed by biodistribution using intravenous and intraarterial delivery. Tail vein administration demonstrated long-term (minimum 5 days) selective accumulation not only in the liver but also in the kidneys. Renal artery injection of microgels resulted in an expected local increase in fluorescence in the target kidney in the first minutes after injection. In contrast, at 1 and 3 h there was an atypical accumulation of the Cy7 fluorescent signal in the opposite kidney. However, at 1 and 5 d the fluorescent signal predominated in the target kidney again and was higher in comparison with intravenous administration. Histological analysis validated the safety of WPI-based microgels using different methods of administration. By fine-tuning the physicochemical properties and delivery methods, the developed microgels offer an adjusted therapeutic approach with reduced side effects. They present new prospects for the treatment of kidney disorders using both intravenous administration and minimally invasive endovascular approach.

Synthesis and antimicrobial activity of yttrium-doped cerium oxide nano-composite against wound pathogen

Abstract Nanocomposite materials have attracted considerable interest in several disciplines owing to their distinctive characteristics and possible uses. The primary objective of this study was to synthesize and characterize a nanocomposite material consisting of cerium that has been doped with yttrium. The shape, structure, and properties of the synthesized nanocomposite was characterized using various characterization techniques including ultraviolet spectrophotometry, Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), X-ray diffraction (XRD), zeta potential measurements, dynamic light scattering (DLS), and Fourier-transform infrared spectroscopy (FTIR).The antibacterial activity of the nanocomposite was assessed against a range of pathogenic bacteria including Gram-positive bacteria - Enterococcus faecalis, Staphylococcus aureus, and Gram-negative bacteria- Escherichia coli, Pseudomonas aeruginosa using standard microbiological techniques. The results indicate that the nanocomposite possesses strong antibacterial properties against a wide range of microorganisms, showcasing its potential as a highly effective antimicrobial agent for diverse applications in the biological, environmental, and industrial fields. Hemolysis is the process of red blood cell destruction, resulting in the release of hemoglobin into the surrounding fluid. In this study, 0.7:0.3M nanocomposite had showed effective biocompatibility with less than 5%. Furthermore, this particular composite remained identical in different time intervals, while other composites would normally fluctuate. Research has shown that meticulous material design and surface modification can reduce the harmful effects on red blood cells, hence improving the safety of nanocomposite for therapeutic purposes. In summary, this study offers valuable information on the creation, analysis, and assessment of nanocomposite materials with antimicrobial properties.

Overcoming fixation and permeabilization challenges in flow cytometry by optical barcoding and multi-pass acquisition.

The fixation and permeabilization of cells are essential for labeling intracellular biomarkers in flow cytometry. However, these chemical treatments often alter fragile targets, such as cell surface and fluorescent proteins (FPs), and can destroy chemically-sensitive fluorescent labels. This reduces measurement accuracy and introduces compromises into sample workflows, leading to losses in data quality. Here, we demonstrate a novel multi-pass flow cytometry approach to address this long-standing problem. Our technique utilizes individual cell barcoding with laser particles, enabling sequential analysis of the same cells with single-cell resolution maintained. Chemically-fragile protein markers and their fluorochrome conjugates are measured prior to destructive sample processing and adjoined to subsequent measurements of intracellular markers after fixation and permeabilization. We demonstrate the effectiveness of our technique in accurately measuring intracellular FPs and methanol-sensitive antigens and fluorophores, along with various surface and intracellular markers. This approach significantly enhances assay flexibility, enabling accurate and comprehensive cellular analysis without the constraints of conventional one-time measurement flow cytometry. This innovation paves new avenues in flow cytometry for a wide range of applications in immuno-oncology, stem cell research, and cell biology.

