Destructive Effects Research Articles

The destruction of cytoplasmic skeleton leads to the change of nuclear structure and the looseness of lamin A submicroscopic network

The interaction between lamin A and the cytoplasmic skeleton plays a key role in maintaining nuclear mechanical properties. However, the effect of destruction of the cytoplasmic skeleton on the 3D submicroscopic structure of lamin A has not been elucidated. In this study, we developed an image quantization algorithm to quantify changes in the submicroscopic structure of the intact lamin A 3D network within the nucleus. We used blebbistatin or nocodazole to disrupt the fibrillar structure of F-actin or tubulin, respectively, and then quantified changes in the lamin A super-resolution network structure, the morphological and mechanical properties of the nucleus and the spatial distribution of chromosomes. Ultimately, we found for the first time that disruption of the cytoplasmic skeleton changes the lamin A submicroscopic network and nuclear structural characteristics. In summary, this study contributes to understanding the trans-nuclear membrane interaction characteristics of lamin A and the cytoplasmic skeleton.

Denatured Nature

Abstract This essay places the narrative of the Spanish writer José A. Cano (b. 1954 in Madrid) within the context of contemporary Spanish ecofiction. Concerned with the state of global humanity, Cano reflects a growing postnational perspective among Spanish writers whose works critically address the challenges of the Anthropocene—in particular, the destructive effects the tenets of Western modernity (Kantian ethics, utilitarian values, human-Nature divide, logic of exploitation, dualistic and anthropocentric thought, etc.) have had on the more-than-human world. Heavily influenced by the Romanian philosopher E. M. Cioran, Cano’s novel La felicidad del Malvado (2023) offers a pessimistic outlook regarding the future of humankind. Miguel de Cervantes’s Don Quixote provides another backdrop for this transatlantic novel, situated between the United States and Madrid, allowing Cervantine humor to balance out Cioran’s omnipresent voice of doom.

Damage assessment method of clay brick masonry load-bearing walls under intense explosions with long duration

The vulnerability of clay brick masonry load-bearing (CBML) walls under low-intensity explosions has been extensively investigated. In recent years, large-scale explosions have raised wide concerns about the destructive effect of intense explosions. Intense explosions induced by large TNT equivalent explosives usually cause severe damage to building structures within several kilometers. Although the damage of building structures under intense explosions and normal low-intensity explosions might be different, the differences have yet received any attention in previous studies. Therefore, this study numerically investigates the dynamic performance of CBML walls under intense explosions with long duration (IELD). Firstly, the numerical model is validated by reproducing experimental records. Then the verified model is utilized to investigate the dynamic response and dynamic modes of CBML walls under IELD. Based on the identified failure mechanism, the effects of several parameters such as axial compression ratio, compressive strengths of masonry materials and wall geometry on the damage degrees of CBML walls are analyzed in detail. The damage index based on the residual axial loading capacity of CBML wall is proposed for damage evaluation. The damage assessment method is established for CBML walls under IELD, which can help to evaluate the damage level of clay brick masonry structures under far-field intense explosive scenarios.

Dental damage: Creating 3D anatomical models to illustrate destructive effects on human teeth

Forensic odontologists often must identify human remains with damaged teeth. This damage is due to high-impact accidents, violence, or disasters. This 2-part study aimed to create two 3D digital models. They should show the destructive effects of physical and chemical agents on human teeth and popular dental materials. Researchers created an e-survey to investigate how digital models are perceived as an educational tool for Forensic Odontology. Also, a systematic review assessed experimental studies on the effects of high temperature on various prosthodontic materials. According to the results of the survey, most participants (n=69; 79%) agreed that they would find a 3D model useful for training. Participants misidentify images of burned and broken teeth under Ellis and Davey system (1970). The systematic review identified dental implant and dental crown as the most studied prosthodontic materials exposed to heat. The researchers designed dental damage model 1 to represent restored and unrestored burnt teeth, postmortem pink teeth, and traumatic injuries. The dental damage model 2 was created to demonstrate the effects of various types of damage to different prosthetic and restorative dental materials, as well as the impact of acid, water, and burial on restorative materials as additional information. Both models were edited, sculpted and painted using 3D modelling software ZBrush (2020. 1.4) and Blender (version 3.6.2). The dental damage models were uploaded and labelled on Sketchfab (Cédric Pinson, Paris, France). The study's materials could transform the teaching of complex tooth changes.

Keep Cool but Don't Freeze: The Influence of William J. Mills Jr. on the Treatment of Frostbite.

