The main results of a numerical investigation into the effects of interface condition on the critical response and predicted performance of flexible pavements with granular bases are presented. In addition, the influence of using linear elastic and non-linear elastic models for granular base characterization, on the design life of typical road structures with granular bases under various combinations of layer interface conditions is examined. Repeated load triaxial tests are carried out and non-linear regression analyses on tests results are performed to determine the constitutive model parameters. The Asphalt Institute distress models for fatigue cracking and rutting using both linear and non-linear analyses are utilized to estimate the pavement design life. It is shown, among others, that interface condition affects significantly the critical response of pavement structures and hence their predicted performance. Furthermore, the results indicate that the use of linear assumption to characterize granular base and sub-base behaviour, grossly over-estimates the design life of pavement structures. This effect strongly depends on interface conditions used between the pavements layers.