Model Test on Acoustic Emission Monitoring of Loess Slope Failure

The three stages of loess collapse are characterized by notable concealment and sudden onset due to the sudden nature of loess collapse and the prolonged duration of the peristaltic deformation stage. Traditional displacement monitoring methods struggle to detect early signals of instability and failure, leading to poor timeliness in disaster warnings. This project begins by examining non-force field information related to the loess collapse process. It focuses on acoustic emission monitoring and employs model tests to identify effective waveguide rods for monitoring loess collapse. Additionally, the project investigates the evolution anomalies of acoustic emission parameters before and after loess collapse failure, aiming to establish early warning criteria for loess collapse based on acoustic emission. This work provides a theoretical basis for monitoring and early warning of loess collapses. This study evaluates five parameters of the active waveguide system: sensor installation method, filling material, waveguide rod wall thickness, outer wrapping material, and outer wrapping wall thickness. The densities of the filler materials were tested using the optimal parameters derived from the tests to identify the best configurations for active acoustic emission (AE) waveguide systems suitable for monitoring loess collapse. Subsequently, a one-sided connected loess collapse model was employed for indoor tests, integrating real-time AE monitoring with the active waveguide method. This model facilitates the exploration of AE response characteristics during loess collapse and the analysis of destructive forms of loess collapse and time-sequence evolution of AE ringing counts throughout the deformation and destruction process. Results indicate that using filler materials with high elasticity modulus, high compactness, and low Poisson’s ratio, along with thin outer wrapping and waveguide rod walls, leads to strong AE signals. As deformation damage of loess collapse intensifies, the number of AE ringing counts notably increases. A rapid rise in cumulative ringing counts can indicate a “sudden increase”, or the b-value may stabilize, providing precursor information for loess collapse.

Impact of the Lyα radiation force on super-Eddington accretion on to a massive black hole

Abstract The viability of super-Eddington accretion remains a topic of intense debate, crucial for understanding the formation of supermassive black holes in the early universe. However, the impact of the Ly$\alpha$ radiation force on this issue remains poorly understood. We investigate the propagation of the Ly$\alpha$ photons and evaluate the Ly$\alpha$ radiation force within a spherically symmetric accreting H i gas on to the central black hole. We solve the radiation transfer equation, incorporating the destruction processes of Ly$\alpha$ photons through two-photon decay and collisional de-excitation. We find that the Ly$\alpha$ photons, originating in the H ii region around black holes, suffer from multiple resonance scattering before being destroyed via two-photon decay and collisional de-excitation. Hence, the Ly$\alpha$ radiation force undergoes a significant amplification, surpassing gravity at the innermost section of the H i region. This amplification, quantified as the force multiplier, reaches approximately 130 and remains nearly constant, regardless of the optical depth at the line center, provided the optical thickness of the flow is within the range of $10^{10\\!-\\!14}$. The requisite lower limit of the product of gas density and black hole mass to realize super-Eddington accretion is found to be in the range $(2\\!-\\!40) \times 10^9\, M_\odot \, {\rm cm}^{-3}$, which is a few to tens of times larger than the minimum value obtained without accounting for the Ly$\alpha$ radiation force. The pronounced amplification of the Ly$\alpha$ radiation force poses a substantial challenge to the feasibility of super-Eddington accretion.

Review of Waste Management in Indonesian Small Islands in the Last Five Years (2018-2023)

Indonesia is a maritime country composed of 16,771 islands consisting of large islands and small islands. One of the environmental problems that occur in small islands. Waste management is a shared focus because sources of water, soil and air pollution can come from waste. Waste management on small islands is very important because small islands have a much higher vulnerability than large islands.. This article aims to identify and analyze waste management in Indonesia's Small Islands and evaluate if its implementation has utilized the technology and concepts of the Industrial Revolution 4.0. Based on the findings of a review of 14 articles published from 2018-2023, with 15 islands as research objects, it was found that most of the small islands used as research objects had not managed their waste properly. The waste is eventually dumped into the sea. The unmanaged factor of this waste can be caused by the geographical conditions on the island which are bordered by the sea, the lack of waste management facilities, the limited land area on small islands and the low awareness and participation of the community in waste management. The rest, several islands have carried out the process of storage, processing, collection and destruction quite well. The waste is turned into handicrafts (bags and souvenirs), ecobricks, garden decorations and plant fertilizers for organic waste as well as the development of innovative waste into diesel fuel. Unfortunately, the intended application based on the Industrial Revolution 4.0 has not been reflected in waste management on these small islands. This is expected to be information and input for the government and managers as a model for other small islands in an effort to manage waste generation on the island's mainland and garbage contamination in the sea.

