Box Design Research Articles

Green Extraction of Antioxidant Flavonoids from Pigeon Pea (Cajanus cajan (L.) Millsp.) Seeds and Its Antioxidant Potentials Using Ultrasound-Assisted Methodology.

Pigeon pea is an important pea species in the Fabaceae family that has long been used for food, cosmetic, and other phytopharmaceutical applications. Its seed is reported as a rich source of antioxidants and anti-inflammatory flavonoids, especially isoflavones, i.e., cajanin, cajanol, daidzein, and genistein. In today’s era of green chemistry and green cosmetic development, the development and optimization of extraction techniques is increasing employed by the industrial sectors to provide environmentally friendly products for their customers. Surprisingly, there is no research report on improving the extraction of these isoflavonoids from pigeon pea seeds. In this present study, ultrasound-assisted extraction (USAE) methodology, which is a green extraction that provides a shorter extraction time and consumes less solvent, was optimized and compared with the conventional methods. The multivariate strategy, the Behnken–Box design (BBD) combined with response surface methodology, was employed to determine the best extraction conditions for this USAE utilizing ethanol as green solvent. Not only in vitro but also cellular antioxidant activities were evaluated using different assays and approaches. The results indicated that USAE provided a substantial gain of ca 70% in the (iso)flavonoids extracted and the biological antioxidant activities were preserved, compared to the conventional method. The best extraction conditions were 39.19 min with a frequency of 29.96 kHz and 63.81% (v/v) aqueous ethanol. Both the antioxidant and anti-aging potentials of the extract were obtained under optimal USAE at a cellular level using yeast as a model, resulting in lower levels of malondialdehyde. These results demonstrated that the extract can act as an effective activator of the cell longevity protein (SIR2/SIRT1) and cell membrane protector against oxidative stress. This finding supports the potential of pigeon pea seeds and USAE methodology to gain potential antioxidant and anti-aging (iso)flavonoids-rich sources for the cosmetic and phytopharmaceutical sectors.

Selection of Sustainable Materials for Energy Savings of Infrastructure-Transportation Project in Ahmedabad, India Using BIM and FCM

This study aims to develop a methodology for the selection of sustainable building materials for the reduction of embodied and operational energy for a complex infrastructure transportation project, i.e., elevated metro rail station of Ahmedabad, India by application of building information modelling (BIM) and factor comparison method (FCM). Evaluation of the alternative building materials and designs to obtain the best energy efficiency has been carried out using Revit Architecture 2018 and Green Building Studio. The achieved average embodied energy savings is about 73%, which is by the suggested alternative materials instead of existing ones. By application of FCM, which is a multi-criteria decision making (MCDM) technique, it has been observed that the polished Kota-stone flooring, stone-floor tile cladding, toughened fibre-glass ceiling and insulated fibre-glass door appear to be the most feasible sustainable material for flooring, wall cladding, ceiling, openings and fenestrations for the design of the metro rail station box in Ahmedabad, India. This study contributes significant knowledge in the field by highlighting the application of BIM as a tool for sustainable development and recommends a few alternate building materials and sustainable designs which would result in the reduction of energy usage for the metro-rail-station and other building structures leading to a sustainable future.

Designing a Smart Drug Box

It is evident that punctuality in taking medicine can be an issue and failure to take appropriate medication as prescribed by the physician on the proper time may lead to health complications. Management of medication is very important for acute illness and long-term health conditions. Smart Drug Box (SDB) connected through a mobile application installed on the patient smartphone can be used to remind the patient as per the prescription by the physician. The construction of the SDB is divided into three phases. The first phase is the box design using Computer Aided-Design (CAD), the second phase is the software design, and the last phase is printing the box. The prototype of our SDB is designed with a miniaturized size and a user friendly-interface. The SDB prototype weighs 350 grams when empty without any medication. This SDB meets the needs of the market in terms of integrating electronic technology and network functionality and can be used by patients at their homes or by nursing facilities. Using the SDB will not only significantly reduce the chances of errors but also enhance and speed up the caretaker follow-up by letting the SDB to take care of medicine management. The proposed SDB is simple to use, affordable and, has high accuracy. The main purpose of this is to improve health care and patient’s overall health condition by giving scheduled reminders, therefore, ensuring patient adherence to the treatment plan in terms of dose time and quantity.

