According to the topology optimization theory and engineering application, a launcher bracket topology optimization finite element model was built, which was based on the multi-body dynamics simulation. The optimal material distribution and the force transmission path of the bracket under the constraint conditions were obtained. The stiffness evaluation standard for bracket structure is established by introducing the specific stiffness structural effectiveness. After comparative and analysis, the simulation results show that the topology optimization design of launcher bracket based on multi-body dynamics can achieve the lightweight design of launcher bracket, strengthen structure stiffness, increase the bracket modal frequency, which are helpful to reduce the initial disturbance of missile launching. The method provides reference for the design of similar products.