ABSTRACT The porous medium combustion (PMC) is an emerging area in liquid fuel combustion, which has the ability to reduce emission and increase the fuel economy. Various operational parameters will affect the performance of liquid fuel-fired Porous Medium Burner (PMB). So, this present work focuses on finding the effect of operational parameters on the performance of PMB and to optimize it. This study was conducted in a double-layered porous burner with self-aspirated pressurized stove. Three input factors were selected, namely, fuel pressure (bar), throttle angle (°), and type of burner (Conventional burner (CB), PMB). The three output responses selected are thermal efficiency (ηth), CO (ppm), and NOX (ppm) emissions. The inscribed central composite design (ICCD) was used to design the experimental run. The response surface methodology (RSM) with desirability approach was used to optimize the multi-objective responses. The statistical analysis with ANOVA confirmed the significance of all the three input variables on the output responses. The regression model was developed with quadratic fit and it well predicts the burner performance and emission with R2 value close to 1. The multi-objective optimum input settings are found by desirability approach, i.e. fuel pressure = 1.60 bar, throttle angle = 161.3°, and burner type = PMB. The corresponding optimized responses are found as ηth = 58.39%, CO = 201. 49 ppm, and NOX = 6.43 ppm. The above optimum settings and responses are confirmed with experimental confirmation test, which is in the satisfactory level.