Constructing differentially 4-uniform involutions over [formula omitted] by using Carlitz form

Differentially 4-uniform involutions on F22k play important roles in the design of substitution boxes (S-boxes). Despite the active researches on differentially 4-uniform permutation, there is not so much research on differentially 4-uniform involutions, especially over the field F2n with 4|n. In this paper, we introduce a new approach to construct differentially 4-uniform involutions by using Carlitz form. With this approach, we explicitly construct two new classes of differentially 4-uniform involutions over F2n with 4|n. We also show that our constructions have high nonlinearity and optimal algebraic degree. With the help of computer, we show that our constructions are CCZ-inequivalent to the known differentially 4-uniform involutions over F28.

Hanoman Obong sebagai Ide Kreatif Penciptaan Night Light Shadow Box

Puppet is a culture of the Indonesian nation. Puppet stories originally developed during the Javanese Hindu era. Pewayangan has been appointed as a masterpiece of world culture by UNESCO on 7 November 2003 or the Masterpiece of Oral and Intangible Heritage of Humanity. One of the familiar characters in puppet stories is Hanoman. However, nowadays people, especially teenagers who call themselves millennials, are less interested in puppet stories. To introduce traditional culture to society and millennial adolescents as the younger generation, breakthroughs or new innovative ways are needed, one of which is media that is popular among young people, namely by making a room decoration lamp called the Night Light Shadow Box. The research method used is descriptive qualitative research methods. The research begins by exploring the Hanoman figure. Furthermore, developing the results of observations that have been made through the product design of the Night Light Shadow Box so as to produce creative products that are in accordance with the interests of the community and millennial youth. The purpose of this research is (1) to create creative products with Hanoman local content vision that can compete with foreign products. (2) can foster understanding and love of the community towards the local culture of the archipelago.

Design and Thermal Analysis of Temperature Control Experiment Box for Final Optic Assembly

The Final Optic Assembly (FOA) is one of the key components of the inertial confinement nuclear fusion device. The temperature change in the FOA is related to the laser frequency conversion efficiency of the frequency doubling crystal. In order to research the temperature control of FOA, this paper considers the internal atmosphere and internal structure of FOA, designed and fabricated a vacuum temperature control experiment box, and set up heat sources inside the box to simulate the internal heating of the FOA. This article uses different radiation heat transfer models to analysis the temperature field of the vacuum experiment box. Compare the thermal simulation results of the S2S model and the DO model, and compare them with the actual temperature of the vacuum experiment box under the same boundary conditions. The results show that the S2S model fits well with the experimental results and is more suitable for thermal analysis of FOA, which is of great significance to the follow-up FOA temperature control research.

Analysis of Pre-Stressed Box Girder Bridge under Different Standard Codes: A Comparative Study

Pre-stressed concrete bridge analysis is completely dependent on the standards and design criteria. Herein, the current study compares like a pre-stressed concrete bridge under the effect of two different loading standards and specifications. The two different loading standards considered herein are IRC 6: 2000 and AASHTO-LRFD standards. Further, the pre-stressed box girder bridge is modelled and analysis in MIDAS CIVIL. On carrying out analysis, the primary structural analysis parameters which are important for the design of structure, are studied. These parameters are shear force, bending moment and torsion in the bridge elements along its length. It became observed that AASHTO standards are uneconomical than IRC standards, due to consideration of heavy weight vehicle load moving on the bridge span. Thus, it might be said that pre-stressed box girder bridge analysis and design should be carried out effectively and optimistically using IRC standards and specifications.

A Box to Put the Baby in: UK Parent Perceptions of Two Baby Box Programmes Promoted for Infant Sleep.

