This study aimed to address the challenges of micro-hydropower generation in low-head environments to expand the proportion of hydropower in renewable energy and achieve a carbon neutrality policy. To achieve these goals, various factors affecting the micro-hydro systems, including geographical constraints, construction costs, and grid connectivity, were reviewed and assessed. The results concluded that a novel type of cross-flow turbine with inverted structures, improved the economic feasibility, productivity, and installability of micro-hydropower plants by reducing head losses in open channels or small streams. The parametric studies consisted of four steps: first, designing the initial inverted cross-flow turbine based on the traditional design rules; for the second and third steps, a parametric study for comparing the runner diameter ratio and the number of blades is conducted; and in the last step optimized turbine was designed. The best efficiency point of the optimized inverted cross-flow turbine was 72.92 % at a runner rotational speed of 170 RPM with a 0.75 runner diameter ratio and 35 blades. The optimized turbine was improved by 7.8 % in power and 7.35 % in efficiency, higher than the initial turbine. From the hill chart comparison between the initial and optimized turbine, operation range expansion was confirmed. Overall, this research demonstrates the potential of the inverted cross-flow turbine under low-head conditions.