Distinguishing between genocide and ethnic cleansing in the Ottoman Empire (1914–23) and why this matters

ABSTRACT The last decades of the Ottoman Empire were characterised by mass violence that saw millions, mostly Ottoman Christians, perishing and forcibly moved within Ottoman borders, or expelled out. While it is generally accepted (except by Turkey and pro-Turkish commentators) that what befell the Armenians in 1915 and 1916 was a Genocide, in recent years many have taken to calling what befell other Ottoman Christians as a genocide as well, referring to a genocide of Armenians, Greeks and Assyrians from 1915 to 1923, and some even to a 30-year genocide. This essay attempts to scrutinise this recent trend, by contrasting what happened to the Armenians and the Greeks during the last years of the Ottoman Empire and during the rise of Nationalist Turkey, namely from 1915 to 1923. It first distinguishes between the terms genocide, genocidal and ethnic cleansing. It then establishes that population numbers are pivotal to genocide, as those killed and those that survived are important to evidence intent and application. The article then delves into the cases, comparing and contrasting across the criteria of intent and destruction processes, and the number of dead and survived. Finally, the article answers why the Armenian case (1915–16) is a Genocide, but not the Greek case (1915–23) or that of the Armenian case (1919–23). This article is important for the overall special issue on mass deportation because it clarifies the differences between various genocidal processes, including mass deportation, ethnic cleansing, and genocide.

Conceptualizing Global Trends

Numerous publications contain high-quality descriptions of causes, processes, and effects of global trends. However, very few of these publications are theoretically guided or aim at theory building. This is a handicap preventing most publications on global trends from developing high-quality explanations and prognostications. This article contains an attempt at developing a conceptual framework for resolving the issue. The attempt is based on the paradigm of social interaction and includes arguments in favor of four global trends: upgrading the rationality of organizations, individualization, spread of instrumental activism, and homogenization of culture. The decomposition of the trends makes it possible to identify their structures and dynamics. The analyzed examples usually refer to constructive processes and effects. In reality, the global trends are internally controversial and bring about both constructive and destructive processes and effects. The most challenging task for future studies concerns the interplay of the internal dynamics of each global trend with the dynamics of the configuration of global trends. The conceptualization of the dynamic configuration of interacting global trends is the core of the diagnosis of the global situation.

Влияние колебаний стока реки Лены на площадь льда в море Лаптевых

The ice regime of the Laptev Sea has significant changes during the last twenty years. After the changes in the ice regime of the Laptev Sea, the influence of river runoff on the processes of seasonal formation and destruction of sea ice have increased. During the period from 2004 to 2022, the average annual ice area in the Laptev Sea has a positive correlation with a fluctuations of Lena runoff. The high-water content years of Lena has stimulated to the speedup of the ice cover formation process in autumn and the shift of the beginning of ice melting in spring to a later date.

PROSPECTS OF THE APPLICATION OF LOW-TEMPERATURE PYROLYSIS PROCESSES FOR THE THERMAL DESTRUCTION OF HYDROCARBON-CONTAINING WASTE OF VARIOUS ORIGINS

A generalized analysis of the existing methods of utilization of hydrocarbon-containing waste of various origins and practical data on the existing experience of using low-temperature pyrolysis processes for the thermal destruction of hydrocarbon-containing municipal and oil waste are presented. A series of studies of thermochemical processes of waste destruction were conducted for both municipal solid waste and industrial waste. The common feature that unites the objects of research is their wide morphology, the presence of the predominant proportion of hydrocarbons and their derivatives. To implement the process of low-temperature pyrolysis of hydrocarbon-containing waste of various origins, a universal installation with a rotating reactor is proposed. The features of its operation, technical characteristics and advantages are presented. The prospects for further development of low-temperature pyrolysis technology for the utilization of unsorted waste groups from sorting complexes are substantiated. Bibl. 30, Fig. 2, Tab. 2.