Between 2016 and 2019, two different infant sleeping-box interventions were implemented in England: (1) shallow polypropylene baby boxes were distributed via a feasibility study to families with Sudden Infant Death Syndrome (SIDS) risk factors; and (2) a commercial–health system partnership scheme distributed cardboard baby boxes to new mothers in particular locations. We conducted parent evaluations of both interventions at the time of implementation. The views of 79 parents receiving polypropylene boxes and 77 parents receiving cardboard boxes were captured using online questionnaires and telephone interviews. Participants provided feedback on education received about using the box, their perception of the box design and materials, their experiences of using the box they received, and whether they would recommend it to others. Parents appreciated that both boxes provided a portable space to place their baby near them anywhere in the home, discouraging other riskier practices. The polypropylene box was rated more favourably regarding transparency, hygiene, and portability outside the home. A minority of parents found the idea of putting their baby in any box unappealing; however, younger mothers and smokers particularly appreciated the ability to safely co-sleep with their babies using the shallower box. Overall, the versatility of the polypropylene box scheme was more positively evaluated than the cardboard baby box scheme, which, stripped of its social value as part of a larger welfare provision, had minimal value for parents that received it.

Distant calibration of low-cost PM and NO2 sensors; evidence from multiple sensor testbeds

Air quality improved significantly over the past decades. Nevertheless, air pollution continuous to have significant health impacts worldwide. To better assess people's exposure to air pollution, there is a need for higher, more personalized monitoring granularity. IoT sensor technologies can meet these requirements and pave the way towards more fine-grained air quality monitoring, improving our understanding while creating a higher public awareness driving behavioural change. This work tested the validity of scalable PM and NO2 calibration algorithms on various types of sensors (SDS011, OPC-N3, SPS30, NO2-A43F) in five different sensor testbeds deployed at various locations in Belgium and the Netherlands. The calibration models account for sensor gain and offset, while compensating for observed sensitivities of low-cost optical and electrochemical sensors. The calibration improves sensor data considerably (accuracy, linearity and correlation) up to sensitizing and supplementary (EU Class 1) categories at hourly and daily resolutions. Thanks to its cloud implementation and openly available input data, this calibration can be provided “as a service” on top of existing sensor networks in any city, on any sensor. Although distant calibration approaches improve sensor data, the ultimate performance will still depend on the applied sensor type, unit (design of sensor box) and granularity of the available reference monitoring network.

Lunch Box Innovation Product Design In The Millennial Era

Almost of kids in the world still bring a lunch box and a bottle of water in their bag when their go to school. His mother always prepares a lunch box complete with a bottle of drinking water, hoping that his son can enjoy his favorite lunch and avoid starvation. Sometimes the mother is very worried when the lunch box has been brought by the child but the water bottle is left behind. Then the mother was willing to take her child's water bottle to her school. This is certainly not expected by either the mother or the child. As a form of concern for the author to this problem, the author proposes a lunch box design with a lunch box lid that also functions as a drinking water bottle. The idea of this design proposal is ones grab, both are food & drink in your hand. The goal is how to make a kids can grab their food and drink easily and practice. So it is proposed to modify a top cover of common foodpack to become a drink bag. The design process begins with analyzing market needs, making sketches, creating 3D design models using the Autodesk Inventor CAD application, material selection, and product evaluation.

Development and optimization of TPGS-based stealth liposome of doxorubicin using Box–Behnken design: characterization, hemocompatibility, and cytotoxicity evaluation in breast cancer cells

The present work reports the development of doxorubicin (DOX) encapsulated α-tocopherol polyethylene glycol 1000 succinate (TPGS)-coated liposomal system (DOX-LIPO-TPGS) by quality by design (QbD) approach and evaluated for its anticancer and hemocompatibility potential. The screening and optimization of formulation variables were performed by the systematic design of experiments (DoE), using Taguchi and Box–Behnken design (BBD) for their desired quality attributes. The QbD optimized DOX-LIPO (DOX encapsulated uncoated liposome) and DOX-LIPO-TPGS formulation showed nano-metric vesicle size (98.2 ± 3.1 and 117.6 ± 3.5 nm) with favourable development parameters, i.e. PDI (0.262 ± 0.008 and 0.123 ± 0.005); ZP (−38.7 ± 0.5 and −36.4 ± 0.7 mV) and % EE (66.8 ± 3.3 and 73.5 ± 3.5%) respectively. The release kinetics parameters suggested, sustained release behaviour of developed liposomal formulations (83.6 ± 2.8 and 69.8 ± 2.2% releases in 72 h, respectively). Cytotoxicity (MTT assay) on the MCF-7 breast cancer cell line and haemolysis assay on RBCs stipulates comparatively higher anticancer potential and better hemocompatibility of DOX-LIPO-TPGS with respect to DOX-LIPO and the plain DOX solution. The study concluded that the QbD based three levels by three factors BBD optimization could be utilized for obtaining liposomal formulations with desired quality attributes. TPGS could be set out as a vital additive to improve the various quality parameters including stealthing character, stability, kinetic release, cytotoxicity, and hemocompatibility of liposomal formulations. This may serve as a focal paradigm for using TPGS-coated liposomes as anticancer drug delivery vehicle in normal and MDR carcinoma.

