Due to the multi-hierarchy,multi-attribute process of product design,the key technology of knowledge reuse in product design based on axiomatic design was studied.With the axiomatic design framework,the design process was decomposed,and the Z map of the requirement domain,functional domain,structure domain,process domain of the product design was put forward.Then,a case-based knowledge reuse method with overall consideration of inter-domanin and intra-domain design information was presented,which adopted the similarity-based retrieving in knowledge reuse algorithm,and got the best reuse objects.Finally,a case was provided to validate and prove the efficiency and feasibility of the method.