Investigation of the impurity effect on the kinetics of thermal decomposition of natural gypsum at high temperatures

Natural gypsum is the most common sulfate on our planet, which is widely used in construction due to its excellent astringent properties, environmental friendliness, thermal and fire resistance, accessibility in nature and low price. Currently, the influence of modifiers, impurities and additives that can improve the strength, acoustic and thermal insulation characteristics of gypsum, which is so important in modern architecture, construction and reducing power consumption, is being increasingly studied. However, additives and impurities, controlled and uncontrolled, as in natural gypsum, can unpredictably affect the thermal stability and fire resistance of gypsum. The purpose of our work is to study the thermal characteristics of gypsum from various deposits in a wide temperature range. Our work shows that the temperature and rate of dissociation of gypsum directly depends on impurities that can change the process of its decomposition. As a result of the decomposition of natural gypsum with impurities, new phases are formed.It has been experimentally shown that the process of thermal destruction of gypsum with impurities has a complex multistage character, which is described by successive reactions of the nth order of the Avrami-Erofeev equation. It can be assumed that the reaction mechanism consists in the rapid formation of numerous nucleation centers on the surface of solid anhydrite. Kinetic parameters of thermal decomposition of gypsum of complex composition and phase formation at high temperatures are calculated. This experimental study shows the dependence of thermal stability on the amount and grade of impurities in gypsum. The results obtained contribute to the improvement of the basic concepts of the mechanism of decomposition of gypsum, as well as the explanation of some high-temperature phase formation processes in nature.

Neuritin attenuates neuroinflammation and apoptosis in early brain injury after subarachnoid hemorrhage via endoplasmic reticulum stress-related inflammatory pathways

Neuroinflammation is a key destructive pathophysiological process in early brain injury (EBI) following subarachnoid hemorrhage (SAH). Recent studies have discovered that endoplasmic reticulum stress-related inflammatory pathways include the IRE1α-TRAF2-NF-κB pathway, PERK-eIF2α-NF-κB pathway, and ATF6-AKT −NF-κB pathway leading to neuroinflammatory response. Neuritin is a neurotrophin that is involved in neuronal plasticity and regeneration. Studies have suggested that Neuritin has a vital role in reducing neuroinflammation, and can also decrease the expression of proteins related to endoplasmic reticulum stress following SAH. This suggests that Neuritin could be a potential therapeutic target for SAH and other neurological conditions. However, the regulatory mechanisms of Neuritin in ER stress-related inflammatory pathways after SAH are not yet fully understood. In this work, we discovered that the activation of ER stress-related inflammatory pathways leads to neuroinflammation, which further aggravates neuronal apoptosis after SAH. Our findings indicate that Neuritin overexpression play a neuroprotective role by inhibiting IRE1α-TRAF2-NF-κB pathway, PERK-eIF2α-NF-κB pathway, and ATF6-AKT-NF-κB pathway associated with endoplasmic reticulum stress. These inhibitory effects on neuroinflammation ultimately reduce nerve cell apoptosis.

Dynamics of Destruction of Two-dimensional Analog Models Discrete Environments with Different Organization of their Structural Compositions

Based on the main phenomenological features of the Coulomb-Navier rheological body, several most characteristic simulated models of discrete environments with different structural compositions have been proposed. Mechanical testing of the specified simulator models allows for investigating the dynamics of deformation (restructuring of composition) of discrete (including loose) environments with varying organization (within a wide range) of their structural compositions. The main thermodynamic peculiarities of the deformation and destruction processes of discrete environment structures under different variations of external loading application schemes have been identified.

A rare cause of a locally destructive process in the glottis area

A rare cause of a locally destructive process in the glottis area

Религиозный фактор в деструктивных социальных процессах (на примере исламизма)

Spiritual and cultural characteristics play a significant role in modern society. The religious factor is one of the key elements that ensure spiritual security, strengthen friendly relations between various ethnic and religious groups, and shape their self-determination. Religion is one of the driving forces of the development of civil society and even determines the degree of its intensity. Due to the increasing influence of religion on political processes, its influence is becoming extremely important for domestic and foreign policy activities, therefore, the government of any state should take into account religious specifics. The religious factor has a powerful consolidating condition in countering the development of destructive processes. At the same time, in order to satisfy personal ambitions and achieve political goals, despite the contradiction of the basic religious principles and doctrines, representatives of destructive religious trends actively use psychological methods of influence, using the faith and beliefs of their followers. The implementation of the proposed measures to ensure spiritual security in various spheres of civil society at all levels of government makes it possible to counteract destructive influences using religious beliefs. The aim of the study is to formulate the main outlines of a balanced policy in the ethno-confessional sphere and based on ideological principles that can provide conditions for agreement and unification of relations between political actors. It is precisely such ideological concepts that can act as a weighty opponent to the destructive process. In this study, methods based on rationalism, dialectics, comparative analysis, historiography were used, structural-functional and civilizational approaches were applied. The results of the research can be used in the development of conceptual documents in the field of security.