The suitability of a glovebox and of a covered still air box design for semi-sterile applications in environmental monitoring

Laminar flow cabinets (LFCs) ensure a safe working space within which product manipulation can be carried out safely excluding contaminations of the product with the environmental microorganisms. However, for environmental monitoring applications mobile laboratories are required and these prefer the lighter gloveboxes (GB; restricted arm movement) or still air boxes (SAB; free arm movement) over the heavier, more expensive LFCs, which need to be regularly maintained. Nevertheless, the efficiency of simple GBs/SABs (no HEPA filter), in providing semi-sterile working conditions has yet to be clearly defined. Consequently, our aim was to assess the suitability of GBs/SABs for semi-sterile applications by using passive and active bioaerosol sample collection procedures within the interior spaces of these boxes. Prior to sample collection the boxes were pre-treated with different spraying preparations (70% ethanol, 2% detergent or sterile water). For a greater restriction of bioaerosol entry, SABs were constructed with covered arm ports and these were classified as partially covered (SABPC) and completely covered SABs (SABCC). Results showed that ethanol sprayed GB and SABCC exhibited microbial aerosol colony counts of zero after one hour of passive sample collection, and active sample collection revealed counts ranging between 1.9 (for GB) - 2.3 Log10CFU/m3 (for SABCC). However, ethanol sprayed SAB and SABPC were ineffective having colony counts of 6.9 and 6.5 Log10CFU/m3, respectively. Other spraying regimes resulted in even higher colony counts (up to 7.3 Log10CFU/m3). Therefore, the ethanol sprayed GB and SABCC could effectively be used for semi-sterile applications, with the SABCC allowing for an unrestricted arm movement within it.

Crashworthiness design of crash box filled with negative Poisson's ratio based on horn structure

In order to improve the crashworthiness of the crash box, the cattle horn is selected as a bionic object. A crash box filled with negative Poisson's ratio honeycomb based on horn structure was designed by extracting its excellent structural characteristics of impact resistance. The axial deformation modes and energy absorption characteristics of bionic crash box are investigated by means of finite element method, and compared with square crash box, diagonal crash box and side-to-side crash box. Under axial impact, the horn-bionic crash box shows significantly better load-carrying and energy-absorbing capacity than the square crash box and the diagonal crash box. On this basis, the thickness parameters, multi-objective optimization design and structure improvement design of horn-bionic crash box are studied successively in this work. The results show that the improved bionic crash box based on horn structure has a typical progressive shrinkage deformation mode. Its SEA reaches 29.9 kJ/kg, which is 2.5 times that of the square crash box, and its PCF is also greatly reduced from 542.4 kN to 391.1 kN. Therefore, the methods of structural improvement such as pre-deformed treatment, constraint beam adjustment and shortening the NPR core can effectively reduce the PCF of the crash box, and improve its energy absorption capacity, so as to obtain better comprehensive crashworthiness. Introducing the key characteristics of the horn structure into the design of the car crash box can effectively improve structural crashworthiness and provide new design guidance for the other energy-absorption components of vehicle.

Optimization of Glycerol Treatment for Improved Flexibility of Dried Bacterial Cellulose Nonwoven Fabric

ABSTRACT Drying of bacterial cellulose nonwoven alters its structural properties due to the collapse of its three-dimensional structure. The dried bacterial cellulose is stiffer, less flexible, brittle and cannot be used as a material for apparel. To improve these properties, this research is aimed to plasticize the bacterial cellulose nonwoven using glycerol. Statistical optimization with Box and Behnken design is performed using major influencing process parameters, such as percentage of glycerol concentration, immersion time, and drying temperature. The glycerol treatment process is optimized against textile properties like thickness, crease recovery, bending length, tensile strength, and elongation. results show that an increment in the glycerol concentration and treatment time reduces the tensile strength and increases the thickness and elongation. Bending length and crease recovery angle reduce with longer treatment time. Lower temperature drying showed positive effects of desirable properties. The statistical optimization process identified 1% of glycerol concentration, 30°C drying temperature, and 33 h of immersion time as an optimum parameter with 84% desirability. The moisture management results indicated that the glycerol treatment converted the waterproof fabric into a fast-absorbing fabric with slow drying. However, the fabrics showed a poor one-way moisture transport capacity.