Dr William J. Mills Jr., an Alaskan orthopedic surgeon, helped establish the current protocols for frostbite treatment and changed a dogma used for more than 140 years that was established by Napoleon's surgeon general of the army, Baron Dominique-Jean Larrey. During Napoleon's 1812 siege of Moscow, Larrey noticed the destructive effects of using open fire heat for warming frozen body parts, so he suggested rubbing snow or immersion in cold water. Dr Mills treated many cold injuries during his medical career. After setting up his medical practice in Anchorage, Alaska, he realized the inefficiency of the established protocols and started researching new treatments for frostbite. Dr Mills followed Meryman's method of rapidly thawing frozen red blood cells in warm water. Mills and his colleagues established a treatment protocol for freezing cold injury that included rapid warming in warm water. These studies resulted in the publication of three key papers in 1960 and 1961. These papers were the first clinical studies that described rapid warming as a treatment. Subsequently, rapid warming, with some variation in water temperatures, has been accepted as the standard of treatment. Due to his outstanding contribution to the treatment of frostbite, he has been referred to as "the nation's leading authority on cold injury." Mills and his colleagues created a new classification system that divided frostbite into two levels, superficial and deep, which was more applicable in clinics than the traditional 4-tier classification. The 2-tier classification is still useful outside of the hospital setting.

Protective Effect of Bio-Scaffold Against Vitrification Damage in Mouse Ovarian Tissue.

Ovarian tissue cryopreservation is regarded as useful method for fertility preservation. This study aimed to preserve most of the follicular reserve from the destructive effects of cryoprotectant solutions and liquid nitrogen. For this purpose, 48 female NMRI mice (8 weeks old) were randomly divided into six groups: Fresh (not vitrified), Vitrification (not encapsulated), Alginate 1 (encapsulated in 1% alginate hydrogel before placing in vitrification solutions), Alginate 2 (encapsulated in 1% alginate hydrogel before placing in liquid nitrogen), Aloe vera 1 (encapsulated in Aloe vera pieces before placing in vitrification solutions), Aloe vera 2 (encapsulated in Aloe vera pieces before placing in liquid nitrogen). After vitrification and warming, the histological evaluation showed that the average number of intact primordial follicles decreased significantly in all groups compared to the Fresh group. (P < 0.05). Results of evaluating the expression of apoptosis-related genes showed that the ratio of Bax/Bcl2 and P53 significantly decreased in the Alginate 2 group compared with the vitrification group. The level of Kit gene (KIT proto-oncogeni receptor tyrosine kinase gene) expression was either the same or lower in the experimental groups than in the vitrification group, but there was no statistically significant difference. Levels of tissue nitric oxide (NO) and malondialdehyde (MDA) in Alginate groups 1 and 2 showed a significant decrease compared with the vitrification group (P < 0.05). To conclude, Encapsulation of ovaries in 1% alginate hydrogel before immersion in liquid nitrogen may reduce the damage caused by cryopreservation.

Ментально-поведенческие особенности поколений россиян (по социологическим материалам)

In the context of the social transformation of Russian society, various contradictions (obvious and latent) took place in different spheres of society. In particular, there are noticeable differences in the mental and behavioral characteristics (traits, characteristics, mentality) of Russians generations causing destructive effects and social conflicts, including in intergenerational relationships. The article is based on the analysis of the problem situation: which positive and negative features are most characteristic of Russians, according to the estimates of respondents of different age and generational groups? The general assessment of their generation by the majority of respondents is generally quite positive. The distribution of positive and negative traits of generations, compiled on the basis of respondents' assessments, shows noticeable mental and behavioral differences between the younger, middle and older generations, especially the younger generation. However, the mental autonomy of the younger generation cannot be considered as a semblance of complete (especially absolute) isolation and separation of youth from other generations. At the same time, according to the sociological data, despite the critical attitude towards the state of large masses of Russians, the potential of patriotism and citizenship is very high and predominant in all age-generational groups.

