In order to solve the problems of restricted classroom and lack of repeated training in good curriculum, the design and development of a school life adaptation curriculum based on VR is proposed. This study identified six life adaptation themes for design and development (recognizing facial expressions, crossing the road, how to get lost, shopping, taking public transport, and job interview) and set the objectives, design principles, specific content, teaching evaluation, and other aspects of virtual reality life adaptation course. Combined with the characteristics of virtual reality, the implementation suggestions and matters needing attention are put forward. The results showed that, in the recognition of human facial expressions, 51 experts thought it was appropriate, 3 experts thought it needed to be modified, and no expert thought it was inappropriate. On the topic of crossing the road, 46 experts thought it was appropriate, eight thought it needed to be modified, and no expert thought it was inappropriate. On the theme of taking public transportation, 48 experts thought it was appropriate, 6 experts thought it needed to be modified, and no expert thought it was inappropriate. For the three major topics of how to get lost, shopping, and job interview, 2-3 experts put forward different opinions and think that the topic is not appropriate mainly because the grade arrangement is not appropriate. Conclusion. The VR-based curriculum for school life adaptation has been reviewed by experts and revised by researchers. It is scientific, interesting, and operable, solves the teaching problems of life adaptation teachers, and provides a safe, reliable, and effective practice channel for students.