This study intends to investigate the dynamic model estimation and the design of an adaptive neural network based controller for a passive planar robot, performing 2-DoF motion pattern which is in interaction with an actuated cable-driven robot. In fact, the main goal of applying this structure is to use a number of light cables to drive serial robot links and track the desired reference model by the robot’s end-effector. The under study system can be used as a rehabilitation setup which is helpful for those with arm disability. In this way, upon applying sliding mode error dynamics, it is necessary to determine a vector that contains the matrices related to the robot dynamics. However, finding these matrices requires the use of computational approaches such as Newton-Euler or Lagrange. In addition, since the purpose of this paper is to express comprehensive methods, so with increasing the number of links and degrees of freedom of the robot, finding the dynamics of the robot becomes more difficult. Therefore, the Adaptive Neural Network (ANN) with specific inputs has been used for estimation unknown matrices of the system and the controller design has been performed based on it. So, the main idea in using an adaptive controller is the fact there is no pre-knowledge for the dynamic modeling of the system since the human arm could have different dynamic properties. Hence, the controller is formed by an ANN and robust term. In this way, the adaptation laws of the parameters are extracted by Lyapunov approach, and as a result, as aforementioned, the asymptotic stability of the whole of the system is guaranteed. Simulation results certify the efficiency of the proposed method. Finally, using the Roots Mean Square Error (RMSE) criteria, it has been revealed that, in the presence of bounded disturbance with different amplitude, adding the robust term to the controller leads to improve the tracking error about 34% and 62%, respectively.