Study on interfacial regulation in real food system: Cellulase-induced steady-state reconstruction of flaxseed-based plant milk and its molecular mechanisms

Cellulase is commonly used for the better release of phytonutrients due to its destructive coordinate effect on plant cell walls. In this study, cellulase hydrolysis showed a new feature: it significantly increased the physicochemical stability of flaxseed-based plant milk (FPM) due to interfacial modification of the oil bodies. Multispectroscopy and rheological measurement were performed to evaluate the stability of FPM, while the mechanical and oxidation stability of flaxseed oil bodies (FOBs) were characterized by rheological and induction period analysis, respectively. Additionally, Cryo-SEM, FTIR, and XRD analysis were used to provide structural information of FOBs' interface. Results revealed that cellulase treatment reduced the particle size and TSI of FPM, and significantly increased the adsorption of total polysaccharides at the FOBs’ interface, with an increase of 20.25 ± 3.77% (P < 0.05). Furthermore, FOBs with enzyme treatment (EN-FOBs) possessed higher elastic modulus (G′) and viscous modulus (G″) at 90 °C than untreated ones. Meanwhile, the induction period of the EN-FOBs was prolonged by 10.47 ± 2.10% (P < 0.05). These findings indicated that cellulase promoted steady-state reconstruction of FPM by contributing to formation of complex interfaces with high mechanical strength. These results offer insight into innovation in plant-based milk processing technology towards green, clean labeling, and high-quality.

Constructive and Destructive Effects of Mediatization in Political Communications in the XXI Century

Constructive and Destructive Effects of Mediatization in Political Communications in the XXI Century

Destructive effect of UV-C light radiation on lettuce growth: risk assessment of long time exposure

Ultraviolet C (UV-C) light technology employs a particular wavelength within the ultraviolet spectrum to deactivate microorganisms, utilizing radiation as its method. UV-C light possesses germicidal properties, effectively disrupting the DNA of microorganisms such as bacteria, viruses and various pathogens, thereby impeding their ability to replicate and induce illness. Additionally, UV-C could enhance the production of phytochemicals and prevent contamination in agricultural applications. However, overexposure to UV-C can cause safety issues, especially for operators handling its utilization in germicidal or sterilization applications. This study investigated the destructive effects of UV-C light on the morphology and chlorophyll content of lettuces exposed to various durations, aiming to assess the risks associated with prolonged exposure. The results showed that prolonged UV-C exposure affects morphological and chlorophyll content changes. The most damaging effect on lettuce morphology and chlorophyll content was found in the 2 h of UV-C exposure treatment. In the 2 h of UV-C exposure treatment, lettuce length was reduced from 6.01 ± 0.80 cm on day 2 to 5.55 ± 0.78 cm on day 3. The lowest fresh weight of lettuce was also found at 2 h of UV-C exposure treatment (4.32 ± 0.94 gr). In addition, the lowest total lettuce stomata aperture was found in 2 h of UV-C treatment (41 units). Furthermore, on day 4, after 2 h of UV-C exposure treatments, the chlorophyll a, chlorophyll b and total chlorophyll content in lettuces were found to be 1.59 ± 0.02 mg g−1 FW, 0.93 ± 0.02 mg g−1 FW and 2.52 ± 0.04 mg g−1 FW, respectively. Therefore, the most destructive effect of UV-C was found during 2 h of UV-C exposure treatment. These findings indicate the dangers of long-term UV-C exposure to lettuce. Practically, this could also have a negative impact on humans. The knowledge gleaned from these findings is useful for safety issues in the industrial application of UV-C.

Mapping the Occupations of Recent Graduates. The Role of Academic Background in the Digital Era

The progressive robotisation and the introduction of artificial intelligence imply economic and social changes. In this paper, we investigate their impact on the occupations of recent Spanish graduates and examine how graduates with different skills can expect their occupations to be transformed by the digital era. To this end –using a three-step approach—we first map occupations in terms of the level of the transformative and destructive effects of digitalization, and determine which groups are most threatened. Second, we characterize the technological occupational groups according to dimensions related to worker and job requirements, such as abilities, skills and tasks performed. Finally, we explore the influence of educational background on the probability of belonging to each group. The analysis relies on three data sources—the main one being microdata from the Survey on Labour Market Insertion of University Graduates (EILU-2019)—which provide exhaustive information about students’ education and training during and after their degree. Results show that only about 15% of graduates hold jobs that have a high probability of being replaced by machines over the next 10–20 years, although a significant number will still face changes in their occupations that will affect skill requirements. Graduates working in these occupations will need a high level of flexibility if they are to adjust to rapid changes and not be displaced. Moreover, certain features of students’ academic background –such as the field of study or more formal education– play a key role and offer some tips to mitigate possible disruptions in graduate employability.

Hydrogen sulfide upregulates hypoxia inducible factors and erythropoietin production in chronic kidney disease induced by 5/6 nephrectomized rats.

