This paper aims to develop a smart multiphysics approach for wind turbine design utilizing Industry 5.0. A new blade profile is developed and optimized by non-dominated sorting genetic algorithm II (NSGA-II) for shape design, and a 3D modeling of wind turbines is proposed. The aerodynamic modeling of a horizontal axis wind turbine (HAWT) is an important step in the design of wind turbines. The blade geometry design plays an important role in a wind turbine to maximize the aerodynamic performance and extract as much kinetic energy as possible from the wind resource. This paper addresses a high-level design and optimization for the parameters of a new blade. Moreover, a 3D modeling of large wind turbines (>7 MW) is proposed that can be used in wind farms. This approach can be used in real-time design in Industry 5.0 using different data from sensors. Finally, the optimized blade increases the produced power by 10% (from 7.5 MW to 8.2 MW). The proposed approach allows people to work alongside machinery to improve processes and provide personalization for companies manufacturing wind turbines.