Efficiently organizing indoor airflow is crucial for optimizing the working environment in large-scale wall construction projects, particularly when constructing liquefied natural gas membrane tanks. This helps prevent membrane corrosion, optimize construction time, and mitigate future safety risks. However, due to their size, these tanks often experience air stratification, posing challenges in meeting simultaneous temperature, humidity, and uniformity requirements during construction. To effectively address this issue, this study developed Computational Fluid Dynamics models that numerically simulated three commonly used ventilation systems: displacement ventilation system, stratified ventilation system, and fabric duct air supply system. Laboratory experiments were conducted to validate the accuracy of numerical simulation. Additionally, response surface methodology (RSM) was used to determine optimal combinations of air supply parameters for superior environmental uniformity control. The findings indicate that the fabric air supply system is more suitable than displacement and stratified ventilation systems for achieving environmental uniformity control in large spaces. It can limit wall temperature nonuniformity coefficient up to 9 % during summer and provide better uniformity in air velocity during winter conditions. Moreover, under summer conditions, the optimal range for air supply speed is between 9.62 m/s - 11.22 m/s with temperatures ranging from 16 °C to 19 °C, while under winter conditions, the optimal range is between 18.3 m/s −19.3 m/s with temperatures ranging from 33.0 °C to 35.0 °C.The optimal design of the ventilation system is advantageous for various building construction scenarios with stringent temperature and humidity requirements, particularly for large-scale buildings.