The voltage sag of coal mine power supply and its influence on the reliability of safety monitoring system

Through the investigation and test of the interference of AC power supply in coal mine, it is found that when the high-power equipment is started or stopped, the obvious voltage drop phenomenon is often caused on the power network, which affects the reliable work of the safety monitoring system connected to the power network. This paper tests the situation of voltage drop on site, and analyzes and verifies the influence of this kind of voltage drop on the stable operation of the monitoring system. When the voltage drops, the equipment may restart, which seriously threatens the normal production safety. Finally, in order to ensure the safe and stable operation of the monitoring system, this paper puts forward some suggestions on the design of uninterrupted power box.

Size- and Time-Dependent Aerosol Removal from a Protective Box during Simulated Intubation and Extubation Procedures

Because the SARS-CoV-2 virus primarily spreads through droplets and aerosols, a protective box could provide adequate protection by shielding medical professionals during the intubation and extubation procedures from generated droplets and aerosols. In this study, size- and time-dependent aerosol concentrations were measured inside and outside the protective box in the particle size ranging from 14 nm to 20 μm during simulated intubation and extubation procedures. An improved protective box with active ventilation was designed based on a plastic bag with armholes covered with latex sheets that utilizes a supportive frame. Coughing during the intubation and extubation procedure was simulated using an aerosol generator which dispersed the aerosol powder into the protective box. During the intubation and extubation procedure, the concentration of particles increased inside the protective box but, due to the high negative airflow, quickly dropped to background levels. The particle concentration of all measured particle sizes decreased within the same time frame. No leakage of particles was observed through the armhole openings. The presented protective box design provides excellent protection against generated droplets and aerosols. The decrease in concentration does not depend on the particle size. Outside the box, particle concentration did not change with time.

Analysis of Key Technologies in the Design of Small and Medium Span Basket Type Steel Box Tied Arch Bridge

In order to ensure the construction quality and safety of small and medium span basket type steel box tied arch bridge, this paper takes a practical project as an example to analyze the key technologies in its design process. It is hoped that this analysis can provide corresponding reference for the design and construction of this kind of arch bridge.

Intubation Ergonomics and Effectiveness using Aerosol Box

The pandemic COVID-19 has caused a rupture and disturbance in many ecosystems, especially in healthcare. Although previously patients were treated and given first-hand treatment especially during life threatening event, currently, the safety of healthcare workers have also become the utmost priority. Due to the nature of COVID-19 virus that is able to spread easily via respiratory droplets and aerosols, using mouth and eyes as the route of entry, healthcare workers need to protect themselves while saving the patients at the same time. Therefore, the most common lifesaving procedure at accident and emergency department was chosen, i.e. the intubation procedure. The aerosol box is introduced and used widely during the intubation procedure, especially in accident and emergency department. The study has three objectives. First, to determine whether the aerosol box can provide protection to its users, secondly to suggest an improvement based on the current design of the aerosol box and thirdly to determine the risk of musculoskeletal injuries among healthcare workers using Rapid Entire Body Assessment (REBA). In this study, direct observation was made during the assessment before suggesting the required recommendation on how to improve the existing aerosol box. The first objective was achieved by conducting a direct observation when participants were conducting the intubation procedure. Any possibility of participants getting exposed to the risk of COVID-19 due to the failure of the box in guarding, was noted by the observer. Recommendation for improvement was made based on these findings, and served the second objective of the study. To achieve the third objective, ergonomics assessment using Rapid Entire Body Assessment (REBA) was conducted. REBA scores represent the severity of musculoskeletal risk imposed to healthcare workers during intubation procedure. Two participants took part in the study voluntarily. Results showed that the aerosol box used in this study does not protect healthcare workers from COVID-19. The current design of aerosol box used must be improvised in order to increase its effectiveness. As for body postures, REBA scores were between medium and high, thus it required immediate corrective actions. With modification, the aerosol box may better protect healthcare workers from being exposed to the COVID-19 virus.

