BackgroundMixers are usually inserted into microalgal photobioreactors to generate vortices that can enhance light/dark cycles of algal cells and consequently enhance biomass productivity. However, existing mixer designs are usually developed using a trial-and-error approach that is largely based on the designer’s experience. This approach is not knowledge-based, and thus little or no understanding of the underlying mechanisms of mixer design for mixing performance of photobioreactors is attained. Moreover, a large pumping cost usually accompanies mixer introduction, and this cost is not favorable for practical applications. This study aims to improve this situation.ResultsIn addition to the individual effects of flow and light fields, improving the synergy (coordination) between these fields may markedly enhance the L/D cycle frequency with a lower increase in pumping costs. Thus, the idea of synergy between flow and light fields is introduced to mixer design. Better synergy can be obtained if (a) the vortex core and L/D boundary are closer to each other and (b) the vortex whose core is too far from the L/D boundary is removed. The synergy idea has two types of applications. First, it can facilitate a better understanding of known numerical and experimental results about mixer addition. Second, and more importantly, the idea can help to develop new rules for mixer design. A helical mixer design is provided as a case study to demonstrate the importance and feasibility of the synergy idea. An effective method, i.e., decreasing the radial height of the helical mixer from the inner side, was found, by which the L/D cycle frequency was enhanced by 10.8% while the pumping cost was reduced by 23.8%.ConclusionsThe synergy idea may be stated as follows: the enhancement of L/D cycle frequency depends not only on the flow and light fields individually but also on their synergy. This idea can be used to enhance our understanding of some known phenomena that emerge by mixer addition. The idea also provides useful rules to design and optimize a mixer for a higher L/D cycle frequency with a lower increase in pumping costs, and these rules will find widespread applications in PBR design.