Biophilic design has gained prominence in architecture as a strategy to integrate natural elements into built environments, aiming to improve human comfort, well-being, and environmental sustainability. This paper critically reviews existing biophilic design frameworks, identifying gaps in their integration of health outcomes and the relationship between indoor and outdoor environments, with a primary focus on indoor environmental quality (IEQ) factors such as air quality, natural light, thermal comfort, and acoustics. The review was conducted systematically, comparing frameworks using criteria such as health benefits, human–nature connections, and user satisfaction. Key findings highlight a lack of comprehensive frameworks that explicitly link biophilic design to measurable improvements in human health, comfort, and satisfaction. To address this gap, the study proposes an enhanced biophilic design framework that bridges IEQ-focused indoor environments with urban outdoor elements, prioritizing human comfort alongside environmental sustainability. The framework also emphasizes the role of post-occupancy evaluation (POE) in assessing the real-world performance of biophilic interventions, particularly in achieving user satisfaction and ensuring long-term effectiveness. This research contributes to the advancement of biophilic design by offering actionable strategies for architects, urban planners, and policymakers to adopt biophilic principles that create resilient, healthy, and sustainable spaces. Additionally, the study emphasizes the need for empirical testing and validation of the proposed framework, including POE and user surveys, to assess its real-world impact on human well-being and satisfaction, thus setting the stage for future research.