Various factors controlling health care in any country, but still there is a weakness in the infrastructure of health care systems in some developing countries, including many Arab countries, due to the shortage of medical specialists personnel, global economic crisis, and wars and disasters that struck many countries. A crying need for a tele-medical care becomes a necessity, and in order to overcoming this weakness we have proposed a multi-agent intelligent Telemedicine system in this research. The proposed system can help solve the shortage of specialists urgently and at lower costs. Furthermore, it can save the efforts of the patients' expensive travel for treatment abroad. Moreover, it can avoid infections from social closeness in times of disasters and pandemics.
 Nowadays Telemedicine systems have gradually become a popular medical model which have always attracted much attention due to the continuous development of the multi-agents' structure and capabilities of the artificial intelligence systems. So we will focus in the prototype design of our system on the algorithms, techniques and devices that support the multi-agents' structure and AI technologies. The Multi-agent approach happens to be a suitable structure for the development of Telemedicine systems. Worth mentioning it can solve problems that are difficult or impossible for an individual agent or a monolithic system, and the AI capabilities will minimize human errors and improve health care outcomes.
 We will start by a state-of-the-art literature survey as conducted on the E-health system architecture, AI capabilities, and multi-agent platform, and then we will illustrate prototype design of the suggested Multi-agent intelligent system for Telemedicine which will contribute in the development of the health care systems in the developing countries.
 Keywords: Healthcare system; Medical System; Artificial Intelligence; Multi-Agent, Telemedicine; Telehealth.