In end stage renal disease )ESRD(, reduced EPO production resulted in decreased oxygen diffusion that cause Hypoxia-inducible factors (HIFs) stabilization. The mechanism of beneficial effects of H2S in chronic kidney disease (CKD) is the aim of the present study to examine the effects of the H2S donor sodium hydrosulfide (NaHS) on renal function parameters, oxidative stress indices and expression levels of HIF-2α gene and erythropoietin protein in 5/6 nephrectomy-induced chronic renal failure in rats. Male rats were assigned into 3 groups (n = 8): Sham, CKD and NaHS groups. In the CKD group, 5/6 nephrectomy was performed. In the sham group, rats were anesthetized but 5/6 nephrectomy was not induced. In the NaHS group, 30 µmol/L of NaHS in drinking water for 8 weeks was adminstrated 4 weeks after 5/6 nephrectomy induction. At the end of the 12 week, blood and renal tissues were taken to evaluate renal function parameters, oxidative stress indices and expression levels of HIF-2α gene and erythropoietin protein. The induction of 5/6 nephrectomy significantly caused renal dysfunction, oxidative stress, increased HIF-2α gene expression and decreased erythropoietin levels in renal tissue samples. NaHS administration resulted in a marked improvement in renal function and oxidative stress indicators, a marked reduction in HIF-2α gene expression as well as an increase in erythropoietin protein levels in comparison with the CKD group. In this study, regional hypoxia and oxidative stress in CKD, may cause the stabilization of the HIFs complexes, although erythropoietin synthesis was not increased due to destructive effects of CKD on the kidney tissues. Administration of NaHS caused up-regulating HIF-erythropoietin signaling pathway.

Numerical investigations of seismic-resilient techniques for legged fluid storage tanks utilising magnetorheological dampers

Different energy-dissipating devices have been proposed in the literature to attenuate the destructive effects of base excitations over fluid storage tanks. These structures have numerous applications in strategic industries and their failure can result in environmental hazards and huge economic losses. Proposed techniques in the literature for seismic energy dissipation of fluid-contained tanks are mostly centred on passive and active control mechanisms. Semi-active control devices using materials with adjustable properties offer advantages of both active and passive systems while removing their drawbacks. In this paper, the performance of a Magnetorheological (MR) damper on the seismic response reduction of fluid storage tanks through the application of three different control strategies including H2/LQG, PID, FOPID, and two passive techniques, i.e. Passive On, and Passive Off has been investigated. Parameters of the semi-active controllers are optimally designed for each aspect ratio and the applied ground motion using the Hunger Game Search (HGS) technique and finally, the semi-active Clipping algorithm commands the voltage to the damper. The fluid-tank-MR damper system has been examined under three Far-Fault and three Near-Fault ground motions. Numerical simulations have demonstrated that depending on the aspect ratio, applied ground motion, and the control strategy, the MR damper can mitigate the peak relative displacements and absolute accelerations of the two major modes of the system, i.e the rigid and impulsive modes, up to 72% and 67%, respectively. This proves the efficacy of these dampers in reducing the maximum base shear and overturning moment, hence mitigating the damage risks in these structures.

Incorrectly Focused Neodymium:Yttrium-Aluminum-Garnet (Nd:YAG) Laser Beam Leads to Massive Destructive Effects in Small-Aperture (Pinhole) Intraocular Lenses.

Pinhole intraocular lenses (IOLs) were developed to improve reading by compensating for loss of accommodative function. The IC-8® Apthera™ is a small-aperture presbyopia-correcting IOL that combines the proven principle of small-aperture optics with an aspheric monofocal lens to deliver a continuous range of vision for patients withcataractsfrom distance to near vision. Posterior capsule opacification is the most common sequela after cataract surgery. It is effectively treated by laser capsulotomy. However, if the laser beam is incorrectly focused, the IOL can be permanently damaged (pits/shots). In this experimental study, yttrium-aluminum-garnet (YAG) pits were purposefully created. Defects were analyzed and compared between the periphery of the ring in the clear area of the hydrophobic acrylic lens and at the carbon black (CB)-polyvinylidene fluoride (PVDF) filtering component (FilterRing™) of the pinhole lens. All defects were made using identical settings/energy levels (2.6mJ). The damage induced to the IC-8® Apthera™ IOL was examined by low-magnification images, light microscopy, scanning electron microscopy, and micro-computed tomography (micro-CT). YAG defects in the carbon black filter ring were much more severe than those in the clear zone due to the high absorption of the carbon black. Massive defects and destruction of the lens with tearing out of fragments and particles were observed. The missing volume calculated from the micro-CT reconstruction was 0.266 mm3, which is 1.6% of the entire IOL volume, or more than 1000 times the volume damaged in the largest shot in the periphery. Based on the results, we highly recommend using the lowest possible energy levels, posterior offset setting, and circular pattern for maximum safety when performing laser capsulotomy with pinhole implants. Care should be taken to avoid creating irreversible iatrogenic defects that may affect overall quality. The safest area for performing capsulotomy seems to be the periphery of the ring segment. Video available for this article.