Modeling of a continuous physical vapor deposition process: Mass transfer limitations by evaporation rate and sonic choking

• Novel evaporation boundary condition is proposed to consider Hertz-Knudsen limitation. • A comprehensive numerical model for continuous PVD processes in OpenFoam is presented. • Non-isentropic losses reduce discharge; this effect decreases with melt temperature. • The isentropic overestimate is 110%–150%, that of the new CFD model only 30%. • Numerical model predictions are relatively insensitive to unknown process parameters. In recent years, Physical Vapor Deposition has been advanced to a continuous process which makes it amenable for in-line, high-quality and energy-efficient galvanization. To achieve the high and uniform mass flow required for in-line production, a Vapor Distribution Box is used, in which the zinc is evaporated. The zinc fills the Vapor Distribution Box at a relatively high pressure and leaves into the coating chamber via nozzles. A reliable modeling approach that can be used in the design and optimization of Vapor Distribution Boxes is as yet not available in the literature. The present paper analyses which phenomena play a major role and therefore have to be included in a simulation model of continuous Physical Vapor Deposition processes, and identifies process parameters which have a significant impact on deposition rate and uniformity. To this end, a model for the flow and heat transfer is developed based on the numerical solution of the compressible Navier–Stokes-Fourier equations in combination with the Launder and Sharma low-Reynolds k- ∊ turbulence model, using the open-source CFD-library OpenFOAM. To account for the vapor mass flow to be limited by both evaporation and sonic choking, a novel inlet boundary condition is proposed based on the Hertz-Knudsen condition. Results from the CFD model are compared to those of analytical models based on isentropic flow, the influence of various modeling parameters is evaluated against experiments, and sensitivity of the process to various process parameters studied. The proposed numerical model predicts mass flow rates with a much better accuracy than analytical models previously proposed in the literature. The latter overpredict the mass flow rate by a factor of 2.1–2.5, whereas the proposed numerical model overpredicts only by a factor of 1.3. Next to the novel Hertz-Knudsen boundary condition, the inclusion of viscous effects is found to be crucial to achieve this improvement, since viscous effects – especially in the boundary layer inside the nozzles – severely reduce the mass flow. The numerical model is shown to be only weakly sensitive to uncertainties in the evaporation coefficients and metal vapor viscosity. For the device studied, the mass flow discharge efficiency was found to be relatively low ( ≈ 40 % ). To increase this efficiency, viscous losses in the nozzle boundary layers have to be reduced, for instance by employing shorter or a bigger radius nozzles (possibly impairing nozzle-to-nozzle uniformity) or by employing a higher melt temperature and vapor pressure.

Shaking Table Test on the Tunnel Dynamic Response under Different Fault Dip Angles

Fault-crossing tunnels are often severely damaged under seismic dynamics. Study of the dynamic response characteristics of tunnels crossing faults is thus of great engineering significance. Here, the Xianglushan Tunnel of the Central Yunnan Water Diversion Project was studied. A shaking table experimental device was used, and four sets of dynamic model tests of deep-buried tunnels with different fault inclination angles were conducted. Test schemes of model similarity ratio, similar material selection, model box design, and sine wave loading were introduced. The acceleration and strain data of the tunnel lining were monitored. Analysis of the acceleration data showed that when the input PGA was 0.6 g, compared with the ordinary tunnel, the acceleration increases by 117% when the inclination angle was 75°, 127% when the inclination angle was 45°, and 144% when the inclination angle was 30°. This indicates that the dynamic response of the cross-fault tunnel structure was stronger than that of the ordinary tunnel, and the effect was more obvious as the fault dip angle decreased. Analysis of the strain data showed that the strain response of the fault-crossing tunnels was more sensitive to the fault dip. The peak strain and increase in fault-crossing tunnels were much larger than those of ordinary tunnels, and smaller fault dips led to larger increases in the strain peak; consequently, the tunnel would reach the ultimate strain and break down when the input PGA was smaller. Generally, the influence of fault inclination on the dynamic response of the tunnel lining should receive increased consideration in the seismic design of tunnels.