РЕГИСТРАЦИЯ МАГНИТОМОДУЛЯЦИОННЫМ ДАТЧИКОМ НИЗКОЧАСТОТНОГО ЭЛЕКТРОМАГНИТНОГО ИЗЛУЧЕНИЯ В ЛАБОРАТОРНЫХ ЭКСПЕРИМЕНТАХ ПО РАЗРУШЕНИЮ ОБРАЗЦОВ ГОРНЫХ ПОРОД

The article presents the results of observations of variations in magnetic induction using magnetomodulation sensors, which made it possible to register the signals of electromagnetic (EM) emission in the range of 0.01–200 Hz generated by rock samples under fast and slow uniaxial loading in laboratory experiments. The description of the equipment and measurement techniques used in the experiments is given. At two modes of loading rock samples differences in EM emission signals reflecting the peculiarities of the development of their destruction processes are found. It is shown that during the destruction of rock samples, the amplitude-frequency spectrum of magnetic field components clearly reveals the contribution of low-frequency harmonics, which is mainly concentrated in the frequency range below 15 Hz. It is established that magnetomodulation sensors have sufficient sensitivity and resolution to observe and register EM emission signals in the frequency range of 0.01–200 Hz, manifested during the destruction of rock samples in the process of their loading.

Dust evolution during a protostellar collapse: Influence on the coupling between the neutral gas and magnetic field

Context. The extent of the coupling between the magnetic field and the gas during the collapsing phase of star-forming cores is strongly affected by the dust size distribution, which is expected to evolve by means of coagulation, fragmentation, and other collision outcomes. Aims. We aim to investigate the influence of key parameters on the evolution of the dust distribution, as well as on the magnetic resistivities during protostellar collapse. Methods. We performed a set of collapsing single-zone simulations with shark. The code computes the evolution of the dust distribution, accounting for different grain growth and destruction processes, with the grain collisions being driven by brownian motion, turbulence, and ambipolar drift. It also computes the charges carried by each grain species and the ion and electron densities, as well as the magnetic resistivities. Results. We find that the dust distribution significantly evolves during the protostellar collapse, shaping the magnetic resistivities. The peak size of the distribution, population of small grains, and, consequently, the magnetic resistivities are controlled by both coagulation and fragmentation rates. Under standard assumptions, the small grains coagulate very early as they collide by ambipolar drift, yielding magnetic resistivities that are many orders of magnitude apart from the non-evolving dust case. In particular, the ambipolar resistivity, ηAD, is very high prior to nH = 1010 cm−3. As a consequence, magnetic braking is expected to be ineffective. In this case, large size protoplanetary discs should result, which is inconsistent with recent observations. To alleviate this tension, we identified mechanisms that are capable of reducing the ambipolar resistivity during the ensuing protostellar collapse. Among them, electrostatic repulsion and grain-grain erosion feature as the most promising approaches. Conclusions. The evolution of the magnetic resistivities during the protostellar collapse and consequently the shape of the magnetic field in the early life of the protoplanetary disc strongly depends on the possibility to repopulate the small grains or to prevent their early coagulation. Therefore, it is crucial to better constrain the collision outcomes and the dust grain’s elastic properties, especially the grain’s surface energy based on both theoretical and experimental approaches.

The Effects of Photodynamic Therapy with Low-Level Diode Laser Compared with Doxorubicin on HT-29 Colorectal Adenocarcinoma Cells Viability.