Production and characterisation of antioxidant and antibacterial polymeric nanoparticles loaded with Oenocarpus bataua phenolic extract

SummaryOne recent trend in the food industry is using natural antioxidants and antimicrobials as additives for developing multi‐functional packaging. In this study, phenolic compounds from patawa (PEP), a neglected Amazon palm tree, were extracted and encapsulated in nanoparticles based on acetylated cashew gum polysaccharide (acCGP) and chitosan (CS) using a nanoprecipitation technique. The primary objective was to evaluate the antioxidant activity and antibacterial properties of PEP and acCGP/CS@PEP. Results from HPLC‐MS showed that PEP is mainly composed of epicatechin, naringenin and rutin. acCGP/CS@PEP nanoparticles showed a spheric and smooth microstructure, observed with 40.1% PEP encapsulation into the nanoparticles. The main encapsulated phenolics were luteolin, quercetin and epicatechin. Also, FTIR spectroscopy, X‐ray diffraction and differential scanning calorimetry analyses evidenced the success of PEP encapsulation. Results from antioxidant activity evidenced that acCGP/CS@PEP has a DPPH scavenging activity 45‐fold higher than the unencapsulated PEP, a 5‐fold higher ferric reducing power and 20‐fold higher antioxidant potential against ABTS. Similarly, acCGP/CS@PEP had higher antibacterial activity against Escherichia coli (MIC = 2.24 mg mL−1), Salmonella enteritis (MIC = 4.48 mg mL−1) and Staphylococcus aureus (MIC = 4.48 mg mL−1). Analysis by SEM evidenced that acCGP/CS@PEP had a potent destructive effect with disruption of the bacterial cell membrane and liberation of cytoplasmic content. These findings demonstrated that PEP could be efficiently encapsulated in acCGP/CS nanoparticles, and this strategy could improve the efficiency of PEP as a bioactive compound for developing active packaging.

Climate apartheid: the failures of accountability and climate justice

PurposeSevere inequality from climate change exists between the Global North and Global South. The North significantly contributes to climate change yet retreats to protect itself against its harmful impacts. Conversely, members of the Global South bear the brunt of the climate crisis with limited protection against its destructive effects. Climate justice aims to address this inequality. This paper explores the effects of climate change reforms and policies that have been established to foster accountability and climate justice.Design/methodology/approachThis research follows a qualitative exploratory case study method. It draws on a supply- and demand-led approach and local accounts to analyse the (in)effectiveness with which six national and international reforms and policies have achieved accountability for climate justice. The research analysed a variety of empirical documents including contemporary research, reports, academic literature, non-government and government documents and policies, media releases and Pacific Islander accounts.FindingsClimate change reforms and policies, which come together to form supply-side accountability, have largely failed to engender accountability in the Global North for the impacts of climate change. Nor have they mitigated climate change to any tangible extent at all. This has created a system of modern-day climate apartheid. Improving accountability and remediating climate injustices going forward will require a focus on demand-led instruments and accountability, which includes the voice of citizens.Originality/valueThis paper responds to AAAJ’s special issue call for examining accounting and accountability with regard to environmental and climate racism. Limited research to date explores the issue of climate apartheid and climate justice and its relationship with accountability. This research attempts to fill that gap.

