University entrepreneurs' psychological wellbeing (PWB) is a gigantic problem that substantially affects their academic performance, health, innovative capabilities, and more comprehensive societal contributions. In this study, we examine mental hindrances, such as stress, anxiety and depression and entrepreneurship-related constructs, such as entrepreneurial purpose (ENSE), entrepreneurial carefulness (ENSS) and entrepreneurial desire (ENRE) that predict PWB among Egyptian university entrepreneurs. In this quantitative study, we used a questionnaire and a convenience sampling strategy to collect cross-sectional data from Egyptian public-sector university students. In total, we collected 328 cases to infer the results. From applying path analysis through AMOS software, this study’s findings exhibit that mental hindrances, such as stress (β = -0.016; p = 0.187), anxiety (β = -0.055; p = 0.115) and depression (β = -0.027; p = 0.280) have a negative effect on entrepreneurs' PWB. Conversely, this study’s results exert, also, the positive influences that ENSE (β = 0.407; p = 0.000), ENSS (β = 0.0221; p = 0.003), and ENRE (β = 0.145; p = 0.000) have on Egyptian university entrepreneurs' PWB. This study’s outcomes support policymakers and university authorities in shaping strategies to reduce stress and anxiety among Egyptian students and inspire individuals to feel positive emotions. These can lead to initiating good proposals and developing hope. Moreover, this study’s findings provide reassurance and inspiration for Egyptian university entrepreneurs and encourage them to enhance their intentions toward entrepreneurship and, in turn, improve their PWB. Ultimately, this study’s outcomes significantly contribute to the existing literature on this topic.