Background and Objective: Colorectal adenocarcinoma is considered one of the major causes of cancer-related lethality among other type of malignancies. Given the several limitations and adverse outcomes of conventional therapeutic regimens against colorectal cancer, the focus of many investigations has been attributed to the introduction of a novel combined regimen with harmless agents. The purpose of the present study was to investigate the effect of combined doxorubicin (DOX) treatment and photodynamic therapy (PDT) on colorectal adenocarcinoma cells. Material and Methods: HT-29 cells were exposed to different concentrations of DOX, low-level (630 nm) diode laser, and methylene blue (MB) as a photosensitizer substrate separately and a combination of them. The cytotoxic effect of the DOX, laser, MB, and their combination and the IC50 value for each treatment group were calculated by 3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT). The malondialdehyde (MDA) content as a biomarker of the lipid peroxidation process and liberated lactate dehydrogenase (LDH) enzyme into supernatant was determined. Results: The results of our study evidenced that a combination of photodynamic light (laser plus MB) and DOX caused a significant reduction in the percentage of HT-29 viable cells compared with control and other treatment groups. In addition, this mentioned combination led to a considerable decrease in IC50 of DOX. Increased cell membrane lipid peroxidation and cell destruction processes in the combination therapy group were proven through significant elevation of MDA content and LDH activity in the medium, respectively. Conclusion: The findings of the present study suggested that DOX combined with PDT had a better therapeutic impact on HT-29 colorectal adenocarcinoma cells. Hence, the simultaneous application of PDT along with antineoplastic drugs improves the chemosensitivity of cancerous cells via the disruption of their membrane and triggering death processes that lead to the decrease of chemotherapeutic agents required doses and undesirable effects.

Study of Structural Defects Evolution in Fine-Grained Concrete Using Computed Tomography Methods

Introduction. When studying composite materials for construction purposes, it is needed to consider the mechanisms of formation of the structure and properties of modern concretes in the process of strength development. In studies of modern composite materials based on cement binder, there is no information about the development of structural defects and destruction of the material at the initial stages of strength development. This information can be obtained using X-ray computed tomography, a promising method of nondestructive testing of the state of the material. Therefore, the objective of this work was to study the formation and propagation of cracks in samples of fine-grained concrete with different fractional composition of sand due to natural processes of cement shrinkage, as well as the mechanics of destruction of samples of modified fine-grained concrete when applying a compressive load at the early stages of strength development. Materials and Methods. The study used fine-grained concrete mixtures of three compositions with different sand gradation. The tomography samples were made by placing fresh mixtures in polymer cylindrical containers. Tomography of the samples immediately after manufacture, as well as after 8 and 51 days, was performed in a YXLON Cheetah microfocus X-ray machine. The composition with two-fraction sand was modified by mechanical activation of the components, 20×20×20 mm cube samples were made. Further, compression tests were performed at the Instron installation after 3 and 7.5 hours, and then — tomography of the destroyed samples.Results. It was established that the destruction of contact zones depended on the ratio of the size of the fractions. In the presence of a bulk of coarse sand grains in concrete, the destruction of contact zones was more pronounced and had a main mode. When using fine or polyfraction sand, contact zones were destroyed locally and had a visually smaller area. The images of the destroyed modified sample, tested 3 hours after manufacturing, showed clear cracks and indents on the edges, which indicated the elastic-plastic nature of the destruction. In 7.5 hours, the edges of the sample upon destruction were covered with a network of small cracks; inside the sample there were also numerous cracks and microcracks, which indicated brittle fracture. Based on the obtained images of the deformed structure of modified concrete, the mechanism of transition from elastic-plastic destruction of the material to brittle one was clearly visible.Discussion and Conclusion. The studied dependences of the influence of the size of fine aggregate on the mechanisms of formation and propagation of structural defects contribute to the theory of the processes of destruction of fine-grained concretes. The results obtained prove the prospects of using X-ray computed tomography as a method of nondestructive testing of the internal structure of fine-grained concrete, including at the early stages of strength development.

Kinetic parameters of thermal decomposition of biofuels and its oil-containing composites

The kinetic features of the decomposition of fuel pellets formed from birch phloem and its composites with the addition of oil-containing waste (OCW) were studied by methods of thermogravimetric analysis carried out in various atmospheric conditions. The characteristic temperature ranges of thermal decomposition of the materials from which pellets are formed were identified, the rates of mass loss and activation energy at the main stages of thermal decomposition were evaluated, and the combustion indices of composite compositions were determined to identify the possibility of using such compositions as alternative fuels. By evaluation of activation energies for each stage of sample decomposition, the limiting influence of certain stages on the process of thermal destruction was established.