Robustness of highly complex radial carpet beams in turbulent atmospheres

In this study, we report observations of propagating radial carpet beams (RCBs) through a turbulent atmosphere at ground level with a 120 m path length. RCBs are a class of nondiffracting, accelerating, self-healing, and self-amplifying beams, and generated in the diffraction of a plane wave from amplitude/phase radial gratings having different spoke numbers. Observations were made at different times of the day. The intensity profile of an RCB becomes complicated when the number of grating spokes used to generate the beam is large, and includes high intensity spots, called main intensity spots (MISs), which are symmetrically placed at the central area around the beam axis and whose number is equal to (twice) the number of spokes of the amplitude (phase) grating used to generate the beam. With the aid of a telescope and a CCD camera, successive frames of the intensity pattern of the RCBs having different levels of structural complexity are recorded at the end of the path. For the data recorded at different times of the day, we calculate the variance of displacements of MISs along the radial direction. We observe that displacements of the MISs increase with increasing mean temperature of the air; on the other hand, as the complexity of the beam intensity pattern increases, the displacements of the MISs decrease. In order to compare the resilience of different RCBs and a well-known structured beam against atmospheric turbulence, we investigate deformation of the intensity profiles of a Laguerre–Gaussian (LG) beam having a topological charge 20 and different RCBs at the end of the path. It is shown that under the same turbulence condition, highly complex RCBs are more resilient to the destructive effects of the atmospheric turbulence. In particular, for the RCBs generated with gratings having 30 spokes and more, the number of MISs of the received intensity patterns is changed by less than 1% even when the turbulence strength is high. But for the LG beam, its intensity ring is clearly broken in different places, which makes it impossible to follow its maximum intensity in the radial direction

GSTP1-A313G genetic polymorphism and the risk of preeclampsia in pregnant women: A study in the northern population of Iran

Preeclampsia or high blood pressure in pregnancy is one of the special disorders during pregnancy. It seems that oxidative stress plays an important role in the occurrence of this disease. The purpose of this study is to investigate the relationship between the A313G polymorphism in exon five of the glutathione S-transferase gene (GSTP1) and the risk of preeclampsia in a case-control study. In this study, blood samples were collected from 70 healthy pregnant women and 70 women with preeclampsia. After genomic DNA extraction, the PCR-RFLP method was performed to check the genotype in GSTP1-A313G and the genotypic frequencies of AA, AG, and GG were determined in all samples. Also, using bioinformatics software, the effect of the above polymorphism on the protein structure was investigated. Statistical analysis for A313G polymorphism showed that AG (OR: 1.1684, 95 % CI: 0.5877–2.3228, p = 0.657) and GG (OR: 1.3793, 95 % CI: 0.3376–5.6359, p = 0.654) genotypes were not associated with risk of preeclampsia in the population of northern Iran. However, bioinformatic analyzes have shown that this polymorphism does have a destructive effect on the protein structure. However, more studies with larger sample sizes are needed to draw firm conclusions.

Factor analysis of innovative activity of the regional economic system

Relevance. Innovation activity is one of the fundamental indicators of the effectiveness of innovation activity in the region. In the context of external challenges and economic instability, innovation is a fundamental vector of development of the domestic economy. However, the effectiveness of innovation activity is currently reduced due to the influence of risk factors of various etiologies. Therefore, the assessment of the factors influencing the innovative activity of the region determines the relevance and significance of the study.The purpose is to determine the influence of factors on the innovative activity of the region and its subjects, taking into account the ranking according to the degree of impact and the possibility of a restraining influence on the innovative potential of the region.Objectives. The following tasks were set and consistently solved in the study: to conduct a theoretical review of the concept of "innovative activity"; to identify factors; to classify and identify the degree of influence on the innovative activity of the region.Methodology. The paper uses a theoretical review of domestic and foreign authors dealing with the issues of factorial influence on the innovative activity of the region and its subjects. During the research, special methods were used: regression analysis, statistical analysis, expert approach, etc.Results. Based on the factor analysis, factors were identified, grouped, classified, and the degree of influence on the innovative activity of the region was determined, which helped to identify the cause of problems in the region (using the example of the Vladimir region).Conclusions. During the study, it was concluded that factor analysis allows us to examine the current state of innovation activity in the region and find the causes that have the greatest destructive effect on the indicator of innovation activity.

Finite Element Method-Peridynamics Coupled Analysis of Slope Stability Affected by Rainfall Erosion

Rainfall is a pivotal factor resulting in the cause of slope instability. The traditional finite element method often fails to converge when dealing with the strongly nonlinear fluid–solid coupling problems, making it impossible to fully analyze the sliding process under the state of slope instability. Therefore, this paper uses the coupling of peridynamics (PD) and the finite element method (FEM) to propose a data exchange mode between the seepage field and the deformation field. The influencing factors of fine particle erosion during rainfall are further considered. According to the damage mechanism of the slope sliding process to the original structure of the soil, a modified erosion constitutive relationship is proposed, which takes into account the destructive effect of plastic deformation on coarse particles. Then, the influence of rainfall duration, rainfall intensity, erosion, and initial saturated permeability coefficient on slope stability was simulated and analyzed. This paper provides a novel concept for slope stability analysis and safety evaluation under rainfall conditions.